Category: 13940-96-0

Electric Literature of 13940-96-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13940-96-0, name is 4-Phenoxybenzene-1,2-diamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of Intermediate AC (395 mg,1 .97 mmol) in EtOH (10 mL) was added 1,3- bis(methoxycarbonyl)-2-methyl-2-thiopseudourea (427 mg,2.07 mmol),and the mixture was heated to reflux for 18h. After cooling to r.t.,Eta0 was added and the resultant solid collected by filtration (washing with EtOH/Et20) to afford the title compound as an off-white solid (436 mg,78%).1H NMR 6H (500 MHz,DMSO-d6) 11 .61 (br s,2H),7.40 (d,J = 8.5 Hz,1 H),7.38 – 7.32 (m,2H),7.09 – 7.03 (m,2H),6.97 – 6.92 (m,2H),6.81 (dd,J = 8.5,2.4 Hz,1 H),3.75 (s,3H); LCMS (Method A): 3.24 min,(284.2,MH+).

The synthetic route of 4-Phenoxybenzene-1,2-diamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLOBACHEM NV; URCH, Christopher, John; JACKSON, Victoria, Elizabeth; JORDAN, Linda; BURGIN, Ryan, Neil; (180 pag.)WO2019/141980; (2019); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13940-96-0, name is 4-Phenoxybenzene-1,2-diamine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 13940-96-0

20 ml of 6N HC1 was added to 1000 mg of 4-phenoxybenzene-l, 2-diamine in round bottom flask. Then add 500 pL of thioglycolicacid. This reaction mixture was refluxed for 4 hours. Excess solvent was evaporated under reduced pressure and to the remaining residue water (30 ml) was added and then extraction with ethyl acetate. The organic solvent was then dried over anhydrous MgS04 and evaporated under reduced pressure. The crude product was directly used in the next step without any further purification. LC.MS: m/z 257.06 (M+H)+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 13940-96-0.

Electric Literature of 13940-96-0, These common heterocyclic compound, 13940-96-0, name is 4-Phenoxybenzene-1,2-diamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

For preparing the 3,4-diamino-diphenyl ether used as starting material, 172.5 g of 5-chloro-2-nitro-aniline were heated for 4 hours under reflux in 500 ml of dimethylformamide with 94 g of phenol in the presence of 150 g of anhydrous potassium carbonate. After cooling, the reaction mixture was diluted with 1000 ml of water, the 3-amino-4-nitro-diphenyl ether that had precipitated was filtered off with suction and purified by recrystallization from isopropanol. Yield: 110 g; melting point: 142C. 103 g Of the 3-amino-4-nitro-diphenyl ether so obtained were hydrogenated in 800 ml of dimethylformamide with Raney nickel under a pressure of 100 atmospheres gauge at room temperature, the catalyst was then removed by filtration and the solution was evaporated under reduced pressure. The 3,4-diamino-diphenyl ether that had formed was obtained in the form of a sirupy mass which was dissolved in ethanol and used in the reaction as described above.

The synthetic route of 13940-96-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hoechst Aktiengesellschaft; US3954791; (1976); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 13940-96-0, The chemical industry reduces the impact on the environment during synthesis 13940-96-0, name is 4-Phenoxybenzene-1,2-diamine, I believe this compound will play a more active role in future production and life.

In a 1000 ml flask equipped with a stirring blade and a reflux condenser, 750 g of a methyl t-butyl ether solution containing 12% by mass of 3,4-diaminodiphenyl ether and 150.8 g (1.13 mol) of acetic anhydride were charged, The reaction was carried out for 2 hours under heating reflux. From the reaction solution, about 500 g of methyl t-butyl ether was distilled off under reduced pressure to obtain a concentrated solution. The obtained concentrated liquid was poured into 1,000 g of a 20% sodium hydroxide aqueous solution to precipitate an N, N-diacetylated product of 3,4-diaminodiphenyl ether to obtain a solid-liquid mixture.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Phenoxybenzene-1,2-diamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JFE CHEMICAL CORPORATION; MORI, HIROAKI; (9 pag.)JP2016/6020; (2016); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem