Category: 2132-62-9

Electric Literature of 2132-62-9, The chemical industry reduces the impact on the environment during synthesis 2132-62-9, name is 1,2-Bis(4-methoxyphenyl)ethyne, I believe this compound will play a more active role in future production and life.

6-chloro-1-(4-chlorophenyl)-3,4-bis(4-methoxyphenyl)-1H-2,1-benzoxaphosphinine 1-oxide (69.1 mg, 88%) as a target product was obtained under the condition of 90 C. for 16 hours, by the same reaction as the Example 1 above, except for using bis(4-chlorophenyl)phosphinic acid (43.0 mg, 0.15 mmol) instead of using phenylphosphonic monoethyl ester of the Example 1 above, and using 1,2-bis(4-methoxyphenyl)ethyne (53.6 mg, 0.23 mmol) instead of using diphenylacetylene of the Example 1 above. (0218) 1H NMR (400 MHz, CDCl3) delta 7.87-7.81 (m, 2H), 7.52-7.44 (m, 3H), 7.29 (td, J=8.1, 2.1 Hz, 1H), 7.17-7.14 (m, 4H), 7.05 (dd, J=4.1, 4.8 Hz, 1H), 6.95 (app d, J=8.7, 2H), 6.67-6.63 (m, 2H), 3.87 (s, 3H), 3.73 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Bis(4-methoxyphenyl)ethyne, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; KNU-INDUSTRY COOPERATION FOUNDATION; Lee, Phil Ho; Park, Young Chul; Jeon, In Cheol; Seo, Jung Min; Seo, Bo Ram; US2015/344506; (2015); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 2132-62-9,Some common heterocyclic compound, 2132-62-9, name is 1,2-Bis(4-methoxyphenyl)ethyne, molecular formula is C16H14O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of a substituted benzamide (1) (0.3 mmol, 1.0 equiv),an alkyne (2) (0.6 mmol or 0.9 mmol, 2.0 equiv or 3.0 equiv),10% Pd/C (0.03 mmol, 10 mol%, Alfa Aesar, No. 044696, eggshell,reduced), NaI·2H2O (0.6 mmol, 2.0 equiv), Cs2CO3 (0.3 mmol, 1.0equiv), and KOAc (0.6 mmol, 2.0 equiv) was weighted in a Schlenktube equipped with a stir bar. DMF (1.0 mL) was added and themixture was stirred at 120 C for 36 h under air. Afterwards, themixture was filtered and washed with H2O (30 mL) and extractedwith CH2Cl2 (3×30 mL). The combined organic phase was driedwith anhydrous Na2SO4. After removal of solvents under reducedpressure, the residue was absorbed to small amounts of silica. Thepurification was performed by flash column chromatography onsilica gel with EA:PE (Petroleum ether) = 1:5 or 1:10 as eluent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,2-Bis(4-methoxyphenyl)ethyne, its application will become more common.

Reference:
Article; Shu, Zhen; Guo, Yuntao; Li, Wei; Wang, Baiquan; Catalysis Today; vol. 297; (2017); p. 292 – 297;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 2132-62-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2132-62-9, name is 1,2-Bis(4-methoxyphenyl)ethyne belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 5 Preparation of 3,4-Bis(4-methoxyphenyl)-1-ethoxybenz[c-1,2]oxaphosphinine 1-oxide 3,4-Bis(4-methoxyphenyl)-1-ethoxybenz[c-1,2]oxaphosphinine 1-oxide (57.0 mg, 90%) as a target compound was obtained under the condition of 90 C. for 12 hours, by the same reaction as the Example 1 above, except for using 1,2-bis(4-methoxyphenyl)ethyne (54.0 mg, 0.23 mmol) instead of using diphenylacetylene of the Example 1 above. 1H NMR (400 MHz, CDCl3) delta 7.95-7.89 (m, 1H), 7.48-7.43 (m, 1H), 7.41-7.37 (m, 1H), 7.19 (dt, J=9.17 Hz, 2.56 Hz, 2H), 7.14-7.10 (m, 2H), 7.00-6.96 (m, 1H), 6.93-6.89 (m, 2H), 7.19 (dt, J=9.20 Hz, 2.52 Hz, 2H), 4.30-4.15 (m, 2H), 3.84 (s, 3H), 3.75 (s, 3H), 1.31 (t, J=4.82 Hz, 3H)

The synthetic route of 1,2-Bis(4-methoxyphenyl)ethyne has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KNU-INDUSTRY COOPERATION FOUNDATION; Lee, Phil Ho; Park, Young Chul; Jeon, In Cheol; Seo, Jung Min; Seo, Bo Ram; US2015/344506; (2015); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2132-62-9 as follows. Formula: C16H14O2

General procedure: A mixture of acetophenone oxime 1a (0.2 mmol), diphenylacetylene 2 (0.24 mmol, 1.2 equiv), [Cp*IrCl2]2 (3 mol%), PivOH (0.06 mmol, 0.3 equiv), Cu(OAc)2. H2O (0.4 mmol, 2 equiv) and MeOH (2 mL) in a 15mL glass vial [sealed with poly(tetrafluoroethylene)(PTFE) cap] was heated at 120 C with vigorous stirring for 24 h. The reaction mixture was cooled to room temperature, diluted with ethyl acetate, and filtered through Celite. The filtrate was concentrated in vacuo and purified by column chromatography on silica gel to give the corresponding product 4.

According to the analysis of related databases, 2132-62-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Lin, Wei; Hu, Xiu-Xiu; Zhuang, Cang-Wei; Wang, Ya-Zhen; Tetrahedron; vol. 75; 22; (2019); p. 3015 – 3023;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 2132-62-9,Some common heterocyclic compound, 2132-62-9, name is 1,2-Bis(4-methoxyphenyl)ethyne, molecular formula is C16H14O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a oven-dried RBF, a solution of Imidazo[1,2,-a]pyridines derivatives 1 (0.5 mmol) and alkyne2 in toluene (2 mL) [Cp*RhCl2]2 (5 mol%), Cu(OAc)2·H2O (2 equiv), Cs2CO3 (30 mol%) wereadded under inert atmosphere. The resulting reaction mixture was heated at 125 C for 7 h.Progression of the reaction was monitored by TLC, while noticing complete consumption ofImidazo[1,2,-a]pyridines derivatives, reaction was brought to room temperature. The additionalamount of acrylate also added if required for complete conversion. The reaction mixture wasdiluted with ethyl acetate (10 mL) and water (15 mL) and then filtered through a plug of celite.The layers were separated, and the organic layer was washed with aqueous saturated brinesolution, dried over Na2SO4. Organic layer was concentrated under reduced pressure.The crudematerial so obtained was purified by column chromatography on silica gel (hexane: ethylacetate :: 70:30). The structure and purity of known starting materials were confirmed by comparison oftheir physical and spectral data (1H NMR, 13C NMR and HRMS ).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,2-Bis(4-methoxyphenyl)ethyne, its application will become more common.

Reference:
Article; Kotla, Siva K. Reddy; Choudhary, Deepak; Tiwari, Rakesh K.; Verma, Akhilesh K.; Tetrahedron Letters; vol. 56; 32; (2015); p. 4706 – 4710;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

2132-62-9, name is 1,2-Bis(4-methoxyphenyl)ethyne, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C16H14O2

take 1,2-dicarbonylmethyl ester-Indolizine 46.6mg (corresponding to 0.20 mmol), 71.5 mg (equivalent to 0.30 mmol) of 1,2-bis(4-methoxyphenyl) acetylene, 4.5 mg of palladium acetate (equivalent to 0.02 mmol), Potassium acetate was 5.0 mg (equivalent to 0.01 mmol), 1.5 ml of dimethylsulfoxide and then stirred under heating at 130 C for 1 hours under 1 atmosphere of oxygen and separated to obtain the sixth number target Product 78.9 mg (yield 84%).

The synthetic route of 2132-62-9 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 2132-62-9, name is 1,2-Bis(4-methoxyphenyl)ethyne, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2132-62-9, HPLC of Formula: C16H14O2

In a clean quartz reactor, add acetophenone oxime (27.0 mg, 0.20 mmol), bis (4-methoxyphenyl) acetylene (57.1 mg, 0.24 mmol), and bis(2-methylallyl) (1,5-cyclooctadiene)ruthenium(II) (3.2 mg, 0.01 mmol), water (0.5 mL), polyethylene glycol 400 (0.5 mL), high-pressure mercury lamp as the photochemical reaction device of the light generating device Stir at room temperature for 24 hours. After the reaction was completed, saturated brine (10 mL) and ethyl acetate (5 mL ¡Á 3) were added for extraction. The ethyl acetate layer was collected, the solvent was removed under reduced pressure, and the residue was separated and purified by silica gel column chromatography (petroleum ether / ethyl acetate = 50/1, v / v) to obtain the target product 62.9 mg, a yellow solid in 89% yield .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Bis(4-methoxyphenyl)ethyne, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sichuan University; Hai Li; Wu Yong; Guan Mei; Lv Songyang; He Maoyao; Yang Zengbao; (8 pag.)CN111039867; (2020); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem