Category: 2741-16-4

Synthetic Route of 2741-16-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2741-16-4, name is Isopropoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To 3-chloroperbenzoic acid dried in vacuo for 1 h prior to use (504mumol) in dry dichloromethane (5mL), was added 3-iododobenzoate succinimidyl ester (458mumol) and the solution was stirred at room temperature for 15min. Anisole (504mumol) was then added, the reaction cooled to -20C and triflic acid (916mumol) added. The solution turned dark. It was stirred for 15min at -20C and the volatiles were removed by rotary evaporation. To the dark residue was added Et2O. The thick oily suspension was stirred for about 45min upon which a deep blue precipitate formed. It was then purified by flash chromatography using aCH2Cl2/ tBuOH gradient from 95:5 to 60:40. The solid obtained was then recrystallized from CH3CN/Et2O to afford white crystals; 4.1.3 3-(Succinimidyloxycarbonyl)phenyl(4-isopropoxyphenyl)iodonium triflate (4b) The procedure was identical to the preparation of 4a, with anisole replaced by isopropoxybenzene and afforded 4b as colorless needles in 8% yield. 1H NMR (CD3CN, 400 MHz, ppm): delta 1.31 (d, 6H), 2.86 (s, 4H), 4.64-4.72 (m, 1H), 7.03 (d, 2H, J = 8.0 Hz), 7.72 (t, 1H, J = 8.0 Hz), 8.03 (d, 2H, J = 8.0 Hz), 8.35 (m, 2H), 8.74 (m, 1H). 13C NMR (CD3CN, 100 MHz, ppm): delta 21.9, 26.5, 72.0, 101.7, 115.1, 120.5, 123.6, 129.4, 134.0, 134.9, 137.0, 139.2, 141.7, 161.2, 163.1, 170.8. 19F NMR (CD3CN, 400 MHz, ppm): delta -79.70. HRMS: C20H19INO5+[M-OTf]+ calc: 480.0308, found: 480.0315

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Isopropoxybenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Guerard; Navarro; Lee; Roumesy; Alliot; Cherel; Brechbiel; Gestin; Bioorganic and Medicinal Chemistry; vol. 25; 21; (2017); p. 5975 – 5980;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 2741-16-4, name is Isopropoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2741-16-4, Recommanded Product: 2741-16-4

(1) O-isopropylphenol (1.0 g, 7.3 mmol) and allyl bromide (14.6 mmol) were successively added to a 25 mL round bottom flask and dissolved in dichloromethane. (0107) (2) Benzyl tributyl ammonium bromide (0.26 g, 0.73 mmol) was added to another 50 mL flask and dissolved in a 1 M NaOH solution. (0108) (3) The solution obtained in (1) was added slowly to the solution obtained in (2) at room temperature and stirred at room temperature for 2 h. The organic phase was separated, and the aqueous phase was extracted with dichloromethane. The organic phases were combined, washed with water and saturated sodium chloride, dried over anhydrous sodium sulfate, and concentrated to give a colorless liquid. The liquid was heated under nitrogen at 250 C. for 2 h, cooled and purified with column chromatography to give a colorless liquid. The colorless liquid was dissolved in absolute ethanol and reduced by addition of Pd/C to give 2-isopropyl-6-propylphenol: 1H NMR (400 MHz, CDCl3) delta 7.06 (dd, J=7.6, 1.6 Hz, 1H), 6.97 (dd, J=7.5, 1.6 Hz, 1H), 6.85 (t, J=7.6 Hz, 1H), 4.75 (s, 1H), 3.22-3.13 (m, 1H), 2.59-2.54 (m, 2H), 1.72-1.59 (m, 2H), 1.26 (d, J=6.9 Hz, 6H), 0.99 (t, J=7.3 Hz, 3H). (0109) (4) The obtained liquid (1.0 g, 5.6 mmol) was dissolved in 20 mL of dichloromethane, into which the catalyst Cu(OH)Cl.TMEDA (50 mg, 0.1 mmol) was added, and stirred at room temperature to give a red solid quinone which was then reduced with sodium hydrosulfite to give 4,4?-dihydroxy-3,3?-diisopropyl-5,5?-dipropylbiphenyl (1.1 g, 55.5%). (0110) 4,4?-dihydroxy-3,3?-diisopropyl-5,5?-dipropylbiphenyl: 1H NMR (300 MHz, CDCl3) delta 7.29 (s, 4H), 6.52 (s, 2H), 3.13-3.08 (m, 2H), 2.43-2.40 (m, 4H), 1.51-1.43 (m, 4H), 1.03 (d, 12H), 0.84-0.81 (m, 6H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Isopropoxybenzene, other downstream synthetic routes, hurry up and to see.