Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 204452-91-5, name is 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine, A new synthetic method of this compound is introduced below., Product Details of 204452-91-5
[0578] Into a 3 I 4-necked round-bottom flask was placed7 -( dimethoxymethyl)-1 ,2,3,4-tetrahydro-1 ,8-naphthyridine(intermediate 4, 114.6 g, 550.3 mmol) in acetonitrile (2 1).This was followed by the addition of NBS (1 03 g, 578 mol) inportions with stirring at 25 C. The resulting solution wasstirred for 30 min at 25 C. The resulting mixture was concentratedunder vacuum and the residue was diluted with1000 ml of diethylether. The mixture was washed with 3xl 00ml of ice/water. The aqueous phase was extracted with 2xl 00ml of diethylether and the organic layers were combined. Theresulting mixture was washed with lxlOO ml of brine, driedover sodium sulfate and concentrated under vacuum to givethe title compound as a light yellow solid. LC-MS: (ES, m/z):[0579] 286.03 [M+Ht. 1H-NMR: (300 MHz, CDCI3 ) o1.86-1.94 (2H, m), 2.70-2.74 (2H, m), 3.9-3.43 (2H, m), 3.47(6H, s), 5.23 (lH, s), 5.58 (lH, s), 7.29 (lH, s).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Novartis AG; Buschmann, Nicole; Fairhurst, Robin Alec; Furet, Pascal; Knoepfel, Thomas; Leblanc, Catherine; Liao, Lv; Mah, Robert; Nimsgern, Pierre; Ripoche, Sebastien; Xiong, Jing; Han, Bo; Wang, Can; Zhao, Xianglin; US2015/119385; (2015); A1;,
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