Category: 17600-72-5

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 17600-72-5, name is 1-Ethoxy-2-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1-Ethoxy-2-methoxybenzene

A 2-way cock with a septum at the tip was attached to a recovery flask containing o-ethoxymethoxybenzene (150 mg, 0.98 mmol) and dried by allowing to stand overnight under reduced pressure in the presence of diphosphorus pentoxide, It was returned to atmospheric pressure with nitrogen. After reducing the pressure with a diaphragm pump again, hydrogen iodide gas (127 mg, 0.99 mmol) was introduced from the septum using a 50 mL syringe and returned to atmospheric pressure by filling with nitrogen and then allowed to stand at 25 C. for 48 hours I put it. After the reaction, the mixture was reduced in pressure by a diaphragm pump to obtain a mixture (139.0 mg) of o-ethoxyphenol, o-methoxyphenol and o-ethoxymethoxybenzene. The yield was determined to be 77%: 9%: 14% o-ethoxyphenol: o-methoxyphenol: o-ethoxymethoxybenzene from the integration ratio of 1 H-NMR using phenanthrene as an internal standard.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 17600-72-5.

Reference:
Patent; Chiba University; Godo Shigen Co., Ltd; Matsumoto, Shoji; Akazome, Motohiro; Otani, Yasuhiko; (14 pag.)JP5725506; (2015); B2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17600-72-5, name is 1-Ethoxy-2-methoxybenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 17600-72-5

10 g of the compound obtained in the preceding stage are cooled to -10 C., 21.84 ml of chlorosulfonic acid and then 13.68 g of phosphorus pentachloride are added dropwise and the mixture is left stirring at -5 C. for 1 hour. The reaction mixture is run onto 250 ml of ice and water and extracted with DCM, the organic phase is dried over Na2SO4 and the solvent is evaporated under vacuum. The residue is chromatographed on silica gel, elution being carried out with the gradient of the cyclohexane/AcOEt mixture from 95/5 (v/v) to 85/15 (v/v). The expected compound is obtained, M.p.=93 C. 1H NMR: CDCl3 (250 MHz): delta (ppm): 1.55, t, 3H, 3.99, s, 3H, 4.23, q, 2H, 6.97-7.02, mt, 1H, 7.46-7.48, mt, 1H, 7.66-7.71, mt, 1H.

The synthetic route of 17600-72-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SANOFI-AVENTIS; US2011/59955; (2011); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 17600-72-5,Some common heterocyclic compound, 17600-72-5, name is 1-Ethoxy-2-methoxybenzene, molecular formula is C9H12O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a stirred solution of aryl methyl ether (20 mmol) and 47% aqueous HBr (4.5 mmol equiv. of substrate) added Aliquat-336 (10 wt. % of substrate) in a single lot. The resulting reaction mixture was heated at 105±5 C, and the progress of reaction was monitored by TLC. After completion of reaction, the reaction mixture was cooled to room temperature and quenched by adding water (25 ml). The resulting reaction mass was extracted with 3×30 ml ethyl acetate. Ethyl acetate layer washed twice with 20 ml of water, dried over anhydrous Na2SO4 and evaporated under reduced pressure. The crude product was purified by silica gel column chromatography using ethyl acetate/hexane system.

The synthetic route of 17600-72-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Waghmode, Suresh B.; Mahale, Ganesh; Patil, Viraj P.; Renalson, Kartik; Singh, Dharmendra; Synthetic Communications; vol. 43; 24; (2013); p. 3272 – 3280;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem