Category: 25245-34-5

Related Products of 25245-34-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 25245-34-5 name is 2-Bromo-1,4-dimethoxybenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a 1-L round-bottom flask reactor, 2-bromo-1,4-dimethoxybenzene (50 g, 230 mmol) and tetrahydrofuran (400 ml) were dissolved. After the mixture was cooled to -78 C., it was added with drops of N-butyl lithium (167 ml, 280 mmol). At the same temperature, the mixture was stirred for 2 hrs before the addition of trimethyl borate (36 ml, 320 mmol). Stirring was conducted overnight at room temperature. After completion of the reaction, 2 N HCl was dropwise added for acidification. Extraction with water and ethyl acetate gave an organic layer which was then dried over magnesium sulfate and concentrated in a vacuum. Recrystallization in heptane and toluene afforded . (20.8 g, 50%)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-1,4-dimethoxybenzene, and friends who are interested can also refer to it.

Reference:
Patent; SFC CO., LTD.; Cha, Soon-Wook; Park, Young-Hwan; Yoon, Seo-Yeon; Shim, So Young; (152 pag.)US2017/18723; (2017); A1;,
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Electric Literature of 25245-34-5,Some common heterocyclic compound, 25245-34-5, name is 2-Bromo-1,4-dimethoxybenzene, molecular formula is C8H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 214 1,2-Dihydro-9-methoxy-2,2,4-trimethyl-5-coumarino[3,4-f]quinoline (Compound 314, structure 41 of Scheme XI, where R1 =H, R2 =methoxy) 2,5-Dimethoxyphenylboronic acid (structure 37 of Scheme XI, where R1 =H, R2 =methoxy). This compound was prepared in a manner similar to that of 5-fluoro-2-methoxyphenylboronic acid (EXAMPLE 107) from 1-bromo-2,5-dimethoxybenzene (2.00 mL, 13.3 mmol), n-BuLi (2.5M in hexanes; 5.34 mL, 13.3 mmol), and trimethylborate (4.5 mL, 40 mmol) to afford 2.43 g (99%) of 2,5-dimethoxyphenylboronic acid which was used without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromo-1,4-dimethoxybenzene, its application will become more common.

Reference:
Patent; Ligand Pharmaceuticals Incorporated; US5688810; (1997); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25245-34-5, name is 2-Bromo-1,4-dimethoxybenzene, This compound has unique chemical properties. The synthetic route is as follows., Safety of 2-Bromo-1,4-dimethoxybenzene

EXAMPLE 214 [1,2-Dihydro-9-methoxy-2,2,4-trimethyl-5-coumarino3,4-f]quinoline (Compound 314, structure 41 of Scheme XI, where R1 =H, R2 =methoxy) 2,5-Dimethoxyphenylboronic acid (structure 37 of Scheme XI, where R1 =H, R2 =methoxy) This compound was prepared in a manner similar to that of 5-fluoro-2-methoxyphenylboronic acid (EXAMPLE 107) from 1-bromo-2,5-dimethoxybenzene (2.00 mL, 13.3 mmol), n-BuLi (2.5M in hexanes; 5.34 mL, 13.3 mmol), and trimethylborate (4.5 mL, 40 mmol) to afford 2.43 g (99%) of 2,5-dimethoxyphenylboronic acid which was used without further purification.

According to the analysis of related databases, 25245-34-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Ligand Pharmaceuticals Incorporated; US5693647; (1997); A;,
Ether – Wikipedia,
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Related Products of 25245-34-5, The chemical industry reduces the impact on the environment during synthesis 25245-34-5, name is 2-Bromo-1,4-dimethoxybenzene, I believe this compound will play a more active role in future production and life.

Example 7: Preparation of 4,4′-dibromo-2,2′,5,5′- tetramethoxybiphenyl (7); [00113] In a 100 ml round-bottom flask, 3.0 g of FeCI3 in 20 ml of CH2CI2 was added to a solution of 5.0 g of 2,5-dimethoxybromobenzene in 50 ml of CH2CI2. The reaction mixture was stirred overnight, and then it was washed with water and brine and dried with magnesium sulfate. The solvent was removed on a rotary evaporator and the residue was purified by column chromatography eluted by hexane/CH2CI2 (3:1) to obtain 3.4 g of 4,4′- dibromo-2,2′,5,5′-tetramethoxybiphenyl (yield 68%) 1HNMR (CDCI3) 57.194 (s, 2 H), 6.841 (s, 2 H), 3.877 (s 3 H), 3.757 (s, 3 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1,4-dimethoxybenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; NATIONAL UNIVERSITY OF SINGAPORE; WO2006/93467; (2006); A1;,
Ether – Wikipedia,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25245-34-5, name is 2-Bromo-1,4-dimethoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 25245-34-5

To a solution of LDA (7.4 mL, 1.1 eq) in THF (15 mL) were added furan (15 mL) and l-bromo-2,5-dimethoxybenzene (2.16 g, 10 mmol) in turn at -78 C. The mixture was stirred at this temperature for 30 mins and quenched with water and then the mixture was allowed to warm up to rt and extracted with ethyl ether (50 mL x 3). The combined organic layers were dried over anhydrous Na2SC>4 and concentrated in vacuo. The residue was purified by silica gel column chromatography (Hex/EtOAc (v/v) = 1/1) to give the title compound as a white solid (2.1 g, 86%). The compound was characterized by the following spectroscopic data: NMR (400MHz, CDC13) delta 7.06 (2H, s), 6.97 (2H, s), 6.54 (2H, s), 5.92 (2H, s), 3.78 (6H, s) ppm.

The synthetic route of 25245-34-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; HU, Bailin; LI, Shifeng; WU, Xiwei; TANG, Changhua; WANG, Chenglin; FANG, Qinghong; YU, Quanxing; ZHANG, Zhikeng; WO2014/131315; (2014); A1;,
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Reference of 25245-34-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25245-34-5 as follows.

General procedure: The Suzuki reaction was performed in a 50 mL round-bottomed flask, aryl halide (0.5 mmol), arylboronic acid (0.65 mmol), K2CO3 (1 mmol), Complex 1 (0.2-1 mol%) and water (4 mL) were charged and stirred for the required time at room temperature for aryl bromides or at 100 C for aryl chlorides. After completion, the mixture was cooled down to room temperature, diluted with water (10 mL) and extracted with diethyl ether (3 × 15 mL). The organic layer was washed with brine (3 × 15 mL), dried over anhydrous Na2SO4. The crude products were chromatographed on silica gel (ethyl acetate/hexane).

According to the analysis of related databases, 25245-34-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Shahnaz, Nasifa; Puzari, Amlan; Paul, Bidisha; Das, Pankaj; Catalysis Communications; vol. 86; (2016); p. 55 – 58;,
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Synthetic Route of 25245-34-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25245-34-5, name is 2-Bromo-1,4-dimethoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

2,5-Dimethoxyphenylboronic acid (Structure 37 of Scheme XI, where R1 =H, R2 =methoxy) This compound was prepared in a manner similar to that of 5-fluoro-2-methoxyphenylboronic acid (EXAMPLE 107) from 1-bromo-2,5-dimethoxybenzene (2.00 mL, 13.3 mmol), n-BuLi (2.5M in hexanes; 5.34 mL, 13.3 mmol), and trimethylborate (4.5 mL, 40 mmol) to afford 2.43 g (99%) of 2,5-dimethoxyphenylboronic acid which was used without further purification.

The synthetic route of 2-Bromo-1,4-dimethoxybenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ligand Pharmaceuticals Incorporated; US5693646; (1997); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 25245-34-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25245-34-5, name is 2-Bromo-1,4-dimethoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a suspension of sodium amide (8.5 g, 218 mmol) in anhydrous THF(100 mL) was added furan (59.3 g, 872 mmol) and the mixture warmed to 50 C under nitrogen. 4 (11 g,50.7 mmol) dissolved in anhydrous THF (20 mL) was added to the reaction mixture which was thenstirred at 50 C for 24 h. After cooled to room temperature, EtOAc (80 mL) and water (80 mL) wereadded to the solution. The organic layer was separated and washed with saturated aqueous NaCl and driedover anhydrous Na2SO4. The solvent was removed under reduced pressure to give a brown oil 5 withoutfurther purification which was dissolved in MeOH (100 mL) containing conc. hydrochloric acid (5 mL)and the mixture heated at reflux for 3 h. MeOH was removed under reduced pressure and the residue between EtOAc and water. The organic layer was washed with a solution of saturated aqueous NaHC03 and saturated aqueous NaCl in sequence and then dried over anhydrous Na2S04. The solvent was evaporated under reduced pressure and the residue was subjected to flash column chromatography (petroleum ether: EtOAc, 10:1, V/V) to give 6 (9.5 g, 91.3%) as white solid

The synthetic route of 2-Bromo-1,4-dimethoxybenzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Qijing; Dong, Jinyun; Huang, Guang; Li, Shaoshun; Heterocycles; vol. 96; 2; (2018); p. 334 – 338;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

25245-34-5, name is 2-Bromo-1,4-dimethoxybenzene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: ethers-buliding-blocks

25 mL single neck flask was charged with 2-bromo-1,4-dimethoxybenzene (1.0 g, 4.6 mmol), AcOH (5 mL),Then slowly add HNO3 (0.4 mL) dropwise,A large number of yellow solid solution was precipitated,After 0.5h,filter,Rinse the residue with plenty of water,Finally dried in a vacuum oven,Obtained bright yellow solid powder compound 4 (1.1 g, 92%).

The synthetic route of 25245-34-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Organic Chemistry Institute; Zhao Xin; Yin Zhijian; Zhan Tianguang; (17 pag.)CN107353242; (2017); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 25245-34-5,Some common heterocyclic compound, 25245-34-5, name is 2-Bromo-1,4-dimethoxybenzene, molecular formula is C8H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-Bromo-1,4-dimethoxybenzene 39a (250 mg, 1.15 mmol), 2-formylphenylboronic acid 34 (207 mg, 1.38 mmol), tetrakis(triphenylphosphine)palladium(0) (133 mg, 0.29 mmol) and CsF (437 mg, 2.88 mmol) were added to a microwave vial in dimethoxyethane (2 mL) as solvent and the solution was degassed for 2 min. The reaction mixture was transferred to a microwave reactor at 150 C and 150 W power with vigorous stirring for 30 min. On completion, the reaction mass was filtered off, adsorbed on silica and subjected to column chromatography (5% EtOAc/Hexane) to yield the product 40a as white low melting solid (246 mg, 1.02 mmol, 88%). 1H NMR (500 MHz, CDCl3) d 9.79 (1H, s, CHO), 8.01-7.97 (1H, m, ArH), 7.64 (1H, td, J = 7.5, 1.2 Hz, ArH), 7.48 (1H, t, J = 7.6 Hz, ArH), 7.38-7.34 (1H, m, ArH), 6.94 (1H, dd, J = 8.9, 3.0 Hz, ArH), 6.90 (1H, d, J = 8.9 Hz, ArH), 6.87 (1H, d, J = 3.0 Hz, ArH), 3.81 (3H, s, OMe), 3.67 (3H, s, OMe); 13C NMR (126 MHz, CDCl3) d 192.5, 153.8, 150.7, 141.6, 134.0, 133.7, 131.0, 127.8, 127.7, 126.6, 117.3, 114.4, 111.8, 55.9, 55.8.

The synthetic route of 25245-34-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Pradeep, Priyamvada; Ngwira, Kennedy J.; Reynolds, Chevonne; Rousseau, Amanda L.; Lemmerer, Andreas; Fernandes, Manuel A.; Johnson, Myron M.; de Koning, Charles B.; Tetrahedron; vol. 72; 51; (2016); p. 8417 – 8427;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem