Category: 2380-78-1

Developing consensus on content and format of e-portfolio for MHPE students: A Delphi study. was written by Ansar, Ambreen;Yasmeen, Rahila;Rizvi, Robina Mushtaq. And the article was included in JPMA. The Journal of the Pakistan Medical Association in 2022.HPLC of Formula: 2380-78-1 The following contents are mentioned in the article:

OBJECTIVE: To build a consensus on portfolio framework for master’s in health professional education students and document programme learning outcomes, tasks for students related to each outcome, and the pieces of evidence regarding the completion of each task. METHODS: The modified Delphi study was conducted from February to July 2020 at Riphah International University, Islamabad, Pakistan, and comprised a three-round electronic-based survey of faculty members associated with the master’s in health professional education programme, alumni, and current students as well as portfolio experts. The panellists had to choose from 10 programme learning outcomes, 75 tasks for students to achieve those outcomes, and 510 pieces of evidence to confirm that the tasks had been done to achieve the outcomes. A consensus cut-off of ≥80% was decided to select the item. RESULTS: Of the 45 stakeholders approached, 41(91.5%) responded in round 1. Of them, 31(75.6%) responded in round 2, while round 3 comprised responses from 31(96.7%) subjects. The draft template was originally derived from the master’s in health professional education programme guide, expert opinions, and systematic literature review available for portfolios of other higher education degrees. The list of items was refined through a pilot study. The final template was approved by the expert panel after 3 iterations. The final list of items included 59 (78.6%) tasks and 105(21%) pieces of evidence related to all the 10 programme learning outcomes. CONCLUSIONS: The important programme learning outcomes, their related tasks, and the required pieces of evidence to be added in the e-portfolio of master’s in health professional education programme students were identified, and recommendations for the format of implementation and assessment were given. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1HPLC of Formula: 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.HPLC of Formula: 2380-78-1

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Identification and quantification of lignin monomers and oligomers from reductive catalytic fractionation of pine wood with GC x GC – FID/MS was written by Dao Thi, Hang;Van Aelst, Korneel;Van den Bosch, Sander;Katahira, Rui;Beckham, Gregg T.;Sels, Bert F.;Van Geem, Kevin M.. And the article was included in Green Chemistry in 2022.Quality Control of 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

Thorough lignin characterization is vital to understand the physicochem. properties of lignin and to evaluate lignocellulose biorefinery processes. In this study, an in-depth characterization of lignin oil, obtained from reductive catalytic fractionation (RCF) of pine wood, was performed with quant. GC x GC – FID anal. and qual. GC x GC – MS. By utilizing high-temperature resistant column sets in the GC x GC system and by applying a derivatization step, unambiguous detection of lignin monomers, dimers, and trimers is enabled. In addition to confirm the identity of eleven monomers, corresponding to 34 wt% of the RCF lignin oil, thirty-six dimers (16 wt%) and twenty-one trimers (7 wt%) were comprehensively identified by anal. of their mass spectra and quantified by a FID, encompassing the identity of an addnl. 23 wt% of the RCF lignin oil. The proposed structures reveal the interlinkages present in the dimeric and trimeric oligomers, containing β-5, β-1, β-β, 5-5, and a minor fraction of β-O-4 and 4-O-5 bonds. Furthermore, aliphatic end-units in the dimeric and trimeric mols. were identified, consisting of various substituents at the C4 position, that have been previously observed in the RCF-derived lignin monomers. To reduce complexity for anal., the RCF oil was separated into six fractions, prior to anal. The structural motifs (inter-unit linkages and end-units) that are found in the different fractions vary significantly, such that the lignin fractions extracted in more polar solvents contained higher mol. weight fragments and more hydroxyl containing structural motifs. The identified structures of individual dimer and trimer mols. by GC x GC align well with and further complement the recent findings from ¹H-¹³C HSQC NMR spectroscopy, demonstrating complementarity between both 2D techniques to obtain a holistic view on both the mol. structures and the distribution of bonds and end-units in RCF oil. The combination of these two techniques provides a powerful tool for future RCF and other lignin depolymerization research. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Quality Control of 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Quality Control of 4-Hydroxy-3-methoxyphenethanol

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Black pepper prevents anemia of inflammation by inhibiting hepcidin over-expression through BMP6-SMAD1/ IL6-STAT3 signaling pathway was written by Banerjee, Somesh;Katiyar, Parul;Kumar, Lokesh;Kumar, Vijay;Saini, Shashank Sagar;Krishnan, Vengadesan;Sircar, Debabrata;Roy, Partha. And the article was included in Free Radical Biology & Medicine in 2021.Electric Literature of C9H12O3 The following contents are mentioned in the article:

Hepcidin, a circulatory hepatic peptide hormone, is associated with systemic iron homeostasis. Inflammation leads to an increase in hepcidin expression, which dysregulates body iron level. The related disorder, anemia of inflammation, is the second most prevalent anemia-related disorder worldwide. In the present study, we conducted in vitro and in vivo studies to evaluate the effect of black pepper (BP) and its major bioactive alkaloid, piperine, on anemia of inflammation. The initial in vitro study using human hepatocyte cell line, HepG2, confirmed that among different black pepper extracts: methanol (BPME), ethanol (BPEE) and aqueous (BPAE), BPME to be most effective in downregulating transcription of hepcidin gene. Further, BPME and piperine significantly downregulated hepcidin protein expression at 200μg/mL and 100μM concentrations, resp. In the next phase, BPME and piperine were found to significantly attenuate BMP-6 and IL-6 induced hepcidin overexpression by downregulating the increased level of pSMAD1 and pSTAT3 proteins, resp. For in vivo study, we first s.c. injected male BALB/c mice with oil of turpentine, thrice within a period of two weeks, in order to enhance the expression of hepcidin. After that, the i.p. administration of BPME and piperine at 70 and 25 mg/kg body weight, resp., on alternate days for a period of another two weeks resulted in downregulation of hepcidin overexpression in diseased mice, as confirmed by RT-PCR and immunoblot anal. The histopathol. of liver tissue confirmed increased iron bioavailability in BPME and piperine treated animals. The mol. docking-based interaction studies demonstrated the binding potential of piperine with SMAD1 and STAT3 proteins. The binding patterns supported the proposed inhibition of hepcidin activating proteins. All together, these findings suggest black pepper as a therapeutic candidate for the treatment of anemia of inflammation. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Electric Literature of C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C9H12O3

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Metabolomics reveals diet-derived plant polyphenols accumulate in physiological bone was written by Alldritt, Isabelle;Whitham-Agut, Beatrice;Sipin, Miguel;Studholme, Jacob;Trentacoste, Angela;Tripp, Jennifer A.;Cappai, Maria Grazia;Ditchfield, Peter;Deviese, Thibaut;Hedges, Robert E. M.;McCullagh, James S. O.. And the article was included in Scientific Reports in 2019.SDS of cas: 2380-78-1 The following contents are mentioned in the article:

Plant-derived secondary metabolites consumed in the diet, especially polyphenolic compounds, are known to have a range of pos. health effects. They are present in circulation after ingestion and absorption and can be sequestered into cells within particular organs, but have rarely been investigated systematically in osteol. tissues. However, a small number of polyphenols and similar mols. are known to bind to bone. For example alizarin, a plant derived anthraquinone and tetracycline (a naturally occurring antibiotic), are both absorbed into bone from circulation during bone formation and are used to monitor mineralization in osteol. studies. Both mols. have also been identified serendipitously in archaeol. human bones derived from natural sources in the diet. Whether an analogus mechanism of sequestration extends to addnl. diet-derived plant-polyphenols has not previously been systematically studied. We investigated whether a range of diet-derived polyphenol-like compounds bind to bone using untargeted metabolomics applied to the anal. of bone extracts from pigs fed an acorn-based diet. We analyzed the diet which was rich in ellagitannins, extracts from the pig bones and surrounding tissue, post-mortem. We found direct evidence of multiple polyphenolic compounds in these extracts and matched them to the diet. We also showed that these compounds were present in the bone but not surrounding tissues. We also provide data showing that a range of polyphenolic compounds bind to hydroxyapatite in vitro. The evidence for polyphenol sequestration into physiol. bone, and the range and specificity of polyphenols in human and animal diets, raises intriguing questions about potential effects on bone formation and bone health. Further studies are needed to determine the stability of the sequestered mols. post-mortem but there is also potential for (palaeo)dietary reconstruction and forensic applications. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1SDS of cas: 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.SDS of cas: 2380-78-1

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Antimicrobial Properties of Corn Stover Lignin Fractions Derived from Catalytic Transfer Hydrogenolysis in Supercritical Ethanol with a Ru/C Catalyst was written by Kalinoski, Ryan M.;Li, Wenqi;Mobley, Justin K.;Asare, Shardrack O.;Dorrani, Masoumeh;Lynn, Bert C.;Chen, Xiaowen;Shi, Jian. And the article was included in ACS Sustainable Chemistry & Engineering in 2020.Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

Converting lignin to value added products at high yields provides an avenue for making ethanol biorefineries more profitable while reducing the carbon footprint of products generally derived from petroleum. In this study, corn stover lignin was depolymerized by catalytic transfer hydrogenolysis (CTH) in supercritical ethanol with a Ru/C catalyst. The lignin derived bio-oil was then sequentially extracted utilizing hexane, petroleum ether, chloroform and Et acetate as solvents in order of less polar to polar and the subsequent bio-oils were characterized using GPC, GC/MS and HSQC NMR. Results show lignin derived compounds were sequentially extracted into groups depending on the solvent polarity. Antimicrobial properties of the bio-oils were screened against Gram-pos. (Bacillus subtilis, Lactobacillus amylovorus, and Staphylococcus epidermidis), Gram-neg. (Escherichia coli) bacteria and yeast (Saccharomyces cerevisiae) by examining microbial growth inhibition. Results show that CTH derived bio-oils inhibited all tested organisms at concentrations less than 3 mg/mL. Total monomer concentration and the presence of specific monomers (i.e., syringyl propane) showed correlations to antimicrobial activity, likely due to cell death or membrane damage. This study provides insights into using sequential extraction to fractionate lignin-derived compounds and correlations between the properties of the extracted compounds and their antimicrobial activity. A lignin-based bio-oil was prepared from catalytic transfer hydrogenolysis of purified corn stover lignin with ethanol and a ruthenium on carbon catalyst. Polar and nonpolar solvents were used to sequentially extract different compounds The raw bio-oil and sequential extraction fractions exhibited antimicrobial properties against Gram-pos./neg. bacteria and yeast, with activity related to total monomer content and specific monomers. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Analysis of chemosensory markers in cigarette smoke from different tobacco varieties by GC×GC-TOFMS and chemometrics was written by Schwanz, Thiago G.;Bokowski, Liane V. V.;Marcelo, Marcelo C. A.;Jandrey, Angela C.;Dias, Jailson C.;Maximiano, Daniel H.;Canova, Luciana S.;Pontes, Oscar F. S.;Sabin, Guilherme P.;Kaiser, Samuel. And the article was included in Talanta in 2019.Computed Properties of C9H12O3 The following contents are mentioned in the article:

Com. cigarettes are made from a blend of different tobacco varieties, which in turn are the results of different agronomic practices and post-harvest curing processes. The highly complex mixture of smoke compounds reflects each tobacco variety and the levels of sensory-relevant markers. Therefore, the aim of this work was to identify potential relevant chemosensory markers in the mainstream smoke of four main types of com. tobaccos and establish any possible relationship between them and the tobacco growing/curing practices. The tobacco samples were segregated into four segments: (1) three curing stages of flue-cured Virginia, (2) three curing stages of air-cured Burley, (3) three geo-regions of sun-cured Oriental and (4) three different process applied to tobacco. One hundred and twenty cigarettes (10 batches per flavor category) were produced and smoked under standard machine-smoking protocols. The mainstream smoke samples collected were extracted and analyzed by GC × GC TOFMS. The processed data was analyzed by partial least square discriminant anal. (PLS-DA) and the selectivity ratio was used to identify key chemosensory markers responsible for the four segments. All models had sensitivity and specificity equal to unity. Flue-cured Virginia (193 markers) and air-cured Burley (184 markers) showed a similar trend for O-heterocycles markers in the lighter leaf colors and N-heterocycles in the darker leaf colors post-processing, but they had compounds of different flavor descriptions, e. g. sweet and nutty. The three geo-regions of sun-cured Oriental (290 markers) also presented O-heterocycles markers in correlation with leaf sugar contents in addition of sucrose esters markers. The three unusually processed tobacco generated many chem. markers (436 markers), some derived from the so-called Cavendish fermentation process with sweet, spicy and peppery notes, whereas the dark fermented air-cured tobacco presented similar descriptors as air-cured Burley. In addition, some polycyclic aromatic hydrocarbons (PAH) were detected as markers from the fire-curing process. The PLS-DA with selectivity ratio evidenced total of 1098 chemosensory markers in cigarette smoke, in which 173 were tentatively identified. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Computed Properties of C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Computed Properties of C9H12O3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Effects of Radix scrophulariae on hyperthyroidism assessed by metabonomics and network pharmacology was written by Zhang, Ning;Lu, Fang;Li, Zihui;Zhao, Hongwei;Pang, Mu;Ye, Tao;Wang, Xijun;Liu, Shumin. And the article was included in Frontiers in Pharmacology in 2021.Recommanded Product: 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

Radix Scrophulariae (Chinese name: Xuanshen), a traditional Chinese herb, is used for the treatment of hyperthyroidism, and in this study, its mechanisms were evaluated by metabonomics and system pharmacol. To study the anti-hyperthyroidism effects of R. Scrophulariae, a male SD rat (180-220 g) model of hyperthyroidism induced by Euthyrox was used. Thirty rats were randomly distributed into three groups: the Model group, the R. Scrophulariae treatment group (RS group) and the healthy Control group. Using the UHPLC/Q-TOF-MS metabolomics approach, 44 metabolites were found to be profoundly altered in the model group, and the levels of these biomarkers were significantly decreased after treatment with R. Scrophulariae. Forty-four metabolites and 13 signaling pathways related to R. Scrophulariae, including the biosynthesis of unsaturated fatty acids, primary bile acid biosynthesis and sphingolipid metabolism, were explored, and linoleic acid metabolism and sphingolipid metabolism were identified as the most relevant metabolic pathways. In addition, the system pharmacol. paradigm revealed that R. Scrophulariae contains 83 active ingredients and is related to 795 genes, and 804 disease genes are related to hyperthyroidism. The construction of the R. Scrophulariaceae-chem. composition-target-hyperthyroidism network identified a total of 112 intersection genes. The enriched gene targets were analyzed, and five pathways were found to be enriched. Among them pathways, the HIF signaling pathway had the highest enrichment score, which indicated that this pathway might be the main signaling pathway related to the treatment of hyperthyroidism by R. Scrophulariae. The integrated approach involving metabolomics and network pharmacol. revealed that R. Scrophulariae might play a role in the treatment of hyperthyroidism by regulating the “IL6-APOA1-cholesterol” pathway and disturbing the HIF signaling pathway. The results demonstrate that the combination of metabolomics and network pharmacol. could be used to reflect the effects of R. Scrophulariae on the biol. network and metabolic state of hyperthyroidism and to evaluate the drug efficacy of R. Scrophulariaceae and its related mechanisms. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Recommanded Product: 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: 4-Hydroxy-3-methoxyphenethanol

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Ether | (C2H5)2O – PubChem

Effect of simultaneous use of microwave and ultrasound irradiation on the sulfuric acid hydrolysis lignin depolymerization was written by Rana, Masud;Nshizirungu, Theoneste;Park, Jeong-Hun. And the article was included in Sustainable Energy & Fuels in 2022.COA of Formula: C9H12O3 The following contents are mentioned in the article:

In this study, the individual and combined effects of microwave (MW) and ultrasound (US) processes on the depolymerization of sulfuric acid hydrolysis lignin (SAHL) were investigated in a hybrid microwave-ultrasound chem. reactor. Results revealed that the combined use of MW and US processes led to better results in terms of high yields of bio-oil and monomer production (43.01 and 6.69 wt%), as compared to the individual use of MW (32.83 and 4.71 wt%) and US (21.60 and 3.58 wt%) processes. The highest yield of bio-oil (63.50 wt%), which contained 13.04 wt% monomers, was achieved under the optimized reaction conditions of 180°C, 80 min, 30% US frequency and a 1,4-dioxane to formic acid ratio of 250 : 50 (volume/volume). Process parameters such as temperature, time and the content of formic acid added to 1,4-dioxane were chosen carefully and optimized using response surface methodol. (RSM). The results of the statistical anal. of variance (ANOVA) showed that the depolymerization temperature and time significantly affected (ρ < 0.05) the yield of bio-oil. In the liquid products, the compounds guaiacol (G1), ethanone, 1-(4-hydroxy-3-methoxyphenyl)-(G3), 2-(4-hydroxy-3-methoxyphenyl)acetaldehyde (G10), 4-Et phenol (H1), 4-Me phenol (H4), and di-Bu phthalate (DBPH) were produced as major monomers. Meanwhile, the GPC results showed that the mol. weight of SAHL (Mw = ∼2156) was significantly reduced to lower mol. weight compounds (Mw = 638). The findings obtained from this study suggest that the applied MW-US-assisted lignin depolymerization process could be a promising alternative to the sep. use of the MW or US process and can pave the way to continue advancing the lignin conversion practices as a renewable and sustainable resource of aromatic chems. Moreover, the proposed method is believed to possess great potential for conversion of a major waste stream from a pulp industry into aromatic chem. production Future work will be directed toward the simultaneous use of MW-US-assisted depolymerization of lignin in a continuous flow process mimicking the optimized conditions obtained under batch MW-US conditions. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1COA of Formula: C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.COA of Formula: C9H12O3

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Ether | (C2H5)2O – PubChem

Phytochemical profiling, molecular docking, and in vitro anti-hepatocellular carcinoid bioactivity of Suaeda vermiculata extracts was written by Mohammed, Hamdoon A.;Almahmoud, Suliman A.;Arfeen, Minhajul;Srivastava, Ashish;El-Readi, Mahmoud Z.;Ragab, Ehab A.;Shehata, Safia M.;Mohammed, Salman A. A.;Mostafa, Ehab M.;El-khawaga, Hend A.;Khan, Riaz A.. And the article was included in Arabian Journal of Chemistry in 2022.COA of Formula: C9H12O3 The following contents are mentioned in the article:

The ATP-binding cassette is the major class of transporters responsible for the efflux of chemotherapeutic agents from cancer cells, resulting in treatment failures of cancer patients. Suaeda vermiculata Forssk. ex. Gmel. is traditionally known for its liver protective activity. The LC-MS based chem. profilings of the sequentially partitioned sub-extracts obtained from the alc. extract of S. vermiculata using n-hexane, chloroform, Et acetate, and n-butanol as fractionating solvents, identified a total of thirty six compounds These sub-extracts were evaluated for their anti-hepatocarcinoma activity against the sensitive HepG2 and doxorubicin (DOX)-resistant, HepG-2/ADR cell lines. A mixture of doxorubicin and sub-extracts at 20 μg/mL doses were also tested for their anti-hepatocarcinoma activity. The exhibited IC50 values for the chloroform, Et acetate, n-hexane, and n-butanol sub-extracts, and the doxorubicin against HepG2, and HepG-2/ADR cell lines were found at 64.5, 66.8, 81.25, 125, 1.3 μg/mL, and 110.1, 91.82, 138.2, 265.7, 4.77 μg/mL levels, resp. However, the treatment of resistant cells with 20 μg/mL of different sub-extracts in combination with the doxorubicin showed significant improvements in the doxorubicin activity against the resistant cells, and the IC50 values for DOX + chloroform, DOX + Et acetate, DOX + n-hexane, and DOX + n-butanol against resistant cells, were at 1.77, 2.05, 2.66, and 2.71 μg/mL levels, resp. The IC50 values exhibited 2.69x, 2.33x, 1.79x and 1.76x-folds reversal of the sensitivity in the resistant cancer cell lines. The mol. docking studies of the compounds identified in the LC-MS chem. profilings, against three ATP-binding cassette proteins i.e., ABCB1, ABCC1, and ABCG2, showed that flavonoids as the major class of compounds responsible for reversal of the resistant cells sensitivities. The predicted binding affinity for the flavonoids against the above mentioned three ATP-binding cassette proteins′ are in the ranges of ~-8 to -11 kcal/mol. Our results clearly indicate that the presence of flavonoids, as the major class of compounds in the S. vermiculata is responsible for the chemosensitization of the resistant HCC-cell lines. Moreover, the structures, 21 (5-O-Me visamminol), 22 (N-trans-feruloyl tyramine), 27 (atractylenolide-III), and 32 (ginsenoside-Rh2) were also identified among the potential ATP-binding cassette′s modulators during the current study. These observations put the S. vermiculata in perspective with the traditionally claimed liver protective efficacy of the plant. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1COA of Formula: C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.COA of Formula: C9H12O3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Active immunization against serum alcohol dehydrogenase normalizes brain dopamine metabolism disturbed during chronic alcohol consumption was written by Mitkin, Nikita A.;Anokhin, Petr K.;Belopolskaya, Maria V.;Frolova, Olga Y.;Kushnir, Ekaterina A.;Lovat, Maxim L.;Pavshintsev, Vsevolod V.. And the article was included in Alcohol (New York, NY, United States) in 2020.Category: ethers-buliding-blocks The following contents are mentioned in the article:

Chronic ethanol consumption in high doses is associated with constitutively elevated activity of the serum alc. dehydrogenase I (ADH I) isoform, which demonstrates a high affinity not only for ethanol but also for a number of bioamine metabolites. Such excessive ADH activity is probably associated with disruptions in the metabolism of neurotransmitters (dopamine, serotonin, and norepinephrine) and subsequent long-term changes in the activity of their receptors. Ultimately, a stable depressive-like condition contributes to the development of patients craving for ethanol intake, frequent disruptions during therapy, and low efficacy of treatment. We applied active immunization against ADH to investigate its efficacy in the reduction of excessive serum ADH activity and regulation of ethanol consumption by chronically ethanol-fed Wistar rats (15% ethanol, 4 mo, free-choice method), and we analyzed its ability to influence the levels of bioamines in the brain. Immunization (2 injections, 2-wk intervals) was performed using a combination of recombinant horse ADH isoenzyme as an antigen and 2% aluminum hydroxide-based adjuvant. The efficacy of immunization was demonstrated by the production of high titers of ADH-specific antibodies, which was consistent with the significantly reduced ADH activity in the serum of chronically ethanol-fed rats. On the 26th day after the first vaccine injection, we registered significantly lower levels of alc. consumption compared to ethanol-fed control animals, and the difference reached 16% on the 49th day of the experiment These observations were accompanied by data that showed reduced levels of ethanol preference in immunized rats. Chronic alc. drinking led to a decrease in dopamine and DOPAL (a direct dopamine metabolite and a high-affinity ADH substrate) levels in the striatum,while immunization neutralized this effect. Addnl., we observed that inhibition of serum ADH activity caused a decrease in peak dopamine levels during acute alc. intake in chronically ethanol-fed rats during ethanol withdrawal that was associated with reduced tyrosine hydroxylase activity in the striatum. The obtained data suggest a significant contribution of ADH to the changes in neurotransmitter systems during chronic alc. consumption and make available new prospects for developing innovative strategies for treatment of excessive alc. intake. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Category: ethers-buliding-blocks).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem