Category: 139115-91-6

Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateIn 2022 ,《Detecting the insoluble protein aggregates in live cells using an AIE derivative of fluorescent protein chromophore》 appeared in Sensors and Actuators, B: Chemical. The author of the article were Liu, Lihua; Jin, Wenhan; Huang, Yanan; Dai, Jianan; Zheng, Xuwei; Liu, Yu; Ju, Minzi; Shen, Baoxing. The article conveys some information:

Many incurable or unmanageable human protein conformational diseases are associated with the misfolding or aggregation of the aberrantly processed or mutant proteins. In this work, we report an aggregation-induced emission (AIE) derivative of fluorescent protein chromophore used to detect the insoluble protein aggregates in live cells. Based on the 4-hydroxybenzylidene-imidazolinone (HBI), we designed and synthesized a series of AIEgens that span a wide range of viscosity coefficients (χ), thus mimicking the viscous microenvironment of a wide variety of amorphous protein aggregates. The mechanism of these AIEgens were systematically investigated using a combination of photophys. studies, computational analyses and structure-function studies. With the aid of the AggTag method, the optimized probe was used to realize the imaging of the aggregated proteome under the control of the proteostasis network. Besides, we also described the formation and decomposition of protein aggregates under the control of small mol. proteostasis regulators. Briefly, we developed a series of AIEgens that explore varying viscosity sensitivities to visualize protein aggregation in live cells as well as study other biol. processes that associated with local viscosity changes. The results came from multiple reactions, including the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 139115-91-6In 2018 ,《Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis》 appeared in Nature (London, United Kingdom). The author of the article were Wyllie, Susan; Thomas, Michael; Patterson, Stephen; Crouch, Sabrinia; De Rycker, Manu; Lowe, Rhiannon; Gresham, Stephanie; Urbaniak, Michael D.; Otto, Thomas D.; Stojanovski, Laste; Simeons, Frederick R. C.; Manthri, Sujatha; MacLean, Lorna M.; Zuccotto, Fabio; Homeyer, Nadine; Pflaumer, Hannah; Boesche, Markus; Sastry, Lalitha; Connolly, Paul; Albrecht, Sebastian; Berriman, Matt; Drewes, Gerard; Gray, David W.; Ghidelli-Disse, Sonja; Dixon, Susan; Fiandor, Jose M.; Wyatt, Paul G.; Ferguson, Michael A. J.; Fairlamb, Alan H.; Miles, Timothy J.; Read, Kevin D.; Gilbert, Ian H.. The article conveys some information:

Visceral leishmaniasis causes considerable mortality and morbidity in many parts of the world. There is an urgent need for the development of new, effective treatments for this disease. Here we describe the development of an anti-leishmanial drug-like chem. series based on a pyrazolopyrimidine scaffold. The leading compound from this series (7, DDD853651/GSK3186899) is efficacious in a mouse model of visceral leishmaniasis, has suitable physicochem., pharmacokinetic and toxicol. properties for further development, and has been declared a preclin. candidate. Detailed mode-of-action studies indicate that compounds from this series act principally by inhibiting the parasite cdc-2-related kinase 12 (CRK12), thus defining a druggable target for visceral leishmaniasis. The experimental process involved the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Application of 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Application of 139115-91-6

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2016,Almaliti, Jehad; Al-Hamashi, Ayad A.; Negmeldin, Ahmed T.; Hanigan, Christin L.; Perera, Lalith; Pflum, Mary Kay H.; Casero, Robert A.; Tillekeratne, L. M. Viranga published 《Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue》.Journal of Medicinal Chemistry published the findings.Category: ethers-buliding-blocks The information in the text is summarized as follows:

A number of analogs of the marine-derived histone deacetylase inhibitor largazole incorporating major structural changes in the depsipeptide ring were synthesized. Replacing the thiazole-thiazoline fragment of largazole with a bipyridine group gave analog (I) with potent cell growth inhibitory activity and an activity profile similar to that of largazole, suggesting that conformational change accompanying switching hybridization from sp3 to sp2at C-7 is well tolerated. Analog I was more class I selective compared to largazole, with at least 464-fold selectivity for class I HDAC proteins over class II HDAC6 compared to a 22-fold selectivity observed with largazole. To our knowledge I represents the first example of a potent and highly cytotoxic largazole analog not containing a thiazoline ring. The elimination of a chiral center derived from the unnatural amino acid (R)-α-methylcysteine makes the mol. more amenable to chem. synthesis and, coupled with its increased class I selectivity, I could serve as a new lead compound for developing selective largazole analogs. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Category: ethers-buliding-blocks)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Category: ethers-buliding-blocks

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Subtype-Selective Fluorescent Ligands as Pharmacological Research Tools for the Human Adenosine A2A Receptor》 was written by Comeo, Eleonora; Kindon, Nicholas D.; Soave, Mark; Stoddart, Leigh A.; Kilpatrick, Laura E.; Scammells, Peter J.; Hill, Stephen J.; Kellam, Barrie. Related Products of 139115-91-6 And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

Among class A G protein-coupled receptors (GPCR), the human adenosine A2A receptor (hA2AAR) remains an attractive drug target. However, translation of A2AAR ligands into the clinic has proved challenging and an improved understanding of A2AAR pharmacol. could promote development of more efficacious therapies. Subtype-selective fluorescent probes would allow detailed real-time pharmacol. investigations both in vitro and in vivo. In the present study, two families of fluorescent probes were designed around the known hA2AAR selective antagonist preladenant (SCH 420814). Both families of fluorescent antagonists retained affinity at the hA2AAR, selectivity over all other adenosine receptor subtypes and allowed clear visualization of specific receptor localization through confocal imaging. Furthermore, the Alexa Fluor 647-labeled conjugate allowed measurement of ligand binding affinities of unlabeled hA2AAR antagonists using a bioluminescence resonance energy transfer (NanoBRET) assay. The fluorescent ligands developed here can therefore be applied to a range of fluorescence-based techniques to further interrogate hA2AAR pharmacol. and signaling.tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Related Products of 139115-91-6) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Related Products of 139115-91-6Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateIn 2015 ,《Protease-triggered siRNA delivery vehicles》 appeared in Journal of Controlled Release. The author of the article were Rozema, David B.; Blokhin, Andrei V.; Wakefield, Darren H.; Benson, Jonathan D.; Carlson, Jeffrey C.; Klein, Jason J.; Almeida, Lauren J.; Nicholas, Anthony L.; Hamilton, Holly L.; Chu, Qili; Hegge, Julia O.; Wong, So C.; Trubetskoy, Vladimir S.; Hagen, Collin M.; Kitas, Eric; Wolff, Jon A.; Lewis, David L.. The article conveys some information:

The safe and efficacious delivery of membrane impermeable therapeutics requires cytoplasmic access without the toxicity of nonspecific cytoplasmic membrane lysis. We have developed a mechanism for control of cytoplasmic release which utilizes endogenous proteases as a trigger and results in functional delivery of small interfering RNA (siRNA). The delivery approach is based on reversible inhibition of membrane disruptive polymers with protease-sensitive substrates. Proteolytic hydrolysis upon endocytosis restores the membrane destabilizing activity of the polymers thereby allowing cytoplasmic access of the co-delivered siRNA. Protease-sensitive polymer masking reagents derived from polyethylene glycol (PEG), which inhibit membrane interactions, and N-acetylgalactosamine, which targets asialoglycoprotein receptors on hepatocytes, were synthesized and used to formulate masked polymer-siRNA delivery vehicles. The size, charge and stability of the vehicles enable functional delivery of siRNA after s.c. administration and, with modification of the targeting ligand, have the potential for extrahepatic targeting. The results came from multiple reactions, including the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated》 were Geraldy, Magalie; Morgen, Michael; Sehr, Peter; Steimbach, Raphael R.; Moi, Davide; Ridinger, Johannes; Oehme, Ina; Witt, Olaf; Malz, Mona; Nogueira, Mauro S.; Koch, Oliver; Gunkel, Nikolas; Miller, Aubry K.. And the article was published in Journal of Medicinal Chemistry in 2019. Formula: C9H19NO4 The author mentioned the following in the article:

The discovery of isoenzyme-selective histone deacetylase (HDAC) inhibitors is critical for understanding the biol. functions of individual HDACs and for validating HDACs as drug targets. The isoenzyme HDAC10 contributes to chemotherapy resistance and has recently been described to be a polyamine deacetylase, but no studies toward selective HDAC10 inhibitors have been published. Using two complementary assays, the authors found tubastatin A, an HDAC6 inhibitor, to potently bind HDAC10. The authors synthesized tubastatin A derivatives and found that a basic amine in the cap group was required for strong HDAC10 binding. HDAC10 inhibitors mimicked knockdown by causing dose-dependent accumulation of acidic vesicles in a neuroblastoma cell line. Furthermore, docking into human HDAC10 homol. models indicated that a hydrogen-bond between a cap group nitrogen and the gatekeeper residue Glu272 was responsible for potent HDAC10 binding. Taken together, the authors’ data provide an optimal platform for the development of HDAC10-selective inhibitors, as exemplified with the tubastatin A scaffold. In the experiment, the researchers used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Formula: C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Formula: C9H19NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kawashita, Seiji; Aoyagi, Koichi; Fukushima, Kyoko; Hantani, Rie; Naruoka, Shiori; Tanimoto, Atsuo; Hori, Yuji; Toyonaga, Yukiyo; Yamanaka, Hiroshi; Miyazaki, Susumu; Hantani, Yoshiji published an article in 2021. The article was titled 《SAR study of small molecule inhibitors of the programmed cell death-1/programmed cell death-ligand 1 interaction》, and you may find the article in Chemical Biology & Drug Design.Related Products of 139115-91-6 The information in the text is summarized as follows:

The development of small mol. inhibitors of programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) has drawn research interest for the treatment of cancer. Recently, we reported the discovery of a novel dimeric core small mol. PD-1/PD-L1 inhibitor. In an effort to discover more potent inhibitors, we further explored the dimeric core scaffold. Our investigations of the structure-activity-relationship revealed that introduction of lipophilic substituents onto one of the di-alkoxylated Ph rings improved binding affinities to PD-L1, and inhibitory activities of PD-1/PD-L1 in cellular assays. Furthermore, conversion of the ether linker part to an olefin linker not only improved binding affinity but also led to slow dissociation binding kinetics. We also explored more potent, as well as downsized, scaffolds. Compounds bearing a linear chain in place of one of the di-alkoxylated Ph rings exhibited good binding affinity with improved ligand efficiency (LE). Representative compounds demonstrated potent inhibitory activities of PD-1/PD-L1 in the submicromolar range in cellular assays as well as cellular function in the mixed lymphocyte reaction (MLR) assay with efficacy comparable to anti-PD-1 antibody. Our results provide applicable information for the design of more potent inhibitors targeting PD-1/PD-L1 pathway. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Related Products of 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Related Products of 139115-91-6Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2018,Journal of the American Chemical Society included an article by Liu, Yu; Wolstenholme, Charles H.; Carter, Gregory C.; Liu, Hongbin; Hu, Hang; Grainger, Leeann S.; Miao, Kun; Fares, Matthew; Hoelzel, Conner A.; Yennawar, Hemant P.; Ning, Gang; Du, Manyu; Bai, Lu; Li, Xiaosong; Zhang, Xin. Product Details of 139115-91-6. The article was titled 《Modulation of Fluorescent Protein Chromophores To Detect Protein Aggregation with Turn-On Fluorescence》. The information in the text is summarized as follows:

We present a fluorogenic method to visualize misfolding and aggregation of a specific protein-of-interest in live cells using structurally modulated fluorescent protein chromophores. Combining photophys. anal., X-ray crystallog., and theor. calculation, we show that fluorescence is triggered by inhibition of twisted-intramol. charge transfer of these fluorophores in the rigid microenvironment of viscous solvent or protein aggregates. Bioorthogonal conjugation of the fluorophore to Halo-tag fused protein-of-interests allows for fluorogenic detection of both misfolded and aggregated species in live cells. Unlike other methods, our method is capable of detecting previously invisible misfolded soluble proteins. This work provides the first application of fluorescent protein chromophores to detect protein conformational collapse in live cells. In the experiment, the researchers used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Product Details of 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Product Details of 139115-91-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2018,Agrawalla, Bikram Keshari; Wang, Tao; Riegger, Andreas; Domogalla, Matthias P.; Steinbrink, Kerstin; Doerfler, Thilo; Chen, Xi; Boldt, Felix; Lamla, Markus; Michaelis, Jens; Kuan, Seah Ling; Weil, Tanja published 《Chemoselective Dual Labeling of Native and Recombinant Proteins》.Bioconjugate Chemistry published the findings.Name: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The information in the text is summarized as follows:

The attachment of two different functionalities in a site-selective fashion represents a great challenge in protein chem. The authors report site specific dual functionalization of peptides and proteins capitalizing on reactivity differences of cysteines in their free (thiol) and protected, oxidized (disulfide) forms. The dual functionalization of interleukin 2 and EYFP proceeded with no loss of bioactivity in a stepwise fashion applying maleimide and disulfide rebridging allyl-sulfone groups. In order to ensure broader applicability of the functionalization strategy, a novel, short peptide sequence that introduces a disulfide bridge was designed and site-selective dual labeling in the presence of biogenic groups was successfully demonstrated. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Name: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Name: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2017,Liu, Yu; Fares, Matthew; Dunham, Noah P.; Gao, Zi; Miao, Kun; Jiang, Xueyuan; Bollinger, Samuel S.; Boal, Amie K.; Zhang, Xin published 《AgHalo: A Facile Fluorogenic Sensor to Detect Drug-Induced Proteome Stress》.Angewandte Chemie, International Edition published the findings.Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The information in the text is summarized as follows:

Drug-induced proteome stress that involves protein aggregation may cause adverse effects and undermine the safety profile of a drug. Safety of drugs is regularly evaluated using cytotoxicity assays that measure cell death. However, these assays provide limited insights into the presence of proteome stress in live cells. A fluorogenic protein sensor is reported to detect drug-induced proteome stress prior to cell death. An aggregation prone Halo-tag mutant (AgHalo) was evolved to sense proteome stress through its aggregation. Detection of such conformational changes was enabled by a fluorogenic ligand that fluoresces upon AgHalo forming soluble aggregates. Using 5 common anticancer drugs, we exemplified detection of differential proteome stress before any cell death was observed Thus, this sensor can be used to evaluate drug safety in a regime that the current cytotoxicity assays cannot cover and be generally applied to detect proteome stress induced by other toxins. In the experimental materials used by the author, we found tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem