Category: 1579-40-4

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1579-40-4, name is Di-p-tolyl Ether, A new synthetic method of this compound is introduced below., HPLC of Formula: C14H14O

In einem mit Argon begasten 100 ML Reaktor werden 2 g 4, 4′-OXYBIS (toluen) (CAS Reg. Nr. 1579-40-4) [10 mmol] in 39.2 ml Acetonitril unter Zusatz von 0.8 ML Dimethylsulfoxid [11. 2 mmol] bei 75 C geloest. Zur Loesung werden 60 mg Cu (OAc) 2, 30 mg FES04-7 H20 und 10 ml Wasser beigefuegt. 10.8 g NA2S208 geloest in 30 ML Wasser werden anschliessend unter heftigem Ruehren zugetropft. Nach 45 Minuten ist die Reaktion beendet. Die organische Phase wird mit Ethylacetat erschoepfend extra- hiert. Die gebildeten Produkte werden mit Hilfe der HPLC untersucht. Die Ausbeute des Dialdehyds 4, 4′-OXYBIS (benzaldehyd) (CAS Reg. Nr. 2215-76-1) betraegt 87 mol%. Damit liegt diese Ausbeute gegenueber den Ausbeuten mit bisher bekannten Oxidationsverfahren von 30-40% wesentlich hoeher, wodurch sich die Selektivitaet des erfindungsgemaessen Verfahrens auszeichnet.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; TEX-A-TEC AG; WO2004/43891; (2004); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 1579-40-4, A common heterocyclic compound, 1579-40-4, name is Di-p-tolyl Ether, molecular formula is C14H14O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In einem mit Argon begasten 100 ml Reaktor werden 2 g 4, 4′-OXYBIS (toluen) (CAS Reg. Nr. 1579-40-4) [10 MMOL] in 39.2 ml Acetonitril unter Zusatz von 1.5 ml Methylphenylsulfoxid [11. 0 mmol] bei 75 C geloest. Zur Loesung werden 60 mg Cu (OAc) 2, 30 mg FES04-7 H20 und 10 ML Wasser beigefuegt. 16.2 g NA2S208 geloest in 30 ml Wasser werden anschliessend unter heftigem Ruehren zugetropft. Nach 45 Minuten ist die Reaktion beendet. Die organische Phase wird mit Ethylacetat erschoepfend extrahiert. Die Ausbeute des Dialdehyds 4, 4′-OXYBIS (BENZALDEHYD) (CAS Reg. Nr. 2215-76-1) betraegt 84 MOL%.

The synthetic route of 1579-40-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TEX-A-TEC AG; WO2004/43891; (2004); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1579-40-4 as follows. category: ethers-buliding-blocks

Chlorosulfonic acid diluted (14.11g, 121.1mmol) in dichloromethane 30ml, was cooled in an ice water bath to 5 .This solution, di (para-tolyl) ether (10.0g, 50.44mmol) in dichloro-methane and then added dropwise to a solution (20ml), The reaction solution is warmed to room temperature was stirred for 2 hours.Was added dropwise distilled water (10ml) to the reaction solution was distilled off dichloromethane to the evaporator.Dropping the resulting solution into a saturated sodium chloride solution of 500ml, and then recovering the resultant precipitate was separated by filtration, and was dissolved by heating in distilled water 400ml.By cooling in ice water and this solution was filtered recovering the resulting precipitate.The resulting solid was dissolved in 50ml of methanol and adding Amberlite IR120 be small (Aldrich Co.) 20g, were stirred at room temperature for 30 minutes.Next, the reaction solution was filtered, concentrated by drying the obtained filtrate, to give a compound A1-1 (4.7g, 14.23mmol)

According to the analysis of related databases, 1579-40-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LG CHEMICAL CO., LTD; PARK, JONG HO; SAH, KONG CHUN; KIM, SUNG HYUN; BAEK, GYUNG LIM; RYU, CHANG HYUN; (91 pag.)KR2015/128789; (2015); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 1579-40-4, name is Di-p-tolyl Ether, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1579-40-4, Computed Properties of C14H14O

EXAMPLE 3 By treating 4,4′-dimethyldiphenyl ether under the same reaction conditions as in Example 2 except that acetylacetone was not added, 1.3 g (6.8 m. moles) of 2.8-dimethyldibenzofuran was obtained and 0.36 g (0.9 m. mole) of the dimer also obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Di-p-tolyl Ether, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; UBE Industries, Ltd.; US4042603; (1977); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 1579-40-4, A common heterocyclic compound, 1579-40-4, name is Di-p-tolyl Ether, molecular formula is C14H14O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To the 250 mL 3-neck RB flask charged di-p-tolylether (10 g, 50.43 mmol), benzoicacid (7.39 g, 60.52 mmol) and ZnCl2 (19.73 g, 144.73 mmol) in POCl3 (15 mL)and stirred mechanically for few minutes. Then the reaction mixture heated up to95C and allowed to stir for 4h. After 4h, color of the reaction mixture turned intodark brown and unable to stir. Then the above reaction mixture cooled to 0C andquenched with crushed ice (40 g) while mechanically stirring. To the above reactionmixture added H2O (150 ml) and allowed to stir at RT for 16h.The obtainedsolid suspension filtered through Buchner funnel and the solid cake washed withH2O (3 × 50 mL) followed by hexane (2 × 100 mL) to get crude DMPx-OH. Thiscrude solid re-dissolved in EtOAc (200 mL) and taken into separating flask andwashed with sat NaHCO3 (2 × 50 mL), the organic layer dried over Na2SO4 andevaporated the solvent on rotary evaporator to get off-white color DMPx-OH 2(10.37 g, 68%).1H NMR (400 MHz, CDCl3) delta: 2.24 (s, 6H), 2.55 (s, 1H), 7.07 (m, 4H), 7.12 (t, J= 0.8 Hz, 2H), 7.19 (m, 1H), 7.29 (m, 2H), 7.40 (dd, J1 = 8.3, 1.1 Hz, 2H).MS: 285.6 (M +).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Penjarla, Srishylam; Prasad, S. Rajendra; Reddy, Dhande Sudhakar; Banerjee, Shyamapada; Penta, Santhosh; Sanghvi, Yogesh S.; Nucleosides, nucleotides and nucleic acids; vol. 37; 4; (2018); p. 232 – 247;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 1579-40-4, The chemical industry reduces the impact on the environment during synthesis 1579-40-4, name is Di-p-tolyl Ether, I believe this compound will play a more active role in future production and life.

Prior to use, NBS was recrystallized from water and the carbon tetrachloride was bubbled with nitrogen, stirred for 45 min with sodium sulfate, and checked by 1H-NMR spectroscopy. To a stirred solution of 4,4′-oxybis(methylbenzene) (28) (5.0 g, 25.2 mmol, 1 eq.) and NBS (8.98 g, 50.4 mmol, 2 eq.) in carbon tetrachloride (125 mL) under nitrogen was added a catalytic amount of AIBN. The reaction mixture was heated to 80-90 C (reflux) and stirred for 6.5 h. The solution was then cooled and the succinimide was removed on a sintered glass filter funnel. The solvent was removed in vacuo to yield the desired product 29 as beige crystals (8.3 g, 93%). A portion (1.82 g) was purified by flash chromatography (10:1 hexane:EtOAc) to yield 29 as white crystals: mp 85-86 C (lit.29 mp 93-95 C). 1H NMR (CDCl3): delta 7.38 (d, 4H), 6.98 (d, 4H), 4.52 (s, 4H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Di-p-tolyl Ether, other downstream synthetic routes, hurry up and to see.

Reference:
Article; McGowan, Meredeth A.; Perreault, Denise M.; Thornton, Nancy B.; Garaas, Sarah D.; Gribble, Gordon W.; Arkivoc; vol. 2018; 5; (2018); p. 334 – 347;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 1579-40-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1579-40-4 as follows.

An H-shaped reactor with two reaction chambers was purged with argon. A stirring bar (1.0 mm × 0.4 mm) was then located in each chamber of the reactor. Sulfuric acid (0.8 mL, 1.47 g, 15.0 mmol) was placed at the bottom of one chamber (chamber 1) of the reactor, and Galden HT-135 (1.0 mL) was slowly added to chamber 1 using a syringe. Subsequently, ammonium formate (443 mg, 7.0 mmol) was added, which formed a third layer in chamber 1. A solution of di-p-tolyl ether (13, 198.6 mg, 1.0 mmol), Pd(OAc)2 (5.5 mg, 2.5 mol%), and K2S2O8 (541.0 mg, 2.0 mmol) in trifluoroacetic acid (2.5 mL) was placed in the other chamber (chamber 2) of the reactor. Rubber septa were fitted to the reactor, and a needle equipped with a balloon was then pricked into the septum of chamber 2. The air in the reactor was withdrawn using a syringe until the balloon was completely flattened. The reactor was the heated in an oil bath at 45 C for 5 h under slow stirring, with care taken not to mix the layers in chamber 1, then allowed to cool to 25 C. The mixture in chamber 2 was transferred to an Erlenmeyer flask containing water using dichloromethane (DCM). The organic layer was separated, and the aqueous layer was extracted with DCM. The combined organic layers were washed with brine then dried over sodium sulfate, filtered, and concentrated. The residue was purified by silica-gel column chromatography using hexane/chloroform (1/4) as the eluent to afford desired product, 2,7-dimethylxanthen-9-one (14, 178.8 mg, 80%) as a white solid. 2,7-Dimethylxanthen-9-one (14) [S14] OCO2MeO S11 1H-NMR (400 MHz, CDCl3): delta 8.12 (2H, d, J = 0.9 Hz, ArH), 7.53 (2H, dd, J = 8.5, 2.1 Hz, ArH), 7.39 (2H, d, J = 8.7 Hz, ArH), 2.47 (6H, s, CH3); 13C-NMR (100 MHz, CDCl3): delta 177.36, 154.42, 135.94, 133.48, 126.02, 121.43, 117.75, 20.89.

According to the analysis of related databases, 1579-40-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Adachi, Yusuke; Matsubara, Hiroshi; Journal of Fluorine Chemistry; vol. 216; (2018); p. 89 – 95;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1579-40-4, name is Di-p-tolyl Ether, A new synthetic method of this compound is introduced below., Safety of Di-p-tolyl Ether

In einem mit Argon begasten 100 ML Reaktor werden 2 g 4, 4′-OXYBIS (toluen) (CAS Reg. Nr. 1579-40-4) [10 mmol] in 39.2 ml Acetonitril unter Zusatz von 0.8 ML Dimethylsulfoxid [11. 2 mmol] bei 75 C geloest. Zur Loesung werden 60 mg Cu (OAc) 2, 30 mg FES04-7 H20 und 10 ml Wasser beigefuegt. 10.8 g NA2S208 geloest in 30 ML Wasser werden anschliessend unter heftigem Ruehren zugetropft. Nach 45 Minuten ist die Reaktion beendet. Die organische Phase wird mit Ethylacetat erschoepfend extra- hiert. Die gebildeten Produkte werden mit Hilfe der HPLC untersucht. Die Ausbeute des Dialdehyds 4, 4′-OXYBIS (benzaldehyd) (CAS Reg. Nr. 2215-76-1) betraegt 87 mol%. Damit liegt diese Ausbeute gegenueber den Ausbeuten mit bisher bekannten Oxidationsverfahren von 30-40% wesentlich hoeher, wodurch sich die Selektivitaet des erfindungsgemaessen Verfahrens auszeichnet.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; TEX-A-TEC AG; WO2004/43891; (2004); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 1579-40-4, A common heterocyclic compound, 1579-40-4, name is Di-p-tolyl Ether, molecular formula is C14H14O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In einem mit Argon begasten 100 ml Reaktor werden 2 g 4, 4′-OXYBIS (toluen) (CAS Reg. Nr. 1579-40-4) [10 MMOL] in 39.2 ml Acetonitril unter Zusatz von 1.5 ml Methylphenylsulfoxid [11. 0 mmol] bei 75 C geloest. Zur Loesung werden 60 mg Cu (OAc) 2, 30 mg FES04-7 H20 und 10 ML Wasser beigefuegt. 16.2 g NA2S208 geloest in 30 ml Wasser werden anschliessend unter heftigem Ruehren zugetropft. Nach 45 Minuten ist die Reaktion beendet. Die organische Phase wird mit Ethylacetat erschoepfend extrahiert. Die Ausbeute des Dialdehyds 4, 4′-OXYBIS (BENZALDEHYD) (CAS Reg. Nr. 2215-76-1) betraegt 84 MOL%.

The synthetic route of 1579-40-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TEX-A-TEC AG; WO2004/43891; (2004); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 1579-40-4, These common heterocyclic compound, 1579-40-4, name is Di-p-tolyl Ether, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Representative Experimental Protocol: 2,7-Dimethyl-9-(4-nitro)phenyl xanthen-9-ol (R = NO2: 3e): Di-p-tolyl ether (1, 5 g, 25.5 mmol), 4-nitro benzoic acid (5.13 g, 30.7 mmol) and ZnCl2 (10 g, 73.4 mmol) are taken into a 100 ml double neck RB flask and charged with POCl3 (7.5 mL) and heated to 95 C for 4 h. The reaction mixture turned into a brown viscous mass that was difficult to stir. The reaction mixture was then cooled to room temperature and crushed ice was added slowly while keeping the low temperature. To the above mixture was added H2O (75 mL) and stirred for 12 h. The above reaction mixture was filtered and the residue was washed with H2O (20 mL) and hexane (20 mL) to afford 4-nitro-DMPx 3e as white powder. The crude product was dissolved in EtOAc and washed with NaHCO3 to remove the excess of 4-nitro benzoic acid. The EtOAc layer was evaporated under reduced pressure to furnish the desired product as fine powder 7.5 g (86%).

The synthetic route of 1579-40-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Banerjee, Shyamapada; Srishylam; Rajendra Prasad; Migawa, Michael T.; Swayze, Eric E.; Sanghvi, Yogesh S.; Tetrahedron Letters; vol. 53; 35; (2012); p. 4669 – 4672;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem