Category: 140715-61-3

Multitarget-directed resveratrol derivatives: anti-cholinesterases, anti-β-amyloid aggregation and monoamine oxidase inhibition properties against Alzheimer’s disease was written by Pan, Long-Fei;Wang, Xiao-Bing;Xie, Sai-Sai;Li, Su-Yi;Kong, Ling-Yi. And the article was included in MedChemComm in 2014.COA of Formula: C10H15NO The following contents are mentioned in the article:

Considering the complex pathogenesis factors of Alzheimer’s disease (AD), the multitarget-directed ligand strategy is expected to provide superior effects to fight AD, instead of the classic one-drug-one-target strategy. Resveratrol, exhibiting important properties against AD, was suggested to be used as a starting compound for the treatment of AD. Based on these reasons, a series of resveratrol derivatives were designed, synthesized and biol. evaluated. Among them, compound 6r, exhibiting moderate cholinesterase inhibition activity (AChE, IC₅₀ = 6.55 μM; BuChE, IC₅₀ = 8.04 μM; SI = 1.23), significant inhibition of Aβ₄₂ aggregation (57.78%, at 20 μM) and acceptable inhibitory activity against monoamine oxidases (MAO-A, IC₅₀ = 17.58 μM; MAO-B, IC₅₀ = 12.19 μM), was a potential anti-Alzheimer agent with balanced activities. Consequently, this study provided useful information for further development of resveratrol derivatives as multitarget-directed agents for AD therapy. This study involved multiple reactions and reactants, such as N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3COA of Formula: C10H15NO).

N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.COA of Formula: C10H15NO

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Ether | (C2H5)2O – PubChem

Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors was written by Yin, Yan;Lin, Li;Ruiz, Claudia;Cameron, Michael D.;Pocas, Jennifer;Grant, Wayne;Schroeter, Thomas;Chen, Weimin;Duckett, Derek;Schuerer, Stephan;Lo Grasso, Philip;Feng, Yangbo. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.SDS of cas: 140715-61-3 The following contents are mentioned in the article:

A series of benzothiazole derivatives as ROCK inhibitors have been discovered. Compounds with good biochem. and cellular potency, and sufficient kinase selectivity have been identified. This study involved multiple reactions and reactants, such as N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3SDS of cas: 140715-61-3).

N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.SDS of cas: 140715-61-3

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Ether – Wikipedia,
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Pyrano-[2,3b]-pyridines as potassium channel antagonists was written by Finlay, Heather J.;Lloyd, John;Nyman, Michael;Conder, Mary Lee;West, Tonya;Levesque, Paul;Atwal, Karnail. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Quality Control of N-(3-Methoxybenzyl)ethanamine The following contents are mentioned in the article:

The design and synthesis of a series of highly functionalized pyrano[2,3-b]pyridines is described. These compounds were assayed for their ability to block the I_Kur channel encoded by the gene hKV1.5 in patch-clamped L-929 cells. Six of the compounds in this series showed sub-micromolar activity, the most potent being 4-(4-ethylbenzenesulfonylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-6-carboxylic acid N-ethyl-N-phenylamide with an IC₅₀ of 378 nM. This study involved multiple reactions and reactants, such as N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3Quality Control of N-(3-Methoxybenzyl)ethanamine).

N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Quality Control of N-(3-Methoxybenzyl)ethanamine

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (Part-II) was written by Sessions, E. Hampton;Chowdhury, Sarwat;Yin, Yan;Pocas, Jennifer R.;Grant, Wayne;Schroeter, Thomas;Lin, Li;Ruiz, Claudia;Cameron, Michael D.;LoGrasso, Philip;Bannister, Thomas D.;Feng, Yangbo. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Application In Synthesis of N-(3-Methoxybenzyl)ethanamine The following contents are mentioned in the article:

Therapeutic interventions with Rho kinase (ROCK) inhibitors may effectively treat several disorders such as hypertension, stroke, cancer, and glaucoma. Herein we disclose the optimization and biol. evaluation of potent novel ROCK inhibitors based on substituted indole and 7-azaindole core scaffolds, e.g. I, II and III (X = N, CH). Substitutions on the indole C3 position and on the indole NH and/or amide NH positions all yielded potent and selective ROCK inhibitors. Improvement of aqueous solubility and tailoring of in vitro and in vivo DMPK properties could be achieved through these substitutions. This study involved multiple reactions and reactants, such as N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3Application In Synthesis of N-(3-Methoxybenzyl)ethanamine).

N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application In Synthesis of N-(3-Methoxybenzyl)ethanamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pyrano-[2,3b]-pyridines as potassium channel antagonists was written by Finlay, Heather J.;Lloyd, John;Nyman, Michael;Conder, Mary Lee;West, Tonya;Levesque, Paul;Atwal, Karnail. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Quality Control of N-(3-Methoxybenzyl)ethanamine The following contents are mentioned in the article:

The design and synthesis of a series of highly functionalized pyrano[2,3-b]pyridines is described. These compounds were assayed for their ability to block the I_Kur channel encoded by the gene hKV1.5 in patch-clamped L-929 cells. Six of the compounds in this series showed sub-micromolar activity, the most potent being 4-(4-ethylbenzenesulfonylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-6-carboxylic acid N-ethyl-N-phenylamide with an IC₅₀ of 378 nM. This study involved multiple reactions and reactants, such as N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3Quality Control of N-(3-Methoxybenzyl)ethanamine).

N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Quality Control of N-(3-Methoxybenzyl)ethanamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (Part-II) was written by Sessions, E. Hampton;Chowdhury, Sarwat;Yin, Yan;Pocas, Jennifer R.;Grant, Wayne;Schroeter, Thomas;Lin, Li;Ruiz, Claudia;Cameron, Michael D.;LoGrasso, Philip;Bannister, Thomas D.;Feng, Yangbo. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Application In Synthesis of N-(3-Methoxybenzyl)ethanamine The following contents are mentioned in the article:

Therapeutic interventions with Rho kinase (ROCK) inhibitors may effectively treat several disorders such as hypertension, stroke, cancer, and glaucoma. Herein we disclose the optimization and biol. evaluation of potent novel ROCK inhibitors based on substituted indole and 7-azaindole core scaffolds, e.g. I, II and III (X = N, CH). Substitutions on the indole C3 position and on the indole NH and/or amide NH positions all yielded potent and selective ROCK inhibitors. Improvement of aqueous solubility and tailoring of in vitro and in vivo DMPK properties could be achieved through these substitutions. This study involved multiple reactions and reactants, such as N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3Application In Synthesis of N-(3-Methoxybenzyl)ethanamine).

N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application In Synthesis of N-(3-Methoxybenzyl)ethanamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Central cholinergic agents. I. Potent acetylcholinesterase inhibitors, 2-[ω-[N-alkyl-N-(ω-phenylalkyl)amino]alkyl]-1H-isoindole-1,3(2H)-diones, based on a new hypothesis of the enzyme’s active site was written by Ishihara, Yuji;Kato, Koki;Goto, Giichi. And the article was included in Chemical & Pharmaceutical Bulletin in 1991.Name: N-(3-Methoxybenzyl)ethanamine The following contents are mentioned in the article:

It has been suggested that the active site of acetylcholinesterase contains a hydrophobic binding site (HBS-1), which is closely adjacent to both the anionic and the esteratic sites. In this paper, we assumed that there exists another hydrophobic binding site (HBS-2), some distance removed from the anionic site. On this assumption, a new working hypothesis was proposed for the design of acetylcholinesterase inhibitors. A series of 2-[ω-[N-alkyl-N-(ω-phenylalkyl)amino]alkyl]-1H-isoindole-1,3(2H)-diones (I, X = e.g., O₂N, OH, Me, Cl, amino group, or COPh, Y = e.g., H, halo OMe, R = H or alkyl, n = 3-9, m = 1-4) was designed based on this hypothesis and tested for its inhibitory activities on acetylcholinesterase. Some in this series were revealed to be more potent than physostigmine. Optimum activity was found to be associated with a five carbon chain length separating the benzylamino group from the 1H-isoindole-1,3(2H)-dione (phthalimide) moiety. Quant. study of substitution effect on the phthalimide moiety revealed that hydrophilic and electron-withdrawing groups enhance the activity. This study involved multiple reactions and reactants, such as N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3Name: N-(3-Methoxybenzyl)ethanamine).

N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Name: N-(3-Methoxybenzyl)ethanamine

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Efficient and Mild Reductive Amination of Carbonyl Compounds Catalyzed by Dual-Function Palladium Nanoparticles was written by Jv, Xinchun;Sun, Shuting;Zhang, Qun;Du, Muyao;Wang, Lan;Wang, Bo. And the article was included in ACS Sustainable Chemistry & Engineering in 2020.Computed Properties of C10H15NO The following contents are mentioned in the article:

Primary amines are valuable building blocks for a large number of chems., developing efficient synthetic routes toward primary amines and particularly those proceeding under mild conditions are highly desirable and rather challenging. Presented here is a highly efficient procedure enabling itself to proceed in H₂O using H₂ of 1 atm (0.1 MPa) for the reductive amination of carbonyl compounds Several palladium-based nanoparticle (Pd-NP) catalysts were prepared, and one emerged to be the most suitable and classified as nanoparticles, due to its high catalytic activity, reactions were allowed to proceed at room temperature using NH₃, and the corresponding primary amines can be afforded with yields of up to 99%. Some control reactions were carried out, revealing that H₂ is pivotal for activating the Pd-NPs. The fact that the Pd-NPs can catalyze both reductive amination of carbonyl compounds and hydrogenation of imines proves Pd-NPs to be a dual-function catalyst, and a plausible mechanism was proposed. A dual-function catalyst promoted the reductive amination of carbonyl compounds with high efficiency using NH₃·H₂O and H₂ (1 atm) under mild conditions and generated H₂O as the sole byproduct. This study involved multiple reactions and reactants, such as N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3Computed Properties of C10H15NO).

N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Computed Properties of C10H15NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and Biological Evaluation of Urea Derivatives as Highly Potent and Selective Rho Kinase Inhibitors was written by Yin, Yan;Lin, Li;Ruiz, Claudia;Khan, Susan;Cameron, Michael D.;Grant, Wayne;Pocas, Jennifer;Eid, Nibal;Park, HaJeung;Schroter, Thomas;LoGrasso, Philip V.;Feng, Yangbo. And the article was included in Journal of Medicinal Chemistry in 2013.COA of Formula: C10H15NO The following contents are mentioned in the article:

(Benzylureido)arylpyrazoles such as I [R = Me, Et, cyclopropyl, Me₂CH, HOCH₂CH₂, MeOCH₂CH₂, H₂NCH₂CH₂, Me₂NCH₂CH₂, 2-(1-pyrrolidinyl)ethyl, 3-(1-pyrrolidinyl)propyl, 2-(4-morpholinyl)ethyl, 3-(4-morpholinyl)propyl, 2-(1-piperidinyl)ethyl, 3-(1-piperidinyl)propyl; R¹ = H, MeO] were prepared to determine the relationship of structure to their inhibition of rho-associated coiled-coil protein kinase II (α) (ROCK-II). The selectivities of (benzylureido)arylpyrazoles for ROCK-II over protein kinase A, their functional activity in vitro, and their stabilities in human liver microsomes were determined The selectivities of selected (benzylureido)arylpyrazoles such as I [R = Me, HOCH₂CH₂, Me₂NCH₂CH₂, 2-(1-pyrrolidinyl)ethyl, 2-(4-morpholinyl)ethyl, 2-(1-piperidinyl)ethyl; R¹ = H, MeO] for ROCK-II over ROCK-I, JNK, and p38α, their inhibition of cytochrome P₄₅₀ isoforms 1A2, 2C9, 2D6, and 3A4, and their i.v. pharmacokinetics (clearance, volume of distribution, half-life, AUC, maximal concentration in plasma, and bioavailablity) at doses of 1 and 2 mg/kg were determined; the structures of selected compounds bound to ROCK-II were also determined by mol. docking calculations Benzylureidoarylpyrazoles lacking tertiary amino groups such as I (R = Me, HOCH₂CH₂; R¹ = H, MeO) had good pharmacokinetic properties in rats, while those possessing tertiary amino groups such as I [R = 2-(1-pyrrolidinyl)ethyl, 2-(4-morpholinyl)ethyl, 2-(1-piperidinyl)ethyl; R¹ = MeO] had poor pharmacokinetic properties in rats but good aqueous solubilities. (α-Substituted benzyl)ureidoarylpyrazoles were potent ROCK-II inhibitors with high selectivities for ROCK-II over protein kinase A and better microsomal stabilities than (benzylureido)arylpyrazoles substituted at either the urea nitrogen atoms or the central aryl ring and are potentially optimizable as ROCK-II inhibitors. This study involved multiple reactions and reactants, such as N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3COA of Formula: C10H15NO).

N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.COA of Formula: C10H15NO

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Ether – Wikipedia,
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Diethylaminoalkylamino derivatives of carbocyclic series was written by Wojahn, Hans;Erdelmeier, Karl. And the article was included in Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft in 1942.Synthetic Route of C10H15NO The following contents are mentioned in the article:

Et₂NCH₂Ac (7 g.) and 5.5 g. m-H₂NC₆H₄OH (I) in 10 cc. EtOH, heated on the water bath for 10 min. and the solution catalytically reduced, give 3 g. of m-hydroxy-[N-(2-diethylamino-1-methylethyl)amino]benzene (II), b₁₆ 185-90°; di-HCl salt, m. 193-4°. I (5.5 g.) and 7.5 g. Et₂N(CH₂)₃Cl, refluxed in 50 cc. C₆H₆ for 12 h., give 6 g. of the N-(3-diethylaminopropyl) isomer of II, b₁₆ 185°; dipicrolonate, m. 214-15°. Et₂NCH₂CMe₂CHO gives the N-(3-diethylamino-2,2-dimethylpropyl) homolog, b₁₄ 180-5°; dipicrolonate, m. 234° (decomposition). 5-Diethylamino-2-pentanone (5.5 g.) and 3.5 g. of I yield 2 g. of the N-[4-diethylamino-1-methylbutyl] homolog of II, b₁₆ 175-8°; dipicrolonate, m. 226°. o-HOC₆H₄CHO and Et₂NCH₂CH₂NH₂, heated 10 min. on the water bath and the Schiff base catalytically reduced, give a poor yield of o-hydroxy-N-(2-diethylaminoethyl)benzylamine (III), b₁₅ 181°; dipicrate, m. 196-7° (decomposition); dipicrolonate, m. 211-12°; the m-HO isomer of III, b₁₄ 184-6°; dipicrolonate, m. 197-9°; the p-HO isomer, b₁₃ 180-2°; dipicrolonate, m. 209°; N-(3-diethylaminopropyl) homolog (IV) of III, b₁₄ 184-7° (3-g. yield from 3.5 g. of o-HOC₆H₄CHO); the m-HO isomer of IV, b₁₆ 200-3°; dipicrolonate, m. 213-15°. o-MeOC₆H₄CH₂NH₂ (5.5 g.) and 5.4 g. of Et₂NCH₂CH₂Cl in 20 cc. EtOH containing 5.5 g. AcONa, refluxed 8 h., give 5 g. of o-methoxy-N-(2-diethylaminoethyl)benzylamine (V), b₁₄ 204-6°; dipicrolonate, yellow, m. 205-7°; p-MeO isomer, b₁₈ 203-5°; dipicrate, m. 140-1°. o-EtO homolog of V, b₁₄ 205-7°; dipicrate, m. 154°. o-MeOC₆H₄CHO and Et₂N(CH₂)₃NH₂ give o-methoxy-N-(3-diethylaminopropyl)benzylamine (VI), b₁₆ 177°; dipicrolonate, m. 212-14°; m-MeO isomer, b₁₃ 191°; dipicrolonate, m. 210-11°; p-MeO isomer, b₁₆ 170°; dipicrolonate, m. 206°; o-EtO homolog of VI, b₁₄ 177°; dipicrolonate, m. 212-14°. o-Methoxy-N-(3-diethylamino-2,2-dimethylpropyl)benzylamine (VII), b₁₄ 186°; dipicrolonate, m. 208-10°; m-MeO isomer, b₁₃ 186°; dipicrolonate, m. 204°; p-MeO isomer, b₁₄ 205°; dipicrolonate, m. 217°. o-EtO homolog of VII, b₁₄ 203-4°; dipicrolonate, m. 202°. o-Methoxy-N-(4-diethylamino-1-methylbutyl)benzylamine, b₁₄ 190-4°; dipicrolonate, m. 149°; m-MeO isomer, b₁₅ 207-13°; dipicrolonate, m. 149°; p-MeO isomer, b₁₄ 203-8°; dipicrolonate, m. 204°. o-MeOC₆H₄CHO, 15 g. MeNH₂.HCl, 15 g. HCO₂Na and 20 g. anhydrous HCO₂H, heated at 150° for 3-4 h., give 13 g. of the formyl derivative, b₁₄ 180-5°; refluxing with 20% HCl for 4 h. gives 8 g. of N-methyl-o-methoxybenzylamine (VIII), b. 226°; picrolonate, m. 176°; p-MeO isomer, b. 238°; formyl derivative, b. 317°. N-Ethyl-o-methoxybenzylamine (IX), b. 238°; formyl derivative, b₁₄ 185-90°; picrolonate, m. 186-80°; m-MeO isomer, b. 245°; formyl derivative, b₁₄ 185-90°; picrolonate, m. 190°; p-MeO isomer, b. 244°; formyl derivative, b₁₄ 187-90°; picrolonate, m. 210°. VIII (3.1 g.), heated with 2.8 g. Et₂NCH₂CH₂Cl and 2.8 g. AcONa in 20 cc. AcOH for 8 h. on the water bath, gives 50% of N-methyl-N-(2-diethylaminoethyl)-o-methoxybenzylamine (X), b₁₄ 170-5°; dipicrolonate, m. 166°; p-MeO isomer, b₁₄ 172-7°; dipicrolonate, m. 195°. N-Et homolog of X, prepared from IX, b₁₄ 185-90°; dipicrolonate, m. 187°; m-MeO isomer, b₁₆ 180-5°; dipicrolonate, m. 200°; p-MeO isomer, b₁₄ 175-80°; dipicrolonate, m. 195°. VIII and Et₂N(CH₂)₃Cl give N-methyl-N-(3-diethylaminopropyl)-o-methoxybenzylamine (XI), b₁₆ 175-80°; dipicrolonate, m. 177°; p-MeO isomer, b₁₄ 195-200°; dipicrolonate, m. 190°. IX gives the N-Et homolog of XI, b₁₄ 187-9°; dipicrolonate, m. 170°; p-MeO isomer, b₁₄ 185-90°; dipicrolonate, m. 210°. This study involved multiple reactions and reactants, such as N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3Synthetic Route of C10H15NO).

N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C10H15NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem