Category: 157869-15-3

On February 14, 2018, Chaisan, Nattawadee; Kaewsri, Wilailak; Thongsornkleeb, Charnsak; Tummatorn, Jumreang; Ruchirawat, Somsak published an article.Category: ethers-buliding-blocks The title of the article was PtCl4-catalyzed cyclization of N-acetyl-2-alkynylanilines: A mild and efficient synthesis of N-acetyl-2-substituted indoles. And the article contained the following:

An efficient synthesis of N-acetyl-2-substituted indole derivatives via direct intramol. hydroamination of N-acetyl-2-alkynylaniline derivatives was developed. The reaction could be applied to a wide range of substrates employing only 1-2 mol% of PtCl4 as the catalyst to furnish the desired indole products in moderate to excellent yields. The current protocol is efficient, reliable and scalable, and could serve as an important tool for convenient and rapid access to this important class of N-heterocyclic skeleton from readily available substrates. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Category: ethers-buliding-blocks

The Article related to indole acetyl substituted preparation acetylalkynylaniline cyclization platinum chloride catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chakrabarty, Indradweep; Inamdar, Suleman M.; Akram, Manjur O.; Gade, Amol B.; Banerjee, Subhrashis; Bera, Saibal; Patil, Nitin T. published an article in 2017, the title of the article was [3+2]-Annulation of platinum-bound azomethine ylides with distal C=C bonds of N-allenamides.Recommanded Product: 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

A Pt-catalyzed, highly regioselective reaction between N-allenamides and imino-alkynes leading to pyrrolo[1,2-a]indoles was described. This represented the first example of [3+2]-annulation of Pt-bound azomethine ylides with the distal C=C bond of N-allenamides. The mechanism of the reaction was established by computational studies. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Recommanded Product: 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to allenamide aryl imino alkyne platinum catalyst regioselective cyclization, aryl tosyl pyrroloindole diastereoselective preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On January 31, 2021, Wang, Dan; Wang, Shi-Chao; Hao, Wen-Juan; Tu, Shu-Jiang; Jiang, Bo published an article.Category: ethers-buliding-blocks The title of the article was Dual Palladium/Scandium Catalysis toward Rotationally Hindered C3-Naphthylated Indoles from β-Alkynyl Ketones and o-Alkynyl Anilines. And the article contained the following:

A new dual palladium/scandium catalysis starting from β-alkynyl ketones and o-alkynyl anilines was reported for the first time, leading to the atom-economic synthesis of rotationally hindered C3-naphthylated indoles I [R1 = Ph, 4-MeC6H4, 4-FC6H4, etc.; R2 = H, 6-F, 7-Me; R3 = cyclopropyl, Ph, 2-naphthyl, etc.; R4 = H, 5-Me, 5-Cl] in moderate to good yields and high regioselectivity. This method could tolerate normal air conditions, and featured the use of palladium/scandium cooperative catalysts without any ligand, facile double annulation involving various internal alkynes, and good functional group tolerance. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Category: ethers-buliding-blocks

The Article related to rotationally hindered c3 naphthylated indole regioselective preparation, ketone alkynyl aniline double annulation palladium catalyst scandium, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ye, Yibin; Cheung, Kelvin Pak Shing; He, Lisi; Tsui, Gavin Chit published an article in 2018, the title of the article was Domino cyclization/trifluoromethylation of 2-alkynylanilines using fluoroform-derived CuCF3: synthesis of 3-(trifluoromethyl)indoles.Related Products of 157869-15-3 And the article contains the following content:

By employing easily accessible 2-alkynylanilines and the well-established fluoroform-derived CuCF3 reagent, a novel class of 3-(trifluoromethyl)indoles could be synthesized in good yields with no ambiguity of the CF3 position. The method utilized a domino cyclization/trifluoromethylation strategy to construct the indole cores with the concomitant installation of the CF3 group. The ultimate source of CF3 is the low-cost industrial byproduct fluoroform (CF3H). The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Related Products of 157869-15-3

The Article related to tosyl trifluoromethyl indole preparation, alkynyl aniline preparation copper trifluoromethane regioselective trifluoromethylation cyclization, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Related Products of 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Heng; Zhu, Yan; Jiang, Cong; Wei, Jia; Liu, Ping; Sun, Peipei published an article in 2022, the title of the article was HOAc catalyzed three-component reaction for the synthesis of 3,3′-(arylmethylene)bis(1H-indoles).SDS of cas: 157869-15-3 And the article contains the following content:

An efficient HOAc catalyzed three-component cyclization and cascade condensation of o-alkynyl anilines with aromatic aldehydes of 2-(arylethynyl)anilines with arylaldehydes was achieved, which leads to the generation of 3,3′-(arylmethylene)bis(1H-indoles) I [R1 = Ph, 4-MeC6H4, 4-FC6H4, etc.; R2 = 5-Me, 5-Cl, 6-Me, etc.; R3 = Ph, 4-MeC6H4, 4-BrC6H4, etc.] with good to excellent yields and high regioselectivity under transition-metal-free conditions. Four new C-C and C-N bonds were effectively formed in a one-pot procedure. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).SDS of cas: 157869-15-3

The Article related to arylmethylene bis indole green regioselective preparation, ortho alkynyl aniline benzaldehyde three component cyclization cascade condensation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.SDS of cas: 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 30, 2020, He, Jiaming; Yu, Yue; Guo, Pengfeng; Liu, Xiang; Zhu, Baofu; Cao, Hua published an article.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline The title of the article was Palladium-Catalyzed C-N Bond Formation: A Straightforward Alkoxymethylation Process for the Synthesis of the C1 and C3-Dialkoxy Indoles. And the article contained the following:

A novel approach for the synthesis of the C1 and C3-dialkoxy indoles was developed for using 2-(phenylethynyl)aniline with formaldehyde and alcs. under the catalysis of acid and palladium acetate. This multicomponent reaction that provided a straightforward alkoxymethylation process constructed substituted indoles was expected to be an important method for the synthesis of indole derivatives The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to phenylethynyl aniline formaldehyde alc palladium carbon nitrogen bond formation, alkoxymethyl phenylindolyl methanol preparation regioselective, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Liang, Shengzong; Hammond, Luisa; Xu, Bo; Hammond, Gerald B. published an article in 2016, the title of the article was Commercial Supported Gold Nanoparticles Catalyzed Alkyne Hydroamination and Indole Synthesis.Formula: C15H13NO And the article contains the following content:

Com. gold nanoparticles supported on titanium dioxide (TiO2) were found to be a highly efficient catalyst for alkyne hydroamination. Terminal alkynes could easily undergo intermol. hydroamination with low catalyst loadings (0.2 mol% Au) under solvent-free conditions. Indoles were efficiently synthesized using microwave heating through intramol. hydroamination. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Formula: C15H13NO

The Article related to hydroamination alkyne alkynylaniline gold nanoparticle titanium dioxide catalyst, indole preparation intramol hydroamination microwave assisted, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Formula: C15H13NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 14, 2022, Cai, Chen; Lu, Yi; Yuan, Chengcheng; Fang, Zheng; Yang, Xiaobing; Liu, Chengkou; Guo, Kai published an article.Recommanded Product: 157869-15-3 The title of the article was Metal-Free C-C Cross Coupling: Electrosynthesis of Azaheterocycles through Anodic Oxidation Cyclization of 1,6-Enynes. And the article contained the following:

A straightforward synthesis of azaheterocycles has been developed through electrochem. aerobic oxidation cyclization using a user-friendly undivided electrolytic cell at room temperature under catalyst-free conditions. This green and practical electrosynthesis strategy features good functional group, diverse electronic and steric properties tolerance. Based on a series of mechanistic investigation, including isotope labeling, singlet oxygen inhibiting, superoxide radical anion inhibiting, radical-trapping, cyclic voltammetry and controlled potential electrolysis experiments, a possible N-centered radical-initiated mechanism was proposed. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Recommanded Product: 157869-15-3

The Article related to azaheterocycle preparation green chem, enyne electrochem aerobic anodic oxidation cyclization, Heterocyclic Compounds (One Hetero Atom): Other Areno- and Diarenopyridines (Acridines, Quinolizines, etc.) and other aspects.Recommanded Product: 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 6, 2020, Dhandabani, Ganesh Kumar; Shih, Chia-Ling; Wang, Jeh-Jeng published an article.Related Products of 157869-15-3 The title of the article was Acid-Promoted Intramolecular Decarbonylative Coupling Reactions of Unstrained Ketones: A Modular Approach to Synthesis of Acridines and Diaryl Ketones. And the article contained the following:

Herein, Lewis acid- or Bronsted acid-promoted intramol. C(sp2)-C(sp2) bond cleavage and a novel C(sp2)-C(sp2) bond-forming cascade reaction to synthesize the acridine motif is reported. The metal-free oxidation of the alkyne motif generated the in situ ketone group extracted via a decarbonylation reaction. The mechanistic studies revealed that the electrophilic N-iodo species triggered key decarbonylation reactions via consecutive dearomatization/aromatization reactions. In addition, this acid-promoted C-C bond activation system with internal alkynes to synthesize bis(heteroaryl) ketones is exploited. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Related Products of 157869-15-3

The Article related to acridine diaryl ketone preparation, ketone alkynylaniline intramol decarbonylative coupling reaction, internal alkyne bond activation, Heterocyclic Compounds (One Hetero Atom): Other Areno- and Diarenopyridines (Acridines, Quinolizines, etc.) and other aspects.Related Products of 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On December 6, 2019, He, Jingjing; Yang, Kang; Zhao, Jianhong; Cao, Song published an article.Name: 2-((4-Methoxyphenyl)ethynyl)aniline The title of the article was LiHMDS-Promoted Palladium-Catalyzed Sonogashira Cross-Coupling of Aryl Fluorides with Terminal Alkynes. And the article contained the following:

A highly efficient Pd-catalyzed Sonogashira coupling of various aryl fluorides with terminal alkynes in the presence of LiHMDS was developed. Both unreactive electron-rich fluoroarenes and electron-poor fluoroarenes proceeded smoothly and afforded the corresponding internal alkynes in moderate to excellent yields. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Name: 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to aryl fluoride terminal alkyne sonogashira coupling palladium catalyst lhmds, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Name: 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem