Category: 2235-01-0

Koellmann, Christoph;Sake, Svenja M.;Jones, Peter G.;Pietschmann, Thomas;Werz, Daniel B. published 《Protecting-Group-Mediated Diastereoselective Synthesis of C4′-Methylated Uridine Analogs and Their Activity against the Human Respiratory Syncytial Virus》. The research results were published in《Journal of Organic Chemistry》 in 2020.Recommanded Product: 2235-01-0 The article conveys some information:

Adjusting the protecting group strategy, from an alkyl ether to a bidentate ketal at the carbohydrate backbone of uridine, facilitates a switchable diastereoselective α- or β-C₄‘/C₅‘-spiro-cyclopropanation. Using these spiro-cyclopropanated nucleosides as key intermediates, we synthesized a variety of C₄‘-methylated D-ribose and L-lyxose configured uridine derivatives by a base-mediated ring-opening of the spiro-cyclopropanol moiety. Investigations of antiviral activity against HRSV were carried out for selected derivatives, showing moderate activity. And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.

For example, the most common synthesis of ethers involves the attack of an alkoxide ion on an alkyl halide. This method is called Williamson ether synthesis.Recommanded Product: 2235-01-0

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Utech, Tina;Koehler, Jens;Wuensch, Bernhard published 《Synthesis of 4-(aminoalkyl) substituted 1,3-dioxanes as potent NMDA and σ receptor antagonists》 in 2011. The article was appeared in 《European Journal of Medicinal Chemistry》. They have made some progress in their research.Application of 2235-01-0 The article mentions the following:

Elongation of the distance between the oxygen heterocycle and the basic amino moiety or ring expansion of the oxygen heterocycle of the NMDA receptor antagonists dexoxadrol and etoxadrol led to compounds with promising NMDA receptor affinity. Herein the combination of both structural features, i.e. elongation of the O-heterocycle – amine distance with a 1,3-dioxane ring is envisaged. The synthesis of aminoethyl-1,3-dioxanes was performed by transacetalization of various acetals with pentane-1,3,5-triol, activation of the remaining free OH moiety with tosyl chloride and subsequent nucleophilic substitution. The corresponding 3-aminopropyl derivatives were prepared by substitution of the tosylates with KCN and LiAlH₄ reduction The highest NMDA receptor affinity was found for 4-(2-aminoethyl)-2-ethyl-2-phenyl-1,3-dioxane (I) followed by 2,2-diphenyl- and 2-Ph analogs.. Generally the NMDA affinity of primary amines is higher than the NMDA affinity of secondary and tertiary amines. Altogether I (K_i = 24 nM) represents the most promising NMDA receptor antagonist of this series exceeding the NMDA affinity of (2-aminoethyl)-1,3-dioxolanes and (2-aminomethyl)-1,3-dioxanes. Whereas I turned out to be selective against σ₁ and σ₂ receptors 4-(2-benzylaminoethyl)-2-phenyl-1,3-dioxane was identified as potent (K_i = 19 nM) and selective σ₁ antagonist, which showed extraordinarily high antiallodynic activity in the capsaicin assay. To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

For example, the most common synthesis of ethers involves the attack of an alkoxide ion on an alkyl halide. This method is called Williamson ether synthesis.Application of 2235-01-0

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sulu, Mustafa;Venanzi, Luigi M. published 《Acetalization and transacetalization reactions catalyzed by ruthenium, rhodium, and iridium complexes with {2-[{Bis[3-(trifluoromethyl)phenyl]phosphino}methyl]-2-methylpropane-1,3-diyl}bis[bis[3-(trifluoromethyl)phenyl]phosphine] (MeC[CH₂P(m-CF₃C₆H₄)₂]₃)》 in 2001. The article was appeared in 《Helvetica Chimica Acta》. They have made some progress in their research.SDS of cas: 2235-01-0 The article mentions the following:

The complexes [RhCl(_3-n)(MeCN)_n(CF₃triphos)](CF₃SO₃)_n (n = 1 or 2; CF₃triphos = MeC[CH₂P(m-CF₃C₆H₄)₂]₃) and [M(MeCN)₃ (CF₃triphos)](CF₃SO₃)_n (M = Ru, n = 2; M = Ir, n = 3) are catalyst precursors for some typical acetalization and transacetalization reactions. The activity of these complexes is higher than those of the corresponding species containing the parent ligand MeC[CH₂P(C₆H₅)₂]₃(Htriphos). Also the complexes [MCl₃(tripod)] (tripod = Htriphos and CF₃triphos) are active catalysts for the above reactions. The complex [RhCl₂(MeCN)(CF₃triphos)](CF₃SO₃) catalyzes the acetalization of benzophenone. To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.SDS of cas: 2235-01-0

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hamada, Nao;Kazahaya, Kiyoshi;Shimizu, Hisashi;Sato, Tsuneo published 《An efficient and versatile procedure for the synthesis of acetals from aldehydes and ketones catalyzed by lithium tetrafluoroborate》. The research results were published in《Synlett》 in 2004.SDS of cas: 2235-01-0 The article conveys some information:

Acetals, e.g., I, were obtained, in good yields, by treatment of aldehydes and ketones with trialkyl orthoformate, and the corresponding alc., in the presence of a catalytic amount of lithium tetrafluoroborate. Due to the mild reaction conditions, this method was compatible with acid-sensitive substrates. And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. SDS of cas: 2235-01-0 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Product Details of 2235-01-0《Fe(III)-Exchanged Montmorillonite as Reusable Heterogeneous Protonic Acid Catalyst for Michael Addition of Indole in Water》 was published in 2017. The authors were Matsuzawa, Ryosuke;Nishimura, Shun;Ebitani, Kohki, and the article was included in《ChemistrySelect》. The author mentioned the following in the article:

Fe³⁺-exchanged montmorillonite (Fe³⁺-mont) was found to be an effective and a reusable heterogeneous acid catalyst for the Michael addition of indole with Me vinyl ketone at 333 K in H₂O to afford 4-(1H-indol-3-yl)butan-2-one in high yields. Investigations on activity of the Fe³⁺-mont catalyst for deprotection of benzophenone dimethylketal and Meerwein-Ponndorf-Verley reduction of furfural suggested that protonic acid sites of the Fe³⁺-mont catalyst were responsible for the present Michael addition of indole. The experimental procedure involved many compounds, such as Dimethoxydiphenylmethane (cas: 2235-01-0) .

For example, the most common synthesis of ethers involves the attack of an alkoxide ion on an alkyl halide. This method is called Williamson ether synthesis.Product Details of 2235-01-0

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of C15H16O2In 2011, Sinhamahapatra, Apurba;Sutradhar, Narottom;Ghosh, Malay;Bajaj, Hari C.;Panda, Asit B. published 《Mesoporous sulfated zirconia mediated acetalization reactions》. 《Applied Catalysis, A: General》published the findings. The article contains the following contents:

A novel, convenient, one step synthetic procedure for the synthesis of mesoporous sulfated zirconia (m-SZ) using zirconium carbonate complex and its use as solid acid catalyst for the acetalization of different carbonyl compound is reported. The high specific BET surface area (234 m² g^-1) of m-SZ is achieved after the removal of the surfactant (cetyltrymethylammonium bromide, CTAB) through calcination at 550 °C for 6 h. Microscopic anal. indicated the presence of spherical particles with worm like pores. DRIFT (diffuse reflectance FTIR) of pyridine adsorbed m-SZ and NH₃-TPD (temperature programmed desorption) anal. suggested the presence of appreciable amount of Broensted acid sites. The synthesized m-SZ showed high catalytic activity towards protection of carbonyl compounds through acetal/ketal formation. For the open ketal (from cyclohexanone and methanol) 97% conversion with 100% selectivity was obtained in 1 h at room temperature under solvent free condition. The catalyst can be easily recycled after separation from the reaction system without considerable loss in catalytic activity. To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.Electric Literature of C15H16O2

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 2235-01-0In 2008, Van Orden, L. J.;Jasti, R.;Rychnovsky, S. D. published 《Product class 1: dialkyl ethers. Synthesis from esters, aldehydes, ketones, and acetals by reduction or alkylation》. 《Science of Synthesis》published the findings. The article contains the following contents:

A review of methods to prepare dialkyl ethers via reduction or alkylation of esters, aldehydes, ketones, and acetals. And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Recommanded Product: 2235-01-0 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of Dimethoxydiphenylmethane《Reduction of ketones with LiAlH₄ complexes of α,α,α’,α’-tetraaryl-1,3-dioxolane-4,5-dimethanols (TADDOLs). A combination of enantioselective reduction and clathrate formation with a discussion of LAH reagents bearing C₂-symmetrical ligands》 was published in 1996. The authors were Seebach, Dieter;Beck, Albert K.;Dahinden, Robert;Hoffmann, Matthias;Kuehnle, Florian N. M., and the article was included in《Croatica Chemica Acta》. The author mentioned the following in the article:

A complex prepared from one equivalent each of LiAlH₄, EtOH and a TADDOL (α,α,α’,α’-tetraaryl-1,3-dioxolane-4,5-dimethanol) reduces aryl alkyl ketones to sec. alcs. with enantiomer ratios (er) up to 96:4. The chiral LAH derivative is used in two-fold excess in THF solution and at dry ice temperatures The ability of TADDOLs to form clathrates diastereoselectivity can be exploited to increase the er of the initially formed alcs. by a simple modification of the work-up procedure and hence, products of very high enantiopurity (er 99:1) can be isolated. When (R,R)-TADDOLs (from (R,R)-tartrate) are applied in the reaction, the 1-aryl-alkanols formed preferentially have (S) configuration, as for the products obtained with the corresponding (P)-BINOL and (P)-BIPHENOL derivatives A common mechanistic model is discussed. And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Reference of Dimethoxydiphenylmethane The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C15H16O2In 2002, Ohmori, Ken;Hachisu, Yoshifumi;Suzuki, Takao;Suzuki, Keisuke published 《Stereogenic tert-alcohols via group-selective hydroalumination: further scope》. 《Tetrahedron Letters》published the findings. The article contains the following contents:

Two classes of bis-alkynyl alcs. were subjected to hydroalumination reaction, which, under suitable conditions, proceeded in a highly group-selective manner. The first set of reactants comprised (4R,5S)-5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-α,α-di-1-hexynyl-2,2-dimethyl-1,3-dioxolane-4-methanol (I) and (4R,5S)-α,α-di-1-hexynyl-5-[(methoxyethoxy)methyl]-2,2-dimethyl-1,3-dioxolane-4-methanol. The second set of reactants comprised (4S)-α,α-di-1-hexynyl-2,2-dimethyl-1,3-dioxane-4-methanol (II) and (4S)-α,α-di-1-hexynyl-2,2-diphenyl-1,3-dioxane-4-methanol. The reaction of I with butyllithium/DIBAL gave (-)-5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-α-1-hexenyl-α-1-hexynyl-2,2-dimethyl-1,3-dioxolane-4-methanol as the major product stereoselectively. Hydroalumination of II gave a 73/27 mixture of (4S)-α-1-hexenyl-α-1-hexynyl-2,2-dimethyl-1,3-dioxane-4-methanol (III) and its epimer. Group selectivity was changed using ethylmagnesium bromide as the reagent, thus yielding the epimer of III as the major product. And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.

The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.Synthetic Route of C15H16O2

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Guthrie, J. Peter;Guo, Junan published 《Acetal formation from methyl formate, pinacolone, and benzophenone: equilibrium constants in methanol and water determined by a chain of transacetalization equilibria》 in 1994. The article was appeared in 《Canadian Journal of Chemistry》. They have made some progress in their research.Application In Synthesis of Dimethoxydiphenylmethane The article mentions the following:

Transacetalization equilibrium constants can be measured in methanol solution This allows a ladder of equilibrium constants to be constructed from acetophenone, for which the equilibrium constant for acetal formation has been measured in methanol, to Me formate, for which it has not. This is the first direct measurement of an equilibrium constant for formation of an acetal of an acyclic ester. We have also determined equilibrium constants for acetal formation from benzophenone and pinacolone. The value for benzophenone is inconsistent with the value reported for the di-Et acetal by Pfeiffer and Adkins (G.J. Pfeiffer and H. Adkins. J. Am. Chem. Soc. 53, 1043 (1931)). We must conclude that their anal. method was subject to systematic errors.Dimethoxydiphenylmethane (cas: 2235-01-0) were involved in the experimental procedure.

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Application In Synthesis of Dimethoxydiphenylmethane The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem