Category: 1515-89-5

Synthetic Route of 1515-89-5, A common heterocyclic compound, 1515-89-5, name is 1-Bromo-3-(methoxymethyl)benzene, molecular formula is C8H9BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

PREPARATION 103 3-Methoxymethylphenylboronic Acid Obtained as a yellow solid (100%), from 1-bromo-3-methoxymethylbenzene (J. Amer. Chem. Soc., 1989, 111, 6311; Tetrahedron 1985, 41, 1435) and trimethyl borate1 using the procedure of Preparation 101. delta(DMSOd6): 3.27 (s,3H), 4.38 (s,2H), 7.31 (m,2H), 7.68 (m,2H), 7.98 (brs,2H).

The synthetic route of 1515-89-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pfizer INC; US6387931; (2002); B1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 1515-89-5, A common heterocyclic compound, 1515-89-5, name is 1-Bromo-3-(methoxymethyl)benzene, molecular formula is C8H9BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 1-bromo-3-methoxymethyl-benzene. (286 mg, 1.42 MMOL) and bis- (PINACOLATE) DIBORON. (397 mg, 1.56 MMOL) in DMSO (8 mL) are added KOAC (419 mg, 4.27 MMOL) and Pd (DPPF) CI2. CH2CI2 (58 mg, 0.071 MMOL). The reaction mixture is stirred at 80 C under nitrogen atomosphere for 1 h. After dilution with ether, the mixture is washed with water (x2) and brine. The organic layer is dried over MGS04, filtered, and concentrated in vacuo. The residue is purified by silica gel column chromatography (n-hexane: EtOAc=10: 1) to give the corresponding boron ester.

The synthetic route of 1515-89-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/69256; (2004); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

1515-89-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1515-89-5, name is 1-Bromo-3-(methoxymethyl)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Reference Example 3 (2S)-3-(3-methoxymethylphenyl)propan-1,2-diol To a solution of the compound prepared in reference example 2 (19.5 g) in THF (10 ml) was added acetic acid (80 ml) and water (10 ml) and the mixture was heated to 60 C and stirred for 6 hours. To the mixture was added water (40 ml) and the mixture was cooled to room temperature, and the precipitate was removed by filtration. The filtrate was concentrated. The precipitate was removed again and the mixture was concentrated. From the obtained oil, the solvent was separated as azeotropic mixture with toluene to give the title compound (8.9 g) having the following physical data. TLC: Rf 0.64 (ethyl acetate: hexane = 2: 1).

The synthetic route of 1515-89-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ONO PHARMACEUTICAL CO., LTD.; EP1114816; (2001); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem