Category: 157869-15-3

On August 18, 2017, Xia, Xiao-Feng; Zhang, Guo-Wei; Wang, Dawei; Zhu, Su-Li published an article.Recommanded Product: 2-((4-Methoxyphenyl)ethynyl)aniline The title of the article was Visible-Light Induced and Oxygen-Promoted Oxidative Cyclization of Aromatic Enamines for the Synthesis of Quinolines Derivatives. And the article contained the following:

The dual transition metal-visible light photoredox catalysis for the synthesis of quinoline derivatives by using dioxygen as an oxygen source is developed. By using visible light, the direct oxidative cyclization of aromatic enamines with alkynes or alkenes can be achieved at mild conditions with an aid of copper or palladium catalysts, and a variety of multisubstituted quinoline derivatives could be obtained in good to moderate yields under mild reaction conditions. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Recommanded Product: 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to oxidative cyclization aromatic enamine quinoline synthesis, visible light induced oxidative cyclization aromatic enamine quinoline, oxygen promoted oxidative cyclization aromatic enamine quinoline and other aspects.Recommanded Product: 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 25, 2021, de Souza, Wanderson C.; Matsuo, Bianca T.; Matos, Priscilla M.; Correia, Jose Tiago M.; Santos, Marilia S.; Koenig, Burkhard; Paixao, Marcio W. published an article.Product Details of 157869-15-3 The title of the article was Photocatalyzed Intramolecular [2+2] Cycloaddition of N-Alkyl-N-(2-(1-arylvinyl)aryl)cinnamamides. And the article contained the following:

N-Alkyl-N-(2-(1-arylvinyl)aryl)cinnamamides were converted into natural product inspired scaffolds via iridium photocatalyzed intramol. [2+2] photocycloaddition The protocol had a broad substrate scope, while operating under mild reaction conditions. Tethering four components forming a trisubstituted cyclobutane core builds rapidly high mol. complexity. This approach allowed the design and synthesis of a variety of tetrahydrocyclobuta[c]quinolin-3(1H)-ones, in yields ranging between 20-99%, and with excellent regio- and diastereoselectivity. Moreover, it was demonstrated that the intramol. [2+2]-cycloaddition of 1,7-enynes-after fragmentation of the cyclobutane ring-leads to enyne-metathesis-like products. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Product Details of 157869-15-3

The Article related to alkyl arylvinyl arylcinnamamide preparation iridium diastereoselective regioselective photochem cycloaddition, diaryl alkyltetrahydrocyclobutaquinolinone preparation, catalysis, cycloaddition, dienes, energy transfer, photocatalysis and other aspects.Product Details of 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 25, 2021, de Souza, Wanderson C.; Matsuo, Bianca T.; Matos, Priscilla M.; Correia, Jose Tiago M.; Santos, Marilia S.; Koenig, Burkhard; Paixao, Marcio W. published an article.Product Details of 157869-15-3 The title of the article was Photocatalyzed Intramolecular [2+2] Cycloaddition of N-Alkyl-N-(2-(1-arylvinyl)aryl)cinnamamides. And the article contained the following:

N-Alkyl-N-(2-(1-arylvinyl)aryl)cinnamamides were converted into natural product inspired scaffolds via iridium photocatalyzed intramol. [2+2] photocycloaddition The protocol had a broad substrate scope, while operating under mild reaction conditions. Tethering four components forming a trisubstituted cyclobutane core builds rapidly high mol. complexity. This approach allowed the design and synthesis of a variety of tetrahydrocyclobuta[c]quinolin-3(1H)-ones, in yields ranging between 20-99%, and with excellent regio- and diastereoselectivity. Moreover, it was demonstrated that the intramol. [2+2]-cycloaddition of 1,7-enynes-after fragmentation of the cyclobutane ring-leads to enyne-metathesis-like products. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Product Details of 157869-15-3

The Article related to alkyl arylvinyl arylcinnamamide preparation iridium diastereoselective regioselective photochem cycloaddition, diaryl alkyltetrahydrocyclobutaquinolinone preparation, catalysis, cycloaddition, dienes, energy transfer, photocatalysis and other aspects.Product Details of 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kondoh, Azusa; Terada, Masahiro published an article in 2018, the title of the article was Bronsted Base-Catalyzed Umpolung Intramolecular Cyclization of Alkynyl Imines.Safety of 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

A novel “umpolung” intramol. cyclization of alkynyl imines, in which the electrophilic imine sp2-carbon formally serves as a nucleophilic site, was developed under Bronsted base catalysis. The reaction involves the unprecedented catalytic generation of α-aminoester enolates from α-iminoesters via the 1,2-addition of the anion of a secondary phosphite to an imine moiety followed by the [1,2]-rearrangement of a dialkoxyphosphoryl moiety from carbon to nitrogen, which is a formal umpolung process, and the intramol. addition to an alkyne. This is a rare example of a [1,2]-rearrangement of a dialkoxyphosphoryl moiety from carbon to nitrogen to generate an α-amino carbanion and the first catalytic carbon-carbon bond forming reaction utilizing the resulting carbanion as a nucleophile. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Safety of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to bronsted base catalyst umpolung intramol cyclization alkynyl imine, crystal structure mol phosphonate indoline preparation stereoselective, brønsted base catalysis, intramolecular cyclization, organocatalysts, rearrangement, umpolung and other aspects.Safety of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xie, Jialin; Guo, Zhonglin; Huang, Yuanqiong; Qu, Yi; Song, Hongjian; Song, Haibin; Liu, Yuxiu; Wang, Qingmin published an article in 2019, the title of the article was One-Pot Copper-Catalyzed Cascade Bicyclization Strategy for Synthesis of 2-(1H-Indol-1-yl)-4,5-dihydrothiazoles and 2-(1H-Indol-1-yl)thiazol-5-yl Aryl Ketones with Molecular Oxygen as an Oxygen Source.Reference of 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

An atom-economical method for synthesizing N-heterocyclic indoles from readily available o-alkynylphenyl isothiocyanates and propargylamine derivatives is reported. This method involves a copper-catalyzed cascade bicyclization process consisting of an intramol. 5-exo-dig hydrothiolation reaction and an intramol. hydroamination reaction and, depending on whether or not mol. oxygen is present, selectively affords Z-isomers of 2-(1H-indol-1-yl)-4,5-dihydrothiazoles, e.g., I (X-rays single crystal structure shown), or 2-(1H-indol-1-yl)thiazol-5-yl aryl ketones in satisfactory yields. Mechanistic studies indicate that mol. oxygen acts as the oxygen source for the ketone moiety in the products. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Reference of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to alkynylphenyl isothiocyanate propargylamine cascade bicyclization copper, indolyl dihydrothiazole preparation mol crystal structure, aryl ketone indolylthiazolyl preparation mol crystal structure, copper cascade bicyclization catalyst and other aspects.Reference of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yu, Liu-Zhu; Wei, Yin; Shi, Min published an article in 2017, the title of the article was Copper-catalyzed trifluoromethylazidation and rearrangement of aniline-linked 1,7-enynes: access to CF3-substituted azaspirocyclic dihydroquinolin-2-ones and furoindolines.Electric Literature of 157869-15-3 And the article contains the following content:

A set of reactions involving copper-catalyzed trifluoromethylazidation and then rearrangement of aniline-linked 1,7-enynes with the relatively poorly reactive Togni reagent and TMSN3 was developed, and provided facile access to structurally diverse and useful CF3-substituted azaspirocyclic dihydroquinolin-2-ones I [R1 = H, 4-Cl, 4-CN, etc.; R2 = Ph, 4-ClC6H4, 2-naphthyl, etc.; R3 = Ms, Bn, Ts, etc.; R4 = Me, Ph] bearing two adjacent quaternary carbon centers. These products were also obtained on a large scale. Moreover, the obtained products were further transformed into a range of synthetically valuable furoindolines bearing three consecutive quaternary carbon centers after reduction by NaBH4. Also, the delivery of multi-functionalized aziridines as a result of alcoholysis and LiAlH4-reduction of corresponding dihydroquinolin-2-ones I [R1 = H, R2 = Ph, R3 = Ts, R4 = Me] demonstrated the synthetic value of this newly developed protocol. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Electric Literature of 157869-15-3

The Article related to arylethynyl phenyl acrylamide copper catalyst regioselective trifluoromethylaziridination rearrangement, trifluromethyl azaspirocyclic dihydroquinolinone diastereoselective preparation sodium borohydride reduction, furoindoline preparation and other aspects.Electric Literature of 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 6, 2020, Ling, Fei; Song, Dingguo; Chen, Linlin; Liu, Tao; Yu, Mengyao; Ma, Yan; Xiao, Lian; Xu, Min; Zhong, Weihui published an article.SDS of cas: 157869-15-3 The title of the article was Syntheses of N-Alkyl 2-Arylindoles from Saturated Ketones and 2-Arylethynylanilines via Cu-Catalyzed Sequential Dehydrogenation/aza-Michael Addition/Annulation Cascade. And the article contained the following:

A Cu-catalyzed and 4-OH-TEMPO-mediated sequential dehydrogenation/aza-Michael addition/annulation cascade reaction for the construction of N-alkyl 2-arylindoles I (R = H, 2-F, 3-OMe, 4-Cl, etc.; R1 = H, F, Cl, OMe, C(O)OCH3; R2 = H; R3 = H, Cl; R2R3 = -CH=CHCH=CH-; R4 = Ph, Me, pyridin-3-yl, thiophen-2-yl, etc.) and from facilely available saturated ketones R4C(O)CH2CH3 and 2-arylethynylanilines 2-RC6H4CC-4-R1-5-R2-6-R3C6HNH2 was described. This reaction shows high regioselectivity and tolerates a variety of functional groups. Moreover, 3-alkyl-substituted indoles II (R5 = Bu, tert-Bu, pentyl, propyl) can also be obtained when using 2-alkylethynylanilines 2-R5CCC6H4NH2 as starting materials. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).SDS of cas: 157869-15-3

The Article related to alkyl arylindole preparation regioselective, arylethynylaniline preparation ketone dehydrogenation michael cyclization tandem copper catalyst, alkylethynylaniline preparation ketone dehydrogenation michael cyclization tandem copper catalyst and other aspects.SDS of cas: 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, He; Cao, Tongxiang; Luo, Hejiang; Chen, Lianfen; Zhu, Shifa published an article in 2019, the title of the article was Enynone-enabled migratory insertion and Schmittel cyclization cascade for the synthesis of furan-fused fluorenes.Category: ethers-buliding-blocks And the article contains the following content:

A new method for the synthesis of furan-/benzo-fused fluorenes through copper(I)-catalyzed coupling of conjugated enynones or α-diazocarbonyl compounds with dialkynylbenzenes were developed. This process included 5-exo-dig cyclization, carbene migratory insertion, Schmittel cyclization and 1,5-H transfer. The obvious advantages of wide substrate scopes, mild reaction conditions and high atom efficiency make this system highly appealing for the construction of six-substituted benzofuran-embedded fluorenes in a one-pot manner. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Category: ethers-buliding-blocks

The Article related to propynylidene alkane dione dialkynylbenzene preparation copper tandem regioselective cyclization, carbonyl fluorenofuran preparation, diazo phenylacetate dialkynylbenzene preparation copper tandem cyclization, benzofluorene carboxylate preparation and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 29, 2021, He, Yu-Ping; Cao, Jian; Wu, Hua; Wang, Qian; Zhu, Jieping published an article.Safety of 2-((4-Methoxyphenyl)ethynyl)aniline The title of the article was Catalytic Enantioselective Aminopalladation-Heck Cascade. And the article contained the following:

Domino processes initiated by intramol. nucleopalladation of alkynes have been developed into powerful synthetic tools for the synthesis of functionalized heterocycles. However, a catalytic enantioselective version of this class of reactions remains scarce. We report herein that reaction of 2-alkynylanilines with prochiral cyclopentenes in the presence of a catalytic amount of Pd(OAc)2, a chiral bidentate pyrox ligand and O2 as terminal oxidant affords the structurally diverse indole-cyclopentene conjugates, e.g., I, bearing two stereocenters in a highly diastereo- and enantio-selective manner. One of the products is converted to a heavily functionalized tetracyclic indolinone derivative The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Safety of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to alkynylaniline cyclopentene diastereoselective enantioselective palladium pyrox aminopalladation heck cascade, indole cyclopentene stereoselective preparation, asymmetric synthesis, domino reactions, homogeneous catalysis, nucleopalladation, oxidative heck reactions and other aspects.Safety of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On September 9, 2022, Xu, Ren-Rui; Bao, Xuanzhang; Huo, Yong-Wang; Miao, Ren-Guan; Wen, Dan; Dai, Weiqi; Qi, Xinxin; Wu, Xiao-Feng published an article.Application In Synthesis of 2-((4-Methoxyphenyl)ethynyl)aniline The title of the article was Palladium-Catalyzed Domino Carbopalladation/Carbonylative Cyclization: Synthesis of Heterocycles bearing Oxindoles and 3-Acylbenzofuran/3-Acylindole Moieties. And the article contained the following:

A novel and straightforward methodol. for palladium-catalyzed carbopalladation-initiated domino carbonylative cyclization to construct bisheterocycles was established. With TFBen as an efficient and convenient CO source, the protocol wass capable of generating oxindole and 3-acylbenzofuran/3-acylindole moieties from the corresponding N-(o-iodoaryl)acrylamides and o-alkynylphenols/o-alkynylanilines with the formation of three C-C bonds and one C-O/C-N bond in a single one-step operation. A wide range of bisheterocycles bearing oxindoles and 3-acylbenzofurans/3-acylindoles were prepared in moderate to excellent yields with good functional group tolerance. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Application In Synthesis of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to iodophenyl acrylamide ethynylphenol tfben palladium tandem carbonylative heterocyclization, benzofuranyl oxindolyl ethanone preparation, ethynylaniline iodoaryl acrylamide tfben palladium tandem carbonylative heterocyclization, oxindolyl indolylethanone preparation and other aspects.Application In Synthesis of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem