Category: 1877-75-4

In silico and pharmacological screenings identify novel serine racemase inhibitors was written by Mori, Hisashi;Wada, Ryogo;Li, Jie;Ishimoto, Tetsuya;Mizuguchi, Mineyuki;Obita, Takayuki;Gouda, Hiroaki;Hirono, Shuichi;Toyooka, Naoki. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.Recommanded Product: 2-(4-Methoxyphenoxy)acetic acid This article mentions the following:

D-Serine is a coagonist of the N-methyl-D-aspartate (NMDA)-type glutamate receptor and its biosynthesis is catalyzed by serine racemase (SR). The overactivation of the NMDA receptor has been implicated in the development of neurodegenerative diseases, strokes, and epileptic seizures, thus, the inhibitors of SR have potential against these pathol. states. Here, we have developed novel inhibitors of SR by in silico screening and in vitro enzyme assay. The newly developed inhibitors have lower IC₅₀ value comparing with that of malonate, one of the standard SR inhibitor. The structural features of novel inhibitors suggest the importance of central amide structure having a phenoxy substituent in their structure for the SR inhibitory activity. The present findings suggest the importance and rational development of new drugs for diseases of NMDAR overactivation. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Recommanded Product: 2-(4-Methoxyphenoxy)acetic acid).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Recommanded Product: 2-(4-Methoxyphenoxy)acetic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Copper-Catalyzed Regioselective Olefination and Trifluoromethylation of Carboxylic Acids To Give (Z)-Trifluoromethyl Enol Esters was written by Lu, Dong;Li, Shuangshuang;Yang, Xiaogang;Yin, Shuang-Feng;Kambe, Nobuaki;Qiu, Renhua. And the article was included in Organic Letters in 2022.Electric Literature of C9H10O4 This article mentions the following:

A method to produce (Z)-trifluoromethyl enol esters via the olefination and trifluoromethylation of carboxylic acids with TMSCF₃ was reported. This synthetic method used inexpensive and easy-to-handle TMSCF₃. It employed a com. available CuCl catalyst to transform a broad range of carboxylic acids into versatile (Z)-trifluoromethyl enol esters with good regio- and stereoselectivity. This protocol allowed the concise synthesis of highly functionalized (Z)-trifluoromethyl enol esters directly from carboxylic acids. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Electric Literature of C9H10O4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Electric Literature of C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and antiviral activity of lycorine derivatives was written by Yang, Ya-Jun;Liu, Jiang-Ning;Pan, Xian-Dao. And the article was included in Journal of Asian Natural Products Research in 2020.COA of Formula: C9H10O4 This article mentions the following:

There are no effective antiviral drugs to treat hand, foot, and mouth disease. In this study, a series of lycorine derivatives were synthesized and evaluated against enterovirus 71 and coxsackievirus A16 in vitro. Derivatives with the phenoxyacyl group at the C-1 position showed higher efficacy and lower toxicity than lycorine. In addition, derivative enhanced the survival rate to 40% in the mouse model of the lethal EV71 infection. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4COA of Formula: C9H10O4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.COA of Formula: C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kinetics of oxidation of phenoxyacetic acid by TPCC in aqueous aceticacid medium was written by Palaniappan, An.;Udhayakumar, R.;Srinivasan, S.;Raju, C.. And the article was included in Chemica Sinica in 2012.Application of 1877-75-4 This article mentions the following:

The kinetics of oxidation of phenoxyacetic acid and several para- and meta-substituted phenoxyacetic acids by tetrakis(pyridine) cobalt(II) chromate (TPCC) in the presence of HClO₄ was studied in aqueous acetic acid medium. The reaction shows unit order dependence each with respect to oxidant and substrate. The order with respect to hydrogen ion concentration is one. The rate of oxidation increases with increase in the percentage of acetic acid and increase in ionic strength has negligible effect on the rate. The addition of Al³⁺ had a noticeable catalytic effect on the reaction rate. In general, the electron releasing substituent accelerates the rate while electron attracting substituent retards the rate of reaction. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Application of 1877-75-4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Application of 1877-75-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Design, synthesis, and antitumor activity evaluation of novel acyl sulfonamide spirodienones was written by Chen, Chen;Luo, Yang;Yin, Honglu;Zhong, Qiu;Zheng, Shilong;Liu, Rui;Zhao, Chong;Wang, Guangdi;He, Ling. And the article was included in Bioorganic & Medicinal Chemistry in 2022.HPLC of Formula: 1877-75-4 This article mentions the following:

Based on the promising results of benzenesulfonamide spirodienones as antineoplastic agents, a series of novel acyl sulfonamide spirodienones I [R = Me, C₆H₅, 4-MeC₆H₄, etc.; R¹ = H, Me] were designed and synthesized for antineoplastic evaluation. Of these, compound I [R = 4-MeC₆H₄, R¹ = H] exhibited remarkable in-vitro antiproliferative activity by arresting the cell cycle and inducing apoptosis of MDA-MB-231 cells. Acute toxicity study demonstrated that compound I [R = 4-MeC₆H₄, R¹ = H] at 100 mg/kg dose caused no obvious toxicity to the major organs of mice. Moreover, compound I [R = 4-MeC₆H₄, R¹ = H] suppressed the growth of murine 4T1 tumor in-vivo. Preliminary enzyme assay showed that I [R = 4-MeC₆H₄, R¹ = H] was a potential MMP2 inhibitor for cancer therapy. In all, these results indicated that compound I [R = 4-MeC₆H₄, R¹ = H] may be a lead compound for the development of anticancer agents. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4HPLC of Formula: 1877-75-4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.HPLC of Formula: 1877-75-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kinetics of oxidation of phenoxyacetic acids by pyridinium hydrobromide perbromide was written by Karunakaran, K.;Elango, K. P.. And the article was included in Journal of Physical Organic Chemistry in 1996.Synthetic Route of C9H10O4 This article mentions the following:

The oxidation of several monosubstituted phenoxyacetic acids by pyridinium hydrobromide perbromide (PHPB) was studied in aqueous acetic acid. The reaction is first order with respect to PHPB. Michaelis-Menten-type kinetics are observed with respect to phenoxyacetic acids. The oxidation of [2,2-²H₂]phenoxyacetic acid exhibits a substantial kinetic isotopic effect. The effect of solvent composition indicates that the transition state is more polar than the reactants. The formation constants of the intermediate phenoxyacetic acid-PHPB complexes and the rates of their decomposition were determined at different temperatures The rates of oxidation of para- and meta-substituted phenoxyacetic acids were correlated with Hammett’s substituent constants The 锜?value is -2璺?9 at 35鎺? The rates of oxidation of ortho-substituted compounds are correlated with Charton’s triparametric equation. A mechanism involving transfer of a hydride ion from the substrate to the oxidant is proposed. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Synthetic Route of C9H10O4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Synthetic Route of C9H10O4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and biological activities of novel 2,5-disubstituted-1,3,4-thiadiazole derivatives was written by Li, Yingjun;Yu, Yang;Jin, Kun;Gao, Lixin;Luo, Tongchuan;Sheng, Li;Shao, Xin;Li, Jia. And the article was included in Youji Huaxue in 2015.Computed Properties of C9H10O4 This article mentions the following:

Sixteen novel 2,5-disubstituted-1,3,4-thiadiazole derivatives containing benzisoselenazolone moiety were synthesized by the reaction of 2-amino-5-substituted-1,3,4-thiadiazoles with ortho-(chloroseleno)benzoyl chloride. The structures were characterized by IR, ¹H NMR spectra and elemental anal. Their biol. activities were evaluated. The exptl. results indicate that some compounds exhibit inhibitory activity against cell division cycle 25B phosphatase (Cdc25B)(IC₅₀=1.67-6.66 娓璵ol璺疞^-1). All the target compounds showed good inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) (IC₅₀=0.73-4.50 娓璵ol璺疞^-1), and some compounds exhibited higher inhibitory activity than pos. control oleanolic acid (IC₅₀=1.90 娓璵ol璺疞^-1). Compound I displayed antitumor activity in vitro for human colon cancer (HCT-8) cell (IC₅₀=12.54 娓璵ol璺疞^-1). Some compounds showed the medium scavenging ability for hydroxyl radical (HO璺? and superoxide anion (O₂^璺?). Some compounds showed the medium scavenging ability for hydroxyl radical (HO璺? and superoxide anion (O₂^璺?), but no scavenging ability for DPPH 璺? In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Computed Properties of C9H10O4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Computed Properties of C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and Biological Activity of Ethyl 4-Alkyl-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylate was written by Mo, Wenyan;Shi, Yanxia;He, Junbo;Li, Baoju;Peng, Hao;He, Hongwu. And the article was included in Journal of Heterocyclic Chemistry in 2016.Related Products of 1877-75-4 This article mentions the following:

A series of novel Et 4-(methyl)-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylates I [R¹ = 4-CH₃, 4-OCH₃, 4-Cl, etc.] and Et 4-(trifluoromethyl)-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylates II [R¹ = H, 4-CH₃, 4-OCH₃, 4-Cl] were synthesized, and their structures were confirmed by IR, ¹H-NMR, MS spectra and elemental anal. The results of preliminary bioassays show that some of the title compounds exhibited moderate to good herbicidal activities. Compared with the fluorine free compounds I [R¹ = 4-F, 2,4-Cl₂, 2-Cl,4-F], the compounds bearing fluorine II [R¹ = 4-F, 2,4-Cl₂, 2-Cl,4-F] showed higher herbicidal activities with 70-100% inhibition against Capsella bursa-pastoris, Amaranthus restroflexus, and Eclipta prostrata at the dosage of 150 g/ha, which indicated that the trifluoromethyl on the thiazole ring was beneficial for the herbicidal activity. Furthermore, compounds II were tested for fungicidal activity against Pseudoperonospora cubensis at 500 娓璯/mL. Compounds II [R¹ = H, 4-F] showed the best fungicidal activity with more than 80% inhibition. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Related Products of 1877-75-4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Related Products of 1877-75-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: Structure-activity relationship study was written by Thanigaimalai, Pillaiyar;Konno, Sho;Yamamoto, Takehito;Koiwai, Yuji;Taguchi, Akihiro;Takayama, Kentaro;Yakushiji, Fumika;Akaji, Kenichi;Kiso, Yoshiaki;Kawasaki, Yuko;Chen, Shen-En;Naser-Tavakolian, Aurash;Schon, Arne;Freire, Ernesto;Hayashi, Yoshio. And the article was included in European Journal of Medicinal Chemistry in 2013.Formula: C9H10O4 This article mentions the following:

This work describes the design, synthesis, and evaluation of low-mol. weight peptidic SARS-CoV 3CL protease inhibitors. The inhibitors were designed based on the potent tripeptidic Z-Val-Leu-Ala(pyrrolidone-3-yl)-2-benzothiazole (I) (K_i = 4.1 nM), in which the P3 valine unit was substituted with a variety of distinct moieties. The resulting series of dipeptide-type inhibitors displayed moderate to good inhibitory activities against 3CL^pro. In particular, compounds (II) (R¹ = OMe, R² = H and R¹ = H, R² = OMe) exhibited good inhibitory activities with K_i values of 0.39 and 0.33 娓璏, resp. These low-mol. weight compounds are attractive leads for the further development of potent peptidomimetic inhibitors with pharmaceutical profiles. Docking studies were performed to model the binding interaction of the compound II (R¹ = OMe, R² = H) with the SARS-CoV 3CL protease. The preliminary SAR study of the peptidomimetic compounds with potent inhibitory activities revealed several structural features that boosted the inhibitory activity: (i) a benzothiazole warhead at the S1′ position, (ii) a 绾?lactam unit at the S1-position, (iii) an appropriately hydrophobic leucine moiety at the S2-position, and (iv) a hydrogen bond between the N-arylglycine unit and a backbone hydrogen bond donor at the S3-position. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Formula: C9H10O4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O閳ユ椊 or N閳ユ椊 bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Formula: C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Substituent and solvent effects on electronic spectra of some substituted phenoxyacetic acids was written by Shanthi, M.;Kabilan, S.. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2007.HPLC of Formula: 1877-75-4 This article mentions the following:

The effects of substituents and solvents have been studied through the absorption spectra of nearly 19 p- and o-substituted phenoxyacetic acids in the range of 200-400 nm. The effects of substituent on the absorption spectra of compounds under present investigation are interpreted by correlation of absorption frequencies with simple and extended Hammett equations. Effect of solvent polarity and hydrogen bonding on the absorption spectra are interpreted by means of Kamlet equation and the results are discussed. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4HPLC of Formula: 1877-75-4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.HPLC of Formula: 1877-75-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem