Category: 20012-63-9

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20012-63-9, name is 2-(Benzyloxy)aniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 20012-63-9

Step L: N-Trifluoroacetyl 2-Benzyloxyaniline (25) To a stirred, near solution of amine (24) (5.0 mM) in dry diethyl ether (30 mL) is added anhydrous sodium carbonate (6.0g., 57 mM) and the resultant mixture cooled in an ice-water bath. Trifluoroacetic anhydride (1.5 mL, 10.6 mM) is added dropwise to this cold mixture over 2 minutes, the color changing to a yellowish red. After 2 hours the cooling-bath is removed and the mixture allowed to stir at ambient temperatures overnight. After filtering, the filtrate is concentrated in vacuo and then pumped to yield 1.3 g. of the title compound (25) as a pale tan (with some reddish-brown color around the edges) crust.

The synthetic route of 20012-63-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK & CO. INC.; EP526093; (1993); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 20012-63-9,Some common heterocyclic compound, 20012-63-9, name is 2-(Benzyloxy)aniline, molecular formula is C13H13NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of this acid chloride in dry methylene chloride (65 ml) was added to a stirred mixture of 2-benzyloxyaniline [3.0 g; prepared as described by Barber et al., J. Chem. Soc., (1961), 2828], pyridine (1.36 g) and dry methylene chloride (65 ml) at 0 C. The mixture was stirred at 10 C. for 2 hours and then was allowed to stand at room temperature overnight. The mixture was washed twice with water and the methylene chloride solution was then dried over magnesium sulphate and evaporated under diminished pressure. The resulting solid was recrystallized from ethanol to give 1-benzyl-2′-benzyloxy-1H-tetrazole-5-carboxanilide (3.1 g), m.p. 140-142 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(Benzyloxy)aniline, its application will become more common.

Reference:
Patent; May & Baker Limited; US4442115; (1984); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem