Category: 207226-31-1

Adding a certain compound to certain chemical reactions, such as: 207226-31-1, name is 1,3-Dibromo-5-(trifluoromethoxy)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 207226-31-1, SDS of cas: 207226-31-1

Dibromide D-l-2a (3.0 g, 9.38 mmol), sodium-tert-butoxide (1.26 mg, 13.13 mmol), BINAP (584 mg, 0.938 mmol) and tris-(dibenzylideneacetone)-palladium (85.9 mg, 0.094 mmol) are suspended in 60 mL toluene, combined with benzophenonimine (2.04 g, 11.25 mmol), and refluxed under an argon atmosphere for 3 d. Then the reaction mixture is filtered and the solvent is eliminated by distillation.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3-Dibromo-5-(trifluoromethoxy)benzene, and friends who are interested can also refer to it.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2009/3999; (2009); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 207226-31-1, These common heterocyclic compound, 207226-31-1, name is 1,3-Dibromo-5-(trifluoromethoxy)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 1,3-dibromo-5-(trifluoromethoxy)benzene (25 g, 78.15 mmol, 1 eq) in i-Pr2O (50 mL) was added n-BuLi (2.5 M, 32 mL, 1.02 eq) at -78C for 0.5 h, then acetone (7.9 g, 136 mmol, 10 mL, 1.74 eq) was added. The mixture was stirred at 20C for 2 h. The reaction mixture was poured into 100 mL of aqueous NH4Cl and the resulting mixture was stirred for 15 min. The organic phase was separated, dried over anhydrous Na2SO4, filtered and evaporated in vacuo to give a residue. The residue was purified by flash silica gel chromatography (ISCO; 80 g SepaFlash Silica Flash Column, Eluent of 0~1% Ethylacetate/Petroleum ethergradient 50 mL/min). The title compound (8 g, 26.75 mmol, 34% yield) was obtained as a yellow liquid. 1H NMR (400 MHz, DMSO-d6) delta ppm 1.94 (s, 6 H), 5.90 (s, 1 H), 7.91 – 8.01 (m, 2 H), 8.19 – 8.25 (m, 1 H).

The synthetic route of 207226-31-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SAINT LOUIS UNIVERSITY; INDALO THERAPUETICS, INC.; RUMINSKI, Peter, G.; GRIGGS, David, W.; SEIWERT, Scott; (155 pag.)WO2018/132268; (2018); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 207226-31-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 207226-31-1, name is 1,3-Dibromo-5-(trifluoromethoxy)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The bromide (3.0 g, 9.38 mmol), tri-nbutyl-l-elhoxyvinyl tin (3.56 g, 9.85 mmol), and PdCl2(Ph3P)2 (0.66 g, 0.94 mmol) were dissolved in toluene and the solution stirred at 95 C for 3 hours. The volatiles were removed in vac, the residue dissolved in 1,4-dioxane (20 mL), aqueous HCl (2 N, 14taunL) added, and the solution stirred rapidly at RT for 1 hour. The mixture was diluted with water (400 mL), followed by aqueous/EtOAc work-up and silica gel chromatography (EtOAc: hexanes (1:19)) to give the titled compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Dibromo-5-(trifluoromethoxy)benzene, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 207226-31-1, These common heterocyclic compound, 207226-31-1, name is 1,3-Dibromo-5-(trifluoromethoxy)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 57 6-(3-Bromo-5-trifluoromethoxy-Phenyl)-4,4-dimethyl-1,4-dihydrobenzo[d][1,3]-oxazin-2-one Prepared from (4,4-dimethyl-1,4-dihydro-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid and 1,3-dibromo-5-trifluoromethoxybenzene according to Procedure B. White solid: mp 214-216 C.; 1H-NMR (DMSO-d6) delta10.4 (s, 1H), 7.99 (s, 1H), 7.73 (s, 1H), 7.68-7.62 (m, 3H), 6.97 (d, 1H, J=8.0 Hz), 1.68 (s, 6H); MS (ESI) m/z 414 ([M’H]-, 100%); Anal. Calc. For C17H13BrF3NO3: C, 49.06, H, 3.15, N, 3.37. Found: C, 49.16, H, 3.05, N, 3.30.

The synthetic route of 207226-31-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Wyeth; Ligand Pharmaceuticals, Inc.; US6444668; (2002); B1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem