Category: 14807-75-1

Dhanure, S. K. published the artcileKinetics of oxidation of thiourea by chloramine-T and p-benzoquinone, COA of Formula: C2H8Cl2N4S2, the publication is Oxidation Communications (2001), 24(1), 91-98, database is CAplus.

The kinetics of oxidation of thiourea by chloramine-T both in acid and alk. medium was studied. In acid medium, the reaction is second order in substrate, first order in oxidant and inverse fractional order in H⁺. In alk. medium the reaction is first order in oxidant, first order in substrate and inverse fractional order in [OH^–]. Stoichiometric experiments reveal that these reactions are mixed: the first one being the formation of disulfide and the second one in a parallel sequence giving urea and sulfate ion. A mechanism is postulated to explain the results. As a parallel study 1,4-benzoquinone was used for the oxidation of thiourea. These reactions occur with facility at pH 3-5; they are very fast below pH 3. The oxidant benzoquinone undergoes decomposition in alk. medium ruling out the possibility of any oxidation of thiourea by benzoquinone in the alk. medium.

Oxidation Communications published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, COA of Formula: C2H8Cl2N4S2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Dhanure, S. K. published the artcileKinetics of oxidation of thiourea by chloramine-T and p-benzoquinone, Computed Properties of 14807-75-1, the publication is Oxidation Communications (2001), 24(3), 400-407, database is CAplus.

Kinetics of oxidation of thiourea by chloramine-T both in acid and alk. medium was studied. In acid medium, the reaction is second order in substrate, first order in oxidant and inverse fractional order in [H⁺]. In alk. medium the reaction is first order in oxidant, substrate and inverse fractional order in [OH^–]. Stoichiometric experiments reveal that these oxidation reactions are mixed reactions: the first one being the formation of disulfide and the second one in a parallel sequence giving urea and sulfate ion. A mechanism is postulated to explain the results. As a parallel study 1,4-benzoquinone was used for the oxidation of thiourea. These reactions occur with facility at pH 3-5; they are very fast below pH 3. The oxidant benzoquinone undergoes decomposition in alk. medium ruling out the possibility of any oxidation by benzoquinone of thiourea in alk. medium.

Oxidation Communications published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Computed Properties of 14807-75-1.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Jirousek, Ludek published the artcilePositive iodine compounds as models of the thyroidal active iodine. Reaction of N-iodosuccinimide and of N-iodophthalimide with thiocarbamide goitrogens, Category: ethers-buliding-blocks, the publication is Journal of Pharmacology and Experimental Therapeutics (1974), 191(2), 341-8, database is CAplus and MEDLINE.

N-iodosuccinimide (I) [516-12-1] and N-iodophthalimide (II) [20919-42-0] reacted with 37 goitrogenic thiocarbamides in dimethyl sulfoxide to form thiocarbamide sulfenyl iodide derivatives as reaction intermediates; nongoitrogenic carbamides and other chem. analogs were unreactive. Structural studies indicated an influence of mesomerisms in the thiocarbamides on the overall reaction pathway. Some potent goitrogens were not oxidized beyond the disulfide stage. Behavior of the N-iodoimides imitates that of thyroidal active iodine more closely than I2 does, suggesting that trapping of pos. iodine is more important than the possible subsequent redox reactions in the mechanism of drug goitrogenicity.

Journal of Pharmacology and Experimental Therapeutics published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Larionov, S. V. published the artcileReaction of 2,4-dithiobiuret with copper(II), silver(I), cadmium(II) and mercury(II) ions, Safety of Formamidine disulfide dihydrochloride, the publication is Izvestiya Sibirskogo Otdeleniya Akademii Nauk SSSR, Seriya Khimicheskikh Nauk (1967), 84-8, database is CAplus.

2,4-Dithiobiuret [HN:C(SH)NHC(SH):NH] (I) is determined by potentiometric titration with either iodine or with H2NC(:NH)SSC(:NH)NH2.2HCl (II). In each case I is converted to III. In the titration with iodine conducted in boiling water, the error is ∼1%. In the titration with II the error is ∼0.3%. Treatment of 0.27 g. of I in 15 ml. of 96% EtOH with a solution of 0.5 g. of CuSO4.5H2O and 1 ml. of 57% HClO4 in 200 ml. H2O (pH ∼2) or in aqueous EtOH yielded a flocculent greenish precipitate, which did not alter on standing. After 30-40 min. the precipitate yielded 0.2 g. CuC2H2N3S2. In a 50% aqueous solution of Me2CO, containing 0.1M HClO4, the reaction of Cu(ClO4)2 with I generated its most intense color (in the 400-550 mμ range) at a molar ratio of about 1:4. Cd(II) in ammoniacal solution reacted with I to give a white precipitate, which rapidly became yellow, presumably due to CdS formation. The reaction of Hg(ClO4)2 with I was followed potentiometrically. A greenish yellow precipitate, corresponding to 1:1 molar stoichiometry, formed and rapidly became black on standing. Titration of I with Ag salts did not give reproducible results.

Izvestiya Sibirskogo Otdeleniya Akademii Nauk SSSR, Seriya Khimicheskikh Nauk published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Safety of Formamidine disulfide dihydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wei, Peter E. published the artcileNew vulcanizing agents for ethylene-propylene elastomers. III, Formula: C2H8Cl2N4S2, the publication is Rubber Chemistry and Technology (1966), 39(4), 1094-104, database is CAplus.

Perchloro-3a,4,7,7a-tetrahydro-4,7-methanonindene and perchloro-1,1′ -bis (2,2′ – cyclopentene) vulcanized ethylene-propylene rubber (I) when used in combination with S and Fe2O3. Vulcanization of I by octachlorocyclopentene (II)-S-Fe2O3 was enhanced by the presence of dithiodiformamidine-2HCl, phenylenediamine-HCl, diaminotoluene-2HCl, diaminophenol-2HCl, dichlorodimethylhydantoin, and trichloroisocyanuric acid. A vulcanization mechanism was given for the II-S-Fe2O3 system which proposes the formation of SF4, which abstracts H. Synergistic effects were observed with I vulcanization with II and tert-Bu2O2. The tensile strength of the polymers was most affected by the synergism.

Rubber Chemistry and Technology published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C8H15NO, Formula: C2H8Cl2N4S2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Busch, M. published the artcileReactions of diazonium salts with thioureas and derivatives, Related Products of ethers-buliding-blocks, the publication is Journal fuer Praktische Chemie (Leipzig) (1938), 173-85, database is CAplus.

cf. Ber. 34, 320(1901). PhNHNHCSNHPh (I) in Me₂CO at -5°, treated with PhN₂Cl in Me₂CO, gives a vigorous evolution of N₂, with the formation of the HCl salt, decomposes 205°, of S-phenyl-1,4-diphenylthiosemicarbazide (II), PhNHNHC(SPh):NPh, m. 75°. II is easily degraded by alkali into I and PhSH. The mother liquor from II yields benzeneazophenyliminomethane thiophenyl ether (III), PhN:NC(SPh):NPh, red, m. 115°; this is the oxidation product of II and is formed from II with H₂O₂ or yellow HgO; III gives II with (NH₄)₂S. The p-nitrophenyl homolog of II forms a HCl salt (IV), pale yellow, decomposes 205°; the free base is so susceptible to hydrolysis that NH₄OH in EtOH gives (p-O₂NC₆H₄S)₂. With HCHO IV yields the diphenyldihydrotriazole ether of p-nitrothiophenol, PhN.N:C(SC₆H₄NO₂).NPh.CH₂, m. 127°; BzH gives the tri-Ph homolog, PhN.N:C(SC₆H₄NO₂).NPh.CHPh, brownish rose, m. 124°. The red azo compound m. 118°. (PhNH)₂CS and p-O₂NC₆H₄N₂Cl (V) in EtOH-Me₂CO at -5° give S-p-nitrophenyldiphenylisothiourea (VI), PhNHC(SC₆H₄NO₂):NPh, light yellow, m. 131°; on recrystallization from EtOH partial decomposition occurs into (PhNH)₂CO and p-O₂NC₆H₄SH; alkali gives complete hydrolysis. The p-Br derivative of VI, p-BrC₆H₄NH(CSC₆H₄NO₂):NPh, light yellow, m. 158°, results in 75% yield from p-BrC₆H₄NHCSHPh. CS(NH₂)₂ and PhN₂Cl in Me₂CO give [H₂NC(:NH)S]₂.2HCl, m. 173-4° (decomposition). V gives 84% of the compound H₂NC(:NH)SN:NC₆H₄NO₂ as the HCl salt; this salt decomposes in absolute EtOH at room temperature PhNHCO₂Et and V in Me₂CO at -5° give the p-nitrophenyl ether of p-nitrobenzenediazohydrosulfide (VII), O₂NC₆H₄N:NSC₆H₄NO₂, citron-yellow, decomposes 142°; it results in varying amounts by coupling different thiourethans with V. PhN:C(SH)OCH₂Ph and V in EtOH-Me₂CO give VII; in C₆H₆ there results the compound PhNHCOSC₆H₄NO₂, m. 158°.

Journal fuer Praktische Chemie (Leipzig) published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kreutzberger, Alfred published the artcileCondensations of α,α¹-dithiobisformamidine with β-diketones, COA of Formula: C2H8Cl2N4S2, the publication is Liebigs Annalen der Chemie (1981), 532-7, database is CAplus.

[H₂NC(:NH)S]₂ reacted with 1-(2-furyl)-4,4,4-trifluoro-1,3-butanedione to give 14% disulfide I and 20% ketone II. MeCOCH₂COCF₃ similarly gave 16% thione III.

Liebigs Annalen der Chemie published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, COA of Formula: C2H8Cl2N4S2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ziegler, E. published the artcileSyntheses of heterocyclics. XLI. Cyclic dichloromalonyl compounds, Formula: C2H8Cl2N4S2, the publication is Monatshefte fuer Chemie (1962), 1376-82, database is CAplus.

cf. ibid. 1062-4; CA 57, 9850b. The method of Baeyer and Bloem (Ber. Deut. Chem. Ges. 15, 2150 (1882)) for chlorination of 4-hydroxycarbostyril (I) was examined in various solvents. Thus, 60 g. I was heated to boiling in a mixture of 220 ml. dioxane, 100 ml. concentrated HCl, and 40 ml. H₂O. After heating was stopped, 200 ml. 30% H₂O₂ was quickly added. After 15 min. the oil which separated gradually crystallized to give 91% 3,3-dichloro-2,4-dioxo-1,2,3,4-tetrahydroquinoline (II), m. 175° (C₆H₆). Yields in other solvents were: H₂O-AcOH, 70%; EtOH, 58%. The following substituted 2,4-dioxo-1,2,3,4-tetrahydroquinolines were prepared in the same way (yield, m.p.): 3,3-dichloro-6,8-dimethyl, quant., 215° (C₆H₆); 1-methyl-3-benzyl-3-chloro (III), 97%, 136.0-6.5° (MeOH). 5,5-Dichlorobarbituric acid, m. 211-15° (dilute HCl), was prepared similarly in 80% yield from barbituric acid, while 5 g. 1-phenyl-3-methyl-2-pyrazolin-5-one was converted in 96% yield to its 4,4-dichloro derivative (IV), m. 61° (dilute alc.). A suspension of 40 g. I in 100 ml. dioxane was heated to 50°, stirred, and 55 ml. SO₂Cl₂ added slowly. Solution began and the mixture was boiled for a short time, cooled, and treated with 300 ml. ice-H₂O to give 96% II. The following 2,4-dioxo-1,2,3,4-tetrahydroquinoline derivatives were prepared from the corresponding 4-hydroxycarbostyrils (yield, m.p.): 3,3-dichloro-6-fluoro, quant., 119° (EtOH); 3,3-dichloro-1-phenyl (V), quant., 200° (PhCl); 3,3-dichloro-1-benzyl (VI), quant., 122° (EtOH); 3-benzyl-3-chloro, 96%, 186° (AcOH). 5-Chlorobarbituric acid, m. 280-90° (decomposition) (H₂O), was similarly prepared in 79% yield. I (4 g.) in 25 ml. dioxane and 15 ml. H₂O was treated with Cl at 80° for 10-15 min., cooled, and 30 ml. H₂O added to give 96% 3,3,6-trichloro-2,4-dioxo-1,2,3,4-tetrahydroquinoline, m. 230-2° (EtOH). II (3 g.) was dissolved in 30 ml. EtOH and 10 ml. AcOH by boiling and 3 g. Zn dust added in small portions. Decolorization began in a few min., after which 150 ml. H₂O was added to precipitate 96.5% 3-chloro-4-hydroxycarbostyril (VII), which sintered at 270° and m. 275-80° (decomposition) (EtOH). Also prepared (name, starting compound, yield, m.p.) were: 1-phenyl-3-methyl-4-chloro-2-pyrazolin-5-one, IV, 94%, 153°; 1-phenyl-3-chloro-4-hydroxycarbostyril, V, quant., 264° (EtOH); 1-benzyl-3-chloro-4-hydroxycarbostyril, VI, quant., 253-4° (BuOH); 1-methyl-3-benzyl-4-hydroxycarbostyril, III, 86%, 213°. VII also was prepared in 94% yield by treating 0.2 g. II with 10 ml. 5% I in dioxane and 0.5 ml. concentrated HCl. CS(NH₂)₂ (3 g.) was partly dissolved in 40 ml. absolute EtOH and 1 ml. alc. HCl by heating at 50°, then the solution of II was added in small portions. Cooling caused precipitation of 2.5 g. diamidino disulfide dihydrochloride, m. 170° (decomposition).

Monatshefte fuer Chemie published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C22H18O2, Formula: C2H8Cl2N4S2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kunzek, Herbert published the artcileSelectively S-protected cysteine peptides. IV. Synthesis of cysteine peptides using the S-ethylthio protecting group. II, Formula: C2H8Cl2N4S2, the publication is Journal fuer Praktische Chemie (Leipzig) (1980), 322(2), 186-98, database is CAplus.

S-Guanylthiocysteine was treated with RSH (R = Et, Me₂CH) to give H-Cys(SR)-OH, which were treated with R¹F [R¹ = p-PhC₆H₄CMe₂O₂C (Bpoc), PhCMe₂O₂C (Ppoc)] to give R¹-Cys(R)-OH (R = Et, R¹ = Bpoc, Ppoc; R = CHMe₂, R¹ = Ppoc). Bpoc-Cys(SEt)-OH and Ppoc-Cys(SEt)-OH were used in the conventional solution synthesis of H-Val-Cys(SEt)-Ala-Leu-OCMe₃, which was coupled to BOC-Cys(SEt)-Cys(Dpm)-Ala-Gly-OH (BOC = Me₃CO₂C, Dpm = CHPh₂) by dicyclohexylcarbodiimide/N-hydroxybenzotriazole to give BOC-Cys(SEt)-Cys(Dpm)Ala-Gly-Val-Cys(SEt)-Ala-Leu-OCM₃ (I). In the above synthesis, the EtS group was stable in all steps, including deprotection of Bpoc and Ppoc group. I was EtS-deblocked by HSCH₂CH₂OH to give BOC-Cys-Cys(Dpm)-Ala-Gly-Val-Cys-Ala-Leu-OCMe₃, which was oxidized to give protected insulin A 6-13 analog II.

Journal fuer Praktische Chemie (Leipzig) published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Formula: C2H8Cl2N4S2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kirchnerova, Jitka published the artcileThe mechanism of the electrochemical oxidation of thiourea, Related Products of ethers-buliding-blocks, the publication is Analytica Chimica Acta (1981), 83-95, database is CAplus.

Cyclic voltammetry and potentiostatic coulometry were used to study the electrochem. oxidation of thiourea [62-56-6] in aqueous solutions of HNO₃, HNO₃-NH₄NO₃, and NH₄NO₃-NH₄OH in MeCN. These studies were carried out at glassy C and/or Pt working electrodes. In MeCN, the cyclic voltammograms show 1 oxidation peak at ±0.6 V and a reduction peak at -0.1 V. In aqueous solutions up to about pH 6, there is a 2nd oxidation peak at 1.3 V which is irreversible and its height is sensitive to acidity. These experiments have confirmed that in acidic and neutral solutions, the oxidation of thiourea proceeds via a slow 1-electron transfer reaction producing a (NH₂)₂CS radical cation [61347-13-5]. Further direct oxidation of this radical takes place only at higher potentials (∼1.2 V) and involves hydration and proton-transfer equilibrium Otherwise, C,C‘-dithiodiformamidinium ion [64035-50-3] is formed by a fast dimerization reaction. Coulometric and chronopotentiometric measurements showed that in strong acid, the 2nd oxidation step involves 1 electron, while at lower acidities the further oxidation involving 3 (and possibly 5 electrons) proceeds in 2 (or 3) steps of very similar potential.

Analytica Chimica Acta published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem