Category: 2235-01-0

Crucello, Juliana;Miron, Luiz F. O.;Ferreira, Victor H. C.;Nan, He;Marques, Marcia O. M.;Ritschel, Patricia S.;Zanus, Mauro C.;Anderson, Jared L.;Poppi, Ronei J.;Hantao, Leandro W. published 《Characterization of the aroma profile of novel Brazilian wines by solid-phase microextraction using polymeric ionic liquid sorbent coatings》 in 2018. The article was appeared in 《Analytical and Bioanalytical Chemistry》. They have made some progress in their research.Related Products of 2235-01-0 The article mentions the following:

In this study, a series of polymeric ionic liquid (PIL) sorbent coatings is evaluated for the extraction of polar volatile organic compounds (VOCs) from Brazilian wines using headspace solid-phase microextraction (HS-SPME), including samples from ‘Isabella’ and ‘BRS Magna’ cultivars-the latter was recently introduced by the Brazilian Agricultural Research Corporation – National Grape & Wine Research Center. The structurally tuned SPME coatings were compared to the com. SPME phases, namely poly(acrylate) (PA) and divinylbenzene/carboxen/poly(dimethylsiloxane) (DVB/CAR/PDMS). The separation, detection and identification of the aroma profiles were obtained using comprehensive two-dimensional gas chromatog. mass spectrometry (GC×GC-MS). The best performing PIL-based SPME fiber, namely 1-hexadecyl-3-vinylimidazolium bis[(trifluoromethyl)sulfonyl]imide with 1,12-di(3-vinylimidazolium)dodecane dibis[(trifluoromethyl)sulfonyl]imide incorporated cross-linker supported on an elastic nitinol wire, exhibited superior performance to DVB/CAR/PDMS regarding the average number of extracted peaks and extracted more polar analytes providing addnl. insight into the aroma profile of ‘BRS Magna’ wines. Four batches of wine were evaluated, namely ‘Isabella’ and ‘BRS Magna’ vintages 2015 and 2016, using highly selective PIL-based SPME coatings and enabled the detection of 350+ peaks. Furthermore, this is the first report evaluating the aroma of ‘BRS Magna’ wines. A hybrid approach that combined pixel-based Fisher ratio and peak table-based data comparison was used for data handling. This proof-of-concept experiment provided reliable and statistically valid distinction of wines that may guide regulation agencies to create high sample throughput protocols to screen wines exported by Brazilian vintners. [Figure not available: see fulltext.]. The experimental procedure involved many compounds, such as Dimethoxydiphenylmethane (cas: 2235-01-0) .

For example, the most common synthesis of ethers involves the attack of an alkoxide ion on an alkyl halide. This method is called Williamson ether synthesis.Related Products of 2235-01-0

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Banerjee, Ashutosh;Schepmann, Dirk;Koehler, Jens;Wuerthwein, Ernst-Ulrich;Wuensch, Bernhard published 《Synthesis and SAR studies of chiral non-racemic dexoxadrol analogues as uncompetitive NMDA receptor antagonists》. The research results were published in《Bioorganic & Medicinal Chemistry》 in 2010.Quality Control of Dimethoxydiphenylmethane The article conveys some information:

A series of chiral non-racemic dexoxadrol analogs with various substituents in position 4 of the piperidine ring was synthesized and pharmacol. evaluated. Only the enantiomers having (S)-configuration at the 2-position of the piperidine ring and 4-position of the dioxolane ring were considered. Key steps in the synthesis were an imino-Diels-Alder reaction of enantiomerically pure imine (S)-13, which had been obtained from D-mannitol, with Danishefsky’s Diene 14 and the replacement of the p-methoxybenzyl protective group with a Cbz-group. It was shown that (S,S)-configuration of the ring junction (position 2 of the piperidine ring and position 4 of the dioxolane ring) and axial orientation of the C-4-substituent ((4S)-configuration) are crucial for high NMDA receptor affinity. 2-(2,2-Diphenyl-1,3-dioxolan-4-yl)piperidines with a hydroxy moiety ((S,S,S)-5 (I), K_i = 28 nM), a fluorine atom ((S,S,S)-6 (II), WMS-2539, K_i = 7 nM) and two fluorine atoms ((S,S)-7 (III), K_i = 48 nM) in position 4 represent the most potent NMDA antagonists with high selectivity against σ₁ and σ₂ receptors and the polyamine binding site of the NMDA receptor. The NMDA receptor affinities of the new ligands were correlated with their electrostatic potentials, calculated gas phase proton affinities (neg. enthalpies of deprotonation) and dipole moments. According to these calculations decreasing proton affinity and increasing dipole moment are correlated with decreasing NMDA receptor affinity. The experimental procedure involved many compounds, such as Dimethoxydiphenylmethane (cas: 2235-01-0) .

The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.Quality Control of Dimethoxydiphenylmethane

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wang, Maw-Ling;Chen, Wei-Hung;Ming-Hsiung published 《Synthesis of dialkoxydiphenylmethane under phase transfer catalytic condition assisted by ultrasonic irradiation》. The research results were published in《Reaction Kinetics and Catalysis Letters》 in 2008.Quality Control of Dimethoxydiphenylmethane The article conveys some information:

The synthesis of dialkoxydiphenylmethanes (DAODPMs) from the reactions of alcs. and dichlorodiphenylmethane (DCDPM) were successfully carried out in a liquid-liquid phase transfer catalytic reaction (LL-PTC). The reactions are greatly enhanced by irradiation with ultrasonic waves. Two sequential reactions in the organic-phase solution proceed to produce the desired product. Only the dichloro-substituted product dialkoxydiphenylmethanes (DAODPM) is obtained, indicating that the second reaction is faster than the first one in the organic phase. Explanations for the phenomena of the exptl. results are provided. And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Quality Control of Dimethoxydiphenylmethane The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kantam, M. Lakshmi;Swapna, V.;Santhi, P. Lakshmi published 《MoO₂(acac)₂– a mild and efficient catalyst for the deprotection of acetals》. The research results were published in《Synthetic Communications》 in 1995.Recommanded Product: 2235-01-0 The article conveys some information:

Molybdenyl(VI) acetylacetonate is an effective catalyst for the deprotection of acetals into the corresponding aldehydes and ketones, in good yields. To a solution of (dimethoxymethyl)-4-methylbenzene in MeCN was added MoO₂(acac)₂ under N to give after 4 g p-tolualdehyde. The experimental procedure involved many compounds, such as Dimethoxydiphenylmethane (cas: 2235-01-0) .

The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.Recommanded Product: 2235-01-0

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Product Details of 2235-01-0《Environmentally friendly organic synthesis using bismuth compounds: bismuth(III) iodide catalyzed deprotection of acetals in water》 was published in 2008. The authors were Bailey, Aaron D.;Baru, Ashvin R.;Tasche, Kendall K.;Mohan, Ram S., and the article was included in《Tetrahedron Letters》. The author mentioned the following in the article:

The chemoselective deprotection of a wide range of acetals and ketals in water is catalyzed by bismuth(III) iodide. Bismuth(III) compounds are remarkably nontoxic and hence are attractive as environmentally friendly catalysts. To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.Product Details of 2235-01-0

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Piergentili, Alessandro;Gentili, Francesco;Ghelfi, Francesca;Marucci, Gabriella;Pigini, Maria;Quaglia, Wilma;Giannella, Mario published 《Muscarinic subtypes profile modulation within a series of new antagonists, bridged bicyclic derivatives of 2,2-Diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine》. The research results were published in《Bioorganic & Medicinal Chemistry》 in 2003.HPLC of Formula: 2235-01-0 The article conveys some information:

A set of new muscarinic antagonists, bridged bicyclic derivatives of 2,2-diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine, was synthesized and tested to evaluate their affinity and selectivity for M₁, M₂, M₃ and M₄ receptor subtypes. The conformational constraint of the lead compound in a bicyclic structure, and the variation in distance and stereochem. of the active functions allowed us to modulate the selectivity of interaction with the M₁-M₃ receptor subtypes. The most interesting compound was (cis,trans)-2-(2,2-diphenylethyl)-5-methyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole oxalate (I oxalate), which is equipotent with Pirenzepine on rabbit vas deferens (M₁-putative) but shows a better selectivity profile.Dimethoxydiphenylmethane (cas: 2235-01-0) were involved in the experimental procedure.

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. HPLC of Formula: 2235-01-0 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tanemura, Kiyoshi;Suzuki, Tsuneo published 《Highly efficient acetalization of carbonyl compounds catalyzed by aniline-aldehyde resin salts》 in 2015. The article was appeared in 《Chemistry Letters》. They have made some progress in their research.Reference of Dimethoxydiphenylmethane The article mentions the following:

Mild procedures for the syntheses of ethylene acetals, e.g., I, and di-Me acetals, e.g., II, from the corresponding aldehydes and ketones catalyzed by 1 mol % of aniline-aldehyde resin salts are described. This methodol. is also useful for the synthesis of di-Me acetals of diaryl ketones. The experimental procedure involved many compounds, such as Dimethoxydiphenylmethane (cas: 2235-01-0) .

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Reference of Dimethoxydiphenylmethane The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Larson, Gerald L.;Fry, James L. published 《Ionic and organometallic-catalyzed organosilane reductions》. The research results were published in《Organic Reactions (Hoboken, NJ, United States)》 in 2008.Application In Synthesis of Dimethoxydiphenylmethane The article conveys some information:

A review on the use of organosilanes as reducing agents in organic synthesis.Dimethoxydiphenylmethane (cas: 2235-01-0) were involved in the experimental procedure.

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Application In Synthesis of Dimethoxydiphenylmethane The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 2235-01-0《A concise diastereoselective approach to (+)-dexoxadrol, (-)-epi-dexoxadrol, (-)-conhydrine and (+)-lentiginosine from (-)-pipecolinic acid》 was published in 2013. The authors were Bhat, Chinmay;Tilve, Santosh G., and the article was included in《Tetrahedron》. The author mentioned the following in the article:

A new diastereoselective pathway for the total synthesis of (+)-dexoxadrol (I), first asym. synthesis of (-)-epi-dexoxadrol (II) and formal synthesis of (-)-β- and (+)-α-conhydrine III (R = OH, R¹ = H; R = H, R¹ = OH, resp.) and (+)-lentiginosine (IV) is presented using com. available (-)-pipecolinic acid. The key reactions utilized are Sharpless asym. dihydroxylation and Wittig reaction. The paper further describes the study of the effect of protecting groups on dihydroxylation of a terminal olefin in piperidine ring system.Dimethoxydiphenylmethane (cas: 2235-01-0) were involved in the experimental procedure.

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Related Products of 2235-01-0 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Banerjee, Isita;Ghosh, Keshab Ch;Oheix, Emmanuel;Jean, Marion;Naubron, Jean-Valere;Reglier, Marius;Iranzo, Olga;Sinha, Surajit published 《Synthesis of protected 3,4- and 2,3-dimercaptophenylalanines as building blocks for Fmoc-peptide synthesis and incorporation of the 3,4-analog in a decapeptide using solid-phase synthesis》 in 2021. The article was appeared in 《Journal of Organic Chemistry》. They have made some progress in their research.Application of 2235-01-0 The article mentions the following:

3,4-Dimercaptophenylalanines and 2,3-dimercaptophenylalanines have been synthesized for the first time by nucleophilic substitution of a protected aminomalonate on 3,4- and 2,3-dimercaptobenzyl bromide derivatives The dithiol functions were protected as thioketals, and the key precursors, diphenylthioketal-protected dimercaptobenzyl bromides, were synthesized via two distinct routes from either dihydroxy benzoates or toluene-3,4-dithiol. Racemic mixtures of the fully protected amino acids were separated by chiral HPLC into the corresponding enantiomers. The absolute configuration of both 3,4- and 2,3-analogs could be assigned based on X-ray crystallog. and VCD/DFT measurements. Thioketal groups were deprotected upon reaction with mercury oxide and aqueous tetrafluoroboric acid followed by treatment with H₂S gas under an argon atm. to obtain the corresponding dimercapto amino acids. The optically pure L-Fmoc-protected (Fmoc = 9-fluorenylmethoxycarbonyl) 3,4-analog (S enantiomer) was successfully incorporated into a decapeptide using standard solid-phase peptide synthesis. Therefore, dithiolene-functionalized peptides are now accessible from a simple synthetic procedure, and this should afford new mol. tools for research into the catalysis, diagnostic, and nanotechnol. fields.Dimethoxydiphenylmethane (cas: 2235-01-0) were involved in the experimental procedure.

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Application of 2235-01-0 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem