Category: 172282-50-7

Adding a certain compound to certain chemical reactions, such as: 172282-50-7, name is 4-(Difluoromethoxy)benzene-1,2-diamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 172282-50-7, SDS of cas: 172282-50-7

Preparation of Intermediate C7. Step 1 . Preparation of C7-1 : To a solution of C4-1 (1 .84 g, 10.93 mmol) and 4-(difluoromethoxy)benzene-1 ,2-diamine (1 .90 g, 10.93 mmol, prepared according to Reference Example 30y of International Patent Publication No. WO 2003/035065, p. 51 1 .) in DMF (40 mL) at rt was added DIPEA (9.5 mL, 54.65 mmol) and HATU (6.23 g, 16.4 mmol). The reaction mixture was stirred at room temperature for 24 h, diluted with ethyl acetate (100 mL), washed with water (100 mL) and brine (50 mL). The mixture was concentrated in vacuo. Purification via silica gel chromatography (EtOAc in hexanes: 20% to 60%) provided C7-1 as the later eluting fraction of two with the similar mass spectra. LCMS-ESr (m/z): [M+H]+ calcd for Ci2H9F4N2O: 289.2; found: 289.0.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(Difluoromethoxy)benzene-1,2-diamine, and friends who are interested can also refer to it.

Reference:
Patent; GILEAD SCIENCES, INC.; BJORNSON, Kyla; KARKI, Kapil K.; LINK, John O.; PYUN, Hyung-Jung; SCHRIER, Adam J.; STEVENS, Kirk L.; TAYLOR, James G.; VIVIAN, Randall W.; ZABLOCKI, Jeff; ZIPFEL, Sheila; WO2014/145095; (2014); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 172282-50-7,Some common heterocyclic compound, 172282-50-7, name is 4-(Difluoromethoxy)benzene-1,2-diamine, molecular formula is C7H8F2N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a mechanical stirrer, Reflux condenser, the thermometer of the four-mouth flask, with lye:Sodium carbonate 6. 6 grams + 20 grams of tap water,Stirring to dissolve, slightly cooling, adding4-difluoromethoxy-o-phenylenediamine 34. 8 g,Stir for 20 min. Heated to 30 C,25-35 C20 g of carbon disulfide was added dropwise,Drop finished 30-40 C insulation condensation 6h,Continue to heat up to 60-70 C insulation 6h, cyclization is complete, add activated carbon decolorization,The filtrate was adjusted to pH 5-6 with sulfuric acid, filtered, washed, dried,5-difluoromethoxy-2-mercapto-1H-benzimidazole was obtained in an amount of 33.2 g,The yield was 95.4% based on 4-difluoromethoxy-o-phenylenediamine.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(Difluoromethoxy)benzene-1,2-diamine, its application will become more common.

Reference:
Patent; ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY; JIANGSU YUXIANG CHEMICAL CO., LTD; ZHANG, ZHIGUO; CHENG, YUNTAO; ZHONG, XUHUI; LI, QINGLONG; CHENG, HONGWEI; (6 pag.)CN103539746; (2016); B;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 172282-50-7, name is 4-(Difluoromethoxy)benzene-1,2-diamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 172282-50-7, Safety of 4-(Difluoromethoxy)benzene-1,2-diamine

Dissolve 8.1 g of 4-difluoromethoxy-o-phenylenediamine in 30 mL of methanol, directly add 35 mL of carbon disulfide and 3.0 g of sodium hydroxide, stir, heat to reflux, and hold for 4 h.Reduce the temperature to room temperature, add 30ml of water, then adjust the pH value to 4 with 10% hydrochloric acid, flocculent precipitates appear, and filter to obtain the crude 2-mercapto-5-difluoromethoxybenzimidazole.Add the obtained crude 2-mercapto-5-difluoromethoxybenzimidazole to a 100 mL flask, and then add 3.0 g of sodium hydroxide, 30 mL of water and 1 g of activated carbon, heat to 80 C, and hold for 1 h.Hot filtration. When the temperature of the filtrate drops to room temperature, adjust the pH value to 4 with a concentration of 10% hydrochloric acid, flocculent precipitates appear, filter,The obtained solid (precipitation) was washed with water to neutrality and dried to obtain a white solid product, 2-mercapto-5-difluoromethoxybenzimidazole, with a yield of 94.5%, a melting point of 260.1-261.5 C, and a purity of more than 99%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Difluoromethoxy)benzene-1,2-diamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Anhui Jin He Industrial Co., Ltd.; Jiang Weiqiang; Chen Chaohui; Sha Lifeng; (6 pag.)CN110590576; (2019); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem