Category: 2398-37-0

He, Jing; Yang, Zhen; Li, Weiwei; Wei, Yueting; Dai, Bin; Zhao, Jixing; Liu, Ping published their research in ChemCatChem in 2021. The article was titled 《Pd-Catalyzed N-Arylations of 3-Aryl-1-tosyl-1H-pyrazol-5-amines with Arylbromides and the Migration of Ts Group》.Safety of 1-Bromo-3-methoxybenzene The article contains the following contents:

An efficient palladium-catalyzed N-arylations of 3-aryl-1-tosyl-1H-pyrazol-5-amines with arylbromides was established. A series of diversified N-arylated products were obtained in excellent yields with broad substrate scope. Importantly, the N-arylated products undergo 1,4- and 1,6-migration reactions of Ts group under the action of Cs2CO3, affording the N-Ts-substituted pyrroles as major products (1,6-migration). Similar results was directly obtained by palladium-catalyzed reactions of 3-aryl-1-tosyl-1H-pyrazol-5-amines with arylbromides in the presence of Cs2CO3 as a base. Mechanistic studies reveal that the Ts-migration was achieved through an intermol. pathway. In the experiment, the researchers used many compounds, for example, 1-Bromo-3-methoxybenzene(cas: 2398-37-0Safety of 1-Bromo-3-methoxybenzene)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Safety of 1-Bromo-3-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sau, Miriam; Pericas, Miquel A.; Martin, Ruben published an article in 2022. The article was titled 《Pd-Catalyzed Arylation of 1,2-Amino Alcohol Derivatives via β-Carbon Elimination》, and you may find the article in Synlett.COA of Formula: C7H7BrO The information in the text is summarized as follows:

Herein, authors describe a Pd-catalyzed arylation of 1,2-amino alcs. with aryl halides enabled by a retroallylation manifold. This protocol constitutes a new entry point to β-arylated aldehydes via the intermediacy of in situ generated enamine intermediates. The protocol is characterized by its exquisite regioselectivity profile and broad substrate scope – including challenging substrate combinations – even in an enantioselective manner. In the experiment, the researchers used 1-Bromo-3-methoxybenzene(cas: 2398-37-0COA of Formula: C7H7BrO)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.COA of Formula: C7H7BrO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 2398-37-0In 2019 ,《A Concise Enantioselective Synthesis of (S)-Preclamol via Asymmetric Catalytic Negishi Cross-Coupling Reaction》 appeared in Synlett. The author of the article were Zhou, Yun; Liu, Chunxiao; Wang, Lifeng; Han, Leng; Hou, Shicong; Bian, Qinghua; Zhong, Jiangchun. The article conveys some information:

A novel, concise, and efficient enantioselective synthesis of (S)-preclamol (87% ee, 51% total yield) has been developed. The key steps of this synthetic approach included cobalt-catalyzed asym. catalytic cross-coupling of α-bromo ester with arylzinc and the reduction of chiral ester to diol with a tertiary carbon atom. Moreover, it was demonstrated that our enantioselective Negishi cross-coupling was a powerful tool to construct stereogenic benzylmethyl center in chiral drugs on a gram scale. The experimental process involved the reaction of 1-Bromo-3-methoxybenzene(cas: 2398-37-0Recommanded Product: 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Recommanded Product: 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Category: ethers-buliding-blocksIn 2021 ,《Synthesis of Selenopyrano[2,3-c]pyrazol-4(1H)-ones and Their C-H Activation》 was published in Synlett. The article was written by Choi, In-Hui; Jalani, Hitesh B.; Jeong, Jin-Hyun. The article contains the following contents:

A multistep protocol for synthesizing selenopyrano[2,3-c]pyrazol-4(1H)-ones I [R1 = Me, Et, i-Pr, cyclopropyl, Ph; R2 = Ph, 4-MeC6H4; R3 = H] and their aryl derivatives I [R1 = Me, Et, i-Pr, cyclopropyl, Ph; R2 = Ph, 4-MeC6H4; R3 = Ph, 3,4-(MeO)2C6H3, 4-O2NC6H4, etc.] was developed for the first time by using selenopyran ring formation via an in situ-generated selenide that reacted directly with α-halo-β-ynone-bearing substituted pyrazoles to provide the corresponding selenopyrano[2,3-c]pyrazol-4(1H)-ones. Subsequent direct C-H arylation of the compounds I effected by palladium-catalyzed Heck reactions permitted the incorporation of arene substituents onto the selenopyrano[2,3-c]pyrazol-4(1H)-ones scaffolds with moderate to good yields, and might be useful for biol. screenings. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-3-methoxybenzene(cas: 2398-37-0Category: ethers-buliding-blocks)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Liu, Le; Nevado, Cristina published their research in Organometallics in 2021. The article was titled 《Diaryl Ether Formation Merging Photoredox and Nickel Catalysis》.Related Products of 2398-37-0 The article contains the following contents:

Photoredox and Ni catalysis are combined to produce diaryl ethers under mild conditions. A broad range of aryl halides and phenol derivatives are cross-coupled in the presence of a readily available organic photocatalyst and NiBr2(dtbpy). Sym. diaryl ethers have also been directly obtained from aryl bromides in the presence of water. Mechanistic investigations support the involvement of Ni(0) species at the outset of the reaction and a Ni(II)/Ni(III)-photocatalyzed single electron transfer process preceding the productive C(sp2)-OAr reductive elimination.1-Bromo-3-methoxybenzene(cas: 2398-37-0Related Products of 2398-37-0) was used in this study.

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Related Products of 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Wu; Qu, Ruiyang; Liu, Weiping; Bourriquen, Florian; Bartling, Stephan; Rockstroh, Nils; Junge, Kathrin; Beller, Matthias published their research in Chemical Science in 2021. The article was titled 《Copper-catalysed low-temperature water-gas shift reaction for selective deuteration of aryl halides》.Product Details of 2398-37-0 The article contains the following contents:

Herein, a practical and stable heterogeneous copper catalyst permits for dehalogenative deuteration via water-gas shift reaction at comparably low temperature This novel approach allows deuteration of diverse (hetero)aryl halides RBr (R = 6-methoxynaphthalen-2-yl, 3-cyano-4-(morpholin-4-yl)phenyl, 2-phenylpyridine, etc.) with good functional group tolerance, and no reduction of the aromatic rings or other easily reducible formyl and cyano groups. Multi-gram experiments show the potential of this method in organic synthesis and medicinal chem. In the experiment, the researchers used many compounds, for example, 1-Bromo-3-methoxybenzene(cas: 2398-37-0Product Details of 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Product Details of 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,ACS Omega included an article by Huang, Wenhua; Zhong, Chun-Hong. Computed Properties of C7H7BrO. The article was titled 《Metal-Free Synthesis of Aryltriphenylphosphonium Bromides by the Reaction of Triphenylphosphine with Aryl Bromides in Refluxing Phenol》. The information in the text is summarized as follows:

A metal-free synthesis of aryltriphenylphosphonium bromides by the reaction of triphenylphosphine with aryl bromides in refluxing phenol is developed. This reaction tolerates hydroxymethyl, hydroxyphenyl, and carboxyl groups in aryl bromides, allowing to synthesize multifunctional aryltriphenylphosphonium bromides, from which facile access to multifunctional aryldiphenylphosphines and their oxides by hydrolysis and subsequent reduction is exemplified. A two-step addition-elimination mechanism with the elimination step being a fast step is also proposed. After reading the article, we found that the author used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Computed Properties of C7H7BrO)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Computed Properties of C7H7BrO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Continuous-Flow Synthesis of Tramadol from Cyclohexanone》 was published in Synlett in 2020. These research results belong to Monos, Timothy M.; Jaworski, Jonathan N.; Stephens, John C.; Jamison, Timothy F.. Quality Control of 1-Bromo-3-methoxybenzene The article mentions the following:

A multioperation, continuous-flow platform for the synthesis of tramadol, ranging from gram to decagram quantities, is described. The platform is segmented into two halves allowing for a single operator to modulate between preparation of the intermediate by Mannich addition or complete the fully concatenated synthesis. All purification operations are incorporated in-line for the Mannich reaction. ‘Flash’ reactivity between meta-methoxyphenyl magnesium bromide and the Mannich product was controlled with a static helical mixer and tested with a combination of flow and batch-based and factorial evaluations. These efforts culminated in a rapid production rate of tramadol (13.7 g°h -1) sustained over 56 reactor volumes A comparison of process metrics including E-Factor, production rate, and space-time yield are used to contextualize the developed platform with respect to established engineering and synthetic methods for making tramadol. In the experimental materials used by the author, we found 1-Bromo-3-methoxybenzene(cas: 2398-37-0Quality Control of 1-Bromo-3-methoxybenzene)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Quality Control of 1-Bromo-3-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Moschona, Fotini; Misirlaki, Christina; Karadimas, Nikolaos; Koutiva, Maria; Savvopoulou, Ioanna; Rassias, Gerasimos published an article in Symmetry. The title of the article was 《Organocatalytic Asymmetric Halocyclization of Allylic Amides to Chiral Oxazolines Using DTBM-SEGPHOS-Mechanistic Implications from Hammett Plots》.Product Details of 2398-37-0 The author mentioned the following in the article:

The intramol. halocyclization of alkenes possessing an internal heteroatom nucleophile leads to multifunctional heterocycles which are useful versatile intermediates in organic synthesis. The asym. chlorocyclization of 2-substituted allylic amides ArC(O)NHCH2C(=CH2)R (R = Ph, 4-FC6H4, pyridin-3-yl, naphthalen-1-yl, etc.; Ar = Ph, 4-MeOC6H4, 4-MeC6H4, etc.) gives access to chiral oxazolines I (X = Cl) bearing a chloromethyl moiety for further synthetic manipulation. The literature reports on this transformation involve complex syntheses of the 2-substituted allylic amides and cryogenic temperatures for achieving high enantioselectivities in the organocatalyzed halocyclization step. Based on the Heck reaction of aryl bromides ArBr (Ar = Ph, 4-CNC6H4, pyridin-3-yl, naphthalen-1-yl, etc.;) and Boc-protected allylamine or allylamine benzamides, a practical synthesis of 2-substituted allylic amides that does not require chromatog. was developed and accomplished their asym. halocyclization reaction with 24-92%ee under practical conditions (5°C, CpME) catalyzed by (S)-(+)-DTBM-SEGPHOS. In addition, using appropriately substituted substrates, Hammett plots were generated and formulated a consistent mechanism for the halocyclization reaction which involves two competing modes of formation of the haliranium intermediate whose relative kinetics are governed by the electronic properties of the substrate. The experimental process involved the reaction of 1-Bromo-3-methoxybenzene(cas: 2398-37-0Product Details of 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Product Details of 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Ma, Na-Na; Ren, Jing-Ao; Liu, Xiang; Chu, Xue-Qiang; Rao, Weidong; Shen, Zhi-Liang published an article in Organic Letters. The title of the article was 《Nickel-Catalyzed Direct Cross-Coupling of Aryl Sulfonium Salt with Aryl Bromide》.Recommanded Product: 1-Bromo-3-methoxybenzene The author mentioned the following in the article:

The direct cross-couplings of aryl sulfonium salts with aryl halides was achieved by using nickel as a reaction catalyst. The reactions proceeded efficiently via C-S bond activation in the presence of magnesium turnings and lithium chloride in THF at ambient temperature to afford the corresponding biaryls in moderate to good yields, potentially served as an attractive alternative to conventional cross-coupling reactions employing preprepared organometallic reagents. After reading the article, we found that the author used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Recommanded Product: 1-Bromo-3-methoxybenzene)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Recommanded Product: 1-Bromo-3-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem