Huang, Jing published the artcileDesign, synthesis and evaluation of potent G-protein coupled receptor 40 agonists, Related Products of ethers-buliding-blocks, the publication is Chinese Chemical Letters (2016), 27(1), 159-162, database is CAplus.
GPR40 has emerged as an attractive drug target for the treatment of type 2 diabetes due to its role in the enhancement of insulin secretion with glucose dependency. With the aim to improve the metabolic and safety profiles, a series of novel phenylpropionic acid derivatives were synthesized. Extensive structural optimization led to identification of compounds I and II as potent GPR40 agonists with moderate liver microsomal stability. All the discovery supported further exploration surrounding this scaffold.
Chinese Chemical Letters published new progress about 1823170-17-7. 1823170-17-7 belongs to ethers-buliding-blocks, auxiliary class Fluoride,Boronic acid and ester,Benzene,Ether,Boronate Esters,Boronic Acids,Boronic acid and ester,, name is 2-(4-(Benzyloxy)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C19H22BFO3, Related Products of ethers-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem