Category: 2752-17-2

Reference of 2752-17-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2752-17-2, name is 2,2′-Oxydiethanamine, This compound has unique chemical properties. The synthetic route is as follows.

1-Hydroxypyrene-2-carbaldehyde 3 (100 mg, 0.41 mmol) wasdissolved in CH2Cl2 and 2,2′-oxybis (ethylamine) (0.02 mL,0.20 mmol) was added to the reaction mixture. The reactionmixture was stirred at RT for 12 h. The precipitate formed wasfiltered and washed with cold CH2Cl2 to give 2 as a yellow solid(176 mg, 76.6%). m.p. 200 C. 1H NMR (CDCl3, 250 MHz): delta 14.53(s, OH), 8.61 (s, 2H), 8.32 (d, J 9.10 Hz, 2H), 7.99-7.80 (m, 8H), 7.54(s, 2H), 7.35 (d, J 8.98 Hz, 2H), 3.91 (s, 8H). 13C NMR (CDCl3,62.5 MHz): delta 167.16, 156.66, 132.52, 132.18, 127.00, 127.12, 126.88,126.81, 126.66, 125.97, 124.77, 124.20, 123.90, 122.96, 121.49, 119.52,115.34, 69.91, 58.44, 30.92. HRMS (FAB) calcd for C38H29N2O3[M + H]+ 561.2100; found 561.2178.

The chemical industry reduces the impact on the environment during synthesis 2,2′-Oxydiethanamine. I believe this compound will play a more active role in future production and life.

Reference:
Article; Hu, Ying; Liu, Yifan; Kim, Gyoungmi; Jun, Eun Jin; Swamy; Kim, Youngmee; Kim, Sung-Jin; Yoon, Juyoung; Dyes and Pigments; vol. 113; (2015); p. 372 – 377;,
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Electric Literature of 2752-17-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2752-17-2 as follows.

Compounds 1 and 2 were prepared by the following procedure: 2-(4-chloro-3-nitrophenyl)-2-oxoethyl 2-aminobenzoate or 2-(4-amino-3-nitrophenyl)-2-oxoethyl 2-aminobenzoate (44.8 mmol) was suspended in polyphosphoric acid (167.3 g). The reaction mixture was heated to 100 C and stirred for 90 min. The mixture was then poured into H2O/crushed ice (700 ml). The precipitated product was filtered, washed with H2O, dried and recrystallized from 2-methoxyethanol. Compounds 3-17 were prepared by the following general procedure: quinolinone 1 (200 mg, 0.63 mmol) was added to a solution of amine (6.3 mmol) and N-methylpyrrolidone (1.0 ml) and the mixture was stirred at 110 C for 2 h. After cooling to room temperature, H2O (20 ml) was added and the pH adjusted to 7 with dilute HCl (1:3). The precipitated solid was collected by suction, washed thoroughly with H2O and dried at 80 C. The crude product was recrystallized from 2-methoxyethanol.

According to the analysis of related databases, 2752-17-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Motyka, Kamil; Hlava?, Jan; Soural, Miroslav; Hradil, Pavel; Krej?i, Petr; Kvapil, Lubomir; Weiss, Milo?; Tetrahedron Letters; vol. 52; 6; (2011); p. 715 – 717;,
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Electric Literature of 2752-17-2,Some common heterocyclic compound, 2752-17-2, name is 2,2′-Oxydiethanamine, molecular formula is C4H12N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The precursor quinoline tetramer acid (100 mg, 0.1 mmol, 2.05 equiv), HBTU (114 mg, 0.3 mmol, 3 equiv), and HOBt (27 mg, 0.2 mmol, 2 equiv) were dissolved in anhydrous DMF under nitrogen. DIEA (173 muL, 1 mmol, 10 equiv) was added and the reaction mixture was stirred at room temperature for 30 min. The diamine (1 equiv) was added and the reaction mixture was stirred at room temperature for 12 h. The reaction mixture was poured into water, extracted three times with toluene, dried over Na2SO4, filtered, and concentrated. The crude was purified by silica-gel chromatography eluting with toluene/ethyl acetate 90/10 v/v, yielding the expected compound as a yellow solid.

The synthetic route of 2752-17-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Delsuc, Nicolas; Poniman, Legiso; Leger, Jean-Michel; Huc, Ivan; Tetrahedron; vol. 68; 23; (2012); p. 4464 – 4469;,
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Electric Literature of 2752-17-2, These common heterocyclic compound, 2752-17-2, name is 2,2′-Oxydiethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: All macrocyclic compounds were obtained as previously described. 20,21 The corresponding diester (1-3) (10 mmol) and diamine (4-8) (10 mmol) were dissolved in MeOH (100 ml). The reaction mixture was stirred for 7 d at rt. After completion of the reaction (monitored by TLC), the solvent was evaporated and the residue was puriofied by chromatography on a silica gel column using 0-5% solutions of MeOH/CH2Cl2. Analytical and spectroscopic data are collected in the Supplementary Materials.

The synthetic route of 2752-17-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Pikus, Grzegorz; Pa?niczek, Ewa; Jurczak, Janusz; Arkivoc; vol. 2017; 2; (2017); p. 534 – 545;,
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Application of 2752-17-2, These common heterocyclic compound, 2752-17-2, name is 2,2′-Oxydiethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

H(5O,2)-CBZ; Several approaches were tried to synthesize the N,N,N’,N’-Tetrakis-(2-amino-ethyl)- 3-oxapentane- l ,5-diamine [H(5O,2)-amine]. It was found that the reaction of 5LIO-amine with CBZ-aziridine provides clean H(5O,2)-CBZ.; 5LIO-amine (0.21 g, 2 mmol) and CbZ-aziridine ( 1.77 g, 10 mmol) were mixed in tert- butanol (30 ml.) at room temperature under N2. The mixture was stirred under a N2 atmosphere at 8O0C for 16 hrs. when TLC showed the completeness of the reaction. The volatile were removed under vacuum and the residue was dissolved in dichloromethane. The appropriate fractions of a gradient flash silica gel column ( 1 -7% methanol in dicholoromethane) were collected and evaporated to dryness to give a pale beige thick oil, yield: 1.28 g, 79%.[0301] ‘ H NMR(300MHz, CDCl3): delta 2.53(s,br, 12H), 3.17(s,br, 4H), 3.83(s, br, 8H), 5.04(s, 8H), 7.29(s,br, 20H). 1 3C NMR (300MHz, CDCI3): delta 38.8, 53.0, 53.6, 69.3, 128.0, 128.1 , 128.4, 136.6, 156.4. MS(FAB+, DTT/DTE): 813.5 (MH+).

The synthetic route of 2752-17-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; WO2008/8797; (2008); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 2752-17-2, These common heterocyclic compound, 2752-17-2, name is 2,2′-Oxydiethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

H(5O,2)-CBZ; Several approaches were tried to synthesize the N,N,N’,N’-Tetrakis-(2-amino-ethyl)- 3-oxapentane- l ,5-diamine [H(5O,2)-amine]. It was found that the reaction of 5LIO-amine with CBZ-aziridine provides clean H(5O,2)-CBZ.; 5LIO-amine (0.21 g, 2 mmol) and CbZ-aziridine ( 1.77 g, 10 mmol) were mixed in tert- butanol (30 ml.) at room temperature under N2. The mixture was stirred under a N2 atmosphere at 8O0C for 16 hrs. when TLC showed the completeness of the reaction. The volatile were removed under vacuum and the residue was dissolved in dichloromethane. The appropriate fractions of a gradient flash silica gel column ( 1 -7% methanol in dicholoromethane) were collected and evaporated to dryness to give a pale beige thick oil, yield: 1.28 g, 79%.[0301] ‘ H NMR(300MHz, CDCl3): delta 2.53(s,br, 12H), 3.17(s,br, 4H), 3.83(s, br, 8H), 5.04(s, 8H), 7.29(s,br, 20H). 1 3C NMR (300MHz, CDCI3): delta 38.8, 53.0, 53.6, 69.3, 128.0, 128.1 , 128.4, 136.6, 156.4. MS(FAB+, DTT/DTE): 813.5 (MH+).

The synthetic route of 2752-17-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; WO2008/8797; (2008); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 2752-17-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2752-17-2, name is 2,2′-Oxydiethanamine, This compound has unique chemical properties. The synthetic route is as follows.

8-hydroxyjulolidine-9-carboxaldehyde0.91 g (4 mmol) was dissolved in 10 mL of ethanol,With two drops of hydrochloric acid2,2′-oxybis (ethylamine)0.22 mL (2 mmol) was slowly added to the solution. The mixture was stirred at room temperature for one day so that the mixed solution was well mixed. After the solvent was removed under reduced pressure, the crude product obtained was purified by column chromatography using a mixed solution of methylene chloride and methanol (MC: MeOH = 10: 1, v / v) to obtain 0.65 g of pure product. It was analyzed by 1 H-NMR, 13 C-NMR, ESI-MS, and EA to confirm that it had the structure of Formula 1, and the yield was 65%.

The chemical industry reduces the impact on the environment during synthesis 2,2′-Oxydiethanamine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Seoul National University of Science and TechnologyIndustry-AcademicCooperation Foundation; Kim, Chul; Song, Uhn Ju; Lee, Myung Mi; (17 pag.)KR2016/34631; (2016); A;,
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Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 2752-17-2, name is 2,2′-Oxydiethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2752-17-2, COA of Formula: C4H12N2O

Mixed nanosized TiO2-SiO2 oxide (0.27 g, 1.9 mmol) was added to a solution of acetoacetic ester (2) (3.75 g,28.8 mmol), 1,5-diamino-3-oxapentane (1a) (1.00 g, 9.6 mmol), and toluene (6 ml). The reaction mixture was stirred for 20 h at 90C. After the reaction was complete (TLC control, eluent 5:4:1 EtOAc-hexane-CHCl3), the nanosized oxide was separated by centrifugation, and toluene was removed by distillation. The obtained oil was purified by silica gel column chromatography, using CHCl3 as eluent, and dried under ambient conditions. Yield 2.33 g (74%), yellow oil. IR spectrum, nu, cm-1: 1141 (nuas, –Alk); 3291 (N-H); 1652,1505 (-O-N); 2930, 2978 (Alk-). 1H NMR spectrum,delta, ppm: 1.12-1.14 (6H, m, 2CH3); 1.90 (6H, s, 2CH3); 3.35-3.39 (4H, m, 2NCH2CH2); 3.51-3.55 (4H, m, 2NCH2CH2); 3.92-3.97 (4H, m, 232); 4.34-4.35 (2, m, 2); 8.59 (2H, s, 2NH). Found, %: 58.46; 8.43; N 8.69.16H28N2O5. Calculated, %: 58.51; 8.59; N 8.53.

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Reference:
Article; Radionova, Elena S.; Fedorova, Olga V.; Titova, Yulia A.; Rusinov, Gennady L.; Charushin, Valery N.; Chemistry of Heterocyclic Compounds; vol. 51; 5; (2015); p. 478 – 482; Khim. Geterotsikl. Soedin.; vol. 51; 5; (2015); p. 478 – 482,5;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2752-17-2 as follows. Product Details of 2752-17-2

5LlO-l,2-HOPOBn; To a solution of l ,2-HOPO(Bn)-thiazolide (644 mg, 2.1 mmol) in dry methylene chloride (20 mL), was added neat 5LIO-amine ( 104 mg, 1.0 mmol). The mixture was stirred overnight, after which time the solvent was removed and the residue was loaded onto a flash silica column. Elution with 2-6% methanol in methylene chloride allowed for the separation and isolation of the benzyl-protected 5L1O- 1 , 2-HOPO(Bn) to give a pale yellow oil (447 mg. 85 % based on amine). [0251] 1 H NMR (500MHz, CDCl3): delta 3.22(s, 8H, CH2), 5.24(s, 4H, benzyl CH2), 6.26(dd, J= I, .2 Hz, 2H, HOPO H), 6.3 l (d, 2H, J = 9.0 Hz, HOPO H), 7.24(dd, 2H, J= 9.0, 2 Hz, ArH), 7.26-7.45(m, 12H, ArH), 7.74(s,br, 2H, amideH). 1 3C NMR ( 125 MHz, CDCI3): delta 38.8, 68.1 , 78.2, 104.7, 121.7, 127.7, 128.3, 129.0, 132.9, 138.3, 143.2, 157.8, 160.0. MS(FAB+): 559.2 (MH ‘).

According to the analysis of related databases, 2752-17-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; WO2008/8797; (2008); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 2752-17-2, These common heterocyclic compound, 2752-17-2, name is 2,2′-Oxydiethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

o-Vanillin (1.82 g, 12 mmol) in EtOH (5 mL) was added dropwise to a 5 mL EtOH solution of3-oxapentane-1,5-diamine (0.52 g, 5 mmol). After the completion of addition, the solutionwas stirred for an additional 4 h at 78C. After cooling to room temperature, the precipitatewas filtered off. The product was dried in vacuo and obtained as a yellow crystalline solid.Yield: 1.59 g (68.0%). Anal. C20H24O5N2: Calcd C, 64.50; H, 6.50; N, 7.52%; found: C, 64.30; H,6.51; N, 7.51%. Selected IR data (KBr, nu/cm-1), 1629(nuC=N), 1256(nuC-O-C), 1047(nuOH). UV-vis(DMF): lambda = 271, 330 nm. Lambdam (DMF, 297 K): 1.7 S cm2 mol-1.

The synthetic route of 2752-17-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Shi, Xinkui; Mao, Shanshan; Shen, Kesheng; Wu, Huilu; Tang, Xia; Journal of Coordination Chemistry; vol. 70; 12; (2017); p. 2015 – 2028;,
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