Category: 139115-91-6

Cassiano, Chiara; Morretta, Elva; Costantini, Matteo; Fassi, Enrico M. A.; Colombo, Giorgio; Sattin, Sara; Casapullo, Agostino published their research in Bioorganic Chemistry in 2021. The article was titled 《Analysis of Hsp90 allosteric modulators interactome reveals a potential dual action mode involving mitochondrial MDH2》.Related Products of 139115-91-6 The article contains the following contents:

Hsp90 (i.e., Heat shock protein 90) is a well-established therapeutic target for several diseases, ranging from misfolding-related disfunctions to cancer. In this framework, we have developed in recent years a family of benzofuran compounds that act as Hsp90 allosteric modulators. Such mols. can interfere with the stability of some relevant Hsp90 client oncoproteins, showing a low μM cytotoxic activity in vitro in cancer cell lines. Here we identify the target profile of these chem. probes by means of chem. proteomics, which established MDH2 (mitochondrial malate dehydrogenase) as an addnl. relevant cellular target that might help elucidate the mol. mechanism of their citotoxicity. Western blotting, DARTS (i.e., Drug Affinity Responsive Target Stability) and enzymic assays data confirmed a dose-dependent interaction of MDH2 with several members of the benzofuran Hsp90 modulators family and a computational model allowed to interpret the observed interactions. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Related Products of 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Related Products of 139115-91-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2011,Spaeth, Andreas; Gonschor, Janina; Koenig, Burkhard published 《Synthesis and binding properties of guanidinium biscarboxylates》.Monatshefte fuer Chemie published the findings.COA of Formula: C9H19NO4 The information in the text is summarized as follows:

The ammonium ion binding site of the enzyme glutaminase HisF inspired the design of guanidinium biscarboxylates as potential self-organized ionophores in mol. recognition. The syntheses of the title compounds based on aliphatic and aromatic building blocks, along with a general method for the preparation of δ-aminoethoxyacetic acids, are presented. Investigation of the binding properties of the title compounds in DMSO and methanol solution revealed no ammonium ion affinity, but interaction of the guanidinium moiety with acetate ions. In the experimental materials used by the author, we found tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6COA of Formula: C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. COA of Formula: C9H19NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2016,Chu, Hualei; Song, Yuanqing; Li, Jiehua; Luo, Feng; Tan, Hong; Huang, Guangsu; Fu, Qiang published 《A novel phosphatidylcholine-modified polyisoprene: synthesis and characterization》.Colloid and Polymer Science published the findings.Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The information in the text is summarized as follows:

Polyisoprene (PI) is the main component of natural rubber. To imitate natural rubber and understand the function of phospholipid in natural rubber, a novel phosphatidylcholine (PC)-modified polyisoprene (PI-pc) was synthesized using a PC and a com. PI. The PI is firstly brominated by N-bromosuccinimide, and then, di-Et malonate is introduced as a branch chain of PI. In sequence, the PC is imported into the branch chain of PI via condensation of the activated ester terminals in di-Et malonate and the amino terminals in PC to obtain the desired product PI-pc. The bulk structure of the prepared PI-pc is carefully characterized with NMR spectra (1H and 31P NMR), Fourier transform IR spectroscopy (FT-IR), gel permeation chromatograph (GPC), and differential scanning calorimetry (DSC). The introduction of PC to the branch chain of PI increases the mol. weight and also the glass transition (Tg) of the PI. The increment of Tgs and melting enthalpy for the PI-pcs from both solution and emulsion indicates that the attached PC is beneficial to the self-assembly of PI chains and thus promotes the crystallization Our present work provides a new method for importing PC to PI to imitate natural rubber, and also, the results could be a footstone for us to explore the effect of phospholipid on the property of natural rubber. The results came from multiple reactions, including the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2017,Zhang, Huaiying; Aonbangkhen, Chanat; Tarasovetc, Ekaterina V.; Ballister, Edward R.; Chenoweth, David M.; Lampson, Michael A. published 《Optogenetic control of kinetochore function》.Nature Chemical Biology published the findings.SDS of cas: 139115-91-6 The information in the text is summarized as follows:

Kinetochores act as hubs for multiple activities during cell division, including microtubule interactions and spindle checkpoint signaling. Each kinetochore can act autonomously, and activities change rapidly as proteins are recruited to, or removed from, kinetochores. Understanding this dynamic system requires tools that can manipulate kinetochores on biol. relevant temporal and spatial scales. Optogenetic approaches have the potential to provide temporal and spatial control with mol. specificity. Here we report new chem. inducers of protein dimerization that allow us to both recruit proteins to and release them from kinetochores using light. We use these dimerizers to manipulate checkpoint signaling and mol. motor activity. Our findings demonstrate specialized properties of the CENP-E (kinesin-7) motor for directional chromosome transport to the spindle equator and for maintenance of metaphase alignment. This work establishes a foundation for optogenetic control of kinetochore function, which is broadly applicable to exptl. probing of other dynamic cellular processes. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6SDS of cas: 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. SDS of cas: 139115-91-6 Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Postupalenko, Viktoriia; Marx, Leo; Viertl, David; Gsponer, Nadege; Gasilova, Natalia; Denoel, Thibaut; Schaefer, Niklaus; Prior, John O.; Hagens, Gerrit; Levy, Frederic; Garrouste, Patrick; Segura, Jean-Manuel; Nyanguile, Origene published an article in 2022. The article was titled 《Template directed synthesis of antibody Fc conjugates with concomitant ligand release》, and you may find the article in Chemical Science.COA of Formula: C9H19NO4 The information in the text is summarized as follows:

Antibodies are an attractive therapeutic modality for cancer treatment as they allow the increase of the treatment response rate and avoid the severe side effects of chemotherapy. Notwithstanding the strong benefit of antibodies, the efficacy of anti-cancer antibodies can dramatically vary among patients and ultimately result in no response to the treatment. Here, we have developed a novel means to regioselectively label the Fc domain of any therapeutic antibody with a radionuclide chelator in a single step chem., with the aim to study by SPECT/CT imaging if the radiolabeled antibody is capable of targeting cancer cells in vivo. A Fc-III peptide was used as bait to bring a carbonate electrophilic site linked to a metal chelator and to a carboxyphenyl leaving group in close proximity with an antibody Fc nucleophile amino acid (K317), thereby triggering the covalent linkage of the chelator to the antibody lysine, with the concomitant release of the carboxyphenyl Fc-III ligand. Using CHX-A′′-DTPA, we radiolabeled trastuzumab with indium-111 and showed in biodistribution and imaging experiments that the antibody accumulated successfully in the SK-OV-3 xenograft tumor implanted in mice. We found that our methodol. leads to homogeneous conjugation of CHX-A′′-DTPA to the antibody, and confirmed that the Fc domain can be selectively labeled at K317, with a minor level of unspecific labeling on the Fab domain. The present method can be developed as a clin. diagnostic tool to predict the success of the therapy. Furthermore, our Fc-III one step chem. concept paves the way to a broad array of other applications in antibody bioengineering. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6COA of Formula: C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. COA of Formula: C9H19NO4 They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2018,Yao, Hong; Wei, Guoxiang; Liu, Yanpeng; Yao, Hequan; Zhu, Zheying; Ye, Wencai; Wu, Xiaoming; Xu, Jinyi; Xu, Shengtao published 《Synthesis, Biological Evaluation of Fluorescent 23-Hydroxybetulinic Acid Probes, and Their Cellular Localization Studies》.ACS Medicinal Chemistry Letters published the findings.COA of Formula: C9H19NO4 The information in the text is summarized as follows:

23-Hydroxybetulinic acid (23-HBA) is a complex lupane triterpenoid, which has attracted increasing attention as an anticancer agent. However, its detailed mechanism of anticancer action remains elusive so far. To reveal its anticancer mode of action, a series of fluorescent 23-HBA derivatives conjugated with coumarin dyes were designed, synthesized, and evaluated for their antiproliferative activities. Subcellular localization and uptake profile studies of representative fluorescent 23-HBA probe 26c were performed in B16F10 cells, and the results suggested that probe 26c was rapidly taken up into B10F10 cells in a dose-dependent manner and mitochondrion was the main site of its accumulation. Further mode of action studies implied that the mitochondrial pathway was involved in 23-HBA-mediated apoptosis. Together, our results provided new clues for revealing the mol. mechanism of natural product 23-HBA for its further development into an antitumor agent. In the experimental materials used by the author, we found tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6COA of Formula: C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. COA of Formula: C9H19NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2016,Fabre, Benjamin; Picha, Jan; Vanek, Vaclav; Selicharova, Irena; Chrudinova, Martina; Collinsova, Michaela; Zakova, Lenka; Budesinsky, Milos; Jiracek, Jiri published 《Synthesis and evaluation of a library of trifunctional scaffold-derived compounds as modulators of the insulin receptor》.ACS Combinatorial Science published the findings.HPLC of Formula: 139115-91-6 The information in the text is summarized as follows:

We designed a combinatorial library of trifunctional scaffold-derived compounds, which were derivatized with 30 different inhouse-made azides. The compounds were proposed to mimic insulin receptor (IR)-binding epitopes in the insulin mol. and bind to and activate this receptor. This work has enabled us to test our synthetic and biol. methodol. and to prove its robustness and reliability for the solid-phase synthesis and testing of combinatorial libraries of the trifunctional scaffold-derived compounds Our effort resulted in the discovery of two compounds, which were able to weakly induce the autophosphorylation of IR and weakly bind to this receptor at a 0.1 mM concentration Despite these modest biol. results, which well document the well-known difficulty in modulating protein-protein interactions, this study represents a unique example of targeting the IR with a set of nonpeptide compounds that were specifically designed and synthesized for this purpose. We believe that this work can open new perspectives for the development of next-generation insulin mimetics based on the scaffold structure.tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6HPLC of Formula: 139115-91-6) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.HPLC of Formula: 139115-91-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Zinc(II)cyclen-peptide conjugates interacting with the weak effector binding state of Ras》 was written by Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard. Recommanded Product: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateThis research focused onzinc cyclen peptide conjugate Ras protein. The article conveys some information:

Zinc(II)cyclen-peptide hybrid compounds and bis-zinc(II)cyclen complexes are prepared as potential binders of the guanine nucleotide binding protein Ras, an important mol. switch in cellular signal transduction. The design of the compounds is based on the previous observation that zinc(II)cyclen complexes could serve as lead compounds for inhibitors of Ras-effector interaction and thus be able to interrupt Ras induced signal transduction. Zinc(II)cyclen selectively stabilizes conformational state 1 of active Ras, a conformational state with drastically decreased affinity to effector proteins like Raf-kinase. To achieve higher binding affinities of such Ras-Raf interaction inhibitors, zinc(II)cyclen conjugates with short peptides, derived from the sequence of the Ras-activator SOS, were prepared by solid phase synthesis protocols. Dinuclear bis-zinc(II)cyclen complexes were obtained from alkyne-azide cycloaddition reactions. NMR investigations of the prepared compounds revealed that the peptide conjugates do not lead to an increase in Ras binding affinity of the metal complex-peptide conjugates. The dinuclear zinc complexes lead to an immediate precipitation of the protein prohibiting spectroscopic investigations of their binding. In the experiment, the researchers used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Recommanded Product: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Recommanded Product: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateAlthough ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Rao, Desaboini Nageswara; Ji, Xincai; Miller, Stephen C. published an article in Chemical Science. The title of the article was 《Silicon functionalization expands the repertoire of Si-rhodamine fluorescent probes》.Name: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The author mentioned the following in the article:

Reported a broad range of silyl modifications that enabled brighter dyes, further red-shifting, new ways to modulate fluorescence and the introduction of handles for dye attachment, including fluorogenic labeling agents for nuclear DNA, SNAP-tag and HaloTag labeling. Modifications to the bridging silicon were therefore of broad utility to improve and expanded the applications of all Si-dyes.tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Name: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Name: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Li, Haiwei; Wang, Shouxin; Ma, Wenxiao; Cheng, Boyang; Yi, Yanliang; Ma, Xinyuan; Xiao, Sulong; Zhang, Lihe; Zhou, Demin published an article in Journal of Medicinal Chemistry. The title of the article was 《Discovery of Pentacyclic Triterpenoid PROTACs as a Class of Effective Hemagglutinin Protein Degraders》.Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The author mentioned the following in the article:

Influenza hemagglutinin that drives viral entry into cells via the membrane fusion process is an up-and-coming antiviral drug target. Herein, we described for the first time the design, synthesis, and biol. characteristics of a new class of pentacyclic triterpenoid-based proteolysis targeting chimeras (PROTACs) to enhance the degradation of hemagglutinin target. Among these PROTACs, V3 (I) showed the best degradation effect on the hemagglutinin with a median degradation concentration of 1.44 μM in a ubiquitin and proteasome-dependent manner and broad-spectrum anti-influenza A virus activity but not affected the entry of influenza virus. Moreover, i.v. injection of V3 (I) protected mice against influenza A virus-induced toxic effects. Further diazirine-containing photo-crosslinking mass spectrometric anal. of hemagglutinin complexes indicated crosslinking to Asn15, Thr31, and Asn27, a novel target of hemagglutinin. Taken together, our data revealed that oleanolic acid-based PROTACs could degrade hemagglutinin protein, providing a new direction toward the discovery of potential anti-influenza drugs. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem