Category: 170015-99-3

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 170015-99-3, name is 2-(4-(Trifluoromethoxy)phenyl)ethanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 170015-99-3

7-Chloro-5-(pyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidine 5k (100 mg, 0.43 mmol) was taken in NMP (4 mL) in a 50 mL round bottom flask under N2. To it was added 2-(4-(trifluoromethoxy)phenyl)ethan-1-amine (107 mg, 0.52 mmol) and the reaction mixture was stirred at rt for 0.5 h. The reaction mixture concentrated in vacuo and the resulting solid taken up in EtOAc and H2O, the organic layer was separated and the aqueous layer extracted with EtOAc (3 * 20 mL). The organic layers combined, washed with brine, dried over Na2SO4 and the solvent removed under reduced pressure. The crude was purified by flash chromatography on silica gel (100-200 mesh) using 32% EtOAc-hexane as eluent to afford 59 as a white solid (45 mg, 48%). M.P. 163-165 C. 1H NMR (400 MHz, DMSO-d6): delta 8.74 (d, J = 4.3 Hz, 1H), 8.55 (bs, 1H), 8.54 (s, 1H), 8.45 (d, J = 8.0 Hz, 1H), 8.01 (t, J = 7.6 Hz, 1H), 7.53-7.56 (m, 1H), 7.43 (d, J = 8.5 Hz, 2H), 7.33 (s, 1H), 7.26 (d, J = 7.9 Hz, 2H), 3.75-3.80 (m, 2H), 3.04-3.08 (m, 2H); 13C NMR (100 MHz, DMSO-d6): delta 159.0, 155.5, 154.9, 153.8, 149.2, 148.1, 146.9, 138.3, 137.4, 130.6, 125.2, 121.4, 120.9, 120.0 (q, J = 260 Hz), 84.5, 43.0, 33.5. LCMS (ESI) m/z 401.10.

The synthetic route of 170015-99-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zuniga, Edison S.; Korkegian, Aaron; Mullen, Steven; Hembre, Erik J.; Ornstein, Paul L.; Cortez, Guillermo; Biswas, Kallolmay; Kumar, Naresh; Cramer, Jeffrey; Masquelin, Thierry; Hipskind, Philip A.; Odingo, Joshua; Parish, Tanya; Bioorganic and Medicinal Chemistry; vol. 25; 15; (2017); p. 3922 – 3946;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 170015-99-3, name is 2-(4-(Trifluoromethoxy)phenyl)ethanamine, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C9H10F3NO

Preparation of Intermediate Ethyl 4-(trifluoromethoxy)phenethylcarbamate (I-51c) Using an analogous procedure and workup as described for the preparation of intermediate I-1c above, 2-(4-(trifluoromethoxy)phenyl)ethanamine (I-51b: 3.1 g, 15.1219 mmol) in chloroform (31 mL) was reacted with chloro ethyl formate (1.72 mL, 18.146 mmol) and 2N Na2CO3 solution (31 mL) at 0 C. The resulting mixture was stirred at room temperature for 3 hours to afford the crude product. Purification by column chromatography on silica gel (10% ethylacetate in hexane) afforded 3.2 g of the product (76% yield). 1H NMR (300 MHz, CDCl3): delta 7.30-7.10 (m, 4H), 4.75-4.65 (m, 1H), 4.15-4.05 (m, 2H), 3.4 (q, 2H), 2.8 (t, 2H), 1.3-1.2 (m, 3H). LCMS: 70.91%, m/z=278.1 (M+1)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 170015-99-3.

Reference:
Patent; NOVARTIS AG; Bock, Mark Gary; Gaul, Christoph; Gummadi, Venkateshwar Rao; Moebitz, Henrik; Sengupta, Saumitra; US2014/45872; (2014); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 170015-99-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 170015-99-3, name is 2-(4-(Trifluoromethoxy)phenyl)ethanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Under nitrogen atmosphere, ethanol (30 mL), immediate III (3 mmol) and titanium (IV) isopropoxide (9 mmol) were added to a three-necked round bottom flask and stirred for 0.5 h, then the substituted ethylamine (3 mmol) was dropped into the solution and stirred for 3 h at room temperature. Subsequently, sodium borohydride (4.5 mmol) was added to the flask slowly, the reductive amination reaction was maintained for 3 h. According to the TLC monitoring results, the ammonia water (2 mol L-1, 10 mL) was poured into the flask to quench the reaction. The resulting mixture was filtered in vacuum and evaporated on rota vapor (Buchi). Hereafter, dissolved the residue with ethyl acetate (50 mL), and the solution was washed with 2 mol L-1 hydrochloric acid (30 mL), saturated aq NaHCO3 solution (30 mL), and brine (40 mL), successively, dried over anhydrous Na2SO4 and filtered. Solvent was evaporated in vacuum, and the residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate as eluents). Finally, the samples were recrystallized from ethyl acetate / petroleum ether to afford target compounds with higher purity.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-(Trifluoromethoxy)phenyl)ethanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Cai, Nan; Cui, Zining; Feng, Zhihui; He, Lu; Ji, Mingshan; Li, Xinghai; Qi, Zhiqiu; Qin, Peiwen; Wang, Kai; Bioorganic and medicinal chemistry letters; (2019);,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 170015-99-3,Some common heterocyclic compound, 170015-99-3, name is 2-(4-(Trifluoromethoxy)phenyl)ethanamine, molecular formula is C9H10F3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

S.3. (5-Chloro-thieno[2,3-d]pyrimidin-4-yl)-[2-(4-trifluoromethoxy-phenyl)-ethyl]-amine (Compound example C.5); 0.5 g (2.4 mmol) 4,5-dichloro-thieno-[2,3-d]-yprimidine are solved in 20 ml toluol. Subsequently 0.271 g (2.7 mmol) triethylamin, a catalytic amount of tetrabutyl- ammoniumiodide and 0.55 g (2.7 mmol) 2-(4-trifluoromethoxyphenyl)-ethylamin are added. The solution is heated under reflux for 6 hours, and stirred further 12 hours at room temperature. The solvent is destillated, the residue is reverted in CH2CI2 and is washed with 2N HCI and H2O. The residue is stirred and sucked off with hexane after being dryed and concentrated. The yield of compound C.5 obtained is 0.73 g (1.9 mmol, 76% of theoretical yield) and has a melting point Tmp of 77-79C. 1H-NMR (CDCI3): 8.50 (s, 1 H), 7.25 (d, 2H), 7.15 (d, 2H), 7.05 (s, 1 H), 6.55 (bs,1 H), 3.90 (t, 2H), 3.00 (t, 2H);

The synthetic route of 170015-99-3 has been constantly updated, and we look forward to future research findings.