Category: 2944-47-0

Anthis, Jeffrey W. published the artcileA New Route to Chelating Bis(aryloxide) Ligands and Their Applications to Tantalum and Titanium Organometallic Compounds, Product Details of C10H14O, the publication is Inorganic Chemistry (2004), 43(2), 716-724, database is CAplus and MEDLINE.

A new route to sterically tuned, chelating bis(aryloxide) ligands is described and demonstrated by the synthesis of 2,2′-ethylenebis(6-isopropylphenol) (1, H₂BIPP) and transition metal complexes of its dianion. The utility of these ligands in titanium and tantalum organometallic chem. is shown in the alkylation of (BIPP)TiCl₂ (7) to form (BIPP)TiMe₂ (8) and (BIPP)Ti(CH₂Ph)₂ (9) and in the alkylation of (BIPP)TaCl₃ (10) and its base adducts to form (BIPP)TaMe₃ (14) and (BIPP)Ta(CH₂Ph)₃ (13). Structural comparisons of the chelating 2,2′-ethylenebis(6-isopropylphenoxide) (BIPP) ligand with its analogous, nonchelating bis(2,6-dialkylaryloxide) ligand set are examined in the x-ray diffraction studies of (BIPP)TaCl₃(THF)·THF and (BIPP)Ta(CH₂C₆H₅)₃.

Inorganic Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Product Details of C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Dreher, Spencer D. published the artcileEfficient Cross-Coupling of Secondary Alkyltrifluoroborates with Aryl Chlorides – Reaction Discovery Using Parallel Microscale Experimentation, Recommanded Product: 2-Isopropylanisole, the publication is Journal of the American Chemical Society (2008), 130(29), 9257-9259, database is CAplus and MEDLINE.

Microscale parallel experimentation was used to discover three catalyst systems capable of coupling secondary organotrifluoroborates with sterically and electronically demanding aryl chlorides and bromides. The ensuing results represent the first comprehensive study of alkylboron coupling to aryl chlorides and, in particular, using secondary alkylboron partners. A ligand-dependent β-hydride elimination/reinsertion mechanism was implicated in the cross-coupling of more hindered substrates, leading to isomeric mixtures of coupled products in some cases.

Journal of the American Chemical Society published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Recommanded Product: 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Paquette, Leo A. published the artcileSynthesis of optically active triazolinediones and examination of their utility for inducing asymmetry in Diels-Alder cycloaddition reactions, Application In Synthesis of 2944-47-0, the publication is Journal of Organic Chemistry (1980), 45(25), 5105-13, database is CAplus.

Optically active triazolinedione derivatives of (-)-PhCHMeNH₂, (+)-dehydroabietylamine acetate, and (+)-camphor, I–III, resp., were prepared and their ability to discriminate between diastereomeric transition states in their Diels-Alder reactions with racemic and optically active p-mentha-2,4-diene and α-phellandrene was studied. In each case plotting the [α]_D of the adduct from the diene of known optical purity and that of the adduct from the racemic dienes vs. diastereomeric purity served to delineate the enantioselectivity and the absolute configuration of the adducts. The triazolinedione derivatives are also useful for nondestructive resolution of compounds

Journal of Organic Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Application In Synthesis of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Burkholder, Timothy P. published the artcileDesign and synthesis of a novel series of [1-(4-hydroxy-benzyl)-1H-indol-5-yloxy]-acetic acid compounds as potent, selective, thyroid hormone receptor β agonists, Product Details of C10H14O, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(7), 1377-1380, database is CAplus and MEDLINE.

The design, synthesis, and structure activity relationships for a series of indoles, e.g., I, as potent, selective, thyroid hormone receptor β (TRβ) agonists is described. Compounds with >50× binding selectivity for TRβ over TRα were generated and evaluation of compound I from this series in a model of dyslipidemia demonstrated pos. effects on plasma lipid endpoints in vivo.

Bioorganic & Medicinal Chemistry Letters published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Product Details of C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Loubinoux, B. published the artcileSelective demethylation of aryl methyl ethers, Formula: C10H14O, the publication is Synthesis (1980), 638-40, database is CAplus.

Title ethers RC₆H₄OMe (R = 3-Me, 4-Me, 2-Me₂CH, 2-MeO, 3-MeO, 4-MeO) were treated with PhMeNNa in the presence of (Me₂N)₃PO to give 80-95% RC₆H₄OH. Monodealkylation of Me ethers of polyhydric phenols, e. g., 1,3,5-trimethoxybenzene and the dimethoxybenzene isomers, was easily achieved. Both Me and benzyl ethers were cleaved but methyl ethers were cleaved more easily.

Synthesis published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Formula: C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Spadafora, Natasha D. published the artcileA complex interaction between pre-harvest and post-harvest factors determines fresh-cut melon quality and aroma, COA of Formula: C10H14O, the publication is Scientific Reports (2019), 9(1), 1-15, database is CAplus and MEDLINE.

Melons are prized for their characteristic aroma, however, pre-harvest growth, stage of ripening at harvest, post-harvest processing and storage conditions lead to quality changes in fresh-cut fruit. We considered changes in metabolites and gene expression over 14 days storage to assess underlying mechanisms and identify potential quality markers. Overall, 99 volatile organic compounds (VOCs) were detected and VOC profiles discriminated between two melon seasons, cut-size, storage temperatures and storage time, although season affected their discriminatory power. Abundance of two VOCs fell rapidly and was not associated with cut size, indicating their use as markers for early changes post-processing. Non-acetate to acetate ester ratio differed between the seasons and correlated with changes in alc. acyl-transferase (CmAAT1) gene expression. Furthermore, CmAAT1 expression clustered with two ester VOCs that may be potential new products of this enzyme. Season also strongly affected post-harvest sugar content, most likely attributable to meteorol. differences during growth. Storage temperature and cut size affected expression of transcription factors ERF71, ERF106, and TINY, whose expression generally rose during storage, probably related to increased stress. Thus, although time × temperature of storage are key factors, pre-harvest conditions and fruit processing impact significantly gene expression and aroma loss post-harvest.

Scientific Reports published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C9H9NO, COA of Formula: C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chang, Hson Mou published the artcileCompounds from Danshen. Part 4. Structure-activity relationship of miltirone, an active central benzodiazepine receptor ligand isolated from Salvia miltiorrhiza Bunge (Danshen), Related Products of ethers-buliding-blocks, the publication is Journal of Medicinal Chemistry (1991), 34(5), 1675-92, database is CAplus and MEDLINE.

Twenty-one o-quinonoid-type compounds, e.g. I–VI and one coumarin-type compound related to miltirone (VII) were synthesized for identification of the key structural elements involved in the reaction of VII with the central benzodiazepine receptor. Based on their inhibition of [³H]flunitrazepam binding to bovine cerebral cortex membranes, it was apparent that ring A of VII is essential for affinity. Although increasing the size of ring A from 6-membered to 7- and 8-membered is well-tolerated, the introduction of polar hydroxyl groups greatly reduces binding affinity. The presence of 1,1-di-Me groups on ring A is, however, not essential, but the iso-Pr group on ring C appears to be critical for binding as its removal decreases affinity by more than 30-fold. Its replacement with an Me group causes only a minimal reduction in affinity. Linking ring A and B with an -CH₂CH₂– bridge results in analog VIII which is 6 times more potent than VII at the central benzodiazepine receptor (IC₅₀ = 0.05 μM).

Journal of Medicinal Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chang, Hson Mou published the artcileStructure elucidation and total synthesis of new tanshinones isolated from Salvia miltiorrhiza Bunge (Danshen), HPLC of Formula: 2944-47-0, the publication is Journal of Organic Chemistry (1990), 55(11), 3537-43, database is CAplus.

Eleven new compounds were isolated from the dried root of Salvia miltiorrhiza Bunge “Danshen”, and their structures were elucidated by spectrometric methods. The total syntheses of 2 new compounds namely, 1,2-didehydromiltirone (I) and 4-methylenemiltirone (II) are also reported.

Journal of Organic Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, HPLC of Formula: 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Chengxi published the artcileEfficient Synthesis of Sterically Hindered Arenes Bearing Acyclic Secondary Alkyl Groups by Suzuki-Miyaura Cross-Couplings, Application In Synthesis of 2944-47-0, the publication is Angewandte Chemie, International Edition (2015), 54(12), 3792-3796, database is CAplus and MEDLINE.

Bulky P,P:O ligands I (R = H, OMe, NMe₂) were designed and synthesized to inhibit isomerization and reduction side reactions during the cross coupling between sterically hindered aryl halides and alkylboronic acids. Suzuki-Miyaura cross-couplings between di-ortho-substituted aryl bromides and acyclic secondary alkylboronic acids using one of these ligands were achieved with high yields. The method also enabled the preparation of ortho-alkoxy/di-ortho-substituted arenes bearing iso-Pr groups in excellent yields. The utility of the synthetic method was demonstrated in a late-stage modification of estrone and in the application to a new synthetic route towards gossypol.

Angewandte Chemie, International Edition published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Application In Synthesis of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Webster-Gardiner, Michael S. published the artcileCatalytic Synthesis of “Super” Linear Alkenyl Arenes Using an Easily Prepared Rh(I) Catalyst, Synthetic Route of 2944-47-0, the publication is Journal of the American Chemical Society (2017), 139(15), 5474-5480, database is CAplus and MEDLINE.

Linear alkyl benzenes (LAB) are global chems. that are produced by acid-catalyzed reactions that involve the formation of carbocationic intermediates. One outcome of the acid-based catalysis is that 1-phenylalkanes cannot be produced. Herein, it is reported that [Rh(μ-OAc)(η²-C₂H₄)₂]₂ catalyzes production of 1-Ph substituted alkene products via oxidative arene vinylation. Since C=C bonds can be used for many chem. transformations, the formation of unsaturated products provides a potential advantage over current processes that produce saturated alkyl arenes. Conditions that provide up to a 10:1 linear:branched ratio have been achieved, and catalytic turnovers >1470 have been demonstrated. In addition, electron-deficient and electron-rich substituted benzenes are successfully alkylated. The Rh catalysis provides ortho:meta:para selectivity that is opposite to traditional acid-based catalysis.

Journal of the American Chemical Society published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C5H5NO3S, Synthetic Route of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem