Category: 157869-15-3

Xia, Xiao-Feng; He, Wei; Wang, Dawei published an article in 2019, the title of the article was Metal-Free Oxidative Annulation/Cyclization of 1,6-Enynes for the Synthesis of 4-Carbonylquinolines.Product Details of 157869-15-3 And the article contains the following content:

Herein, the development of a metal-free oxidative annulation reaction of 1,6-enynes, leading to 4-carbonylquinolines by using dioxygen as a green sustainable oxidant is reported. Key advances include the use of readily available tert-Bu nitrite (TBN) to promote radical annulation of 1,6-enynes and easy-to-handle reaction conditions. Preliminary mechanistic studies including radical capture reactions and isotope labeling experiments are also conducted. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Product Details of 157869-15-3

The Article related to carbonylquinoline preparation green chem metal free, enyne tandem intramol radical cyclization oxygen insertion, aminoalkyne alkenylaniline michael addition radical annulation and other aspects.Product Details of 157869-15-3

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Ether – Wikipedia,
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On October 4, 2017, Sharma, Shivani; Pathare, Ramdas S.; Sukanya; Maurya, Antim K.; Goswami, Bhagyashree; Agnihotri, Vijai K.; Sawant, Devesh M.; Pardasani, Ram T. published an article.Synthetic Route of 157869-15-3 The title of the article was Microwave assisted metal-/oxidant-free cascade electrophilic sulfenylation/5-endo-dig cyclization of 2-alkynylanilines to generate diversified 3-sulfenylindoles. And the article contained the following:

A metal-/oxidant-free sustainable protocol for the synthesis of 3-sulfenylindoles based on electrophilic cyclization of 2-alkynylanilines has been developed under microwave irradiation Herein, catalytic amount of iodine and stoichiometric amount of sulfonyl hydrazides were employed as catalyst and electrophiles resp. to induce the 5-endo-dig cyclization of 2-alkynylanilines. This strategy allows a wide substrate scope, demonstrates good functional group tolerance, utilizes easily available reagents and overcome multistep synthesis. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Synthetic Route of 157869-15-3

The Article related to sulfenylindole microwave synthesis sulfenylation cyclization alkynylaniline sulfonyl hydrazide, cascade electrophilic sulfenylation cyclization alkynylaniline sulfonyl hydrazide and other aspects.Synthetic Route of 157869-15-3

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Ether – Wikipedia,
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Otani, Takashi; Jiang, Xue; Cho, Kinryo; Araki, Rino; Kutsumura, Noriki; Saito, Takao published an article in 2015, the title of the article was Lewis Acid-Catalyzed or Base-Promoted Regioselective Cycloisomerization of N-Imidoyl-o-alkynylanilines for Synthesis of N-Imidoyl-(1H)-indoles and 4-Alkylidene-3,4-dihydroquinazolines.SDS of cas: 157869-15-3 And the article contains the following content:

The product selectivity control for the synthesis of imidoylindoles I (R1 = 4-Tol, Ph, t-Bu, n-Pr, etc; R2 = Ph, n-Pr, i-Pr; R3 = Ph, Et) and 4-alkylidenedihydroquinazolines II (R4 = 4-CH3OC6H4, 4-F3CC6H4, cyclohexyl, etc; R5 = Ph, n-Pr, i-Pr, t-Bu) from N-imidoyl-o-alkynylanilines via silver triflate-catalyzed cycloisomerization or tetrabutylammonium fluoride-promoted cyclization were described. The product selectivity depends mainly on the catalyst/promoter used, and on the substituents on the alkyne and amidine functions of the substrates. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).SDS of cas: 157869-15-3

The Article related to indole imidoyl quinazoline dihydro alkylidene preparation diastereoselective regioselective, aniline alkynyl imidoyl cycloisomerization silver triflate catalyst cyclization tbaf and other aspects.SDS of cas: 157869-15-3

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Ether – Wikipedia,
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On February 17, 2016, Ortiz-Cervantes, Carmen; Flores-Alamo, Marcos; Garcia, Juventino J. published an article.Recommanded Product: 2-((4-Methoxyphenyl)ethynyl)aniline The title of the article was Synthesis of pyrrolidones and quinolines from the known biomass feedstock levulinic acid and amines. And the article contained the following:

A series of N-(alkyl/aryl/aralkyl)-5-methyl-2-pyrrolidones I [R = t-Bu, c-hex, Bn, etc.] was prepared via ruthenium nanoparticles- catalyzed reductive amination of levulinic acid with various amines using formic acid as the hydrogen source. Ruthenium nanoparticles with a mean diameter of cal 3.8 nm were prepared by thermal decomposition of [Ru3(CO)12] in solvent-free conditions. When these reductive thermal reactions were carried out without the catalyst, the pyrrolidons were obtained with low yield and poor selectivity. The reductive amination reaction between levulinic acid and 2-ethynyl aniline surprisingly produced 2-(2,4-dimethylquinolin-3-yl)acetic acid. Furthermore, synthesis of substituted quinolines II [R1 = H, Et; R2 = H, Me, OMe] was achieved through p-toluenesulfonic acid-promoted condensation of levulinic acid and 2-alkynyl anilines. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Recommanded Product: 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to pyrrolidone preparation, levulinic acid primary amine reductive amination ruthenium nanoparticle catalyst, quinoline preparation, alkynyl aniline levulinic acid condensation and other aspects.Recommanded Product: 2-((4-Methoxyphenyl)ethynyl)aniline

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On April 1, 2016, Li, Jianxiao; Li, Chunsheng; Yang, Shaorong; An, Yanni; Wu, Wanqing; Jiang, Huanfeng published an article.Synthetic Route of 157869-15-3 The title of the article was Assembly of 3-Sulfenylbenzofurans and 3-Sulfenylindoles by Palladium-Catalyzed Cascade Annulation/Arylthiolation Reaction. And the article contained the following:

A novel and efficient palladium-catalyzed cascade annulation/arylthiolation reaction has been developed to afford functionalized 3-sulfenylbenzofuran and 3-sulfenylindole derivatives in moderate to good yields from readily available 2-alkynylphenols and 2-alkynylanilines in ionic liquids This protocol provides a valuable synthetic tool for the assembly of a wide range of 3-sulfenylbenzofuran and 3-sulfenylindole derivatives with high atom- and step-economy and exceptional functional group tolerance. Moreover, the employment of ionic liquids under mild reaction conditions makes this transformation green and practical. Furthermore, this approach enriched current C-S bond formation chem., making a valuable and practical method in synthetic and medicinal chem. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Synthetic Route of 157869-15-3

The Article related to sulfenylbenzofuran preparation, sulfenylindole preparation, benzofuran indole sulfenyl preparation, palladium catalyst cascade annulation arylthiolation alkynylphenol alkynylaniline and other aspects.Synthetic Route of 157869-15-3

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Ether – Wikipedia,
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Zhu, Xin-Yu; Han, Ya-Ping; Li, Ming; Li, Xue-Song; Liang, Yong-Min published an article in 2018, the title of the article was Copper-Catalyzed Radical Sulfonylation of N-Propargylindoles with Concomitant 1,2-Aryl Migration.Product Details of 157869-15-3 And the article contains the following content:

A novel copper-catalyzed cascade radical sulfonylation of N-propargyl-substituted indoles with concomitant 1,2-aryl migration was described. The protocol, which has good functional-group tolerance, provides practical, versatile and atom-economical method of accessing a new class of fascinating 2-sulfonated pyrrolo[1,2-伪]indole derivatives in moderate to good yields through the formation of the new C-S, C-C and C=O bonds in a one-step. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Product Details of 157869-15-3

The Article related to copper catalyzed radical sulfonylation propargylindole aryl migration, sulfonated pyrrolo indolone atom economical preparation, crystal mol structure methoxyphenyl tosyl pyrrolo indolone and other aspects.Product Details of 157869-15-3

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Ether – Wikipedia,
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Dhandabani, Ganesh Kumar; Mutra, Mohana Reddy; Wang, Jeh-Jeng published an article in 2018, the title of the article was Palladium-Catalyzed Regioselective Synthesis of 1-Benzoazepine Carbonitriles from o-Alkynylanilines via 7-endo-dig Annulation and Cyanation.Application of 157869-15-3 And the article contains the following content:

A three-component, one-pot cascade reaction involving an imination/annulation/cyanation sequence was reported for the synthesis of 1-benzoazepine carbonitrile derivatives I [R = 2-thienyl, Ph, 3-ClC6H4, etc.; R1 = H, 8-Me, 7-CF3, etc.; R2 = H, 2-Me, 3-Me, 3-t-Bu] using readily available o-alkynylanilines, cyclic ketones and trimethylsilyl cyanide. This regio- and stereoselective reaction was achieved by combining palladium(II) trifluoroacetate and copper(II) acetate in DMSO. The important features of this method included a broad substrate scope, the use of trimethylsilyl cyanide as a cyanating agent, the formation of two C-C bonds and one C-N bond, mild reaction conditions and good product yields. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Application of 157869-15-3

The Article related to benzoazepine carbonitrile preparation regioselective diastereoselective crystal structure mol, alkynylaniline cyaclohexane tmscn cascade imination annulation cyanation palladium catalyst and other aspects.Application of 157869-15-3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Beibei; Ju, Zhanfeng; Zhou, Mi; Su, Kongzhao; Yuan, Daqiang published an article in 2019, the title of the article was A Reusable MOF-Supported Single-Site Zinc(II) Catalyst for Efficient Intramolecular Hydroamination of o-Alkynylanilines.Electric Literature of 157869-15-3 And the article contains the following content:

The exploitation of new and active earth-abundant metal catalysts is critical for sustainable chem. production Herein, we demonstrate the design of highly efficient, robust, and reusable ZnII-bipyridine-based metal-organic framework (MOF) catalysts for the intramol. hydroamination of o-alkynylanilines to indoles. Under similar conditions homogeneous catalytic systems mainly provide hydrolyzate. Our results prove that MOFs support unique internal environments that can affect the direction of chem. reactions. The ZnII-catalyzed hydroamination reaction can be conducted without addnl. ligands, base, or acid, and is thus a very clean reaction system with regard to its environmental impact. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Electric Literature of 157869-15-3

The Article related to alkynylaniline intramol hydroamination metal organic framework supported zinc catalyst, indole preparation, heterogeneous catalysis, hydroamination, indoles, metal-organic frameworks, zinc and other aspects.Electric Literature of 157869-15-3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Sifeng; Wang, Zihao; Xiao, Haitao; Bian, Zhaoxiang; Wang, Jun published an article in 2020, the title of the article was Enantioselective synthesis of indole derivatives by Rh/Pd relay catalysis and their anti-inflammatory evaluation.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

An efficient Rh/Pd relay catalyzed intermol. and cascade intramol. hydroamination for the synthesis of exclusive trans 1-indolyl dihydronaphthalenols (up to 88% yield, 99% ee) I [R = n-Bu, 3-thienyl, phenyl; R1 = H, 5,8-di-Me, 5,8-di-MeO, etc.] was described under mild conditions. Moreover, the in-silico and in-vitro screening showed that the novel 1-indolyl dihydronaphthalenol products were potent lead compounds for treating inflammation disease. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to oxabenzonorbornadiene phenylethynyl aniline palladium rhodium tandem enantioselective diastereoselective hydroamination, indolyl dihydronaphthalenol preparation antiinflammatory mol docking and other aspects.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
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Liang, Hao; He, Xiaobo; Zhang, Yaqi; Chen, Bin; Ouyang, Jia-sheng; Li, Yongsu; Pan, Bendu; Subba Reddy, Chitreddy V.; Chan, Wesley Ting Kwok; Qiu, Liqin published an article in 2020, the title of the article was Copper-catalyzed (4+1) and (3+2) cyclizations of iodonium ylides with alkynes.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

The copper(II)-catalyzed (4+1) cyclizations and copper(I)-catalyzed (3+2) cycloadditions of iodonium ylides R(O)CC(=IC6H5)C(O)R1 [R = R1 = OMe, OEt, OCH2CF3; RR1 = -N(CH3)C(O)N(CH3)-] and 5-methyl-3-(2-phenylethynyl)pyridin-2-amine and alkynes 2-NHR2-4-R3-C6H3CCR4 (R2 = H, CH3; R3 = H, Cl; R4 = Ph, isoquinolin-4-yl, thiophen-2-yl, etc.) and 2-OH-4-R5-5-R6C6H2CCR4 (R5 = R6 = H, R5R6 = -CH=CH-CH=CH-) were successfully developed by employing efficient and safe iodonium ylides instead of traditional diazo compounds Highly functionalized di-Me (E)-3-benzylideneindoline-2,2-dicarboxylates I and II and Me 5-(2-hydroxyphenyl)-2-methoxy-4-phenylfuran-3-carboxylates III were conveniently prepared in moderate to excellent yields. The possible reaction mechanisms were also discussed. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to dimethyl benzylideneindoline dicarboxylate preparation diastereoselective, methyl hydroxyphenyl methoxyphenylfuran carboxylate preparation, iodonium ylide alkyne cycloaddition copper catalyst and other aspects.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem