Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 22807-80-3, name is 1-Bromo-4-(tert-butoxymethyl)benzene, A new synthetic method of this compound is introduced below., Computed Properties of C11H15BrO
(E)-N-(tert-butyl)-2-(4-bromophenyl)-2-oxoacetimidoyl cyanide employs the following steps:1 In a 1000 ml reactor, add 7.29 g of p-bromobenzyl tert-butyl ether, 13.60 ml of t-butyl isocyanide, 0.78 g of silver trifluoromethanesulfonate, and 13.60 g of 2,3-dichloro-5,6-dicyano -1,4-benzoquinone, 300 ml of chlorobenzene, heated to 80 C. The reaction is followed by thin layer chromatography until the reaction material disappears;2 After the reaction is completed, it is cooled to room temperature. The product was extracted with ethyl acetate and washed with saturated brine. After drying, the solvent was removed on a rotary evaporator to obtain a crude product;3 Crude product was purified by column chromatography (peel ether: ethyl acetate = 100:1) to afford 6.24 g of (E)-N-(t-butyl)-2-(4-bromophenyl)-2-oxo Iminoacetyl cyanide having a structural formula of 71%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.