Category: 2235-01-0

Jiang, Yan;Yin, Hong-liang;Wang, Li-li;Sun, Xiao-qiang published 《Synthesis of heterocyclic ethers chiral ligands》 in 2014. The article was appeared in 《Huaxue Shiji》. They have made some progress in their research.Application In Synthesis of Dimethoxydiphenylmethane The article mentions the following:

Using L-tartaric acid and benzophenone as reactants, a family of heterocyclic ether chiral ligands ((4S,5S)-2,2-diphenyl-5-((pyridin-2-ylmethoxy) methyl)-1,3-dioxolane-4-yl) methanol I and 2,2′-((((4S, 5S)-2,2-dip-henyl-1,3-dioxolane-4,5-diyl) bis (methylene)) bis (oxy) bis (methylene)) dipyridine II were synthesized via esterification, ketal and reduction reactions. There were two methene groups between the chiralcenter and the ligand atoms, this increased the flexible of chiral ligands, and the catalytic performance was primarily discussed. The experimental procedure involved many compounds, such as Dimethoxydiphenylmethane (cas: 2235-01-0) .

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Application In Synthesis of Dimethoxydiphenylmethane The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Quality Control of Dimethoxydiphenylmethane《Direct Transformation of Silica from Natural Resources to Form Tetramethoxysilane》 was published in 2020. The authors were Putro, Wahyu S.;Fukaya, Keisuke;Choi, Jun-Chul;Choi, Seong Jib;Horikoshi, Toshio;Sato, Kazuhiko;Fukaya, Norihisa, and the article was included in《Bulletin of the Chemical Society of Japan》. The author mentioned the following in the article:

A simple and practical method for direct synthesis of tetramethoxysilane (TMOS) from silica (SiO₂) and methanol was achieved using a base catalyst and acetal as a dehydrant under carbon dioxide (CO₂). The production of TMOS was strongly influenced by the kind of the acetal used, with 2,2-dimethoxypropane identified as the most effective dehydrant. Authors observed that the acetal used enabled the production of a high yield of di-Me carbonate (DMC), which promoted the TMOS production DMC is an intermediate product from the reaction of CO₂ and methanol, which supported the SiO2 depolymerization process. When the reaction is conducted with 2,2-dimethoxypropane at 260° for 24 h, TMOS can be produced in up to 59% yield. For practical applications, the TMOS synthesis has been developed on a 250 mL and 1 L-scale reaction with constant yield (>50%) from various silica resources. The experimental procedure involved many compounds, such as Dimethoxydiphenylmethane (cas: 2235-01-0) .

The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.Quality Control of Dimethoxydiphenylmethane

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ngai, Courtney;Sanchez-Marsetti, Colomba M.;Harman, W. Hill;Hooley, Richard J. published 《Supramolecular Catalysis of the oxa-Pictet-Spengler Reaction with an Endohedrally Functionalized Self-Assembled Cage Complex》. The research results were published in《Angewandte Chemie, International Edition》 in 2020.Application In Synthesis of Dimethoxydiphenylmethane The article conveys some information:

An endohedrally functionalized self-assembled Fe₄L₆ cage complex can catalyze oxa-Pictet-Spengler cyclizations of tryptophols and various aldehyde derivatives, showing strong rate accelerations and size-selectivity. Selective mol. recognition of substrates controls the reactivity, and the cage is capable of binding and activating multiple different species along the multistep reaction pathway. The combination of a functionalized active site, size-selective reactivity, and multistep activation, all from a single host mol., illustrates the biomimetic nature of the catalysis. To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

For example, the most common synthesis of ethers involves the attack of an alkoxide ion on an alkyl halide. This method is called Williamson ether synthesis.Application In Synthesis of Dimethoxydiphenylmethane

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gregg, Brian T.;Golden, Kathryn C.;Quinn, John F. published 《Indium(III)trifluoromethanesulfonate as a mild, efficient catalyst for the formation of acetals and ketals in the presence of acid sensitive functional groups》 in 2008. The article was appeared in 《Tetrahedron》. They have made some progress in their research.Category: ethers-buliding-blocks The article mentions the following:

Aldehydes and ketones, including acetophenone and benzophenone, are readily protected under mild, neutral conditions in the presence of various alcs. or orthoformates and catalytic amounts of indium(III) trifluoromethanesulfonate (<0.8 mol %) under either room temperature or mild heating conditions to give the corresponding cyclic and acyclic acetals and ketals in good to excellent yields. Acid sensitive functional groups, N-Boc, THP, and TBDMS do not undergo competitive deprotection under the reported conditions. The experimental procedure involved many compounds, such as Dimethoxydiphenylmethane (cas: 2235-01-0) .

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Category: ethers-buliding-blocks The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Formula: C15H16O2In 1995, Mori, Yuji;Asai, Motoya;Okumura, Akiko;Furukawa, Hiroshi published 《Total synthesis of the polyene macrolide antibiotic roxaticin. I. Synthesis of the polyol fragment of roxaticin using a four-carbon chain extension strategy》. 《Tetrahedron》published the findings. The article contains the following contents:

The C11-C26 polyol fragment, I, of roxaticin containing eight chiral centers has been prepared in a reiterative manner using coupling reactions of chiral dithianes and epoxides followed by stereoselective reductionDimethoxydiphenylmethane (cas: 2235-01-0) were involved in the experimental procedure.

For example, the most common synthesis of ethers involves the attack of an alkoxide ion on an alkyl halide. This method is called Williamson ether synthesis.Formula: C15H16O2

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Franchini, Silvia;Sorbi, Claudia;Linciano, Pasquale;Carnevale, Gianluca;Tait, Annalisa;Ronsisvalle, Simone;Buccioni, Michela;Del Bello, Fabio;Cilia, Antonio;Pirona, Lorenza;Denora, Nunzio;Iacobazzi, Rosa Maria;Brasili, Livio published 《1,3-Dioxane as a scaffold for potent and selective 5-HT_1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity》. The research results were published in《European Journal of Medicinal Chemistry》 in 2019.Application of 2235-01-0 The article conveys some information:

A series of compounds generated by ring expansion/opening and mol. elongation/simplification of the 1,3-dioxolane scaffold were prepared and tested for binding affinity at 5-HT_1AR and α₁ adrenoceptors. The compounds with greater affinity were selected for further functional studies. N-((2,2-diphenyl-1,3-dioxan-5-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-ammonium hydrogen oxalate I emerged as highly potent full agonist at the 5-HT_1AR (pKi 5-HT_1A = 8.8; pD₂ = 9.22, %E_max = 92). The pharmacokinetic data in rats showed that the orally administered I has a high biodistribution in the brain compartment. Thus, I was further investigated in-vivo, showing an anxiolytic and antidepressant effect. Moreover, in the formalin test, the above compound was able to decrease the late response to the noxious stimulus, indicating a potential use in the treatment of chronic pain. And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.

The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.Application of 2235-01-0

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

SDS of cas: 2235-01-0《Product subclass 7: organometallic compounds of potassium》 was published in 2006. The authors were Mordini, Alessandro;Valacchi, M., and the article was included in《Science of Synthesis》. The author mentioned the following in the article:

A review of the preparation and application of potassium organometallic compounds in organic synthesis. To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. SDS of cas: 2235-01-0 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Safety of DimethoxydiphenylmethaneIn 2017, Wu, Zhiyong;Leboeuf, David;Retailleau, Pascal;Gandon, Vincent;Marinetti, Angela;Voituriez, Arnaud published 《Enantioselective gold(I)-catalyzed rearrangement of cyclopropyl-substituted 1,6-enynes into 2-oxocyclobutyl-cyclopentanes》. 《Chemical Communications (Cambridge, United Kingdom)》published the findings. The article contains the following contents:

A gold(I)-catalyzed cycloisomerization/ring expansion sequence allows the highly enantioselective synthesis of 2-oxocyclobutylcyclopentane derivatives from cyclopropyl-substituted enynes [e.g., I → cis-II + trans-III (87%, cis/trans = 4.9/1, 99% ee cis) when conducted in wet toluene]. The bimetallic [(R)-MeO-DTBM-BIPHEP-(AuCl)₂] complex was found to be the best precatalyst, affording the desired cyclobutanones in high yields and enantioselectivities (up to 99% ee). The usefulness of the method was further demonstrated by preparing the tricyclic core scaffold of russujaponol D (IV). And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.

For example, the most common synthesis of ethers involves the attack of an alkoxide ion on an alkyl halide. This method is called Williamson ether synthesis.Safety of Dimethoxydiphenylmethane

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C15H16O2《Improved Benson Increments for the Estimation of Standard Enthalpies of Formation and Enthalpies of Vaporization of Alkyl Ethers, Acetals, Ketals, and Ortho Esters》 was published in 2002. The authors were Verevkin, Sergey P., and the article was included in《Journal of Chemical and Engineering Data》. The author mentioned the following in the article:

This work was undertaken for the evaluation and revision of group-additivity values necessary for predicting standard enthalpies of formation and enthalpies of vaporization of ethers, acetals, ketals, and ortho esters by means of Benson’s group-additivity methodol. The database on the standard molar enthalpies of vaporization ΔlgH_m⁰ has been extended with measurements on several acetals, ketals, and ortho esters using the transpiration method. The standard molar enthalpies of formation Δ_fH_m⁰ (g, 298.15K) of alkyl ethers, acetals, ketals, and ortho esters were derived using the data for the Δ_fH_m⁰(l or cr, 298.15K) from the literature and the present results for the enthalpies of vaporization or sublimation. The current database of exptl. data for enthalpies of formation and enthalpies of vaporization at 298.15 K have been used to reevaluate the values of the Benson’s increments for of alkyl ethers, acetals, ketals, and ortho esters. The group-additivity parameters and strain corrections useful in the application of the Benson’s correlation are presented in tabular form, together with a description of their evaluation. To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.Synthetic Route of C15H16O2

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kawabata, Tomonori;Kato, Masaki;Mizugaki, Tomoo;Ebitani, Kohki;Kaneda, Kiyotomi published 《Highly efficient deprotection of acetals by titanium cation-exchanged montmorillonite as a strong solid acid catalyst》. The research results were published in《Chemistry Letters》 in 2003.HPLC of Formula: 2235-01-0 The article conveys some information:

Deprotection of various kinds of acetals proceeded efficiently in the presence of Ti⁴⁺-exchanged montmorillonite as a recyclable strong solid acid catalyst. Other metal-exchanged montmorillonites were also used in deprotection of dimethoxydiphenylmethane. To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. HPLC of Formula: 2235-01-0 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem