Category: 157869-15-3

Liu, Jianchao; Xiao, Xiao; Han, Puren; Zhou, Huiwen; Yin, Qi-Shuang; Sun, Jian-Song published an article in 2020, the title of the article was Palladium-catalyzed C-glycosylation and annulation of o-alkynylanilines with 1-iodoglycals: convenient access to 3-indolyl-C-glycosides.Name: 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

An efficient and practical approach for the synthesis of 3-indolyl-C-Δ1,2-glycosides through a palladium-catalyzed annulation/C-glycosylation sequence of o-alkynylanilines with 1-iodoglycals has been developed. This methodol. has a wide scope of substrates and gives access to 3-indolyl-C-Δ1,2-glycosides in high yields. Furthermore, the product obtained here exhibits a high utility for further transformations. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Name: 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to c aryl glycoside preparation iodoglycal annulation, alkynylaniline annulation glycosylation palladium catalyzed indolylglycoside, Carbohydrates: Glycosides and other aspects.Name: 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
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Nomura, Sayaka; Endo-Umeda, Kaori; Makishima, Makoto; Hashimoto, Yuichi; Ishikawa, Minoru published an article in 2016, the title of the article was Development of Tetrachlorophthalimides as Liver X Receptor β (LXRβ)-Selective Agonists.SDS of cas: 157869-15-3 And the article contains the following content:

Liver X receptor (LXR) agonists are candidates for the treatment of atherosclerosis via induction of ABCA1 (ATP-binding cassette A1) gene expression, which contributes to reverse cholesterol transport (RCT) and to cholesterol efflux from the liver and intestine. However, LXR agonists also induce genes involved in lipogenesis, such as SREBP-1c (sterol regulatory binding element protein 1c) and FAS (fatty acid synthase), thereby causing an undesirable increase in plasma and hepatic triglyceride (TG) levels. Recent studies indicate that LXRα contributes to lipogenesis in liver, and selective LXRβ activation improves RCT in mice. Therefore, LXRβ-selective agonists are promising candidates to improve atherosclerosis without increasing plasma or hepatic TG levels. However, the ligand-binding domains in the two LXR isoforms α/β share high sequence identity, and few LXR ligands show subtype selectivity. In this study the authors identified a tetrachlorophthalimide analog as an LXRβ-selective agonist. Structural development led to (E)-4,5,6,7-tetrachloro-2-(2-styrylphenyl)isoindoline-1,3-dione (I), which shows potent and selective LXRβ agonistic activity in reporter gene assays. In binding assays, compound I bound to LXRβ preferentially over LXRα. It also induced the expression of ABCA1 mRNA but not SREBP-1c mRNA in cells. Compound I appears to be a promising lead compound for therapeutic agents to treat atherosclerosis without the side effects induced by LXRα/β dual agonists. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).SDS of cas: 157869-15-3

The Article related to tetrachlorophthalimide liver x receptor beta agonist, abca1, srebp-1c, agonists, atherosclerosis, liver x receptor (lxr), Pharmacology: Structure-Activity and other aspects.SDS of cas: 157869-15-3

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On September 17, 2020, Ban, Shintaro; Endo, Tomotake; Matsui, Rikako; Morita, Nobuyoshi; Hashimoto, Yoshimitsu; Tanaka, Kosaku III; Tamura, Osamu published an article.Synthetic Route of 157869-15-3 The title of the article was Intramolecular activation of imidate with cationic gold(I) catalyst: A new benzylation reaction of alcohols. And the article contained the following:

Benzylation of alcs. with benzyl (Z)-2,2,2-trifluoro-N-(2-alkynylphenyl)acetimidates I (R1 = nBu, C6H5, 4-CF3C6H4, 4-MeOC6H4; R2 = H, NO2, OMe) in the presence of a cationic gold(I) catalyst was investigated. Reagent I (R1 = C6H5; R2 = OMe) was the most effective, affording benzyl ethers in good yields. This results indicate that these gold(I)-activated imidates are effective leaving groups. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Synthetic Route of 157869-15-3

The Article related to benzyl ether preparation gold catalyst, alc imidate benzylation, General Organic Chemistry: Synthetic Methods and other aspects.Synthetic Route of 157869-15-3

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On February 19, 2021, Fang, Xiaolan; Cao, Ji; Ding, Weijie; Jin, Huile; Yu, Xiaochun; Wang, Shun published an article.Electric Literature of 157869-15-3 The title of the article was Copper-Catalyzed Aerobic Oxidative Cyclization of 2-Alkynylanilines with Nitrosoarenes: Synthesis of Organic Solid Mechanoluminescence Compounds of 4-Oxo-4H-cinnolin-2-ium-1-ide. And the article contained the following:

An efficient Cu(I)/DMAP/air system for the one-pot synthesis of 4-oxo-4H-cinnolin-2-ium-1-ides I [R = Ph, 4-ClC6H4, 3-thienyl, etc.; R1 = H, 6-Me, 5-Cl, etc.; R2 = H, 4-Me, 4-Cl, 4-Br, 4-MeO], which were often difficult to prepare by traditional routes from substituted 2-alkynylanilines and nitrosoarenes, was developed. These 4-oxo-4H-cinnolin-2-ium-1-ides had practical applications as mechanoluminescent materials. Preliminary mechanistic experiments were performed and a plausible mechanism for this tandem process was proposed. The use of an inexpensive copper catalyst and mol. oxygen as the oxygen source and the oxidant made this an attractive green protocol with potential synthetic applications. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Electric Literature of 157869-15-3

The Article related to oxo cinnoliniumide green preparation, alkynylaniline nitrosoarene tandem aerobic oxidative cyclization copper catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Electric Literature of 157869-15-3

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Villanueva, Omar; Weldy, Nina Mace; Blakey, Simon B.; MacBeth, Cora E. published an article in 2015, the title of the article was Cobalt catalyzed sp3 C-H amination utilizing aryl azides.Related Products of 157869-15-3 And the article contains the following content:

A dinuclear Co(II) complex supported by a modular, tunable redox-active ligand system is capable of selective C-H amination to form N-containing 5-, 6- and 7-membered heterocycles, I [R = H, Me; R1 = H, CF3, OMe; R2 = C6H5, 4-F3CC6H4, 4-H3COC6H4, 3-pyridinyl, 1-phenylsulfonyl-1H-indol-3-yl; X = (CH2)n; n = 1, 2, 3] and 5-methoxy-2-phenyl-1H-indole from aryl azides 2-N3-5-R1C6H3(CH2)nCH(R)(R2) in good yields at low (1 mol%) catalyst loading. The reaction is tolerant of medicinally relevant heterocycles. The synthetic versatility obtained using low loadings of an earth abundant transition metal complex represents a significant advance in catalytic C-H amination technol. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Related Products of 157869-15-3

The Article related to indoline preparation, azide aryl amination cobalt catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Related Products of 157869-15-3

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On May 20, 2016, Li, Pengfei; Weng, Yunxiang; Xu, Xianxiang; Cui, Xiuling published an article.Application of 157869-15-3 The title of the article was Access to Indole Derivatives from Diaryliodonium Salts and 2-Alkynylanilines. And the article contained the following:

An efficient, environmentally friendly, and operationally simple procedure to 1,2-disubstituted indoles from 2-alkynylanilines and diaryliodonium salts has been developed. This reaction proceeds smoothly under metal-free conditions. The products obtained could be transferred into 3,3′-diindolylmethane with DMSO catalyzed by palladium. The isotopic label experiments indicated that the methylene group in 3,3′-diindolylmethane is derived from DMSO. The diverse indoles were obtained in up to 90% yield for 28 examples. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Application of 157869-15-3

The Article related to indole preparation green chem, alkynylaniline diaryliodonium salt, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application of 157869-15-3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Qiao; Cai, Yun; Hu, Yuanyuan; Jin, Hongwei; Chen, Fener; Liu, Yunkui; Zhou, Bingwei published an article in 2021, the title of the article was Nickel-catalyzed cyclization of 1,7-enynes for the selective synthesis of dihydrocyclobuta[c]quinolin-3-ones and benzo[b]azocin-2-ones.Reference of 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

A nickel-catalyzed cyclization of N-(o-ethynylaryl)acrylamides for selective syntheses of dihydrocyclobuta[c]quinolin-3-ones I [R1 = Ph, 2-MeOC6H4, 4-ClC6H4, etc.; R2 = H, Me, Ph; R3 = Me, Et, Bn, methoxymethyl; R4 = H, 7-Me, 6-Cl, etc.] and benzo[b]azocin-2-ones II [R5 = Ph, 4-MeC6H4, 3-thienyl, etc.; R6 = H, Me, Ph; R7 = Me, Bn, methoxymethyl; R8 = H, 8-Me, 8-CN, etc.] was reported. The two varied products I and II could be easily obtained by tuning the reaction temperature This reaction featured easy temperature-control, high efficiency and gram-scale synthesis. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Reference of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to dihydrocyclobutaquinolinone chemoselective preparation, enyne cyclization nickel catalyst, benzoazocinone chemoselective preparation, cyclization enyne nickel catalyst, Heterocyclic Compounds (One Hetero Atom): Higher-Membered Rings and other aspects.Reference of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On October 31, 2021, Phetcharawetch, Jongkonporn; Betterley, Nolan M.; Reutrakul, Vichai; Soorukram, Darunee; Leowanawat, Pawaret; Kuhakarn, Chutima published an article.Related Products of 157869-15-3 The title of the article was Synthesis of 3-((trifluoromethyl)thio)indoles via trifluoromethylthiolation of 2-alkynyl azidoarenes with AgSCF3. And the article contained the following:

Direct and effective trifluoromethylthiolation of 2-alkynyl azidoarenes 2-CCR-4-R1-5-R2C6H2N3 (R = n-Bu, Ph, thiophen-2-yl, 2H-1,3-benzodioxol-5-yl, etc.; R1 = H, Me, Cl, CF3, etc.; R2 = H, Cl) with silver(I) trifluoromethanethiolate (AgSCF3) has been developed for the construction of 3-((trifluoromethyl)thio)indoles I. The trifluoromethylthiolation protocol is compatible with a broad substrate scope, providing a variety of 3-((trifluoromethyl)thio)indoles in moderate to good yields within one step, open-air, and short reaction time. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Related Products of 157869-15-3

The Article related to trifluoromethylthio indole preparation, alkynyl azidoarene silver trifluoromethanethiolate trifluoromethylthiolation, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Related Products of 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bard, Jeremy P.; Deng, Chun-Lin; Richardson, Hannah C.; Odulio, Jacob M.; Barker, Joshua E.; Zakharov, Lev N.; Cheong, Paul H.-Y.; Johnson, Darren W.; Haley, Michael M. published an article in 2019, the title of the article was Synthesis, photophysical properties, and self-dimerization studies of 2-λ5-phosphaquinolin-2-ones.Related Products of 157869-15-3 And the article contains the following content:

Authors have rationally designed and synthesized a library of phosphaquinolinone derivatives containing various electron-donating and -withdrawing groups on two positions of the scaffold. Distinct trends are observed between the substituents on R1 and R2 with both the photophys. properties of the mols. and their dimerization strengths. With withdrawing groups upon the scaffold, dimerization constants surpass 500 M-1 in H2O-saturated CDCl3. Computational studies on the dimeric structures corroborate the exptl. findings. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Related Products of 157869-15-3

The Article related to phosphaquinolinone preparation crystal mol structure photophysics dimerization, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Related Products of 157869-15-3

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On May 18, 2018, Wang, Xu; He, Dandan; Huang, Yubing; Fan, Qihang; Wu, Wanqing; Jiang, Huanfeng published an article.Product Details of 157869-15-3 The title of the article was Copper-Catalyzed Synthesis of Substituted Quinazolines from Benzonitriles and 2-Ethynylanilines via Carbon-Carbon Bond Cleavage Using Molecular Oxygen. And the article contained the following:

A copper-catalyzed process for the synthesis of substituted quinazolines from benzonitriles and 2-ethynylanilines using mol. oxygen (O2) as sole oxidant is described. The mild catalytic system enabled the effective cleavage of the C-C triple bond and construction of new C-N and C-C bonds in one operation. Furthermore, the compound N,N-dimethyl-4-(2-(4-(trifluoromethyl)phenyl)quinazolin-4-yl)aniline (3dj) exhibited obvious aggregation-induced emission phenomenon, and the fluorescence quantum yield (ΦF,film) and lifetime (τfilm) were measured to be 45.5% and 5.8 ns in thin films state, resp. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Product Details of 157869-15-3

The Article related to copper catalyzed cyclization benzonitrile ethynylaniline carbon bond cleavage oxygen, diphenyl quinazoline preparation crystal mol structure, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Product Details of 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem