Category: 2050-47-7

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2050-47-7, name is 4,4′-Oxybis(bromobenzene), This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 4,4′-Oxybis(bromobenzene)

All manipulations were performed under an inert atmosphere of nitrogen. A Schlenk flask equipped with a condenser was charged with 4- bromophenylether (3.90 g), carbazole (4.34 g), 18-crown-6 (0.70 g), Cu (1.65 g) and K2CO3 (3.60 g) and 1, 2-dichlorobenzene (150 mL). The resulting mixture was heated to 180 C for four days. After cooling to room temperature, water was added and the mixture was stirred overnight. The organic layer was isolated and the water layer was washed with water. The combined organic layers were dried over MgSO4 and the solvent was evaporated to give a brown oil. The desired product was isolated by crystallization from CH2CI2/MeOH to give an off-white powder in 58% yield (3. 5 g) 1H NMR (CD2CI2, 500 MHz): 6 8.14 (d, 1H), 7. 58 (d, 1H), 7.42 (m, 2H), 7.35 (d, 1H), 7.27 (m, 1H).

According to the analysis of related databases, 2050-47-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; E.I. DUPONT DE NEMOURS AND COMPANY; WO2005/82851; (2005); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2050-47-7, name is 4,4′-Oxybis(bromobenzene), A new synthetic method of this compound is introduced below., Application In Synthesis of 4,4′-Oxybis(bromobenzene)

Bis- (4-bromophenyl) ether (30 g, 0.092 mol), a, a, a-trichlorotoluene (22 ml, 0. 15 mol), aluminum chloride (20 g, 0.15 mol) in dichloromethane (75 ml) were stirred at room temperature for 1 hour. The reaction mixture was poured into water (100 ml) and hexane (300 ml and the suspension was stirred overnight. The mixture was then filtered, washed with water (230 ml) and hexane 400 ml) and dried to give the title compound as a crystalline solid (34.94 g, yield: 88%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ISIS PHARMACEUTICALS, INC.; WO2005/77966; (2005); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem