Category: 2944-47-0

Fu, Xiangkai published the artcilePerfluorooctanesulfonic acid catalyzed Friedel-Crafts alkylation with olefins in gas-liquid phase, Application In Synthesis of 2944-47-0, the publication is Chinese Chemical Letters (1993), 4(4), 307-10, database is CAplus.

Solid superacid perfluorooctanesulfonic acid (POSA) catalyzed Friedel-Crafts alkylation of aromatic hydrocarbons with olefins in gas-liquid phase. The alkylations gave good yields with simple operation and easy work up. The amount of the catalyst used in the reactions was small and could be reused. The optimum temperature of the reactions and the effect of the amount of the catalyst used in the reactions are also discussed.

Chinese Chemical Letters published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Application In Synthesis of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sardashti, A. R. published the artcileChemical composition of the essential oil of A. kermanensis from Taftan area by GC/MS technique, Product Details of C10H14O, the publication is International Journal of Agriculture and Crop Sciences (2012), 4(9), 561-563, 3 pp., database is CAplus.

The aerial parts of A. Kermanensis were subjected to hydro distillation by a Clevenger-type apparatus to produce an oil in 1.87% weight/weight yield. It was then analyzed by GC/MS. Identification of the compounds was carried out by comparison of their mass spectra with those of authentic sample together with the relative retention indexes. 37 Components were identified representing 97.04% of the oil. It contained mainly oxygenated monoterpenes (71.68%) with 1,8 cineole (56.55%), Borneol (5.28%) Geranyl perpionate (4.05%), camphor (4.48%), beta Thujone (2.84%), 4-Terpineol (2.77%) and unknown compound (2.94%) as the major constituents. The amount of Sesquiterpenes were representing (1.30% weight/weight) of the total oil. The results clearly showed the richness of oil in monoterpenes, which may be due to the collection of plant material during the flowering period.

International Journal of Agriculture and Crop Sciences published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Product Details of C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Jacquesy, Rose published the artcileIsomerization and oxidation of simple ketones in superacid medium, Related Products of ethers-buliding-blocks, the publication is Bulletin de la Societe Chimique de France (1978), 255-62, database is CAplus.

Treatment of cyclohexanones having a tertiary C α or β to the CO group, e.g., carvomenthone (I, R = Me, Z = O, Z¹ = H₂), menthone(I, R = Me, Z = H₂, Z¹ = O), I (R = H, Z = H₂ Z¹ =O) with HF-SbF₅ gave the isomerization, ring contraction, or dehydrogenation derivatives, e.g., II (R¹-R⁴ = Me, Et, Me, H; H, Me, H,CHMe₂), III, IV (R⁵-R⁸ = H, CH₂CHMe₂, H, Me; Me, CHMe₂, Me, H; H, Me H, CHMe₂ via protonation of the O whereas 3-methyl- and 3,3,5-trimethylcyclohexanone did not react with the acids. However, in cyclohexenones, dehydrogenation occurred only if the product was stable, e.g., V (R⁹ = H, R¹⁰ = CHMe₂) dehydrogenated with HF-SbF₅ to give the conjugated VI whereas with V (R⁹ = R¹⁰ = Me; R⁹ = H, R¹⁰ = Et) no dehydrogenation products were obtained.

Bulletin de la Societe Chimique de France published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ruan, Zheming published the artcileSubstituted diaryl ether compounds as retinoic acid-related orphan Receptor-γt (RORγt) agonists, SDS of cas: 2944-47-0, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 127778, database is CAplus and MEDLINE.

The discovery of a series of substituted diarylether compounds as retinoic acid related orphan receptor γt (RORγt) agonists is described. Compound 1 was identified from deck mining as a RORγt agonist. Hit-to-lead optimization led to the identification of lead compound 5, which possesses improved potency (10x). Extensive SAR exploration led to the identification of a potent and selective compound 22, that demonstrated an improved pharmacokinetic profile and a dose-dependent pharmacodynamic response. However, when dosed in a MC38 syngeneic tumor model, no evidence of efficacy was observed

Bioorganic & Medicinal Chemistry Letters published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, SDS of cas: 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wang, Xue Chao published the artcileA new method for synthesis of o-isopropyl substituted aromatic compounds, Application In Synthesis of 2944-47-0, the publication is Chinese Chemical Letters (1992), 3(5), 329-32, database is CAplus.

Heteroatom-directed aromatic lithiation reactions used for the regiospecific synthesis of o-iso-Pr substituted phenolic and benzyl alc. compounds are described. Thus, lithiation of, e.g., PhOMe or PhCH₂OH with BuLi in THF followed by treatment with Me₂CO gave alcs. which on dehydration with H₂SO₄ containing a catalytic amount of p-toluenesulfonic acid followed by hydrogenation over Raney Ni gave desired compounds, e.g., 76% 2-Me₂CHC₆H₄OMe and 61% 2-Me₂CHC₆H₄CH₂OH, resp.

Chinese Chemical Letters published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C42H63O3P, Application In Synthesis of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Schuster, Ingeborg I. published the artcileEnhancement of the resonance interaction of out-of-plane methoxy groups by ortho-substituents in crowded anisoles, COA of Formula: C10H14O, the publication is Journal of Organic Chemistry (1988), 53(25), 5819-25, database is CAplus.

The ¹⁷O and ¹³C NMR chem. shifts of substituted anisoles provide evidence that the resonance interaction of methoxy groups which are perpendicular to the aromatic ring in crowded anisoles is influenced, to varying degrees, by ortho substituents. Enhancement of methoxy-to-aryl electron delocalization, brought about by these groups, follows the order isopropyl < ethyl < methyl << methoxy (in-plane) < tert-Bu. By an anal. of the mol. structures of several 3,5-dialkylanisic acids, related to 2,6-dialkylanisoles, this order becomes explicable in terms of repulsions between the lone pair electrons of the methoxy oxygen and bonding electrons of the proximate substituents. Methoxy groups that lie in the mol. plane are not similarly affected by neighboring substituents.

Journal of Organic Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C24H12, COA of Formula: C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bompart, Jacques published the artcileSynthesis of new β-blocking analogs of bevantolol, SDS of cas: 2944-47-0, the publication is Annales Pharmaceutiques Francaises (1985), 42(6), 537-45, database is CAplus.

The 9 bevantolol analogs I (R¹ = OMe, Cl, OPh, SMe, CHMe₂; R² = OH, Cl, OMe, OPh, SMe, CHMe₂) were prepared None of the compounds showed activity comparable to that of propranolol when tested for inhibition of isoprenaline-induced tachycardia and hypotension in dogs.

Annales Pharmaceutiques Francaises published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, SDS of cas: 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Calimsiz, Selcuk published the artcileNegishi cross-coupling of secondary alkylzinc halides with aryl/heteroaryl halides using Pd-PEPPSI-IPent, Formula: C10H14O, the publication is Chemical Communications (Cambridge, United Kingdom) (2011), 47(18), 5181-5183, database is CAplus and MEDLINE.

Pd-PEPPSI-IPent has proven to be an excellent catalyst for the Negishi cross-coupling reaction of secondary alkylzinc reagents with a wide variety of aryl/heteroaryl halides. Importantly, β-hydride elimination/migratory insertion of the organometallic leading to the production of isomeric coupling products has been significantly reduced using the highly-hindered Ipent ligand.

Chemical Communications (Cambridge, United Kingdom) published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Formula: C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Olah, George A. published the artcileFriedel-Crafts alkylation of anisole and its comparison with toluene. Predominant ortho-para substitution under kinetic conditions and the effect of thermodynamic isomerizations, Recommanded Product: 2-Isopropylanisole, the publication is Journal of the American Chemical Society (1984), 106(18), 5284-90, database is CAplus.

The AlCl₃-, BF₃-, and 65% HPF₆-catalyzed Friedel-Crafts alkylation of anisole with alkyl halides and alcs. was examined The alkylation of anisole with lower catalyst concentrations under mild conditions shows predominant ortho/para directing effects hdgenerally with a ratio of ∼2:1, with the amount of meta isomer <3%. With swamping catalyst conditions the amount of meta substitution in methylation and ethylation can substantially increase. The isomer distribution in tert-butylation changes with time due to rapid ortho-para interconversion. Consequently, the AlCl₃-catalyzed isomerization of isomeric alkylanisoles was also studied. In case of tert-butylanisoles, the ortho isomer shows relatively rapid conversion into para followed by much slower isomerization to meta. The para and meta isomers show isomerization to meta-para mixtures Isomerization of ethyl-, isopropyl-, and benzylanisoles is generally slow whereas methylanisoles do not isomerize. Comparing the alkylation results of anisole with those of toluene indicates that the latter are readily affected by concurrent (and in some cases consecutive) isomerization. As the barrier for isomerization in the benzenium ion intermediates of the alkylations is higher in the case of MeO- than Me-substituted systems, anisole tends to give the kinetically controlled ortho-para alkylation products and the amount of meta isomer is low. Study of alkylation of 3,5-di- and 2,4,6-trideuteriated toluene and anisole and comparing retained D contents with isomer distributions shows that alkylated product formation in the case of toluene, but not of anisole, is preceded by intramol. 1,2-alkyl, and H-D shifting, resulting also in increased meta substitution. This effect is most predominant in methylation and ethylation where the alkyl shifts are intramol. but not in tert-butylation and benzylation, where alkyl transfer is intermol. Isopropylation is intermediate in nature. No simple selectivity-reactivity relation is indicated in the alkylation reactions. As shown in benzylations with increasingly electron-donating and -withdrawing substituted benzyl chlorides, the overall rate (i.e., substrate selectivity) and isomer distributions (i.e., regioselectivity) are not determined in the same step, as significantly decreased substrate selectivity is not accompanied by loss of positional selectivity. Previously reported alkylations showing a high degree of meta substitution, therefore, must have been affected by thermodynamically controlled rearrangement processes, including intramol. alkyl and H shifts in the arenium ion intermediates of the alkylation reactions. These are to be differentiated from possible subsequent product isomerizations. Under predominantly kinetic conditions anisole as well as toluene is substantially ortho-para directing in alkylations, as in other electrophilic aromatic substitutions.

Journal of the American Chemical Society published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Recommanded Product: 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chupka, E. I. published the artcileCalculation of electron structures of some guaiacylpropane series compounds using the MO-LCAO method, Product Details of C10H14O, the publication is Sovrem. Metody Issled. Khim. Lignina (1970), 52-7, database is CAplus.

Electron structure of guaiacylpropane compounds was studied for the Me groups by the simple Hueckel method with the use of a heteroatom model. Charges on atoms, bond orders, and free valence indexes are presented. The direction of electrophilic substitution for the systems and their comparative acidities were discussed.

Sovrem. Metody Issled. Khim. Lignina published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Product Details of C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem