Category: 2944-47-0

Yi, Wen-Bin published the artcileFriedel-Crafts alkylation in fluorous biphasic system catalyzed by rare earth(III) perfluorooctanesulfonate, Recommanded Product: 2-Isopropylanisole, the publication is Yingyong Huaxue (2006), 23(2), 212-214, database is CAplus.

Rare earth (III) perfluorooctanesulfonate salts (catalysts) were prepared and used in Friedel-Crafts alkylation in fluorous biphasic systems. Perfluorohexane, perfluoromethylcyclohexane, perfluorotoluene, perfluorooctane, perfluorooctyl bromide and perfluorodecalin can be used as the fluorous solvent for this kind of reaction. The catalytic activities of other rare earth metal salts with different ligands were tested. The results show that Yb(OSO₂C₈F₁₇)₃ [1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-1-octanesulfonic acid ytterbium(3+) salt], ,and C₁₀F₁₈ were the best catalyst and fluorous solvent resp. The yield of alkylation of anisole with benzyl alc. was 96% in the presence of Yb(OSO₂C₈F₁₇)₃ and C₁₀F₁₈. By simple phase-separation the fluorous phase containing only catalyst could be re-utilized up to five times with a slight decrease in activity.

Yingyong Huaxue published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C18H26ClN3O, Recommanded Product: 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Secinti, Hatice published the artcileTotal Syntheses of Multicaulins via Oxidative Photocyclization of Stilbenes, Application In Synthesis of 2944-47-0, the publication is Journal of Natural Products (2014), 77(9), 2134-2137, database is CAplus and MEDLINE.

The Wittig reaction of 3-isopropyl-4-methoxybenzaldehyde and 2,3-dimethylbenzylphosphonium bromide afforded the corresponding stilbene mixture I. Oxidative photocyclization of stilbene I with iodine facilitated the first total synthesis of 7-isopropyl-6-methoxy-1,2-dimethylphenanthrene, multicaulin (II). The O-demethylation of II with BBr₃ afforded the 7-isopropyl-1,2-dimethylphenanthren-6-ol, O-demethylmulticaulin (III).

Journal of Natural Products published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C16H10O5, Application In Synthesis of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yi, Wen-Bin published the artcileRare earth(III) perfluorooctanesulfonates catalyzed Friedel-Crafts alkylation in fluorous biphase system, Application of 2-Isopropylanisole, the publication is Journal of Fluorine Chemistry (2005), 126(5), 831-833, database is CAplus.

The catalyst of rare earth(III) perfluorooctanesulfonates (RE(OSO₂C₈F₁₇)₃, RE = Sc, Y, La-Lu) were prepared from either rare earth(III) chlorides or oxides and perfluorooctanesulfonic acid. The perflates thus obtained act as novel catalysts for Friedel-Crafts alkylation in fluorous biphasic system. Perfluorohexane (C₆F₁₄), perfluoromethylcyclohexane (C₇F₁₄), perfluorotoluene (C₇F₈), perfluorooctane (C₈F₁₈), perfluorooctyl bromide (C₈F₁₇Br), and perfluorodecalin (C₁₀F₁₈, cis- and trans-mixture) can be used as fluorous solvents for this reaction. By simple separation of the fluorous phase containing only catalyst, alkylation can be repeated many times.

Journal of Fluorine Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C3H8N2S, Application of 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Burnell, Robert H. published the artcileApproach to the synthesis of candelabrone and synthesis of 3,7-diketo-12-hydroxyabieta-8,11,13-triene., Product Details of C10H14O, the publication is Canadian Journal of Chemistry (1992), 70(5), 1446-54, database is CAplus.

An approach to the synthesis of aromatic diterpenes was tested for its generality. Phenylacetonitriles with increasing substitution on the aromatic ring were prepared and alkylated with geranyl bromide and the resulting dienes, e.g. I, subjected to cationic cyclization. The less-substituted examples afforded tricyclic products of the required stereochem., e.g. II, while the more highly substituted compounds cyclized with reduced yields or not at all. One of the intermediates III was used to synthesize nimosone IV, a natural diterpene isolated originally from Chamaecyparis formosensis and recently from Azadirachta indica.

Canadian Journal of Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Product Details of C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Burnell, Robert H. published the artcileSynthesis of aromatic diterpenes. Synthesis of 12-hydroxyabieta-8,11,13-triene-3,7-dione, Recommanded Product: 2-Isopropylanisole, the publication is Synthetic Communications (1991), 21(1), 127-32, database is CAplus.

Model studies involving cationic cyclization. of suitable dienes have provided a synthesis of the title compound (I). Preparation of the dienes from available aromatic starting materials and the modification of the cyclized products are described. Thus, nitrile II in MeNO₂ was treated with PhSMe and BF₃ to give III, which was converted to I in 4 steps.

Synthetic Communications published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Recommanded Product: 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Royer, Rene published the artcileReactions induced by pyridine hydrochloride. VI. Comparison of the sensitivities to dealkylation by pyridine hydrochloride of alkyl ethers of phenols according to their structures, Safety of 2-Isopropylanisole, the publication is Bulletin de la Societe Chimique de France (1970), 3647-50, database is CAplus.

Increasing the dealkylation temperature of β-naphthyl alkyl ethers or the demethylation temperature of mono- or disubstituted anisoles with pyridinium hydrochloride decreases the effect of steric factors. The demethylation rates and product yields at 155° decreased in the order: PhOMe > o-MeC6H4OMe > o-EtC6H4OMe > o-BuC6H4-OMe; at reflux temperature the demethylation rates of these compounds were similar. The steric factors (proximity, branching of the substituents) are counterbalanced by the inductive effects and to some extent by the symmetry of the ethers. The dealkylation conditions must be optimized for each ether sep.

Bulletin de la Societe Chimique de France published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Safety of 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Royer, Rene published the artcileReactioons induced by pyridine hydrochloride. IX. Possible uses of pyridine hydrochloride analogs for the dealkylation of phenolic ethers, COA of Formula: C10H14O, the publication is Bulletin de la Societe Chimique de France (1971), 4362-7, database is CAplus.

Pyridine hydrobromide (I) gave higher dealkylation yields of 2-alkoxynaphthalenes than pyridine hydrochloride (II), although temperatures >250° had to be used instead of ∼220°. The 2-naphthol yield from 2-isobutoxynaphthalene was 91% with I, compared with 11% for II. I also gave higher dealkylation yields of substituted anisoles, except those with large substituents next to the methoxy group. Thus for 2,6-diisopropylanisole demethylation was accompanied by isopropyl cleavage. PhNH2.HCl was less efficient than II as a dealkylating agent. 2,4-Lutidine hydrochloride was too sublimable to be used, but 3- and 4-picoline hydrochlorides were effective replacements for II. 2-Picoline retained too much H2O to be useful. Et2NH.HCl, BuNH2.HCl, and iso-BuNH2.HCl were less efficient dealkylating agents than II.

Bulletin de la Societe Chimique de France published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, COA of Formula: C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Han, Chong published the artcileNegishi Coupling of Secondary Alkylzinc Halides with Aryl Bromides and Chlorides, Recommanded Product: 2-Isopropylanisole, the publication is Journal of the American Chemical Society (2009), 131(22), 7532-7533, database is CAplus and MEDLINE.

An efficient palladium-catalyzed process has been developed for Negishi coupling of secondary alkylzinc halides with a wide range of aryl bromides and activated aryl chlorides. A palladium catalyst composed of a new biaryldialkylphosphine ligand, CPhos, effectively promotes the rate of the reductive elimination step relative to the rate of the undesired β-hydride elimination. The broad substrate scope and excellent ratio of the desired secondary to the undesired primary coupling product make this method a powerful and reliable tool for C(sp³)-C(sp²) bond formation.

Journal of the American Chemical Society published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Recommanded Product: 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ghosal, Manuka published the artcileTotal synthesis of (±)-shonanyl methyl ether and (±)-ferruginyl methyl ether, Related Products of ethers-buliding-blocks, the publication is Tetrahedron Letters (1989), 30(26), 3469-70, database is CAplus.

An efficient reductive methylation of the tricyclic ketone I in anhydrous NH₃ provided the β,γ-unsaturated ketone II in high yield which was subsequently converted into (±)-shonanyl Me ether (III) and (±)-ferruginyl Me ether (IV).

Tetrahedron Letters published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bhattacharyya, A. C. published the artcileGas chromatography of monohydric phenols via O-methylation, Related Products of ethers-buliding-blocks, the publication is Analytical Chemistry (1968), 40(12), 1873-6, database is CAplus.

Monohydric phenols were determined by gas chromatog., after conventional O-methylation, on an 8% Apiezon L/celite column at 140° or a 10% Apiezon L/celite column at 180°. N carrier gas and a flame ionization detector were used. The aryl Me ether was chromatographed as a 0.2-μl. aliquot of a concentrated Et2O solution The procedure gave quant. etherification of 34 phenols. A 8-component synthetic mixture of phenols was analyzed, using the column at 140° [component, weight % present (as phenol), weight % found (as phenol), given]: 3-methylanisole, 13.87, 13.39; 2,6-dimethylanisole, 6.53, 7.38; 2,5-dimethylanisole, 11.84, 11.80; 3,5-dimethylanisole, 23.70, 23.60; 2,4,6-trimethylanisole, 8.62, 9.58; 2-methyl-4-ethylanisole, 9.63, 8.36; 4-tert-butylanisole and 2,3,5-trimethylanisole, 22.07, 22.35; 2,3,4-trimethylanisole, 3.74, 3.54. The anal. was applied to distillates of tar acids obtained from hydrogenation experiments of Assam coal and from a com. high-temperature carbonization plant.

Analytical Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem