Category: 1758-46-9

Related Products of 1758-46-9,Some common heterocyclic compound, 1758-46-9, name is 2-Phenoxyethylamine, molecular formula is C8H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a suspension of 2, 6-dichloronicotinic acid (960 mg, 5 mmol) in toluene (9 mL) was added SOC12 (547 mL, 7.5 mmol) and 2 drops of DMF. The mixture was heated at 90°C for 2 h, then cooled to room temperature. The solvent was removed in vacuo and the residual yellow oil was dried under high vacuum overnight. The residue was dissolved in anhydrous THF (20 mL) and cooled TO-78°C. Triethylamine (2.1 mL, 15 mmol) and 2-phenoxyethylamine (653 PL, 5 mmol) were added, and the reaction was stirred for 1.5 H, then quenched by pouring into a mixture of saturated NAHC03 and CH2C12. The aqueous layer was extracted with CH2C12. The organic extracts were combined and dried (MGS04), then concentrated to give a yellow oil, which was purified by flash chromatography on silica gel eluting with 35percent EtOAc/hexane to give the amide as a white solid (1.78 g, 82percent). MS (ES+) m/z (M+H) += 311. 16. 1H NMR (400 MHz, CDC13) : 8 3.87-3. 91 (m, 2H), 4.17 (t, J = 5.21 Hz, 2H), 6.90-7. 04 (m, 4H), 7.26-7. 32 (m, 2H), 7.36 (d, J = 8.05 Hz, 1H), 8.09 (d, J = 8. 05 Hz, 1H). HPLC : Retention time = 2.91 min (Method A).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Phenoxyethylamine, its application will become more common.

These common heterocyclic compound, 1758-46-9, name is 2-Phenoxyethylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2-Phenoxyethylamine

Example s; 2-Isopropyl-4-[(2-phenoxyethyl)amino]-5-phenyIisothiazol-3(2.pound.f)-one 1,1-dioxide EPO A solution of 4-chloro-2~isopropyl-5-phenylisothiazol-3(2H)-one 1,1-dioxide (0.20Og, OJOOmmol), TEA (0.106g, 1.050mmol) and 2-phenoxyethylamine (0.144g, 1.050mmol) in MeCN (3mL) was heated at in a microwave reactor 120°C for 5 mins. The residue was 5 purified by silica gel column chromatography (Horizons Biotage) using a 65:35 mixture of heptane and EtOAc as eluant to give the title compound (0.262g, 97percent); 1H NMR (500 MHz, CDCl3): 87.57-7.54 (m, 2H), 7.49-7.45 (m, 3H), 7.32-7.27 (m, 2H), 7.02-6.97 (m, IH), 6.86- 6.83 (m, 2H), 5.71-5.66 (br m, IH), 4.46-4.39 (m, IH), 3.89 (t 2H), 3.27 (q 2H), 1.60 (d 6H); 13C NMR (125 MHz, CDCl3): delta 158.5, 158.2, 135.6, 131.7, 130.0, 129.8, 129.1, 125.1, 121.8, 10 114.7, 108.0, 65.8, 47.8, 43.6, 20.4; Mass Spectrum: M-H+ 387.

The synthetic route of 2-Phenoxyethylamine has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 1758-46-9, name is 2-Phenoxyethylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C8H11NO

A mixture of intermediate compound 15 (prepared according to A7.g) (0.000078 mol), 2-phenoxyethanamine (0.000156 mol), N,N,N-tributyl-l-butanaminium bromide (0.000078 mol) and K2CO3 (0.000156 mol) in CH3CN (0.5 ml) was heated in a micro- wave oven for 15 minutes at 120 ¡ãC and then resin-linked-CHO (0.000312 mol) and CH2Cl2 (1 ml) were added. The reaction mixture was heated in a microwave oven for 20 minutes at 100 ¡ãC and the solids were filtered off. The solvent was evaporated and the residue was purified in a manifold (eluent 1: EtOAc; eluent 2: CH2Cl2/CH3OH 96/4). The product fractions were collected and further purified by Catch in an ISOLUTE SCX-3 cartridge and then released with CH3OHTNH3. Finally, the desired fractions were purified by high-performance liquid chromatography, then the product fractions were collected and the solvent was evaporated. Yield: 0.0066 g of final compound 28 (18 percent).

The synthetic route of 2-Phenoxyethylamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2006/67139; (2006); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1758-46-9, name is 2-Phenoxyethylamine, A new synthetic method of this compound is introduced below., COA of Formula: C8H11NO

EXAMPLE 1 : Preparation of 2-phenoxyethylamine 2-hydroxypropane-1 ,2,3- tricarboxylate (= 2-phenoxyethylamine citrate): compound IV2-Phenoxyethylamine 2-hydroxypropane-1 ,2,3-tricarboxylate (compound IV)is obtained by salification of phenoxyethylamine with citric acid, according to the following reaction: Ethanol Citric acid 15 h room temperature phenoxyethylamineMW = 137 18 MW = 137 18 192 13 C8H11 NO C6H8O7120 g of phenoxyethylamine (RN 1758-46-9 commercially available from the company Aldrich, ref. 40,726-7) are dissolved in 2L of ethanol in a reactor equipped with a mechanical stirrer. 56.04 g of citric acid are then added. A compact precipitate rapidly forms (vigorous stirring required).After stirring for 15 hours, the compact solid is filtered off on a sinter funnel and is then washed with 150 ml of ethanol. The solid obtained is dried in a desiccator under vacuum at 500C. Recovered mass: 145 g. The reaction yield is 82percent.Phenoxyethylamine (starting material) may also be prepared according to one of the processes described in the literature and indicated previously in the description (cf. hereinabove).

The synthetic route of 1758-46-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; L’OREAL; DALKO, Maria; LEREBOUR, Geraldine; WO2010/4016; (2010); A1;,
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Electric Literature of 1758-46-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1758-46-9, name is 2-Phenoxyethylamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

0.137 g (1 mmol) of phenoxyethylamine, 1.0 mmol of triethylamine, Catalytic amount of 4-dimethylaminopyridine (DMAP), 20 mL of dichloromethane, 1.2 mmol of (R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenoxy]propanoyl chloride was added dropwise under ice bath The dichloromethane solution was dissolved in about 15 minutes and allowed to react at room temperature for 1 hour. After the reaction is completed, the organic layer is washed with water and washed with saturated brine. Dry, desolvent, The crude product was subjected to column chromatography [V petroleum ether: V ethyl acetate = 7:1 to 5:1] to afford white (R)-2-N-(2-phenoxyethyl)-2-[4-(6 -chloroquinoxaline-2-yloxy)phenoxy]propanamide, mp 150-153 C, yield 78.3%,

The synthetic route of 2-Phenoxyethylamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Anhui Agricultural University; Tian Shengni; Yang Zihui; Ye Aihua; Huang Shixia; Li Junhong; Tian Qi; (8 pag.)CN108689921; (2018); A;,
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Adding a certain compound to certain chemical reactions, such as: 1758-46-9, name is 2-Phenoxyethylamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1758-46-9, Application In Synthesis of 2-Phenoxyethylamine

General procedure: To a solution of 2-phenoxy-ethylamine (5 eq.) or 2-(2-methoxyphenoxy-)ethylamine (5 eq.) in 2-methoxyethanol(25 mL per mmol of amine) the appropriate aliphatic chloride33-39 (1 eq.) and KI (cat.) was added. The mixturewas refluxed for18-48 h and concentrated. The residue was suspended in CHCl3and washed with 1M NaOH, brine, dried over anhydrous Na2SO4and concentrated. The crude was purified by flash chromatographyto give the titled compound.4.1.2.1 2-(2,2-Diphenyl-1,3-dioxolan-4-yl)-N-(2-phenoxyethyl)ethan-1-amine (17) Pale yellow liquid (74% yield). TLC (cicloexane/EtOAc 3:7): Rf?=?0.38. 1H NMR (600?MHz, Chloroform-d) delta 1.71-1.76 (m, 1H), 1.83-1.89 (m, 1H), 1.98 (bs, 1H), 2.73-2.77 (m, 1H), 2.80-2.84 (m, 1H), 2.92 (t, J?=?5.1?Hz, 2H), 3.63 (t, J?=?7.5?Hz, 1H), 3.97 (t, J?=?5.1, 2H), 4.05 (t, J?=?7.2?Hz, 1H), 4.16-4.20 (m, 1H), 6.77-6.94 (m, 3H), 7.13-7.28 (m, 8H), 7.36-7.49 (m, 4H). 13C NMR (151?MHz, CDCl3) delta 33.65, 46.64, 48.85, 67.06, 70.02, 75.60, 114.54, 120.89, 126.20, 127.96, 128.05, 128.16, 129.48, 142.64, 158.78. MS (ESI): m/z [M + H]+: 389.2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Phenoxyethylamine, and friends who are interested can also refer to it.

Reference:
Article; Franchini, Silvia; Sorbi, Claudia; Linciano, Pasquale; Carnevale, Gianluca; Tait, Annalisa; Ronsisvalle, Simone; Buccioni, Michela; Del Bello, Fabio; Cilia, Antonio; Pirona, Lorenza; Denora, Nunzio; Iacobazzi, Rosa Maria; Brasili, Livio; European Journal of Medicinal Chemistry; vol. 176; (2019); p. 310 – 325;,
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Application of 1758-46-9, A common heterocyclic compound, 1758-46-9, name is 2-Phenoxyethylamine, molecular formula is C8H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 73: (6-BROMO-PYRIDIN-3-YLMETHYL)- (2-PHENOXV-ETHYL)-AMINE A solution of 2-bromo-pyridine-5-carbaldehyde (500MG, 2. 69MMOL) and 2- (PHENOXY)- ethylamine (594mg, 4.3mmol) in anhydrous ethanol (14ML) was stirred at room temperature for 7 hours. Sodium borohydride (102mg, 2. 7MMOL) was then added to the solution, and the resultant mixture was allowed to stir for a further 3 hours before being quenched with water. The resultant mixture was concentrated, to provide (6-BROMO- pyridin-3-ylmethyl)- (2-phenoxv-ethvl)-amine (quantitative), which was’used without further purification. LCMS (Method B): RT = 1. 79 minutes; 307 309 (M+H) +.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ARGENTA DISCOVERY LIMITED; WO2005/14588; (2005); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 1758-46-9, A common heterocyclic compound, 1758-46-9, name is 2-Phenoxyethylamine, molecular formula is C8H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To 2.45mmol of carboxylic acid derivatives (47) dissolved in 0.7mL of dry pyridine were added 0.1mL of phosphorous oxychloride. The mixture was led to?10¡ãC and then was added 39.2mmol of the appropriate amine or alcohol. The reaction was stirred at room temperature for 16h, then was added water and the product extracted with ethylacetate. The organic layer was washed with a NaHCO3 solution, dried and concentrated. The residue was purified by flash chromatography (Ethyl acetate 9: Light Petroleum 1).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Federico, Stephanie; Margiotta, Enrico; Salmaso, Veronica; Pastorin, Giorgia; Kachler, Sonja; Klotz, Karl-Norbert; Moro, Stefano; Spalluto, Giampiero; European Journal of Medicinal Chemistry; vol. 157; (2018); p. 837 – 851;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 1758-46-9,Some common heterocyclic compound, 1758-46-9, name is 2-Phenoxyethylamine, molecular formula is C8H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of 2-phenoxy-ethylamine (5 eq.) or 2-(2-methoxyphenoxy-)ethylamine (5 eq.) in 2-methoxyethanol(25 mL per mmol of amine) the appropriate aliphatic chloride33-39 (1 eq.) and KI (cat.) was added. The mixturewas refluxed for18-48 h and concentrated. The residue was suspended in CHCl3and washed with 1M NaOH, brine, dried over anhydrous Na2SO4and concentrated. The crude was purified by flash chromatographyto give the titled compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Phenoxyethylamine, its application will become more common.

Reference:
Article; Franchini, Silvia; Sorbi, Claudia; Linciano, Pasquale; Carnevale, Gianluca; Tait, Annalisa; Ronsisvalle, Simone; Buccioni, Michela; Del Bello, Fabio; Cilia, Antonio; Pirona, Lorenza; Denora, Nunzio; Iacobazzi, Rosa Maria; Brasili, Livio; European Journal of Medicinal Chemistry; vol. 176; (2019); p. 310 – 325;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 1758-46-9,Some common heterocyclic compound, 1758-46-9, name is 2-Phenoxyethylamine, molecular formula is C8H11NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Et3N (4.3 mmol) and 97% EtOCOCl (4.3 mmol) in dry CHCl3(25 mL) were added to a solution of the suitable carboxylic acid 24a,24b or 25 (4.3 mmol) at 0 C. After 30 min at 0 C under stirring asolution of the suitable amine (2-phenoxyethanamine, 2-(2-methoxyphenoxy)ethanamine [37], 2-(2,6-dimethoxyphenoxy)ethanamine [38], or 1-(2-methoxyphenyl)piperazine) (4.3 mmol)in dry CHCl3 (10 mL) was added and the reaction mixture was left atroom temperature for 3 h. The solution was washed with 2 N HCl and 2 N NaOH. The organic layer was dried over Na2SO4. After evaporation of the solvent the residue was purified by column chromatography eluting with cyclohexane/EtOAc (7:3). 4.1.11.1. trans-N-(2-Phenoxyethyl)-3-phenyl-1,4-dioxane-2-carboxamide (26a). This compound was prepared starting from 24a and 2-phenoxyethanamine: a solid was obtained (73% yield;mp 109-110 C). 1H NMR (CDCl3) d 3.56 (m, 2H), 3.84e4.01 (m, 6H),4.08 (d, 1H, J 9.0 Hz), 4.42 (d, 1H, J 9.0 Hz), 6.60 (br t, 1H,exchangeable with D2O), 6.86e7.38 (m, 10H). ESI/MS: m/z 328.2[M H]. Anal. Calcd for C19H21NO4: C, 69.71%; H, 6.47%; N, 4.28%.Found: C, 69.87%; H, 6.23%; N, 4.39%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Phenoxyethylamine, its application will become more common.

Reference:
Article; Del Bello, Fabio; Bonifazi, Alessandro; Giorgioni, Gianfabio; Quaglia, Wilma; Amantini, Consuelo; Morelli, Maria Beatrice; Santoni, Giorgio; Battiti, Francisco O.; Vistoli, Giulio; Cilia, Antonio; Piergentili, Alessandro; European Journal of Medicinal Chemistry; vol. 168; (2019); p. 461 – 473;,
Ether – Wikipedia,
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