Category: 2358-54-5

Tennie, Iris K. published the artcilePolymeric ¹⁹F MRI Contrast Agents Prepared by Ring-Opening Metathesis Polymerization/Dihydroxylation, Product Details of C4H7F3O2, the publication is Macromolecules (Washington, DC, United States) (2020), 53(23), 10386-10396, database is CAplus.

The capability of ring-opening metathesis polymerization (ROMP) to efficiently incorporate bulky monomers and conserve olefin bonds during polymerization was exploited to design water-soluble fluoropolymers, which were evaluated as potential quant. ¹⁹F magnetic resonance imaging (MRI) contrast agents. The fluoromonomeric units comprised 3, 6, 9, or 18 magnetically equivalent fluorine atoms. Aqueous solubility was achieved through dihydroxylation of the partially unsaturated polymeric backbone and by tetraethylene glycol (TEG)-based linker incorporation, ammonium quaternization, or copolymerization

Macromolecules (Washington, DC, United States) published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C20H12N2O2, Product Details of C4H7F3O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bezencon, Olivier published the artcileDiscovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies, SDS of cas: 2358-54-5, the publication is Journal of Medicinal Chemistry (2017), 60(23), 9769-9789, database is CAplus and MEDLINE.

The authors report the discovery and pharmacol. characterization of N-(1-benzyl-1H-pyrazol-3-yl)-2-phenylacetamide derivatives as potent, selective, brain-penetrating T-type calcium channel blockers. Optimization focused mainly on solubility, brain penetration, and the search for an aminopyrazole metabolite that would be neg. in an Ames test. This resulted in the preparation and complete characterization of compound 66b (ACT-709478 (N-(1-((5-cyanopyridin-2-yl)methyl)-1H-pyrazol-3-yl)-2-(4-(1-(trifluoromethyl)cyclopropyl)phenyl)acetamide)), which has been selected as a clin. candidate.

Journal of Medicinal Chemistry published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C4H7F3O2, SDS of cas: 2358-54-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Luqing published the artcileSynthesis and Surface Activities of Novel Succinic Acid Double-Tailed Sulfonate Fluorinated Surfactants, Formula: C4H7F3O2, the publication is Journal of Surfactants and Detergents (2016), 19(3), 559-565, database is CAplus.

In this study, four environmentally friendly succinic acid double-tailed sulfonate fluorinated surfactants were synthesized from maleic anhydride, fluoroalkyl alcs., namely 1-(1H,1H,7H-Dodecafluoroheptyloxy) ethanol, 1-(1H,1H,5H-octafluoropentyloxy) ethanol, 1-(1H,1H,3H-tetrafluoropropoxy) ethanol, 1-(1H,1H-trifluoroethyloxy) ethanol, and sodium hydrogensulfite. The surfactant structure was characterized by FT-IR, ¹H NMR, and ¹⁹F NMR . Thermogravimetric results showed that the fluorinated surfactants were stable up to relatively high temperature The Krafft points of the four novel succinic acid double-tailed sulfonate fluorinated surfactants were all below 0°C. The lowest CMC value for the synthesized four double-tailed fluorine surfactants is about 0.076 mmol L^-1, far less than that of ammonium perfluorooctanoate (PFOA), demonstrating that double-tailed surfactants have higher surface activity than surfactants with one fluoroalkyl chain. The replacement of alkyl groups with oxyethylene groups enhances the hydrophilicity of the obtained fluorinated surfactants. Based on these findings, the synthesized surfactants may be environmentally friendly alternatives to PFOA and exhibit promising potential in industry applications.

Journal of Surfactants and Detergents published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C38H74Cl2N2O4, Formula: C4H7F3O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Heilmann, S. M. published the artcileO-Hydroxyethylation of 1,1-dihydroperfluorinated alcohols, Name: 2-(2,2,2-Trifluoroethoxy)ethanol, the publication is Journal of Fluorine Chemistry (1992), 59(3), 387-96, database is CAplus.

A convenient transformation of 1,1-dihydroperfluorinated alcs. into O-hydroxyethyl derivatives (R_FCH₂OCH₂CH₂OH) is described in which ethylene carbonate is utilized as the alkylating agent. Tetraalkylammonium iodides and trialkylamines are effective catalysts.

Journal of Fluorine Chemistry published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C4H7F3O2, Name: 2-(2,2,2-Trifluoroethoxy)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Tollefson, Michael B. published the artcile1-(2-(2,2,2-Trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors, COA of Formula: C4H7F3O2, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(10), 3125-3128, database is CAplus and MEDLINE.

1H-Pyrazolo[4,3-d]pyrimidines were previously disclosed as a potent second generation class of phosphodiesterase 5 (PDE5) inhibitors. This work explores the advancement of more selective and potent PDE5 inhibitors resulting from the substitution of 2-(2,2,2-trifluoroethoxy)ethyl at the 1 position in the so-called alkoxy pocket.

Bioorganic & Medicinal Chemistry Letters published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C19H21N3O, COA of Formula: C4H7F3O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem