Category: 2062-98-8

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, A new synthetic method of this compound is introduced below., Recommanded Product: Perfluoro(2-methyl-3-oxahexanoyl) fluoride

The same operation as in Example 1-1 was carried out except that the starting materials were changed as shown in Table 1.The GC purity of the recovered crude liquid was 97%.In addition, measurement1the H-NMR and19F.-NMR spectra confirmed the title compound as a main component (fluorine content = 58.5% by mass)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Asahi Glass Co Ltd;; Qing, Shanyuanzhi; Ye, Cunshunping; (28 pag.)CN105492418; (2016); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, A new synthetic method of this compound is introduced below., Safety of Perfluoro(2-methyl-3-oxahexanoyl) fluoride

Into a flask under a nitrogen gas atmosphere, 26 g of the compound (62) and 100 g of R225 were introduced. With cooling with ice, 91 g of the compound represented by Rf2-C(O)F was dropwise added thereto while stirring inside of the flask. Inside of the flask was further stirred, and then, the content was concentrated and filtrated to obtain 88 g of compound (52).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Asahi Glass Company, Limited; EP2039672; (2009); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 2062-98-8

Under argon gas protection, ice bath and condensed reflux, 16.6 g (0.05 mol) of hexafluoroepoxypropanedimer (CF3CF2CF2OCF(CF3) COFcontaining acyl fluoride end group wasobtained from Zhejiang ring provided fluoro material Co.) was slowly added dropwise step 2obtained on ethylphenyl copper (I) bromide solution, stirring the reaction at room temperature for 4 hours and then quenched with 60mL water antishould, with no (50mL ¡Á 3) water was extracted with ether, the organic phases were combined and dried over anhydrous sodium sulfate, anhydrous sodium sulfate was removed by filtration under reducedpressure of the solvent in the filtrate was distilled off, the residual mixture was purified by silica gel column chromatography (petroleum ether as eluant Purification to obtain acolorless slightly viscous liquid, i.e., 13.0 g of fluorine-containing epoxy oligomer ethylbenzene, and the yield was 62.0%.

The synthetic route of 2062-98-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shaanxi Normal University; Chen Jiangang; Yang Zhaoting; Liu Zhaotie; Yang Le; Shen Shukun; Liu Zhongwen; Jiang Jinqiang; Hao Zhengping; (7 pag.)CN108373407; (2018); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 2062-98-8, A common heterocyclic compound, 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, molecular formula is C6F12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 2: Example for preparation of CF3CF2CF2OCF (CF3) CF2OCOCF (CF3) OCF2CF2CF3 (1b) (fluorination step)[0090] Compound (3b) (200.0 g) obtained in Example 1, was dissolved in CF3CF2CF2OCF(CF3)COF (hereinafter referred to as compound (4b), 1000.0 g). On the other hand, into a 3000 mL autoclave made of nickel, NaF powder (260.5 g) was. put, and compound (4b) (2000.0 g) was added, followed by stirring and cooling to -10 DEG C. After supplying nitrogen gas for 1 hour, fluorine gas diluted to 20% with nitrogen gas, was supplied at a flow rate of 22.59 L/hr for 1 hour, and while supplying it at the same flow rate, the above fractional solution was injected over a period of 60 hours. [0091] Then, while supplying fluorine gas diluted to 20% with nitrogen gas, while maintaining the above flow rate, 20 mL of a solution of compound (4b) in benzene (0.01 g/mL) was injected, the outlet valve of the autoclave was closed, and when the pressure became 0.12 MPa, the inlet valve of the autoclave was closed, followed by stirring for 1 hour. Further, such an operation was repeated 4 times during a period until the temperature rose from -10 DEG C to room temperature and thereafter 5 times at room temperature. During the period, benzene was supplied in a total of 1.800 g, and compound (4b) was injected in a total of 281.0 g. Thereafter, nitrogen gas was supplied for 2 hours, and the reaction mixture was taken out by decantation. The obtained crude liquid was concentrated by an evaporator, and the product was quantified by <19>F-NMR, whereby it contained CF3CF2CF2OCF (CF3) CF2OCOCF (CF3) OCF2CF2CF3 (compound (1b)) in a yield of 69%. A part of the crude liquid was taken and distilled under reduced pressure to obtain compound (1b) . The boiling point of compound (1b) was from 46 to 51 DEG C/5.2 kPa.; EXAMPLE 3: Example for preparation of compound (1b) by a continuous process[0092] Using compound (2b) (75.5 g, 0.640 mol) and compound (1b) obtained in Example 2 (213.1 g, 0.321 mol), the reaction was carried out in the same manner as in Example 1 to obtain compound (3b) (amount: 272.4 g, 0.634 mol). The yield of compound (3b) as quantified by <1>H-NMR, was 99%. Then, the compound (3b) was reacted with fluorine in the same manner as in Example 2 to obtain compound (1b) (amount: 294.0 g, 0.44 mol). The same operation was repeated to finally obtain 3000 g of compound (1b).

The synthetic route of 2062-98-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASAHI GLASS COMPANY LTD.; EP1352892; (2003); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

2062-98-8, These common heterocyclic compound, 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

F[CF(CF3)CF2O]6CF(CF3)C(O)F, a precursor of hydrofluoroether F[CF(CF3)CF2O]7CH3, was formed by oligomerization of hexafluoropropylene oxide. To the reaction vessel, potassium fluoride (10.0 g), hexafluoropropylene oxide dimer (150.0 g) and tetraethylene glycol dimethyl ether (2.5 L) were added at 10 C under stirring.To the round bottom flask was introduced hexafluoropropylene oxide (830 g, 5.0 mol) over 1 hour.The lower acyl fluoride phase product is collected and consists mainly of hexafluoropropylene oxide oligomers. The crude product was further purified by distillation to obtain a product of a hexafluoropropylene oxide heptamer having a purity of 98% as determined by gas chromatography, and used in the next alkylation reaction. The structure of the product was characterized by infrared spectroscopy and 19F NMR.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2062-98-8.

Reference:
Patent; Tianjin Changlu Chemical New Materials Co., Ltd.; Yan Rui; He Guangrui; (15 pag.)CN109608312; (2019); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, A new synthetic method of this compound is introduced below., 2062-98-8

To the thus-obtained unpurified Compound A (3.86 g), were added 20 mL of tetrahydrofuran and 4.6 mL (57 mmol) of pyridine. Then, 15.1 g (45.6 mmol) of C3F7OCF(CF3)COF was added, dropwise, while keeping an internal temperature in the range of from 0 C. to 10 C. After completion of the dropwise addition, the internal temperature was elevated to a temperature in the range of from 20 C. to 30 C., and the reaction mixture was stirred for 1 hour. Then, 50 mL of a saturated sodium bicarbonate aqueous solution was added thereto, dropwise, and then 50 mL of ethyl acetate was added, followed by separation. Then, concentration of the resultant mixture was conducted, thereby to obtain 13.6 g (16.9 mmol, 89%) of Exemplified compound (I-6).The below-shown are identification data of the Exemplified compound (I-6).1H NMR (300 MHz, CDCl3): delta 1.18 to 1.31 (m, 9H), 3.90 to 4.09 (m, 2H), 4.14 to 4.49 (m, 4H), 4.78 to 4.90 (m, 1H)19F NMR (282.4 MHz, CDCl3): delta -131.85 (m, 2F), -129.75 (s, 2F), -86.64 (m, 2F), -86.11 (m, 2F), -82.17, -82.09 (s (doublet), 3F), -81.40 (s, 3F), -80.33 (m, 2F), -79.79 (m, 2F)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; FUJIFILM Corporation; US7501545; (2009); B2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 2062-98-8

Put 0.51 g (4.2 mmol) of 4-ethylphenol into a three-necked flask, add 20 mL of dichloromethane, and add 1.99 g (6 mmol) of hexafluoropropylene oxide dimer (CF3CF2CF2OCF (CF3 ) COF, provided by Zhejiang Huanxin Fluorine Materials Co., Ltd., recorded as FEOCOF), after the addition, add 0.05mL (0.0007mmol) N, N-dimethylformamide (DMF), and slowly add 0.4mL ( 0.003 mmol) dry triethylamine,After the dropwise addition was completed, the reaction was stirred at 40 C. for 2 h.After the reaction, 20 mL of deionized water was added and extracted with dichloromethane (20 mL ¡Á 3). The organic phases were combined and dried over MgSO 4, filtered, and rotary evaporated to obtain a crude product. The crude product was separated by silica gel column chromatography (eluted with petroleum ether). Agent) to obtain a colorless slightly viscous liquid, that is, the target product, with a yield of 99.1%.

The synthetic route of 2062-98-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shaanxi Normal University; Yang Le; Chen Jiangang; Liu Zhaotie; Zhang Qiyu; Li Ruiqing; Shen Shukun; Liu Zhongwen; (11 pag.)CN110776426; (2020); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, A new synthetic method of this compound is introduced below., 2062-98-8

EXAMPLE 11 EXAMPLE OF PRODUCTION OF COMPOUND (71a); Into a flask (internal capacity: 300 mL) under a nitrogen gas atmosphere, CH3COCH2OH (50.0 g), R-225 (81.6 g) and NaF (85.3 g) were put, and stirring was continued while the internal temperature of the flask was kept to be at most 10C. FCOCF(CF3)OCF2CF2CF3 (213.3 g) was dropwise added thereto over a period of two hours, and then the internal temperature of the flask was returned to 25C and stirring was carried out for 12 hours. Into a filtrate obtained by pressure filtration of a solution in the flask, a saturated sodium hydrogen carbonate aqueous solution (200 mL) was added to obtain a double layered solution. The organic layer was separated and washed with water (200 mL) and dehydrated with magnesium sulfate and then concentrated by an evaporator, to obtain a concentrate (230.7 g). In the concentrate, the following compound (71a) was contained, and a GC purity of the compound (71a) was 87.2%. The reaction was separately carried out under the same conditions, whereby a concentrate (96.0 g) having a GC purity of 96.5% was obtained. The concentrate obtained by the reaction twice was distilled under reduced pressure, and as a result, a fraction (281.3 g) of 67 to 71C/1.06 kPa (absolute pressure) was obtained. The fraction was analyzed by GC and NMR, and as a result, it was confirmed that the compound (71a) having a purity of 97.9% was formed. 1H-NMR (300.4 MHz, solvent: CDCl3, standard: TMS) delta (ppm): 2.21 (s, 3H), 4.91 (q, 16.5 Hz, 2H). 19F-NMR (282.6 MHz, solvent: CDCl3, standard: CFCl3) delta (ppm): -79.6 to -80.3 (1F), -81.7 to -81.8 (3F), -82.4 to -82.5 (3F), -86.5 to -87.0 (1F), -130.1 to -130.2 (2F), -132.8 (1F).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ASAHI GLASS COMPANY LTD.; EP1679311; (2006); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

2062-98-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2062-98-8 name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 11 A mixture of ethanolamine (13 g, 28 mmole) and ether (30 mL) was cooled to 15 C. Perfluoro-2-methyl-3-oxahexanoyl fluoride (33 g in ether 50 mL) was added dropwise to keep the reaction temperature below 25 C. After the addition, the reaction mixture was stirred at room temperature for one hour. The solid was removed by filtration and the filtrate was washed with hydrochloric acid (0.5N, 30 mL), water (2 times 30 mL), sodium hydrogen carbonate solution (0.5N, 20 mL), water (30 mL), and sodium chloride solution (saturated, 20 mL). It was then concentrated and dried in vacuum over night at room temperature to give a white solid 35 g, yield 95%. H NMR (CDCl3) 1.67 (br s, 1H), 3.57 (m, 2H), 3.80 (t, J=5 Hz, 2H), 6.91 (br s, 1H) ppm. F NMR (CDCl3) -81.2 (dm, J=148 Hz, 1F), -81.7 (t, J=7 Hz, 3F), -82.7 (d, J=3 Hz, 3F), -85.2 (dm, J=148 Hz, 1F), -130.1 (s, 2F), -133.2 (m, 1F) ppm. The product is N-(perfluoro-2-methyl-3-oxahexanoyl)-2-aminoethanol.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Perfluoro(2-methyl-3-oxahexanoyl) fluoride, and friends who are interested can also refer to it.

Reference:
Patent; E.I.DU PONT DE NEMOURS AND COMPANY; US2010/233419; (2010); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem