Category: 2944-47-0

Seong, Chaehyeon published the artcileTotal Synthesis of 1-Oxomiltirone and Arucadiol, COA of Formula: C10H14O, the publication is Synlett (2020), 31(19), 1953-1956, database is CAplus.

A practical and efficient approach for the total synthesis of arucadiol (I) and 1-oxomiltirone (II) is reported. The key step, which involves an intramol. [4+2] cycloaddition catalyzed by gold(III) bromide or copper(II) triflate, leads to the formation of 6-6-6-fused aromatic abietane core.

Synlett published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C6H10F3NO, COA of Formula: C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Pandiarajan, Karuppiah published the artcileMultinuclear magnetic resonance spectroscopic and semiempirical molecular orbital (AM1) studies of substituted anisoles, Formula: C10H14O, the publication is Bulletin of the Chemical Society of Japan (1994), 67(10), 2639-46, database is CAplus.

¹³C, ¹⁵N, and ¹⁷O NMR spectra have been recorded for 4-nitroanisole , its 2-methyl-, 2-chloro-, 2-bromo-, 2-iodo-, 2,6-dimethyl-, 2,6-dichloro-, 2,6-dibromo-, and 2,6-diiodo-derivatives, also nitrobenzene , its 3-methyl-, 3-chloro-, 3-bromo-, and 3-iodo-derivatives and 3,5-dichloro- and 3,5-dibromo-derivatives Anal. of the chem. shifts of carbon bearing nitro group and nitro oxygens in these compounds suggests that presence of one substituent ortho- to the methoxyl group enhances its resonance interaction with the benzene ring whereas presence of two ortho-substituents inhibits this resonance. However, in no case the resonance is completely inhibited. The extent of enhancement or inhibition is almost independent of the nature of the ortho-substituent. This conclusion has also been arrived by analyzing the reported chem. shifts of the para-carbons in 2,6-disubstituted and 2-substituted anisoles and the corresponding carbons in m-disubstituted benzenes. Though evidence could not be obtained for steric enhancement of resonance using methoxyl oxygen chem shifts, anal. of these chem. shifts in di-ortho-substituted anisoles and 3,5-dimethylnitrobenzene furnishes evidence for steric inhibition of resonance. However, ¹⁵N chem. shifts are of no use in studying these phenomena. Semiempirical MO calcns using AM1 Hamiltonian suggest that the methoxyl group is coplanar with the benzene ring in anisole, 4-nitroanisole and 2-substituted-4-nitroanisoles but is perpendicular to the benzene ring in 2,6-disubstituted-4-nitroanisoles. Moreover, in 2-substituted-4-nitroanisoles the O-Me group is anti to the 2-substituent.

Bulletin of the Chemical Society of Japan published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Formula: C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Guo, Ying published the artcileA ligand-free, powerful, and practical method for methoxylation of unactivated aryl bromides by use of the CuCl/HCOOMe/MeONa/MeOH system, Category: ethers-buliding-blocks, the publication is Research on Chemical Intermediates (2015), 41(11), 8651-8664, database is CAplus.

A ligand-free, powerful, and practical method for mono and polymethoxylation of unactivated aryl bromides has been developed; CuCl was used as catalyst, HCOOMe as cocatalyst, and methanolic MeONa as both nucleophile and solvent. This eco-friendly procedure is characterized by operational simplicity, inexpensive substrates (unactivated mono to polybromoarenes), full conversion, and direct recovery of pure MeOH.

Research on Chemical Intermediates published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Choi, Won-Sik published the artcileSynthesis and antifungal activities of isopropylphenyl derivatives, Quality Control of 2944-47-0, the publication is Han’guk Eungyong Sangmyong Hwahakhoeji (2007), 50(3), 178-186, database is CAplus.

42 Compounds such as ester, sulfonyl ester, phosphoryl ester and ether derivatives of 4-isopropylphenol and 2-isopropylphenol were synthesized. These derivatives were identified by IR, GC/MS and ¹H-NMR spectra. Their in vitro antifungal activities were tested against 10 plant pathogenic fungi. Among them, several compounds showed potent in vitro antifungal activity. The selected compounds showing potent in vitro antifungal activity were tested for their in vivo antifungal activities against 5 plant diseases such as rice blast, rice sheath blast, cucumber anthracnose, cucumber gray mold and tomato late blight. As a result, 2-isopropylphenyl piperonylate (I) showed a potent in vivo antifungal activity against cucumber anthracnose and tomato late blight, 4-isopropylphenyl 4-methoxybenzenesulfonate (II) effectively inhibited the development of rice blast.

Han’guk Eungyong Sangmyong Hwahakhoeji published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Quality Control of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zawadiak, Jan published the artcileThe liquid-phase oxidation of isomeric methoxy-(1-methylethyl)benzenes with oxygen to the hydroperoxides, Computed Properties of 2944-47-0, the publication is International Journal of Chemical Kinetics (2004), 37(1), 10-16, database is CAplus.

The kinetics of liquid-phase oxidation of 1-methoxy-2-(1-methylethyl)benzene (1a), 1-methoxy-3-(1-methylethyl)benzene (1b), and 1-methoxy-4-(1-methylethyl)benzene (1c) with oxygen as oxidant to yield the corresponding 1-methyl-1-(2-methoxyphenyl)ethyl (2a), 1-methyl-1-(3-methoxyphenyl)ethyl (2b), and 1-methyl-1-(4-methoxyphenyl)ethyl (2c) hydroperoxides was studied. The oxidizabilities of 1a, 1b, and 1c were established over the temperature range 50-120°C. The overall activation energies of oxidation were determined for 1b and 1c over the temperature range 50-120°C. Thermal stability of 2a and 2b and the initiating properties of hydroperoxides 2a, 2b, and 2c were studied. Long-term noncatalytic oxidations of 1b and 1c to resp. hydroperoxides were carried out.

International Journal of Chemical Kinetics published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C6H8O6, Computed Properties of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kitamura, Seiya published the artcileRational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa, Safety of 2-Isopropylanisole, the publication is Journal of Medicinal Chemistry (2016), 59(10), 4790-4799, database is CAplus and MEDLINE.

The virulence factor cystic fibrosis transmembrane conductance regulator (CFTR) inhibitory factor (Cif) is secreted by Pseudomonas aeruginosa and is the founding member of a distinct class of epoxide hydrolases (EHs) that triggers the catalysis-dependent degradation of the CFTR. We describe here the development of a series of potent and selective Cif inhibitors by structure-based drug design. Initial screening revealed 1a (KB2115), a thyroid hormone analog, as a lead compound with low micromolar potency. Structural requirements for potency were systematically probed, and interactions between Cif and 1a were characterized by X-ray crystallog. On the basis of these data, new compounds were designed to yield addnl. hydrogen bonding with residues of the Cif active site. From this effort, three compounds were identified that are 10-fold more potent toward Cif than our first-generation inhibitors and have no detectable thyroid hormone-like activity. These inhibitors will be useful tools to study the pathol. role of Cif and have the potential for clin. application.

Journal of Medicinal Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Safety of 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Fan, Ju-di published the artcileAnalysis on the chemical compounds of essential oil from Centipeda minima in Guizhou by simultaneous distillation and extraction method, Synthetic Route of 2944-47-0, the publication is Anhui Nongye Kexue (2009), 37(15), 6986-6987, 6991, database is CAplus.

The objective of this study was to explore the chem. composition of essential oil from Centipeda min. (L) A.Br.et Aschers in Guizhou and provide the basis for its further exploitation and utilization. The essential oil of C. min. was extracted by simultaneous distillation and extraction and analyzed by gas chromatog.-mass spectrometry. The relative contents of each component in the essential oil were obtained by normalization of peak areas. Results show that 55 compositions were identified which added up to96.45% in the essential oil. It was concluded that the main compositions of essential oil from C. min. were trans-chrysanthenyl acetate (62.46%) and beta-bisabolene(4.69%), thymol (3.88%),verbenol(3.03%), 1,1,5,6,6,9,9-heptamethyl-10-methylene-spiro[2.7]dec-4-ene and carvacrol(2.57%).

Anhui Nongye Kexue published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Synthetic Route of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Brieger, Gottfried published the artcileConvenient O-alkylation of phenols, Recommanded Product: 2-Isopropylanisole, the publication is Journal of Chemical and Engineering Data (1968), 13(4), 581-2, database is CAplus.

The preparation of several aryl-methyl ethers by refluxing excess MeI with the corresponding phenols is described. HCONMe2 was the solvent used, and anhydrous K2CO3 was the base. Yields for several phenols are given.

Journal of Chemical and Engineering Data published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Recommanded Product: 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Barcelo, Gerard published the artcilePentaalkylguanidines as etherification and esterification catalysts, Formula: C10H14O, the publication is Tetrahedron (1990), 46(6), 1839-48, database is CAplus.

Several pentaalkylguanidines were prepared and found to be superior catalysts for the preparation of aryl and aralkyl ethers from carbonates and for the methylation of phenols with Me₂CO₃. They also act as effective catalysts for esterification of acids with alkyl chloroformates but not for the acetylation of tertiary alcs. with Ac₂O.

Tetrahedron published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Formula: C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Pompeo, Matthew published the artcilePd-PEPPSI-IPent^Cl: A Highly Effective Catalyst for the Selective Cross-Coupling of Secondary Organozinc Reagents, Safety of 2-Isopropylanisole, the publication is Angewandte Chemie, International Edition (2012), 51(45), 11354-11357, database is CAplus and MEDLINE.

A series of Pd-PEPPSI complexes with various substitution pattern on the heterocyclic carbene backbone were designed, prepared and studied as catalysts in Negishi cross-coupling reactions of aryl and heteroaryl halides or triflates with secondary organozinc nucleophiles. In all the cases, the selectivity for the normal, non-rearranged products was observed Computational studies revealed that the relative barrier difference between reductive elimination and β-hydride elimination correlate well with observed selectivities. The best results were shown by the Pd-PEPPSI-IPent^cl complex which demonstrated unprecedented selectivity leading to virtually one (desired) isomer for reactions of a wide selection of alkylzincs and highly functionalized (hetero)aromatic halides and triflates.

Angewandte Chemie, International Edition published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Safety of 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem