Category: 2357-52-0

2357-52-0, name is 4-Bromo-2-fluoroanisole, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C7H6BrFO

A mixture of 4-Bromo-2-fluoro-1-methoxybenzene (107 g, 0.5244 mol, from step (ii) above ), CuCN (70.4 g, 0.7866 mol) in dry DMF (150 ml) was stirred at 120 C overnight. The reaction mixture was cooled to room temperature, diluted with water and extracted with ethyl acetate. Organic layer was washed with water and brine and dried over sodium sulfate. Solvent evaporation under reduced pressure followed by column chromatography over silica gel using 3% ethyl acetate in petroleum ether gave the sub-title compound (24.4 g) as a solid.

The synthetic route of 2357-52-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; WO2005/123748; (2005); A1;,
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Electric Literature of 2357-52-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2357-52-0, name is 4-Bromo-2-fluoroanisole, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 101 (2R)-1-(3-Fluorobiphenyl-4-yloxy)-4-(3-pyridyl)-2-butanol STR126 a) 3-Fluoro-4-methoxybiphenyl Prepared according to the method as described in Example 33a) from 4-bromo-2-fluoroanisole (1.0 g), benzeneboronic acid (0.6 g), tetrakis(triphenylphosphine)palladium(0) (0.12 g), toluene (15 ml), ethanol (3 ml) and aqueous sodium carbonate (2 M, 5 ml) with heating at 120 C. for 2 hours. After work up the residue was purified by chromatography over silica eluding with ethyl acetate:hexane (1:9) to give the sub-title compound as a white solid (0.99 g). m.p. 86-87 C. MS (EI) 202 (M)+ 1 H NMR (DMSO-d6) 7.65(2 H, dd); 7.55(1 H, dd); 7.5-7.4(3 H, m); 7.33(1 H, t); 7.25(1 H, t); 3.88(3 H, s).

The chemical industry reduces the impact on the environment during synthesis 4-Bromo-2-fluoroanisole. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2357-52-0, name is 4-Bromo-2-fluoroanisole, A new synthetic method of this compound is introduced below., Formula: C7H6BrFO

General procedure: To a solution of compound 1a-e (10.0 mmol,1.0 eq) in anhydrousTHF (20 mL) was slowly added n-BuLi (6 mL of 2.5 M solution inhexane, 15.0 mmol, 1.5 eq) at 78 C. The mixture was stirred for1 h and triisopropyl borate (50.0 mmol, 5.0 eq) was added by syringe.The solutionwas stirred for another 1 h and allowed towarmto 25 C overnight. The reactionwas cooled to 0 C, followed by thesequential addition ofwater (5 mL) and 2N HCl (5 mL). After 10 min,an additional 35 mL of 2N HCl was added and the mixture wasfurther stirred for 30 min. The mixture was extracted with ethylacetate (20 mL * 3) and the combined organic layers wereconcentrated to a thick oil under reduced pressure. Crystallizationwith cold hexane yielded a white solid.

The synthetic route of 2357-52-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sang, Yali; Han; Pannecouque, Christophe; De Clercq, Erik; Zhuang, Chunlin; Chen; European Journal of Medicinal Chemistry; vol. 182; (2019);,
Ether – Wikipedia,
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