Category: 2398-37-0

Application of 2398-37-0,Some common heterocyclic compound, 2398-37-0, name is 1-Bromo-3-methoxybenzene, molecular formula is C7H7BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A round-bottomed flask was charged acetyl chloride (4.20g, 53.56mmol, leq), AICI3 (7.13g, 53.56mmol, leq), and carbon disulfide (80mL). To the mixture was added dropwise a solution of 3-bromoanisole (9.75g, 52.13mmol) in carbon disulfide (20mL) and stirred for 16 h. The resulting solution was diluted with ice water (l OOmL) and extracted with CH2G12 (50mLx3). The extracts were washed with H20, brine, and IN NaOH (30mL). The organic layer was dried over MgS04 and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/hexanes = 1 :10) to afford the title compound (6.2g, 51%).1H NMR (300MHz, CDC13) delta 7.48(dd, J = 8.4Hz, 1,2Hz, 1H), 7.04(brs. 1H), 6.76(dd, 1H), 3.74(s, 3H), 2.52(s, 3H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-3-methoxybenzene, its application will become more common.

Reference:
Patent; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HEO, Jung Nyoung; BAE, Myung-Ae; KIM, Nack Jeong; CHANG, Sung Youn; KANG, Namsook; YOO, Sung Eun; HWANG, Eun Sook; WO2011/30955; (2011); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

These common heterocyclic compound, 2398-37-0, name is 1-Bromo-3-methoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C7H7BrO

The advantageous effect of adding zinc chloride to an amination reaction was demonstrated in the amination reaction of 3-bromoanisole. the results of which are summarized in Table 10. When 3-bromoanisole was reacted under the standard lithium amide amination conditions, using lithium amide (10 eq.) in the presence of (CyPF-^-Bu)PdCl2 (1 mol%) in DME gave a complicated mixture of products was obtained (Table 10, Entry 1). When conducted in the presence of zinc chloride and TMEDA, however, the reaction could successfully gave the desired monoarylation product, 3-methoxyaniline, although at high concentrationsN,N-dimethyl-3-methoxyaniline was formed in a significant amount as a by- product (Table 10, Entries 3 and 4). Under optimized conditions (Table 10, Entries 8 and 9), 3-methoxyaniline was formed selectively in good yield.

The synthetic route of 1-Bromo-3-methoxybenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; YALE UNIVERSITY; WO2007/109365; (2007); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2398-37-0, name is 1-Bromo-3-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 2398-37-0

Acetyl chloride (3.56 mL, 0.06 mol) is added dropwise to a stirred suspension of 3-bromoanisole (9.35 g, 0.05 mol) and AlCl3 (8.00 g, 0.06 mol) in dichloromethane (50 mL) at 0 C under argon. The resulting mixture is stirred at 0 0C for 40 min and then at room temperature for 1 h, and diluted with H2O (100 mL) and 2 N HCl (35 mL), and extracted with ethyl acetate (2 x 100 mL and 50 mL). The extract is washed (brine) and dried. After solvent removal at reduced pressure, the residue is purified on silica gel (12.5% to 14.3% ethyl acetate/hexane) to give 9.55 g (83%) of 2 as a colorless liquid. IR 2964, 1688, 1596, 1252 cm”1; 1H NMR (CDCI3) delta 2.66 (s, 3H, CH3CO), 3.88 (s, 3H, CH3O), 6.91 (dd, J= 8.4 Hz, 2.4 Hz, IH, 5-PhH), 7.19 (d, J= 2.4 Hz, IH, 3- PhH), 7.63 ppm (d, J= 8.4 Hz, IH, 6-PhH).

According to the analysis of related databases, 2398-37-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BURNHAM INSTITUTE FOR MEDICAL RESEARCH; MERCOLA, Mark; DAWSON, Marcia, I.; CASHMAN, John; WO2010/33643; (2010); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 2398-37-0, A common heterocyclic compound, 2398-37-0, name is 1-Bromo-3-methoxybenzene, molecular formula is C7H7BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a reaction tube charged with NBS (1.5 equiv, 0.3 mmol), catalyst (10 mol%, 0.02 mmol) and CH3CN (1.0 mL),was added para-chloroanisole 1a (0.2 mmol). After being stirred at room temperature for 12 h in dark, the reaction was quenched by saturated aq. solution of Na2S2O3 (2 mL). The resulting mixture was extracted by ethyl acetate (3 5 mL). The combined organic extracts were washed by brine (10 mL), dried over Na2SO4 and filtered through a pad of Celite. The filtrate was concentrated under reduced pressure and the residuewas purified by flash chromatography on a silica gel column with petroleum ether/dichloromethane (5:1) as the eluent to give 4.3.1. 2-Bromo-4-chloroanisole (2a)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Pramanick, Pranab Kumar; Hou, Zhen-Lin; Yao, Bo; Tetrahedron; vol. 73; 50; (2017); p. 7105 – 7114;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Some common heterocyclic compound, 2398-37-0, name is 1-Bromo-3-methoxybenzene, molecular formula is C7H7BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 2398-37-0

General procedure: Compound 7a was prepared by reacting 3-bromo-2-methyl-5-thienylboronic acid (3.0g, 11.3mmol) with 3-bromobenzonitrile (2.47g, 13.6mmol) in the presence of Pd(PPh3)4 (0.15g, 0.01mmol) and Na2CO3 (2.0 mol L-1, 50 mL) in tetrahydrofuran (THF) (80mL containing 10% water). After refluxing for 16h, the product was extracted with diethyl ether. The organic layer was dried over MgSO4, filtrated, and evaporated. The crude product was purified by column chromatography on SiO2 using petroleum ether as the eluent and 2.0g of 7a obtained as a yellowish solid in 53% yield.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2398-37-0, its application will become more common.

Reference:
Article; Wang, Renjie; Pu, Shouzhi; Liu, Gang; Chen, Bing; Tetrahedron; vol. 69; 26; (2013); p. 5537 – 5544;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 2398-37-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2398-37-0 as follows.

The advantageous effect of adding zinc chloride to an amination reaction was demonstrated in the amination reaction of 3-bromoanisole. the results of which are summarized in Table 10. When 3-bromoanisole was reacted under the standard lithium amide amination conditions, using lithium amide (10 eq.) in the presence of (CyPF-^-Bu)PdCl2 (1 mol%) in DME gave a complicated mixture of products was obtained (Table 10, Entry 1). When conducted in the presence of zinc chloride and TMEDA, however, the reaction could successfully gave the desired monoarylation product, 3-methoxyaniline, although at high concentrationsN,N-dimethyl-3-methoxyaniline was formed in a significant amount as a by- product (Table 10, Entries 3 and 4). Under optimized conditions (Table 10, Entries 8 and 9), 3-methoxyaniline was formed selectively in good yield.

According to the analysis of related databases, 2398-37-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; YALE UNIVERSITY; WO2007/109365; (2007); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 2398-37-0, Name is 1-Bromo-3-methoxybenzene, SMILES is COC1=CC(Br)=CC=C1, in an article , author is Meral, Serhan, once mentioned of 2398-37-0, SDS of cas: 2398-37-0.

Ultrasonic-assisted cloud point microextraction and spectrophotometric determination of Ponceau 4R in various beverage samples using Non-iconic surfactant PONPE 7.5

In the current study, a simple, cheap, and fast analytical procedure, termed ultrasonic-assisted cloud point microextraction (UA-CPME), combined with UV-VIS spectrophotometry, was developed for the pre-concentration and identification of Ponceau 4R in some beverage samples. Ponceau 4R was extracted from aqueous solution using polyethylene glycol mono-p-nonylphenyl ether (PONPE 7.5) as extraction solvent in the presence of Cu(II) at pH 6.0. Variables influencing the UA-CPME extraction efficiency such as pH, metal type and amount, temperature, ultrasonic effect, solvent type, non-ionic surfactant type and concentration were optimised in detail. Under optimum conditions, the analytical properties of the developed method were as follows: linear working range, 20-750 mu g L-1; limit of detection, 6.5 mu g L-1; and the pre-concentration factor, 200. The relative standard deviation (RSD%) obtained for 50 mu g L-1 (n = 5) of Ponceau 4R was 2.9%. The accuracy and precision of the method were evaluated by intra-day and inter-day studies. Finally, the developed method has been successfully applied to the separation and identification of Ponceau 4R in the selected samples and the recoveries ranged from 94.3 to 104.2%

Interested yet? Read on for other articles about 2398-37-0, you can contact me at any time and look forward to more communication. SDS of cas: 2398-37-0.

Synthetic Route of 2398-37-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 2398-37-0, Name is 1-Bromo-3-methoxybenzene, SMILES is COC1=CC(Br)=CC=C1, belongs to ethers-buliding-blocks compound. In a article, author is Messerly, Richard A., introduce new discover of the category.

Understanding how chemical structure affects ignition-delay-time phi-sensitivity

phi-sensitivity is the change in ignition delay time (IDT) with respect to the fuel-to-air equivalence ra tio (phi). High phi-sensitivity is a desirable fuel property for applications in advanced compression ignition and multi-mode engine designs. Understanding how phi-sensitivity depends on chemical structure is essential for selecting promising biofuels from the ever-growing list of proposed candidates. In this study, we investigate the effect of chemical structure on phi-sensitivity with experiment, simulation, and theory. Experimental Advanced Fuel Ignition Delay Analyzer (AFIDA) measurements for 2,4-dimethylpentane and diisopropyl ether provide evidence that branching and functional groups strongly impact phi-sensitivity. Further insights into this dependence are obtained with phi-D kinetic simulations with existing mechanisms for n-pentane, diethyl ether, 3-pentanone, n-heptane, 2-methylhexane, 2,4-dimethylpentane, and 2,2,3-trimethylbutane. Quantum mechanical (QM) G4 calculations of low-temperature reactions help explain the observed experimental and simulation trends. Specifically, these QM calculations provide theoretical estimates of the ketohydroperoxide (KHP) dissociation rates, the HO2 formation rates from peroxy radical (ROO), and the cross-over temperatures, i.e., the temperature at which ROO dissociation is favored compared to hydroperoxyl radical (QOOH) formation. Each of these reaction rates is compared to the n-alkane reference point to determine the impact of branching and different functional groups. Although kinetic mechanisms typically assume that KHP dissociation rates are invariant of chemical environment, our QM results suggest that this rate can span a range of roughly two orders of magnitude. We also discuss the importance of including the peroxy-hydroperoxy (OO-OOH) hydrogen transfer reaction for branched ethers. Finally, the insights gained assist in proposing a highly phi-sensitive compound, namely, isopropyl propyl ether. (C) 2020 The Combustion Institute. Published by Elsevier Inc. All rights reserved.

Synthetic Route of 2398-37-0, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 2398-37-0.

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 2398-37-0, Name is 1-Bromo-3-methoxybenzene, SMILES is COC1=CC(Br)=CC=C1, in an article , author is Nadalin, A., once mentioned of 2398-37-0, Safety of 1-Bromo-3-methoxybenzene.

Validation of an in-house bovine serum enzyme immunoassay for progesterone measurement

Measuring circulating progesterone (P4) of dairy cows is a key component of many research studies dealing with basic and applied reproduction physiology. The gold standard in dairy cows for the measurement of P4 in serum is radioimmunoassay (RIA), but it generates radioactive waste and requires licensed facilities. The purpose of this study was to develop and validate an in-house competitive enzyme immunoassay (EIA) to measure the P4 concentration in serum of dairy cattle. The secondary objective was to validate a commercial EIA. In the present study, a competitive HA was developed using commercially available antibodies and conjugates. Ninety-six well microtiter plates were coated with the secondary antibody and incubated overnight. Following a washing step, the wells were blocked using the primary antibody. Serum samples were prepared by first extracting P4 using petroleum ether, then diluted in working conjugate solution. Samples were pipetted into the coated and blocked plates, then the matching HRP conjugate label (P4-3-HRP, East Coast Rio, North Berwick, ME) was added. The plates were incubated for 2 h, then washed. The substrate solution was added, and the plate was incubated up to 1 h at room temperature in the dark until a blue color had developed. A stop solution was added, and the optical density measured on a microplate reader was set at 450 nm. The binding proportion was calculated by a visible spectrum absorbance reader, and the amount of P4 was calculated using a log-logit regression line. The commercial EIA was executed as suggested by the manufacturer. The validation of the in-house EIA was done by calculating the inter- and intraassay coefficients of variation (CV) and evaluating the parallelism of diluted samples. The results from the in-house and commercial EIA were also compared with the ones from the RIA graphically (scatterplots and Bland-Altman plots) and statistically, using the Spearman correlation coefficient (r) and the Cohen’s kappa statistics using a threshold of 1.0 rig/mL (kappa). For the in-house EIA, the intraassay CV were all <10%, but the interassay for samples with small and large P4 concentration had CV of 12.5 and 11.0%, respectively. The correlations between the results from the EIA and the RIA were strong (in-house: r = 0.90; commercial: r = 0.83). At small concentrations (<1.0 ng/mL), however, the correlation with the gold standard was weak (in-house: r = 0.27; commercial: r = 0.14). This was likely due to the lack of accuracy at small concentrations, also shown by the absence of parallelism in samples <= 0.4 ng/mL. In conclusion, results from both the in-house and commercial EIA strongly correlated with the gold standard, but less so at smaller concentrations. The in-house EIA offers good accuracy to measure P4 in samples with a concentration >0.4 ng/mL, and a perfect agreement with RIA using a threshold of 1.0 ng/mL.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 2398-37-0, you can contact me at any time and look forward to more communication. Safety of 1-Bromo-3-methoxybenzene.

Application of 2398-37-0, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 2398-37-0, Name is 1-Bromo-3-methoxybenzene, SMILES is COC1=CC(Br)=CC=C1, belongs to ethers-buliding-blocks compound. In a article, author is Feng, Mengna, introduce new discover of the category.

Improving dielectric properties of poly(arylene ether nitrile) composites by employing core-shell structured BaTiO3@polydopamine and MoS2@polydopamine interlinked with poly(ethylene imine) for high-temperature applications

For organic film capacitors, the dielectric materials with high-k, flexible and high heat-resistance are desired. Herein, a kind of hybrid particles were fabricated via self-polymerization and crosslinking reaction, containing core-shell structured BaTiO3@polydopamine (BT@PDA) and MoS2@polydopamine (MoS2@PDA) interlinked with poly(ethylene imine) (PEI) to perserve better interfacial interaction and uniform dispersion in poly(arylene ether nitrile) (PEN) composites. The results suggest that the designed PEN-based composites demonstrate remarkable dielectric responses. The incorporation of hybrid particles endows the polymer composites with high relative dielectric constant and comparable low dielectric loss due to the construction of diffuse electrical double layer and more micro-capacitor networks in PEN-based composites. Particularly, the dielectric constant of composite loaded with 15 wt% hybrid particles is about 254% higher than that of PEN matrix at 1 kHz, while maintaining a relatively low dielectric loss (< 0.03). More importantly, the PEN-based composites maintain their dielectric constants from room temperature to 160 degrees C, thus exhibiting outstanding permittivity-temperature stability, which can better meet the requirements of high temperature applications. In conclusion, this is a feasible way to incorporate hybrid particles containing core-shell structured BT@PDA and MoS2@PDA into polymer matrix to design dielectric composites with excellent permittivity-temperature stability. (C) 2020 Elsevier B.V. All rights reserved. Application of 2398-37-0, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 2398-37-0.