Category: 2944-49-2

Adding a certain compound to certain chemical reactions, such as: 2944-49-2, name is 1-Methoxy-2,3-dimethylbenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2944-49-2, HPLC of Formula: C9H12O

A mixture of 2,3-dimethylanisole (50g, 0.37 mol), CU2, 1 sulfate pentahydrate (90 g, 0.36 mol), and potassium peroxydisulfate (301 g, 1.11 mol) in acetonitrile/water (1: 1,2. 6 L) was stirred vigorously and heated to reflux for 30 minutes. Thin layer chromatography (Hexane: EtOAc, 8: 2) showed no starting material and one new spot. The reaction was cooled to room temperature and extracted with CH2CL2 (4L) and washed with water (2L). The layers were separated and the aqueous layer was again extracted with CH2CL2. The organic layers were combined and concentrated, 55 g obtained (-100%), product was taken on as is. H-NMR (DMSO-D6) : 10.05 (s, 1H), 7.78 (m, 1H), 6.95 (m, 1H), 6.88 (s, 1H), 3.84 (s, 3H), 2.6 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methoxy-2,3-dimethylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ELI LILLY AND COMPANY; WO2004/63155; (2004); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2944-49-2, name is 1-Methoxy-2,3-dimethylbenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 2944-49-2

Carbon tetrachloride (100 ml) will be 3 – methoxy ortho-xylene crude product dilution dissolved, added to the mixed liquid in the N – bromo succinimide (NBS, 34.0 g, 190.4 mmol) and 2,2′-azobisisobutyronitrile (AIBN, 0.30 g), after mixing the heated to 77 C stirring reflux 24 h. TLC detection reaction has been substantially completely, cooling stop stirring, filtering the reaction solution, saturated sodium bisulfite solution for fragrance (50 ml × 2) washing twice, static layering, the collection of organic phase, the organic phase dried with anhydrous sodium sulfate 12 h. Filtering, environment friendly with silica gel column chromatography, eluting agent is pure petroleum ether, to obtain white solid 7.70 g, yield 69.2%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shandong University; Ma Shutao; Jin Chaobin; Wang Yinhu; Gu Xinjie; (32 pag.)CN108929260; (2018); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 2944-49-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2944-49-2 name is 1-Methoxy-2,3-dimethylbenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of the above crude product (2) (3.5g) in tetrachloromethane (C4Cl4) (100mL) at room temperature were added N-bromosuccinimide (NBS) (34.0g, 190.4mmol) and 2,2′-azobis(2-methylpropionitrile) (AIBN) (0.3g). The resulting reaction mixture was allowed to stir under reflux for 24h. After reaction completion, the reaction mixture was filtered and washed using the saturated NaHSO4 solution to remove the residual bromine. The organic layer was dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The residue was purified by flash chromatography to give a white solid (7.70 g, 72.4% in the two-step yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methoxy-2,3-dimethylbenzene, and friends who are interested can also refer to it.

Reference:
Article; Jin, Chaobin; Alenazy, Rawaf; Wang, Yinhu; Mowla, Rumana; Qin, Yinhui; Tan, Jin Quan Eugene; Modi, Natansh Deepak; Gu, Xinjie; Polyak, Steven W.; Venter, Henrietta; Ma, Shutao; Bioorganic and Medicinal Chemistry Letters; vol. 29; 7; (2019); p. 882 – 889;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 2944-49-2,Some common heterocyclic compound, 2944-49-2, name is 1-Methoxy-2,3-dimethylbenzene, molecular formula is C9H12O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 2,3-dimethylanisole (10.00 g, 73.4 mmol) in acetonitrile (500 ml) was added to a mixture of copper(II) sulphate pentahydrate (18.14 g, 72.7 mmol) and potassium peroxodisulphate (59.81 g, 0.22 mol) in water (700 ml) and heated for 30 min at reflux. After cooling, water (100 ml) and dichloromethane (150 ml) were added and the phases were separated. The aqueous phase was extracted with dichloromethane (2×200 ml). The combined organic phases were dried over anhydrous sodium sulphate, filtered and concentrated on a rotary evaporator. 4:1 n-heptane/ ethyl acetate (200 ml) was added to the brown oil and this was filtered over silica gel. The filtrate was concentrated on a rotary evaporator. 4.63 g (30.8 mmol; 42%) of a gradually crystallizing yellowish oil was obtained.1H-NMR (CDCl3, 400 MHz): delta=10.63 (s, 1H; HC?O), 7.37 (t, 1H; J=8.0 Hz; Ar-H), 6.80 (m, 2H; Ar-H), 3.88 (s, 3H; O-CH3), 2.56 (s, 3H; Ar-CH3).13C-NMR (CDCl3, 100.6 MHz): delta=192.2 (C?O), 163.0 (Ar-C), 141.9 (Ar-C), 134.4 (Ar-CH), 123.9 (Ar-CH), 123.1 (Ar-C), 108.9 (Ar-CH), 55.6 (O-CH3), 21.4 (CH3).

The synthetic route of 2944-49-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ivoclar Vivadent AG; Moszner, Norbert; Hendrik, John; Lamparth, Iris; Barner-Kowollik, Christopher; Krappitz, Tim; Feist, Fiorian; (14 pag.)US2020/79888; (2020); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2944-49-2, name is 1-Methoxy-2,3-dimethylbenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 2944-49-2

(0464) 1-Methoxy-2,3-dimethylbenzene (13.6 g, 100 mmol), NBS (39.2 g, 220 mmol) and benzoperoxide (242 mg, 1 mmol) were dissolved in carbon tetrachloride (200 mL). The mixture was heated to 90 C. and reacted for 12 h. After the reaction, the mixture was cooled to room temperature, and filtrated. The filtrate was concentrated to get the title compound as a crude product (30 g).

The synthetic route of 2944-49-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Xuanzhu Pharma Co., Ltd.; WU, Frank; (117 pag.)US2017/112833; (2017); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2944-49-2, name is 1-Methoxy-2,3-dimethylbenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 2944-49-2

(0464) 1-Methoxy-2,3-dimethylbenzene (13.6 g, 100 mmol), NBS (39.2 g, 220 mmol) and benzoperoxide (242 mg, 1 mmol) were dissolved in carbon tetrachloride (200 mL). The mixture was heated to 90 C. and reacted for 12 h. After the reaction, the mixture was cooled to room temperature, and filtrated. The filtrate was concentrated to get the title compound as a crude product (30 g).

The synthetic route of 2944-49-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Xuanzhu Pharma Co., Ltd.; WU, Frank; (117 pag.)US2017/112833; (2017); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem