Category: 1877-75-4

Quaternary Ammonium Polyamidoamine Dendrimer Modified Quantum Dots as Fluorescent Probes for p-Fluorophenoxyacetic Acid Detection in Aqueous Solution was written by Xu, Xiao;Cao, Yuan-Cheng;Liu, Jun′An;Lin, Yongjun. And the article was included in Journal of Fluorescence in 2017.Safety of 2-(4-Methoxyphenoxy)acetic acid This article mentions the following:

The wide use of pesticide p-fluorophenoxyacetic acid has caused the serious environmental contaminant. A novel fluorescent probe for sensitive detection of p-fluorophenoxyacetic acid in aqueous solutions based on 3.0G quaternary ammonium polyamidoamine (PAMAM) dendrimer modified quantum dots (QDs) (PAMAM@QDs) was reported. Through the solvent-evaporation method, quaternary ammonium PAMAM was employed to modify the QDs. Poloxamer 188 was used to improve the solubility and stability. The resultant PAMAM@QDs dispersed well in water. Fluorescence (FL) spectroscopic study showed that the FL intensity of the PAMAM@QDs was enhanced in the presence of p-fluorophenoxyacetic acid. Under optimal conditions, the enhanced FL intensity as a function of concentration matched very well in the range of 1 ∼ 200 μg/mL of p-fluorophenoxyacetic acid, while the lower limits of detection were found to be 0.16 μg/mL. These results show that PAMAM@QDs is a promising luminescent probe for the detection of pesticides. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Safety of 2-(4-Methoxyphenoxy)acetic acid).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Safety of 2-(4-Methoxyphenoxy)acetic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

An Efficient One-Pot Synthesis of 2-(Aryloxyacetyl)cyclohexane-1,3-diones as Herbicidal 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors was written by Wang, Da-Wei;Lin, Hong-Yan;He, Bo;Wu, Feng-Xu;Chen, Tao;Chen, Qiong;Yang, Wen-Chao;Yang, Guang-Fu. And the article was included in Journal of Agricultural and Food Chemistry in 2016.COA of Formula: C9H10O4 This article mentions the following:

4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) is an important target for new bleaching herbicides discovery. To search for novel HPPD inhibitors, a series of 2-(aryloxyacetyl)cyclohexane-1,3-diones were rationally designed and synthesized by an efficient one-pot procedure using of N,N’-Carbonyldiimidazole (CDI), triethylamine, and acetone cyanohydrin in CH₂Cl₂. A total of 58 triketone compounds were prepared in good to excellent yields. Some of the synthesized compounds displayed potent Arabidopsis thaliana HPPD (AtHPPD) inhibitory activity. 2-(2-((1-Bromonaphthalen-2-yl)oxy)acetyl)-3-hydroxycyclohex-2-en-1-one (I) displayed high, broad-spectrum and post-emergent herbicidal activity at the rate of 37.5-150 g ai/ha, nearly as potent as mesotrione against some weeds. Furthermore, I showed good crop safety against maize and canola at the rate of 150 g ai/ha, indicating that I might have the potential as herbicide for the weed control in maize and canola fields. I is the first HPPD inhibitor showing good crop safety towards canola. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4COA of Formula: C9H10O4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.COA of Formula: C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Poly(phenylenevinylene) analogs with ring substituted polar side chains and their use in the formation of hydrogen bonding based self-assembled multilayers was written by Benjamin, Iris;Hong, Haiping;Avny, Yair;Davidov, Dan;Neumann, Ronny. And the article was included in Journal of Materials Chemistry in 1998.Application of 1877-75-4 This article mentions the following:

Poly(arylenevinylene) homopolymers and copolymers with polar hydroxy and carboxy moieties attached to the aromatic Ph ring were prepared The copolymers and the related homopolymers are copoly[5-(2-hydroxyethoxy)-2-methoxy-1,4-phenylenevinylene/1,4-phenylenevinylene], co(PHydroxyV-PV), and copoly(5-carboxymethoxy-2-methoxy-1,4-phenylenevinylene/1,4-phenylenevinylene), co(PCarboxyV-PV). For co(PHydroxyV-PV) the photoluminescence and electroluminescence spectra can be adjusted over a range of 100 nm as a function of the percentage of the hydroxy-substituted Ph ring. For co(PCarboxyV-PV) the observed spectral features are a function of the pH from which the final conjugated polymer was prepared The optical d. and photoluminescence of co(PCarboxyV-PV) films prepared from solutions at pH = 12 were significantly blue-shifted compared to polymers prepared from pH = 2 solutions at up to 30% substitution at the Ph ring. The presence of the polar side chain was used to form self-assembled multilayer films, poly(ethyleneimine)/poly(styrenesulfonate)/co(PHydroxyV-PV), based on hydrogen bonding interactions rather than electrostatic forces. The luminescence spectra in the layered systems were blue-shifted compared to the spin coated films. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Application of 1877-75-4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Application of 1877-75-4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Expedient Synthesis of 3-Alkoxymethyl- and 3-Aminomethyl-Pyrazolo[3,4-b]pyridines was written by Beutner, Gregory L.;Kuethe, Jeffrey T.;Kim, Mary M.;Yasuda, Nobuyoshi. And the article was included in Journal of Organic Chemistry in 2009.Safety of 2-(4-Methoxyphenoxy)acetic acid This article mentions the following:

An effective strategy has been developed for the preparation of 3-alkoxymethyl-pyrazolo[3,4-b]pyridines, i.e. I, compounds that are currently not readily accessible by existing synthetic methods. Further manipulation of these compounds allows for access to 3-alkoxymethyl-pyrazolo[3,4-b]pyridines with a variety of substitution patterns as well as 3-aminomethyl-pyrazolo[3,4-b]pyridines. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Safety of 2-(4-Methoxyphenoxy)acetic acid).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Safety of 2-(4-Methoxyphenoxy)acetic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Copper-Catalyzed Regioselective Olefination and Trifluoromethylation of Carboxylic Acids To Give (Z)-Trifluoromethyl Enol Esters was written by Lu, Dong;Li, Shuangshuang;Yang, Xiaogang;Yin, Shuang-Feng;Kambe, Nobuaki;Qiu, Renhua. And the article was included in Organic Letters in 2022.Electric Literature of C9H10O4 This article mentions the following:

A method to produce (Z)-trifluoromethyl enol esters via the olefination and trifluoromethylation of carboxylic acids with TMSCF₃ was reported. This synthetic method used inexpensive and easy-to-handle TMSCF₃. It employed a com. available CuCl catalyst to transform a broad range of carboxylic acids into versatile (Z)-trifluoromethyl enol esters with good regio- and stereoselectivity. This protocol allowed the concise synthesis of highly functionalized (Z)-trifluoromethyl enol esters directly from carboxylic acids. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Electric Literature of C9H10O4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Electric Literature of C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and antiviral activity of lycorine derivatives was written by Yang, Ya-Jun;Liu, Jiang-Ning;Pan, Xian-Dao. And the article was included in Journal of Asian Natural Products Research in 2020.COA of Formula: C9H10O4 This article mentions the following:

There are no effective antiviral drugs to treat hand, foot, and mouth disease. In this study, a series of lycorine derivatives were synthesized and evaluated against enterovirus 71 and coxsackievirus A16 in vitro. Derivatives with the phenoxyacyl group at the C-1 position showed higher efficacy and lower toxicity than lycorine. In addition, derivative enhanced the survival rate to 40% in the mouse model of the lethal EV71 infection. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4COA of Formula: C9H10O4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.COA of Formula: C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In silico and pharmacological screenings identify novel serine racemase inhibitors was written by Mori, Hisashi;Wada, Ryogo;Li, Jie;Ishimoto, Tetsuya;Mizuguchi, Mineyuki;Obita, Takayuki;Gouda, Hiroaki;Hirono, Shuichi;Toyooka, Naoki. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.Recommanded Product: 2-(4-Methoxyphenoxy)acetic acid This article mentions the following:

D-Serine is a coagonist of the N-methyl-D-aspartate (NMDA)-type glutamate receptor and its biosynthesis is catalyzed by serine racemase (SR). The overactivation of the NMDA receptor has been implicated in the development of neurodegenerative diseases, strokes, and epileptic seizures, thus, the inhibitors of SR have potential against these pathol. states. Here, we have developed novel inhibitors of SR by in silico screening and in vitro enzyme assay. The newly developed inhibitors have lower IC₅₀ value comparing with that of malonate, one of the standard SR inhibitor. The structural features of novel inhibitors suggest the importance of central amide structure having a phenoxy substituent in their structure for the SR inhibitory activity. The present findings suggest the importance and rational development of new drugs for diseases of NMDAR overactivation. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Recommanded Product: 2-(4-Methoxyphenoxy)acetic acid).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Recommanded Product: 2-(4-Methoxyphenoxy)acetic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Microwave-assisted synthesis of 4-amino-3-[2-benzo[b]furyl]-5-mercapto-1,2,4-triazole and its derivatives was written by Wang, Xi-Cun;Quan, Zheng-Jun;Li, Zheng. And the article was included in Youji Huaxue in 2005.Electric Literature of C9H10O4 This article mentions the following:

4-Amino-3-(2-benzofuryl)-5-mercapto-1,2,4-triazole was synthesized by the reactions of 2-benzo[b]furoyl hydrazine with CS₂ and next hydrazine under microwave irradiation Treatment of the resulting 4-amino-5-mercapto-1,2,4-triazole with aromatic carboxylic acids (or aryloxyacetic acids), α-bromoacetophenones and aromatic aldehydes under microwave irradiation yielded the corresponding 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles, 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines and 4-arylideneamino-5-mercapto-1,2,4-triazole in good to moderate yields, resp. The structures of all these new compounds were confirmed by elemental analyses, IR, ¹H NMR and MS spectra. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Electric Literature of C9H10O4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Electric Literature of C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis of 2-[(aryloxy)methyl]benzimidazole derivatives was written by Cui, Wen-hui;Zhang, You-min;Wei, Tai-bao. And the article was included in Hecheng Huaxue in 2006.Electric Literature of C9H10O4 This article mentions the following:

Twelve derivatives of 2-[(aryloxy)methyl]-1H-benzimidazole were synthesized using HCl as a catalyst and the structures were identified by ¹H NMR, IR and elemental anal. Six of the compounds are reported for the first time. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Electric Literature of C9H10O4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Electric Literature of C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis, crystal structure and biological evaluation of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines was written by Khan, Imtiaz;Zaib, Sumera;Ibrar, Aliya;Rama, Nasim Hasan;Simpson, Jim;Iqbal, Jamshed. And the article was included in European Journal of Medicinal Chemistry in 2014.SDS of cas: 1877-75-4 This article mentions the following:

Nitrogen-containing heterocycles are of particular interest and significant importance for the discovery of potent bioactive agents in pharmaceutical industry. The present study reports the synthesis of a library of new conjugated heterocycles including I [R¹ = 4-FC₆H₄OCH₂, 2-furyl, 3-furyl, etc.] and II [R² = 3-ClC₆H₄, 4-biphenyl, 1-naphthyl, etc.] by cyclocondensation reaction of 4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol with various substituted aromatic acids and phenacyl bromides, resp. The structures of newly synthesized compounds were characterized by elemental anal., IR, ¹H and ¹³C NMR spectroscopy and in case of I [R¹ = 2-furyl] by x-ray crystallog. anal. Newly synthesized triazolothiadiazoles and thiadiazines were screened for acetyl- and butyryl-cholinesterases and alk. phosphatase inhibition. Almost all of the compounds showed good to excellent activities against acetylcholinesterase more than the reference drugs. Compound I [R¹ = 4-MeOC₆H₄OCH₂] exhibited IC₅₀ value 0.77±0.08 μM against acetylcholinesterase and I [R¹ = 2-F-4-Cl-C₆H₃] showed IC₅₀ 9.57±1.42 μM against butyrylcholinesterase. Among all the tested compounds, I [R¹ = 2-F-4-Cl-C₆H₃] also proved as excellent inhibitor of alk. phosphatase with IC₅₀ 0.92±0.03 μM. These heteroaromatic hybrid structures were also tested for their anticancer activity against lung carcinoma (H157) and kidney fibroblast (BHK-21) cell lines and leishmanias. Variable cell growth inhibitory activities were obtained and many compounds exhibit potent %inhibition. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4SDS of cas: 1877-75-4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.SDS of cas: 1877-75-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem