Category: 2674-34-2

Related Products of 2674-34-2, These common heterocyclic compound, 2674-34-2, name is 1,4-Dibromo-2,5-dimethoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Boronate ester 10 (1.00g, 3.15mmol), dibromoarene 11 (310mg, 1.05mmol), and K2CO3 (1.88g, 13.6mmol) in toluene (40mL), EtOH (10mL), and H2O (5mL) was sparged with Ar for 1h. Pd(PPh3)4 (120mg, 0.10mmol) was added, the mixture was sparged for an addition 15min with Ar, and then refluxed for 16h. The reaction mixture was allowed to cool to rt and 30mL of H2O was added to the reaction. The reaction mixture was extracted with Et2O (3×30mL). The combined organics were dried with Na2SO4 and the solvent removed under vacuum. The product was isolated with column chromatography to afford a white/light yellow solid (506mg, 93%), mp 151-154C. 1H NMR (CDCl3): delta 7.83 (d, J=8.5Hz, 2H), 7.45-7.44 (m, 4H), 6.84 (s, 2H), 3.71 (s, 12H), 1.38 (s, 18H). 13C NMR (CDCl3): delta 168.7, 154.9, 150.3, 138.2, 130.6, 129.3, 128.9, 128.4, 124.3, 113.0, 56.0, 51.6, 35.0, 31.18. FTIR (cm-1): 1725.25. UV-vis (CH2Cl2) lowest E abs lambdamax [nm] ( [M-1cm-1]): 326 (10,609). Em. (CH2Cl2) lambdamax [nm]: 409. Anal. Calcd for C32H38O6: C, 74.11; H, 7.39. Found: C, 73.98; H, 7.38.

Statistics shows that 1,4-Dibromo-2,5-dimethoxybenzene is playing an increasingly important role. we look forward to future research findings about 2674-34-2.

Reference:
Article; Dressler, Justin J.; Miller, Sarah A.; Meeuwsen, Brian T.; Riel, Asia Marie S.; Dahl, Bart J.; Tetrahedron; vol. 71; 2; (2015); p. 283 – 292;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

2674-34-2, name is 1,4-Dibromo-2,5-dimethoxybenzene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: ethers-buliding-blocks

1, 4-diamino -2, 5- […] (1, 4-diamino-2, 5-dimethoxybenzene) (16.9mmol) and 30 parts by weight of diethyl ether (70 ml) at -78 C 1.55N of agitating n-BuLi (16.8mmol) in 11 ml of hexane of. input additional are mixed together. 1.5 in the maintaining -78 C mixture adaptation stirring time. Dichloro d methyl thread column (8.4mmol) and 30 parts by weight of diethyl ether in the -78 C a 2 ml is closed after charging additional adaptation stirring during night at room temperature. After 1.5 reflux time was are input, in water and and stirring. possibility layer hexane and water extraction of water and balancer in a washing machine after the washing phosphorous in the magnesium sulfate expresses water after to remove, is every. D-1 compounds via fractional distillation (45% yield) is obtained.

The synthetic route of 2674-34-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LG DISPLAY CO., LTD.; SIN, IN AEY; LEE, SUNG JAE; BIN, JONG KWAN; LEE, BANG SOOK; SAW, BO MIN; YU, YOUNG JU; (45 pag.)KR2015/64794; (2015); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 2674-34-2,Some common heterocyclic compound, 2674-34-2, name is 1,4-Dibromo-2,5-dimethoxybenzene, molecular formula is C8H8Br2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of compound Q-9 (5.0 g, 16.77 mmol) in CH3CN (50 mL) was heated to 100 0C, followed by the addition of a solution of eerie ammonium nitrate (CAN, 14 g, 25.54 mmol) in water (75 mL) over a period of 30 min. The reaction mixture was then allowed to cool to room temperature and stirred for another 30 min. The resulting precipitate was filtered, washed with water (20 mL), and dried under high vacuum to furnish compound Q-10 (2.6 g, 58%) as a yellow solid. TLC Rf = 0.4 (petroleum ether – EtOAc, 9:1); MS (ES) mlz 266 (M – H)”.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,4-Dibromo-2,5-dimethoxybenzene, its application will become more common.

Reference:
Patent; SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; DJABALLAH, Hakim; ANTCZAK, Christophe; WO2010/129049; (2010); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 2674-34-2, name is 1,4-Dibromo-2,5-dimethoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2674-34-2, Product Details of 2674-34-2

Reacting a compound of formula 4 with sodium hydride in tetrahydrofuran as a solvent at -78 C for two hours,At the same time, the compound of formula 5 was reacted with n-butyllithium using tetrahydrofuran as a solvent at -78 C for one hour, and then mixed at -78 C for two hours.Add N, N-dimethylformamide and stir for five minutes, add methyl iodide to react at room temperature for twelve hours, add water to quench the reaction,The crude product was subjected to column chromatography with ethyl acetate and petroleum ether system to obtain intermediate formula 6 required for Suzuki Coupling Reaction, with a reaction yield of 52%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,4-Dibromo-2,5-dimethoxybenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chinese Academy Of Sciences Physics And Chemistry Technology Institute; University of the Chinese Academy of Sciences; Cong Huan; Fan Yangyang; (9 pag.)CN110272332; (2019); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 2674-34-2, name is 1,4-Dibromo-2,5-dimethoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2674-34-2, SDS of cas: 2674-34-2

General procedure: To an N-heterocycle was added a solution of i-PrMgCl*LiCl (1.33 M, 1.8 eq. with respect to N-heterocycle, in THF) and (i-Pr)2NH (0.1 with respect to N-heterocycle). The mixture was stirred at room temperature under an argon atmosphere for 18 hours. An electrophile was added and the mixture was stirred at room temperature for 20 minutes. The reaction was quenched by addition of saturated aqueous NH4Cl (20 mL), and a saturated Na2S2O3 solution (20 mL) in the case of I2 as an electrophile. The mixture was extracted three times with EtOAc, the organic layer was dried over MgSO4, filtered and the solvent was removed under reduced pressure.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Nxumalo; Dinsmore; Synthetic Communications; vol. 45; 21; (2015); p. 2478 – 2484;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 2674-34-2, The chemical industry reduces the impact on the environment during synthesis 2674-34-2, name is 1,4-Dibromo-2,5-dimethoxybenzene, I believe this compound will play a more active role in future production and life.

Example 6: Preparation of 4-bromo-2,2′,5,5′- tetramethoxybiphenyl (6); [00111] In an argon flushed two-neck round-bottom flask, a mixture of 1.02 g (5.0 mmol) of sodium 2,5-dimethoxyphenylboronate, 3.0 g (10 mmol) of 2,5-dibromo-1 ,4-dimethoxybenzene, 60 mg (1 mol%) of tetrakis(triphenylphosphine)palladium, 20 ml of 2 M sodium carbonate and 50 ml of THF was added and heated at reflux for two hours. After cooling, the reaction mixture was extracted with ethyl acetate and the organic phase was EPO washed with brine and dried over magnesium sulfate. After the solvent was removed on a rotary evaporator, the residue was purified by column chromatography eluted with hexane/CH2CI2 (4:1) to give 1.0 g 4-bromo- 2,25,5′-tetramethoxybiphenyl (yield 63%). 1HNMR (CDCI3) 57.187 (s, 1 H), 6.836-6.951 (m, 4 H), 3.869 (s, 3 H), 3,814 (s, 3 H), 3.757 (s, 6 H). 13CNMR (CDCI3) 5153.788, 151.830, 151.596, 150.278, 128.277, 127.995, 117.615, 117.293, 115.897, 113.924, 112.933, 110.019, 57.291 , 57.042, 56.897, 56.171.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,4-Dibromo-2,5-dimethoxybenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; NATIONAL UNIVERSITY OF SINGAPORE; WO2006/93467; (2006); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 2674-34-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2674-34-2 as follows.

Into a 200-mL three-neck flask were put 8.9 g (30 mmol) of 1,4-dibromo-2,5-dimethoxybenzene, 10 g (72 mmol) of 2-fluorophenylboronic acid, 15 mL of toluene, 15 mL of diethylene glycol dimethyl ether (diglyme), and 60 mL of a sodium carbonate aqueous solution (2.0 mol/L). This mixture was degassed by being stirred while the pressure in the flask was reduced. After the degassing, the atmosphere in the flask was replaced with nitrogen, and the mixture was heated to 80 C. To this mixture was added 0.69 g (0.60 mmol) of tetrakis(triphenylphosphine)palladium(0), and the mixture was stirred at the same temperature for 2 hours. The mixture was cooled down to room temperature and degassed again under reduced pressure. Then, the atmosphere in the flask was replaced with nitrogen, and the mixture was heated to 80 C. After the heating, 0.69 g (0.60 mmol) of tetrakis(triphenylphosphine)palladium(0) was added to this mixture, and the mixture was heated at the same temperature for 5 hours. After the heating, 2.0 g (14 mmol) of 2-fluorophenylboronic acid was added to this mixture, and the mixture was further stirred at the same temperature for 3 hours. After the heating, the mixture was cooled down to the room temperature and degassed under reduced pressure. Then, the atmosphere in the flask was replaced with nitrogen. This mixture was heated to 80 C., 0.64 g (0.55 mmol) of tetrakis(triphenylphosphine)palladium(0) and 3.0 g (21 mmol) of 2-fluorophenylboronic acid were added to the mixture, and the mixture was stirred at the same temperature for 2 hours. After the stirring, the mixture was cooled down to the room temperature, and the mixture was separated into an organic layer and an aqueous layer. The obtained aqueous layer was subjected to extraction with toluene three times, the extracted solution and the organic layer were combined, and this mixture was washed with saturated saline and dried with anhydrous magnesium sulfate. The obtained mixture was gravity-filtered, and then the obtained filtrate was concentrated to give a compound. The obtained compound was recrystallized with toluene to give 2.5 g of a target. The compound obtained by the concentration of the filtrate was purified by column chromatography (a developing solvent: a mixed solvent of hexane and ethyl acetate in a ratio of 30:1) to give 0.3 g of a target. The targets were 2.8 g in total, and the yield was 29%. A synthesis scheme of the above synthesis method is shown in (A-1) below.

According to the analysis of related databases, 2674-34-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Semiconductor Energy Laboratory Co., Ltd.; Kawakami, Sachiko; Ishiguro, Yoshimi; Takahashi, Tatsuyoshi; Hamada, Takao; Seo, Hiromi; Seo, Satoshi; (113 pag.)US9997725; (2018); B2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 2674-34-2, These common heterocyclic compound, 2674-34-2, name is 1,4-Dibromo-2,5-dimethoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Boronate ester 10 (1.00g, 3.15mmol), dibromoarene 11 (310mg, 1.05mmol), and K2CO3 (1.88g, 13.6mmol) in toluene (40mL), EtOH (10mL), and H2O (5mL) was sparged with Ar for 1h. Pd(PPh3)4 (120mg, 0.10mmol) was added, the mixture was sparged for an addition 15min with Ar, and then refluxed for 16h. The reaction mixture was allowed to cool to rt and 30mL of H2O was added to the reaction. The reaction mixture was extracted with Et2O (3×30mL). The combined organics were dried with Na2SO4 and the solvent removed under vacuum. The product was isolated with column chromatography to afford a white/light yellow solid (506mg, 93%), mp 151-154C. 1H NMR (CDCl3): delta 7.83 (d, J=8.5Hz, 2H), 7.45-7.44 (m, 4H), 6.84 (s, 2H), 3.71 (s, 12H), 1.38 (s, 18H). 13C NMR (CDCl3): delta 168.7, 154.9, 150.3, 138.2, 130.6, 129.3, 128.9, 128.4, 124.3, 113.0, 56.0, 51.6, 35.0, 31.18. FTIR (cm-1): 1725.25. UV-vis (CH2Cl2) lowest E abs lambdamax [nm] ( [M-1cm-1]): 326 (10,609). Em. (CH2Cl2) lambdamax [nm]: 409. Anal. Calcd for C32H38O6: C, 74.11; H, 7.39. Found: C, 73.98; H, 7.38.

Statistics shows that 1,4-Dibromo-2,5-dimethoxybenzene is playing an increasingly important role. we look forward to future research findings about 2674-34-2.

Reference:
Article; Dressler, Justin J.; Miller, Sarah A.; Meeuwsen, Brian T.; Riel, Asia Marie S.; Dahl, Bart J.; Tetrahedron; vol. 71; 2; (2015); p. 283 – 292;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2674-34-2, name is 1,4-Dibromo-2,5-dimethoxybenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 1,4-Dibromo-2,5-dimethoxybenzene

The 1,4-dibromo-2,5-dimethoxybenzene (T-13) (25.0g, 84.47mmol, Tokyo Kasei Kogyo),4-methoxyphenyl boronic acid (T-14) (28.2g, 185.84mmol, Tokyo Kasei Kogyo),Bis (di – t-butyl (4-dimethylaminophenyl) phosphine) dichloropalladium (II)(0.30g, 0.42mmol),Trisodium phosphate dodecahydrate (96.33g, 253.42mmol),Tetrabutylammonium bromide (TBAB) (5.45g, 16.89mmol),Toluene (100ml), isopropanol (100ml)And water(100ml) were mixedIt was heated at reflux for 5 hours.The reaction mixture was allowed to cool to room temperature filtered,The filtrate was washed with water (200ml) and saturated brine (100ml) washedDried over anhydrous magnesium sulfate,Concentrated under reduced pressure.By column chromatography (the eluent:Toluene / ethyl acetate = 9/1 (volume ratio)) and the residue was purified,To obtain the compound (T-15) (27.9g, 84.47mmol, 94.3%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; JNC Co., Ltd.; JNC Petrochemical Co., Ltd.; Kobayashi, Masahide; Goto, Yasuyuki; Kobayashi, Takahiro; (94 pag.)CN105358523; (2016); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

2674-34-2, name is 1,4-Dibromo-2,5-dimethoxybenzene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C8H8Br2O2

1, 4-diamino -2, 5- […] (1, 4-diamino-2, 5-dimethoxybenzene) (16.9mmol) and 30 parts by weight of diethyl ether (70 ml) at -78 C 1.55N of agitating n-BuLi (16.8mmol) in 11 ml of hexane of. input additional are mixed together. 1.5 in the maintaining -78 C mixture adaptation stirring time. Dichloro d methyl thread column (8.4mmol) and 30 parts by weight of diethyl ether in the -78 C a 2 ml is closed after charging additional adaptation stirring during night at room temperature. After 1.5 reflux time was are input, in water and and stirring. possibility layer hexane and water extraction of water and balancer in a washing machine after the washing phosphorous in the magnesium sulfate expresses water after to remove, is every. D-1 compounds via fractional distillation (45% yield) is obtained.

The synthetic route of 2674-34-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LG DISPLAY CO., LTD.; SIN, IN AEY; LEE, SUNG JAE; BIN, JONG KWAN; LEE, BANG SOOK; SAW, BO MIN; YU, YOUNG JU; (45 pag.)KR2015/64794; (2015); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem