Category: 23783-42-8

Guazzelli, Elisa published the artcileSingle-chain folding and self-assembling of amphiphilic polyethyleneglycol-modified fluorinated styrene homopolymers in water solution, Name: 2,5,8,11-Tetraoxatridecan-13-ol, the main research area is amphiphilic polyethyleneglycol modified fluorinated styrene homopolymer self assembling.

Amphiphilic tetrafluorostyrene monomers (EFSn) carrying in the para position a polyethyleneglycol (PEG) chain with varied lengths (n = 3-13) were synthesized and polymerized by ARGET-ATRP to obtain the corresponding amphiphilic homopolymers pEFSn-x with controlled and tailored polymerization degrees (x = 8-135). All polymers presented a reversible thermoresponsive LCST-type behavior, in water/methanol mixture when n ≤ 4 or in pure water when n ≥ 8, with a cloud point (Cp) temperature in the range 30-40°C strictly dependent on the length of the PEG side chain. Combined small angle X-scattering (SAXS) and dynamic light scattering (DLS) measurements were used to study the self-assembly behavior in water of the water-soluble amphiphilic homopolymers. SAXS confirmed the formation of compact-sized and spherical single-chain self-folded nanostructures below Cp, that generally presented small hydrodynamic diameters (Dh ≤ 11 nm) as proven by DLS anal. Above Cp, much larger multi-chain aggregates were formed (Dh ≥ 800 nm), that reversibly turned back to collapsed nanostructures on cooling below the Cp temperature By contrast, the polymers were not able to self-assemble in THF or DMF solutions, in which they adopted conventional random coil conformations.

Polymer published new progress about Amphiphiles. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Name: 2,5,8,11-Tetraoxatridecan-13-ol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Czysch, Christian published the artcileNontoxic N-Heterocyclic Olefin Catalyst Systems for Well-Defined Polymerization of Biocompatible Aliphatic Polycarbonates, COA of Formula: C9H20O5, the main research area is heterocyclic olefin catalyst biocompatible aliphatic polycarbonate ring opening polymerization; nanocarrier drug delivery system.

Herein, N-heterocyclic olefins (NHOs) are utilized as catalysts for the ring-opening polymerization (ROP) of functional aliphatic carbonates. Aiming for the polymerization of monomers with high side chain functionality, six-membered carbonates derived from 2,2-bis(hydroxymethyl)propionic acid (bis-MPA) served as model compounds Tuning the reactivity of NHO from predominant side chain transesterification at room temperature toward ring-opening at lowered temperatures (-40°C) enables controlled ROP. These refined conditions give narrowly distributed polymers of the hydrophobic carbonate 5-methyl-5-benzyloxycarbonyl-1,3-dioxan-2-one (MTC-OBn) (D < 1.30) at (pseudo)first-order kinetic polymerization progression. For the active ester monomer 5-methyl-5-pentafluorophenyloxycarbonyl-1,3-dioxane-2-one (MTC-PFP) with elevated side chain reactivity, a cocatalysis system consisting of NHO and the Lewis acid magnesium iodide is required to retune the reactivity from side chains toward controlled ROP. The broad feasibility of our findings was further demonstrated by the synthesis of block copolymers for bioapplications and their successful nanoparticular assembly. The polycarbonate block copolymer mPEG44-b-poly(MTC-OBn) enables phys. entrapment of hydrophobic dyes in sub-20 nm micelles, whereas the active ester block copolymer mPEG44-b-poly(MTC-PFP) is postfunctionalizable by covalent dye attachment. Both block copolymers thereby serve as platforms for phys. or covalent modification of nanocarriers for drug delivery. ACS Polymers Au published new progress about Amphiphiles. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, COA of Formula: C9H20O5.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Han, Jianxiong published the artcileRu-Se Coordination: A New Dynamic Bond for Visible-Light-Responsive Materials, Recommanded Product: 2,5,8,11-Tetraoxatridecan-13-ol, the main research area is ruthenium terpyridine biquinoline selenoether complex preparation amphiphilicity photodissociation; UV vis spectra ruthenium terpyridine biquinoline selenoether amphiphilic complex.

Photodynamic bonds are stable in the dark and can reversibly dissociate/form under light irradiation Photodynamic bonds are promising building blocks for responsive or healable materials, photoactivated drugs, nanocarriers, extracellular matrixes, etc. However, reactive intermediates from photodynamic bonds usually lead to side reactions, which limit the use of photodynamic bonds. Here, we report that the Ru-Se coordination bond is a new photodynamic bond that reversibly dissociates under mild visible-light-irradiation conditions. We observed that Ru-Se bonds form via the coordination of a selenoether ligand with [Ru(tpy)(biq)(H2O)]Cl2 (tpy = 2,2′:6′,2”-terpyridine, biq = 2,2′-biquinoline) in the dark, while the Ru-Se bond reversibly dissociates under visible-light irradiation No side reaction is detected in the formation and dissociation of Ru-Se bonds. To demonstrate that the Ru-Se bond is applicable to different operating environments, we prepared photoresponsive amphiphiles, surfaces, and polymer gels using Ru-Se bonds. The amphiphiles with Ru-Se bonds showed reversible morphol. transitions between spherical micelles and bowl-shaped assemblies for dark/light irradiation cycles. The surfaces modified with Ru-Se-bond-containing compounds showed photoswitchable wettability. Polymer gels with Ru-Se cross-links underwent photoinduced reversible sol-gel transitions, which can be used for reshaping and healing. Our work demonstrates that the Ru-Se bond is a new type of dynamic bond, which can be used for constructing responsive, reprocessable, switchable, and healable materials that work in a variety of environments.

Journal of the American Chemical Society published new progress about Amphiphiles. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Recommanded Product: 2,5,8,11-Tetraoxatridecan-13-ol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hu, An published the artcileA Consequence of Dispersity on the Self-Assembly of Amphiphilic Homopolymers Containing Main-Chain Azobenzene, Synthetic Route of 23783-42-8, the main research area is self assembly amphiphilic homopolymer azobenzene.

The self-assembly of amphiphilic oligomers/polymers is a versatile and promising approach for creating nonspherical polymeric nanoparticles. Discrete amphiphilic oligomers/polymers with molecularly defined structures are ideal candidates for fabricating smart nanoparticles and for achieving a deeper understanding of structure-controlled self-assembly. Herein, discrete and disperse amphiphilic homopolymers of PAZOnTEG2n, with hydrophobic azobenzene are designed and synthesized as the main chains tethered with hydrophilic tetraethylene glycol monomethyl ether (TEG) units, to accurately investigate the impact of dispersity on their self-assembly in solution The discrete-PAZO8TEG16 in DMF/water and in THF/water results in the formation of 2D lamellae, while the dispersed counterpart prefers to self-assemble into spherical micelles. The significant difference is due to their distinction between interior structures of assembly. Furthermore, photoisomerization of azobenzene triggers dissociation/reassembly for discrete polymeric nanoparticles but no obvious change for the dispersed counterparts under irradiation with UV/vis light. This work reveals the influence of dispersity on the self-assembly of amphiphilic polymers and stimuli-responsive properties of their nanomaterials, which is desirable for universal applicability in fabricating smart 2D lamellas.

Macromolecular Chemistry and Physics published new progress about Amphiphiles. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Synthetic Route of 23783-42-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Mukherjee, Anurag published the artcileUltrathin Two Dimensional (2D) Supramolecular Assembly and Anisotropic Conductivity of an Amphiphilic Naphthalene-Diimide, Application In Synthesis of 23783-42-8, the main research area is supramol structure self assembly naphthalene diimide chromophore.

Two-dimensional (2D)-supramol. assemblies of π-conjugated chromophores are relatively less common compared to a large number of recent examples on their low dimensional (0D or 1D) assemblies or 3D architectures. This article reports a rational design for the 2D supramol. assembly of an amphiphilic core-substituted naphthalene-diimide derivative (cNDI-1). The building block contains a naphthalene-diimide (NDI) chromophore, sym. substituted with two dodecyl chains from the aromatic core while the imide positions are functionalized with two hydrophilic wedges containing oligo-oxyethylene chains. In water, it exhibits entropically favorable self-assembly with a critical aggregation concentration of 1.5 x 10-5 M and a lower critical solution temperature of 55°C. The UV/vis absorption spectrum in water shows bathochromically shifted absorption bands compared to that of the monomeric dye in THF, indicating offset π-stacking among the NDI chromophores. C-H sym. and asym. stretching frequencies in the FT-IR spectrum support the presence of organized hydrocarbon chains in trans conformation in the self-assembled state, similar to that in the crystalline n-alkanes, which is further supported by studying the general polarization (GP) values of a noncovalently entrapped Laurdan dye. The at. force microscopy (AFM) image shows the formation of ultrathin (height < 2.0 nm) ribbons for the spontaneously assembled sample which eventually produces a large-area 2D nanosheet by the lateral organization. The powder X-ray diffraction pattern of the drop-casted film, prepared from the preformed aggregates, reveals sharp peaks that indicate a crystalline lamellar packing along the direction of the 2D growth. Differential scanning calorimetry trace shows the melting of the crystalline alkyl chain domain at T > 75°C, which destroys the 2D assembly. Local-scale photoconductivity of the ordered 2D assembly, studied by the flash-photolysis time-resolved microwave conductivity (FP-TRMC) technique, reveals an anisotropic conductivity with ~3 times larger conductivity along the parallel direction compared to that along the perpendicular one.

Langmuir published new progress about Chromophores. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Application In Synthesis of 23783-42-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Varela-Aramburu, Silvia published the artcileIntroducing Hyaluronic Acid into Supramolecular Polymers and Hydrogels, Synthetic Route of 23783-42-8, the main research area is hyaluronic acid supramol polymer hydrogel functional biomaterial.

The use of supramol. polymers to construct functional biomaterials is gaining more attention due to the tunable dynamic behavior and fibrous structures of supramol. polymers, which resemble those found in natural systems, such as the extracellular matrix. Nevertheless, to obtain a biomaterial capable of mimicking native systems, complex biomols. should be incorporated, as they allow one to achieve essential biol. processes. In this study, supramol. polymers based on water-soluble benzene-1,3,5-tricarboxamides (BTAs) were assembled in the presence of hyaluronic acid (HA) both in solution and hydrogel states. The coassembly of BTAs bearing tetra(ethylene glycol) at the periphery (BTA-OEG4) and HA at different ratios showed strong interactions between the two components that led to the formation of short fibers and heterogeneous hydrogels. BTAs were further covalently linked to HA (HA-BTA), resulting in a polymer that was unable to assemble into fibers or form hydrogels due to the high hydrophilicity of HA. However, coassembly of HA-BTA with BTA-OEG4 resulted in the formation of long fibers, similar to those formed by BTA-OEG4 alone, and hydrogels were produced with tunable stiffness ranging from 250 to 700 Pa, which is 10-fold higher than that of hydrogels assembled with only BTA-OEG4. Further coassembly of BTA-OEG4 fibers with other polysaccharides showed that except for dextran, all polysaccharides studied interacted with BTA-OEG4 fibers. The possibility of incorporating polysaccharides into BTA-based materials paves the way for the creation of dynamic complex biomaterials.

Biomacromolecules published new progress about Crosslinking. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Synthetic Route of 23783-42-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wang, Shixue published the artcileSynthesis of Y-Shaped OEGylated Poly(amino acid)s: The Impact of OEG Architecture, Computed Properties of 23783-42-8, the main research area is PEGylation polyamino acid glutamic structure.

OEGylation is an attractive approach to modifying poly(amino acid)s. OEG conjugation improves water-solubility of poly(amino acid)s, and confers possible thermal-responsive functionality for the conjugated poly(amino acid)s. Nevertheless, the impact of OEG architecture and the manner in which the OEG moiety interferes with the performances of poly(amino acid)s remain a work in progress. In this study, a series of new linear and Y-shaped OEG-substituted poly(glutamic acid)s were designed and synthesized. It is found that the thermoresponsive behavior of OEGylated poly(glutamic acid)s experiences steric repulsion effect, the strengths of which are architecture and length-dependent, and grows pronounced only when the number of the OEG units is ≥6. Notably, the Y-shaped architecture is able to stabilize the helicity of poly(glutamic acid) backbones, while maintaining higher α-helical conformation than its linear counterparts. In sum, our result indicate that Y-shaped architecture is more appropriate toward OEGylating poly(amino acid)s for biomedical applications.

Biomacromolecules published new progress about Conformation. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Computed Properties of 23783-42-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gran, Evan Rizzel published the artcileHuman astrocytes and astrocytoma respond differently to resveratrol, Computed Properties of 23783-42-8, the main research area is resveratrol human astrocyte astrocytoma; Astrocytes; Astrocytoma; Glutathione; Miktoarm polymers; Reactive oxygen species; Resveratrol.

A fundamental problem in oncol. is that anticancer chemotherapeutics kill both cancer and healthy cells in the surrounding tissues. Resveratrol is a natural antioxidant with intriguing and opposing biol. properties: it reduces viability of some cancer cells but not of non-transformed ones (in equimolar concentrations). Therefore, we examined resveratrol in human non-transformed primary astrocytes and astrocytoma. Resveratrol reduced reactive oxygen species in astrocytes, but not in astrocytoma. Such cell-type dependent response is particularly evident with analyses at the single cell level showing clear population difference in high and low glutathione levels. Due to resveratrol′s poor aqueous solubility that limits its use in clinics, we incorporated it into stimulus-responsive micelles assembled from miktoarm polymers. This could be an attractive chemotherapeutic delivery strategy in nano-oncol. As a proof of principle, we show that these formulations containing resveratrol markedly decrease astrocytoma viability, particularly in combination with temozolomide, a first line chemotherapeutic for astrocytoma.

Nanomedicine (New York, NY, United States) published new progress about Antioxidants. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Computed Properties of 23783-42-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Inomata, Koya published the artcileRuthenium-catalyzed selective hydrosilylation reaction of allyl-functionalized PEG derivatives, Formula: C9H20O5, the main research area is polyethylene glycol allyl ether derivative ruthenium catalyzed selective hydrosilylation.

Reactions of allyl-functionalized poly(ethylene glycol) (PEG) derivatives with alkoxysilanes proceeded efficiently to furnish the corresponding hydrosilylated products in good to excellent yields using a ruthenium catalyst, [RuCl2(nbd)]n. A preliminary mechanistic study supported the pivotal role of the PEG moiety, which coordinated to the ruthenium atom during the reaction to achieve high reaction selectivity. This method may be applicable to the synthesis of various PEGs with a silyl terminus, which is useful as biocompatible and low toxic silane coupling agents.

Tetrahedron Letters published new progress about Hydrogenation. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Formula: C9H20O5.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yen, Hao-Chi published the artcileModulation of the Hydrophilicity on Asymmetric Side Chains of Isoindigo-Based Polymers for Improving Carrier Mobility-Stretchability Properties, Related Products of ethers-buliding-blocks, the main research area is hydrophilicity isoindigo polymer carrier mobility stretchability.

To realize high-performance and intrinsically stretchable materials for field-effect transistor (FET) devices, a plethora of approaches about structure design were explored. Herein, we report a new approach to control the carrier mobility-stretchability properties of the polymers by tuning the hydrophilicity and asym. side-chain combination. A series of isoindigo-bithiophene (II2T)-based semiconducting polymers with three kinds of side chains including carbosilane side chain, semifluorinated side chain, and oligoether side chain were synthesized for investigating the structure-mobility and structure-stretchability relationships. The mol. stacking pattern and orientation of the derived polymers could be controlled by altering the hydrophilicity and asym. side-chain combination. The side chains of carbosilane and oligoether and a semifluorinated side chain could provide an order edge-on stacking, conformability and backbone aggregation, and an irregular solid-state aggregation, resp. Among them, P(Si-O) with oligoether and a carbosilane side chain exhibited an enhanced μh of 0.56 cm2 V-1 s-1, edge-on stacking, and aggregation behavior owing to the favorable intermol. interaction between the oligoether side chain and the asym. side chain to mitigate the steric hindrance. Also, P(Si-O) possessed a remarkable stretchability of (92%,⊥, 82%,‖) orthogonal μh retention under 100% strain and almost unchanged μh was observed after 1000 stretching-releasing cycles at 60% strain. The exptl. results suggested that the combination and hydrophilicity of side chain played a pivotal role in developing semiconducting polymers with a high performance and an intrinsic stretchability.

Macromolecules (Washington, DC, United States) published new progress about Crystallinity. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Related Products of ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem