Category: 139115-91-6

In 2017,Wieczorek, Achim; Werther, Philipp; Euchner, Jonas; Wombacher, Richard published 《Green- to far-red-emitting fluorogenic tetrazine probes – synthetic access and no-wash protein imaging inside living cells》.Chemical Science published the findings.Synthetic Route of C9H19NO4 The information in the text is summarized as follows:

Fluorogenic probes for bioorthogonal labeling chem. are highly beneficial to reduce background signal in fluorescence microscopy imaging. 1,2,4,5-Tetrazines are known substrates for the bioorthogonal inverse electron demand Diels-Alder reaction (DAinv) and tetrazine substituted fluorophores can exhibit fluorogenic properties. Herein, we report the synthesis of a palette of novel fluorogenic tetrazine dyes derived from widely-used fluorophores that cover the entire emission range from green to far-red. We demonstrate the power of the new fluorogenic probes in fixed and live cell labeling experiments and present the first example of intracellular live cell protein imaging using tetrazine-based probes under no-wash conditions. In the experiment, the researchers used many compounds, for example, tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Synthetic Route of C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Synthetic Route of C9H19NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《A MedChem toolbox for cereblon-directed PROTACs》 were Steinebach, Christian; Sosic, Izidor; Lindner, Stefanie; Bricelj, Alesa; Kohl, Franziska; Ng, Yuen Lam Dora; Monschke, Marius; Wagner, Karl G.; Kroenke, Jan; Guetschow, Michael. And the article was published in MedChemComm in 2019. Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The author mentioned the following in the article:

A modular chem. toolbox was developed for cereblon-directed PROTACs. A variety of linkers was attached to a CRBN ligand via the 4-amino position of pomalidomide. We used linkers of different constitution to modulate physicochem. properties. We equipped one terminus of the linker with a set of functional groups, e.g. protected amines, protected carboxylic acids, alkynes, chloroalkanes, and protected alcs., all of which are considered to be attractive for PROTAC design. We also highlight different opportunities for the expansion of the medicinal chemists’ PROTAC toolbox towards heterobifunctional mols., e.g. with biotin, fluorescent, hydrophobic and peptide tags. In the experimental materials used by the author, we found tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateAlthough ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2015,Li, Daliang; Huang, ZhiJiang; Chen, Shiuhwei; Hu, Zeping; Li, Wen-hong published 《GLP-1 Receptor Mediated Targeting of a Fluorescent Zn2+ Sensor to Beta Cell Surface for Imaging Insulin/Zn2+ Release》.Bioconjugate Chemistry published the findings.Synthetic Route of C9H19NO4 The information in the text is summarized as follows:

The pancreatic islet beta cell plays an essential role in maintaining the normal blood glucose level by releasing insulin. Loss of functional beta cell mass leads to diabetes, a disease affecting ∼9% of the population worldwide. There has been great interest and intense effort in developing imaging probes for monitoring islet beta cells, and glucagon-like peptide-1 receptor (GLP-1R) has emerged as a valuable biomarker for targeting beta cells. However, efforts thus far in GLP-1R mediated beta cell labeling and imaging has largely, if not exclusively, focused on developing imaging probes for monitoring beta cell mass, and few studies have investigated imaging beta cell function (insulin release) through GLP-1R. We now report the design and synthesis of a bioconjugate, ZIMIR-Ex4(9-39), that consists of a fluorescent Zn2+ sensor and a truncated exendin 4 peptide for imaging insulin/Zn2+ release in islet beta cells. In vitro, the conjugate bound to Zn2+ with high affinity and displayed a robust fluorescence enhancement upon Zn2+ chelation. When added to beta cells at submicromolar concentration, ZIMIR-Ex4(9-39) rapidly labeled cell surface in minutes to report the dynamics of insulin/Zn2+ release with high spatiotemporal resolution Future explorations of this approach may lead to probes for tracking beta cell function using different imaging modalities. The experimental process involved the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Synthetic Route of C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Synthetic Route of C9H19NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2012,Gule, Nonjabulo P.; Bshena, Osama; de Kwaadsteniet, Michele; Cloete, Thomas E.; Klumperman, Bert published 《Immobilized Furanone Derivatives as Inhibitors for Adhesion of Bacteria on Modified Poly(styrene-co-maleic anhydride)》.Biomacromolecules published the findings.SDS of cas: 139115-91-6 The information in the text is summarized as follows:

The ability of brominated furanones and other furanone compounds with 2(3H) and 2(5H) cores to inhibit bacterial adhesion of surfaces as well deactivate (destroy) them has been previously reported. The furanone derivatives 4-(2-(2-aminoethoxy))-2,5-dimethyl-3(2H)-furanone and 5-(2-(2-aminoethoxy)-ethoxy)methyl-2(5H)-furanone were synthesized in our laboratory These furanone derivatives were then covalently immobilized onto poly(styrene-co-maleic anhydride) (SMA) and electrospun to fabricate nonwoven nanofibrous mats with antimicrobial and cell-adhesion inhibition properties. The electrospun nanofibrous mats were tested for their ability to inhibit cell attachment by strains of bacteria commonly found in water (Klebsiella pneumoniae Xen 39, Staphylococcus aureus Xen 36, E. coli Xen 14, Pseudomonas aeruginosa Xen 5, and Salmonella typhimurium Xen 26). 1H NMR, electrospray mass spectroscopy (ES-MS), and attenuated total reflectance FTIR spectroscopy (ATR-FTIR) were used to confirm the structures of the synthesized furanones as well as their successful immobilization on SMA. To ascertain that the immobilized furanone compounds do not leach into filtered water, samples of water, filtered through the nanofibrous mats were analyzed using gas chromatog. coupled with mass spectroscopy (GC-MS). The morphol. of the electrospun nanofibers was characterized using SEM.tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6SDS of cas: 139115-91-6) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. SDS of cas: 139115-91-6 Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2016,Yamaura, Kei; Kiyonaka, Shigeki; Numata, Tomohiro; Inoue, Ryuji; Hamachi, Itaru published 《Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry》.Nature Chemical Biology published the findings.Electric Literature of C9H19NO4 The information in the text is summarized as follows:

The fast inhibitory actions of γ-aminobutyric acid (GABA) are mainly mediated by GABAA receptors (GABAARs) in the brain. The existence of multiple ligand-binding sites and a lack of structural information have hampered the efficient screening of drugs capable of acting on GABAARs. The authors have developed semisynthetic fluorescent biosensors for orthosteric and allosteric GABAAR ligands on live cells via coupling of affinity-based chem. labeling reagents to a bimol. fluorescence quenching and recovery system. These biosensors were amenable to the high-throughput screening of a chem. library, leading to the discovery of new small mols. capable of interacting with GABAARs. Electrophysiol. measurements revealed that one hit, 4,4′,4”-(4-propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (PPT), was a novel neg. allosteric modulator capable of strongly suppressing GABA-induced chloride currents. Thus, these semisynthetic biosensors represent versatile platforms for screening drugs to treat GABAAR-related neurol. disorders, and this strategy can be extended to structurally complicated membrane proteins. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Electric Literature of C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Electric Literature of C9H19NO4 They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2015,Wold, Erik D.; Axup, Jun Y.; Felding, Brunhilde H.; Smider, Vaughn V. published 《Fc-small molecule antibody mimetics》.Bioconjugate Chemistry published the findings.Synthetic Route of C9H19NO4 The information in the text is summarized as follows:

Antibody therapeutics are a promising drug class due to their high specificity and favorable pharmacokinetics. While there are many methods for the development of antibodies specific to disease associated antigens, selecting antibodies against functional epitopes with high specificity and affinity can be difficult for certain epitopes. We describe a generalizable method for synthesizing antibody mimetics by site specifically conjugating small mols. (with high affinity and specificity to disease associated antigens) to an Fc fragment to develop drugs with the benefits of an antibody. As a proof of concept, an E269pAcPhe Fc antibody Fc fragment was produced and subsequently site-specifically labeled with a linker-modified folic acid compound to generate an Fc-folic acid antibody-mimetic. This was chosen as the model system because the high-affinity folate receptor FR-α is highly expressed in a number of cancer types including breast and ovarian cancer. The specificity of the Fc-folic acid conjugate was assessed via flow cytometry with the folate-receptor pos. breast cancer cell line MDA-MB-231 by measuring Fc-folic acid binding in both the absence and presence of an excess of folic acid. Fc-small mol. conjugates could be developed into a unique class of antibody-like therapeutics. In addition to this study using tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate, there are many other studies that have used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Synthetic Route of C9H19NO4) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Synthetic Route of C9H19NO4Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Synthesis and biological evaluation of berberine derivatives as a new class of broad-spectrum antiviral agents against Coxsackievirus B》 was published in Bioorganic Chemistry in 2020. These research results belong to Zeng, Qing-Xuan; Wang, Hui-Qiang; Wei, Wei; Guo, Ting-Ting; Yu, Lian; Wang, Yan-Xiang; Li, Yu-Huan; Song, Dan-Qing. Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The article mentions the following:

A series of novel berberine (BBR) analogs were prepared and tested for their antiviral potencies against six different genotype Coxsackievirus B (CVB1-6) strains, taking BBR core for structural modification. Structure-activity relationship (SAR) research revealed that introduction of a primary amine through a linker at position 3 might be beneficial for both antiviral activity and safety. Compound 14c displayed most promising inhibitory potency with IC50 values of 3.08-9.94μM against tested CVBs 2-6 strains and satisfactory SI value of 34.3 on CVB3, better than that of BBR. Also, 14c could inhibit CVB3 replication through down-regulating the expression of VP1 protein and VP1 RNA. The mechanism revealed that 14c could suppress host components JNK-MAPK, ERK-MAPK and p38-MAPK activation. Therefore, BBR derivatives were considered to be a new class of anti-CVB agents with an advantage of broad-spectrum anti-CVB potency. In the experimental materials used by the author, we found tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2017,Hao, Hongye; Deng, Ya; Wu, Yingke; Liu, Siyuan; Lin, Weiwei; Li, Jiehua; Luo, Feng; Tan, Hong published 《Synthesis of biodegradable waterborne phosphatidylcholine polyurethanes for soft tissue engineering applications》.Regenerative Biomaterials published the findings.HPLC of Formula: 139115-91-6 The information in the text is summarized as follows:

To further improve the biocompatibility of polyurethanes, a new lysine 2-(2-aminoethoxy)ethanol phosphatidylcholine (LAPC) is synthesized to use as chain extender for preparing a series of phosphatidylcholine polyurethanes (PCPUs). Poly (ε-caprolactone) (PCL) and poly(ethylene glycol) (PEG) are used as soft segments, and L-lysine Et ester diisocyanate (LDI), LAPC and L-lysine are used as hard segments. The obtained PCPUs exhibit appropriate mech. properties with break elongation of 1000-1700%, tensile strength of 7-22 MPa, and relatively high elastic modulus of 11-18 MPa, which could admirably satisfy the requirement for soft tissue engineering scaffolds. The phosphatidylcholine structures can increase the hydrophilicity of PCPU surfaces, which effectively reduce protein adsorption and platelet adhesion while promoting the cell proliferation. In addition, the LAPC chain extender, PCPU films and ultimate degradation products of PCPUs are proved to be nontoxic in cytotoxicity test. More interestingly, the cytokine release test of macrophages manifests that both LAPC and PCPU degradation products could effectively improve the proliferation of macrophages and induce them into a wound-healing phenotype. Thus, the obtained PCPUs have greatly potential applications of soft tissue engineering scaffolds for tissue repair and wound healing. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6HPLC of Formula: 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. HPLC of Formula: 139115-91-6 They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2018,Vasta, James D.; Corona, Cesear R.; Wilkinson, Jennifer; Zimprich, Chad A.; Hartnett, James R.; Ingold, Morgan R.; Zimmerman, Kristopher; Machleidt, Thomas; Kirkland, Thomas A.; Huwiler, Kristin G.; Ohana, Rachel Friedman; Slater, Michael; Otto, Paul; Cong, Mei; Wells, Carrow I.; Berger, Benedict-Tilman; Hanke, Thomas; Glas, Carina; Ding, Ke; Drewry, David H.; Huber, Kilian V. M.; Willson, Timothy M.; Knapp, Stefan; Muller, Susanne; Meisenheimer, Poncho L.; Fan, Frank; Wood, Keith V.; Robers, Matthew B. published 《Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement》.Cell Chemical Biology published the findings.Name: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The information in the text is summarized as follows:

For kinase inhibitors, intracellular target selectivity is fundamental to pharmacol. mechanism. Although a number of acellular techniques have been developed to measure kinase binding or enzymic inhibition, such approaches can fail to accurately predict engagement in cells. Here we report the application of an energy transfer technique that enabled the first broad-spectrum, equilibrium-based approach to quant. profile target occupancy and compound affinity in live cells. Using this method, we performed a selectivity profiling for clin. relevant kinase inhibitors against 178 full-length kinases, and a mechanistic interrogation of the potency offsets observed between cellular and biochem. anal. For the multikinase inhibitor crizotinib, our approach accurately predicted cellular potency and revealed improved target selectivity compared with biochem. measurements. Due to cellular ATP, a number of putative crizotinib targets are unexpectedly disengaged in live cells at a clin. relevant drug dose. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Name: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Name: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,ACS Chemical Biology included an article by Takashima, Ippei; Kusamori, Kosuke; Hakariya, Hayase; Takashima, Megumi; Vu, Thi Hue; Mizukami, Yuya; Noda, Naotaka; Takayama, Yukiya; Katsuda, Yousuke; Sato, Shin-ichi; Takakura, Yoshinobu; Nishikawa, Makiya; Uesugi, Motonari. COA of Formula: C9H19NO4. The article was titled 《Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment》. The information in the text is summarized as follows:

Cell-based therapy is a promising approach to restoring lost functions to compromised organs. However, the issue of inefficient cell engraftment remains to be resolved. Herein, we take a chem. approach to facilitate cell engraftment by using self-assembling mols. which modify two cellular traits: cell survival and invasiveness. In this system, the self-assembling mol. induces syndecan-4 clusters on the cellular surface, leading to enhanced cell viability. Further integration with Halo-tag technol. provided this self-assembly structure with matrix metalloproteinase-2 to functionalize cells with cell-invasion activity. In vivo experiments showed that the pretreated cells were able to survive injection and then penetrate and engraft into the host tissue, demonstrating that the system enhances cell engraftment. Therefore, cell-surface modification via an alliance between self-assembling mols. and ligation technologies may prove to be a promising method for cell engraftment. In addition to this study using tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate, there are many other studies that have used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6COA of Formula: C9H19NO4) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.COA of Formula: C9H19NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem