Category: 18312-57-7

Qi, Li; Liu, Jian; Ronk, Michael; Gallegos, Alejandra; Fujimori, Kiyoshi; Luo, Yanxin; Li, Kim; Lee, Hans; Nashed-Samuel, Yasser published the artcile< A Holistic Approach of Extractables and Leachables Assessment of Rubber Stoppered Glass Vial Systems for Biotechnology Products>, Recommanded Product: 2,2′-(Tridecylazanediyl)diethanol, the main research area is rubber stoppered glass vial extractable leachable biotechnol; Extractables; Glass vials; Holistic approach; ICH Q3D; Leachables; Rubber stoppers; Toxicology.

Rubber stoppered glass vial systems are widely used as primary containers for storing and delivering therapeutic protein products to patients. Addressing concerns and regulatory expectations related to the risk to biol. drug product quality and patient safety from rubber stoppered glass vial systems requires implementation of an extractable and leachable evaluation program based on material understanding, risk assessment, literature review, and a comprehensive scientifically sound anal. testing methodol. The extractable and leachable study design consisted of twelve drug products filled in twelve different size glass vials capped with laminated and nonlaminated rubber stoppers made from three different rubber formulations. Design of the model solvents was successful as they had little to no anal. interference and mimicked the formulation conditions and generated representative extractables capable of predicting leachables. The extraction conditions of time and temperature were appropriate as not to degrade the test materials or the extractable compounds, and yet generated significant quantities for identification of the extractable compounds with confidence. The extractables testing results were capable of predicting the leachable profiles of the twelve drug products. In each case, the leachable profile was a subset of the extractable profile. The organic and elemental impurities of the leachable profiles of drug products were the end-to-end verification of the quality of the glass vials, rubber stoppers and drug product lifecycles. Overall, the holistic approach was fully successful in the qualification of different vial systems as primary containers and delivery systems for different biotherapeutic products to ensure product quality and patient safety.

Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) published new progress about Bioavailability. 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Recommanded Product: 2,2′-(Tridecylazanediyl)diethanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Qi, Li; Liu, Jian; Ronk, Michael; Gallegos, Alejandra; Fujimori, Kiyoshi; Luo, Yanxin; Li, Kim; Lee, Hans; Nashed-Samuel, Yasser published the artcile< A Holistic Approach of Extractables and Leachables Assessment of Rubber Stoppered Glass Vial Systems for Biotechnology Products>, Recommanded Product: 2,2′-(Tridecylazanediyl)diethanol, the main research area is rubber stoppered glass vial extractable leachable biotechnol; Extractables; Glass vials; Holistic approach; ICH Q3D; Leachables; Rubber stoppers; Toxicology.

Rubber stoppered glass vial systems are widely used as primary containers for storing and delivering therapeutic protein products to patients. Addressing concerns and regulatory expectations related to the risk to biol. drug product quality and patient safety from rubber stoppered glass vial systems requires implementation of an extractable and leachable evaluation program based on material understanding, risk assessment, literature review, and a comprehensive scientifically sound anal. testing methodol. The extractable and leachable study design consisted of twelve drug products filled in twelve different size glass vials capped with laminated and nonlaminated rubber stoppers made from three different rubber formulations. Design of the model solvents was successful as they had little to no anal. interference and mimicked the formulation conditions and generated representative extractables capable of predicting leachables. The extraction conditions of time and temperature were appropriate as not to degrade the test materials or the extractable compounds, and yet generated significant quantities for identification of the extractable compounds with confidence. The extractables testing results were capable of predicting the leachable profiles of the twelve drug products. In each case, the leachable profile was a subset of the extractable profile. The organic and elemental impurities of the leachable profiles of drug products were the end-to-end verification of the quality of the glass vials, rubber stoppers and drug product lifecycles. Overall, the holistic approach was fully successful in the qualification of different vial systems as primary containers and delivery systems for different biotherapeutic products to ensure product quality and patient safety.

Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) published new progress about Bioavailability. 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Recommanded Product: 2,2′-(Tridecylazanediyl)diethanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Davidescu, C. M.; Popa, A. published the artcile< Quaternary ammonium salts grafted on gel-type styrene-divinylbenzene copolymers>, Reference of 18312-57-7, the main research area is styrene divinylbenzene copolymer chloromethylated amine quaternization; quaternary ammonium salt styrene divinylbenzene copolymer.

Polymer-grafted quaternary ammonium salts were prepared by polymer-analogous direct quaternization of chloromethylated styrene-7% divinylbenzene copolymers. More simpler procedures for the calculation of the functionalization degrees and the statistical modeling of the structural repetitive unit of the copolymer are reported.

Buletinul Stiintific al Universitatii “Politehnica” din Timisoara Romania, Seria Chimie Industriala si Ingineria Mediului published new progress about Quaternary ammonium compounds, polymers Role: SPN (Synthetic Preparation), PREP (Preparation). 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Reference of 18312-57-7.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yan, Jincan; Zeng, Xiangqiong; van der Heide, Emile; Ren, Tianhui published the artcile< The tribological performance and tribochemical analysis of novel borate esters as lubricant additives in rapeseed oil>, Formula: C17H37NO2, the main research area is rapeseed oil lubricant additive borate ester tribofilm XANES XPS.

Two novel borate esters, tris (4-dodecylphenyl) borate and 2-(2-(4-dodecylphenoxy)-1, 3, 6, 2-dioxazaborocan-6-yl) ethanol were synthesized and applied as anti-wear and extreme pressure additives in rapeseed oil. The borate esters possess high anti-wear and extreme pressure properties. XANES and XPS were used to analyze the composition and structure of boundary films at the worn surfaces. It is shown that the additives form a protective film at the rubbed surfaces based on B2O3 and/or BN. B-N synergetic effect was found in the results which suggests that tribofilms composed of BN are to be preferred over tribofilms that consists of B2O3.

Tribology International published new progress about Friction. 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Formula: C17H37NO2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Popa, Adriana; Davidescu, Corneliu-Mircea; Trif, Radu; Ilia, Gheorghe; Iliescu, Smaranda; Dehelean, Gheorghe published the artcile< Polycationic biocides with pendant quaternary groups. II. Synthesis and antimicrobial activity of ammonium salts grafted on ""gel""-type styrene-divinylbenzene copolymers against Staphylococcus aureus and escherichia coli>, Safety of 2,2′-(Tridecylazanediyl)diethanol, the main research area is quaternary chloromethylated styrene divinylbenzene copolymer antimicrobial agent.

Various ammonium salts grafted on “”gel””-type styrene-divinylbenzene copolymers were prepared and their antimicrobial activity against Staphylococcus aureus and Escherichia coli was assessed by the column system. The antimicrobial activity is strongly dependent on the structure. The length of the alkyl chain has been found to affect significantly the biol. activity.

Revue Roumaine de Chimie published new progress about Antimicrobial agents. 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Safety of 2,2′-(Tridecylazanediyl)diethanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nahan, Keaton; Sussman, Eric M.; Oktem, Berk; Schultheis, Lester; Wickramasekara, Samanthi published the artcile< Screening for extractables in additive-manufactured acrylonitrile butadiene styrene orthopedic cast>, Related Products of 18312-57-7, the main research area is acrylonitrile butadiene styrene orthopedic cast extractable safety; 3D printing; Acrylonitrile butadiene styrene (ABS); Additive manufacturing; Chemical characterization; Extractables; Medical devices.

The use of additive-manufactured components in medical applications, specifically medical devices (e.g., orthopedic casts), has increased in recent years. Such devices may be fabricated at the point of care using consumer-grade additive manufacturing Limited studies have been conducted to evaluate the extractable substances of these devices. Chem. characterization followed by toxicol. risk assessment is one means of evaluating safety of devices. This study was designed to determine the extractables profile of additive-manufactured materials according to filament grade and post-processing method. Feedstocks for additive manufacturing were tested as filament and manufactured casts, while the cast from consumer-grade filament (CGF) was post-processed. Samples were extracted using three solvents of varying polarities. Extracts were analyzed by gas chromatog./mass spectrometry (GC/MS) and liquid chromatog./mass spectrometry (LC/MS) techniques. In GC/MS anal., isopropanol extracts generated fewer compound identifications for USP Class VI filament (USPF)-based casts (3) compared with the resp. filament (17) while hexane generated the most compound identifications for the finished cast manufactured from CGF. CGF was found to have the highest number of nonvolatile extractables for isopropanol (15) and hexane (34) by pos. ion LC/MS. Addnl., CGF produced more non-polar extractables in hexane than the USPF. A known polymer byproduct and potential genotoxicant, styrene acrylonitrile (SAN) trimer, was one of the compounds identified in both GC/MS and LC/MS at quantities ranging from 19 to 270μg g-1. Overall these results suggested that the extractables profile was affected by the filament material, printing procedure, and post-processing method.

Talanta published new progress about Additive manufacturing. 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Related Products of 18312-57-7.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wedler, C.; Haage, K.; Herbst, M.; Tischer, H.; Knofe, E. published the artcile< Preparation and some properties of amine oxides derived from defined ethylene oxide adducts>, Recommanded Product: 2,2′-(Tridecylazanediyl)diethanol, the main research area is amine oxide preparation solubility; bishydroxyethylalkylamine oxide preparation solubility; thermal analysis bishydroxyethylalkylamine oxide; addition ethylene oxide amine.

Procedures for the prepn of bis(hydroxyethyl)alkylamine oxides are presented. The solubilities and DTA of a number of amine oxides are also reported.

Abhandlungen der Akademie der Wissenschaften der DDR, Abteilung Mathematik, Naturwissenschaften, Technik published new progress about Addition reaction. 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Recommanded Product: 2,2′-(Tridecylazanediyl)diethanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ma’arif, Burhan; Fitri, Hilwa; Saidah, Nisfatul Lailatus; Najib, Luqman Alfani; Yuwafi, Achmad Hamdan; Atmaja, Ria Ramadhani Dwi; Inayatillah, Fidia Rizkiah; Dianti, Meilina Ratna; Laswati, Hening; Agil, Mangestuti published the artcile< Prediction of compounds with antiosteoporosis activity in Chrysophyllum cainito L. leaves through in silico approach>, Name: 2,2′-(Tridecylazanediyl)diethanol, the main research area is Chrysophyllum antiosteoporosis leaf phytoestrogen; Chrysophyllum cainito L.; antiosteoporosis; in silico; phytoestrogen.

The aims of this study were to analyze the metabolite profiling results of various extract of Chyrsophyllum cainito L. leaves, which contain phytoestrogen, through in silico study against 3OLS protein, an X-ray protein of ERβ, so it can predict the types of the phytoestrogen contents which have antiosteoporosis property. In silico anal. was carried out for the compounds from the metabolite profiling data of C. cainito leaves from our previous study. The structure compounds from metabolite profiling results of various extract of C. cainito leaves were prepared with Avogadro 1.0.1 software, mol. docking was done using PyRx 0.8 software, and Biovia Discovery Studio Visualizer 2016 software was used to visualize the structure of compounds against 3OLS protein. The physicochem. characteristics of the compounds were analyzed using the SwissADME web tool. It was known that there were total 11 compounds in C. cainito leaves that predicted as phytoestrogens which have ERβ agonist properties against 3OLS protein. The ERβ agonist was a compound that has parameters similar to 17β-estradiol in its interaction with 3OLS protein, which has a pharmacophore distance of 10.862 Å, and binding to amino acids His 475 and Glu 305 or Arg 346 at receptor-ligand docking simulation. C. cainito leaves contain 11 compounds that are predicted to be phytoestrogens with ERβ agonist properties, which is responsible for antiosteoporosis activity.

Journal of Basic and Clinical Physiology and Pharmacology published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Name: 2,2′-(Tridecylazanediyl)diethanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Elhag, Amro S.; Chen, Yunshen; Noguera, Jose; Reddy, Prathima P.; Hirasaki, George J.; Nguyen, Quoc P.; Johnston, Keith P. published the artcile< Switchable amine surfactants for CO2 foams in high temperature enhanced oil recovery>, Electric Literature of 18312-57-7, the main research area is carbon dioxide foam switchable amine surfactant oil recovery.

This paper describes about the switchable amine surfactants for carbon dioxide foams in high temperature enhanced oil recovery.

Preprints – American Chemical Society, Division of Energy & Fuels published new progress about Brines. 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Electric Literature of 18312-57-7.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xue, Yu; Vughs, Dennis; Hater, Wolfgang; Huiting, Hans; Vanoppen, Marjolein; Cornelissen, Emile; Verliefde, Arne; Brunner, Andrea M. published the artcile< Liquid chromatography-high-resolution mass spectrometry-based target and nontarget screening methods to characterize film-forming amine-treated steam-water systems>, Product Details of C17H37NO2, the main research area is liquid chromatog high resolution mass spectrometry target nontarget screening; screening film forming amine treated steam water systems.

Film-forming amine products (FFAP) are frequently used as corrosion inhibitors in steam-water systems. To have a better understanding of their behavior in the treated system, a liquid chromatog. coupled to the high-resolution mass spectrometry (LC-HRMS) method was developed. This method enabled the concurrent targeted quant. anal. of the film-forming amine oleyl propylenediamine (OLDA) and the nontarget screening (NTS)-based anal. of potential degradation products of FFAP or other organic matter in the system. The method was applied to samples collected from an FFAP-treated industrial steam-water system. OLDA was detected at a concentration of 0.027 mg/L after the FFAP dosing in the low-pressure steam drum. A feature (a combination of mass-to-charge ratio and retention time associated with a signal intensity) prioritization workflow was designed and applied to the NTS results to focus on the potential thermal degradation products of FFAP that could affect the studied steam-water system. Six features were prioritized from a total of 4596 detected features. Structural elucidation of these features was attempted based on mass spectrometry fragmentation data. One of the prioritized features was successfully identified as 2,2′-(tridecylimino)diethanol, presumably a degradation product of the FFAP emulsifier. Because of the chem. structure of the mol., 2,2′-(tridecylimino)diethanol was considered as noncorrosive to the system. Overall, the developed LC-HRMS method facilitated the efficient anal. of OLDA with a limit of quantification of 0.002 mg/L and a comprehensive monitoring of organic matter across the steam-water system, including potential degradation products of the dosed FFAP.

Industrial & Engineering Chemistry Research published new progress about Boiler waters. 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Product Details of C17H37NO2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem