Category: 139115-91-6

In 2014,Zhang, Hong-Wu; Wang, Li-Qin; Xiang, Qing-Feng; Zhong, Qian; Chen, Lu-Ming; Xu, Cai-Xia; Xiang, Xian-Hong; Xu, Bo; Meng, Fei; Wan, Yi-Qian; Deng, David Y. B. published 《Specific lipase-responsive polymer-coated gadolinium nanoparticles for MR imaging of early acute pancreatitis》.Biomaterials published the findings.Product Details of 139115-91-6 The information in the text is summarized as follows:

Currently, available methods for diagnosis of acute pancreatitis (AP) are mainly dependent on serum enzyme anal. and imaging techniques that are too low in sensitivity and specificity to accurately and promptly diagnose AP. The lack of early diagnostic tools highlights the need to search for a highly effective and specific diagnostic method. In this study, we synthesized a conditionally activated, gadolinium-containing, nanoparticle-based MRI nanoprobe as a diagnostic tool for the early identification of AP. Gadolinium diethylenetriaminepentaacetic fatty acid (Gd-DTPA-FA) nanoparticles were synthesized by conjugation of DTPA-FA ligand and gadolinium acetate. Gd-DTPA-FA exhibited low cytotoxicity and excellent biocompatibility when characterized in vitro and in vivo studies. L-arginine induced a gradual increase in the intensity of the T1-weighted MRI signal from 1 h to 36 h in AP rat models. The increase in signal intensity was most significant at 1 h, 6 h and 12 h. These results suggest that the Gd-DTPA-FA as an MRI contrast agent is highly efficient and specific to detect early AP. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Product Details of 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Product Details of 139115-91-6 They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Tri- and tetravalent photoactivable cross-linking agents》 was written by Welle, Alexandre; Billard, Francois; Marchand-Brynaert, Jacqueline. Related Products of 139115-91-6This research focused ontrivalent tetravalent photoactivable cross linking agent preparation. The article conveys some information:

A modular synthesis of photoactivable crosslinking agents is described, using an aromatic core, di- or triethyleneglycol spacers and photoaffinity labeling synthons that feature either perfluorophenyl azide or aryl(trifluoromethyl)diazirine motifs. Sym. and nonsym. trivalent structures, e.g. I [L = CH2CH2OCH2CH2NH], were obtained from phloroglucinol and dopamine, resp. Sym. tetravalent structures resulted from the coupling of two dopamine derivatives with oxalyl chloride. The experimental process involved the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Related Products of 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Related Products of 139115-91-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Synthesis of oxygen-heterocycles having linker components for trapping cysteine derivatives》 was written by Yoshioka, Eito; Minato, Ikko; Takashima, Hideki; Miyabe, Hideto. Computed Properties of C9H19NO4 And the article was included in Heterocycles in 2020. The article conveys some information:

Tricyclic oxygen-heterocycles having a linker component were synthesized for the site-specific modification of proteins and peptides. The linker components were initially introduced by Sonogashira-Hagihara cross coupling of 5-bromo-2-hydroxybenzaldehyde and a variety of alkynes. Next, the desired oxygen-heterocycles were synthesized by the condensation reaction of coupling products with cyclohexane-1,3-dione in the presence of N,N-diisopropylethylamine. Finally, the trapping ability of these oxygen-heterocycles was demonstrated by the representative reaction of 7-(3-(benzyloxy)prop-1-yn-1-yl)-4a-hydroxy-2,3,4,4a-tetrahydro-1H-xanthen-1-one with glutathione as a nucleophile having a thiol group. In the experiment, the researchers used many compounds, for example, tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Computed Properties of C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Computed Properties of C9H19NO4Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 139115-91-6In 2011 ,《Ionic polypeptides with unusual helical stability》 appeared in Nature Communications. The author of the article were Lu, Hua; Wang, Jing; Bai, Yugang; Lang, Jason W.; Liu, Shiyong; Lin, Yao; Cheng, Jianjun. The article conveys some information:

Water-soluble peptides that adopt stable helical conformations are attractive motifs because of their importance in basic science and their broad utility in medicine and biotechnol. Incorporating charged amino-acid residues to improve peptide solubility, however, usually leads to reduced helical stability because of increased side-chain charge repulsion, reduced side-chain hydrophobicity and the disruption of intramol. hydrogen bonding. Here, we show that water-soluble, ultra-stable α-helical polypeptides can be produced by elongating charge-containing amino-acid side chains to position the charges distally from the polypeptide backbone. The strategy has been successfully applied to the design and synthesis of water-soluble polypeptides bearing long, charged side chains and various functional moieties that possess unusual helical stability against changing environmental conditions, including changes in the pH and temperature and the presence of denaturing reagents.tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Recommanded Product: 139115-91-6) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Recommanded Product: 139115-91-6 They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C9H19NO4In 2017 ,《Assaying RNA Localization in Situ with Spatially Restricted Nucleobase Oxidation》 was published in ACS Chemical Biology. The article was written by Li, Ying; Aggarwal, Mahima B.; Nguyen, Kim; Ke, Ke; Spitale, Robert C.. The article contains the following contents:

The authors report herein a novel chem.-genetic method for assaying RNA localization within living cells. RNA localization is critical for normal physiol. as well as the onset of cancer and neurodegenerative disorders. Despite its importance, there is a real lack of chem. methods to directly assay RNA localization with high resolution in living cells. The authors’ novel approach relies on in situ nucleobase oxidation by singlet oxygen generated from spatially confined fluorophores. The authors’ novel method can identify RNA mols. localized within specific cellular compartments. The authors anticipate that this platform will provide the community with a much-needed methodol. for tracking RNA localization within living cells and set the stage for systematic large scale anal. of RNA localization in living systems. In the experiment, the researchers used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Synthetic Route of C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Synthetic Route of C9H19NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2018,Sameshima, Tomoya; Yamamoto, Takeshi; Sano, Osamu; Sogabe, Satoshi; Igaki, Shigeru; Sakamoto, Kotaro; Ida, Koh; Gotou, Mika; Imaeda, Yasuhiro; Sakamoto, Junichi; Miyahisa, Ikuo published 《Discovery of an Irreversible and Cell-Active BCL6 Inhibitor Selectively Targeting Cys53 Located at the Protein-Protein Interaction Interface》.Biochemistry published the findings.Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The information in the text is summarized as follows:

B-cell lymphoma 6 (BCL6) is the most frequently involved oncogene in diffuse large B-cell lymphomas (DLBCLs). BCL6 shows potent transcriptional repressor activity through interactions with its corepressors, such as BCL6 corepressor (BCOR). The inhibition of the protein-protein interaction (PPI) between BCL6 and its corepressors suppresses the growth of BCL6-dependent DLBCLs, thus making BCL6 an attractive drug target for lymphoma treatments. However, potent small-mol. PPI inhibitor identification remains challenging because of the lack of deep cavities at PPI interfaces. This paper reports the discovery of a potent, cell-active, small-mol. BCL6 inhibitor, BCL6-i (8), that operates through irreversible inhibition. First, we synthesized an irreversible lead compound 4, which targets Cys53 in a cavity on the BCL6 BTB domain dimer by introducing an irreversible warhead to a high-throughput screening hit compound 1. Further chem. optimization of 4 based on kinact/KI evaluation produced BCL6-i with a kinact/KI value of 1.9 × 104 M-1s-1, corresponding to a 670-fold improvement in potency compared to 4. By exploiting the property of irreversible inhibition, engagement of BCL6-i to intracellular BCL6 was confirmed. BCL6-i showed intracellular PPI inhibitory activity between BCL6 and its corepressors, thus resulting in BCL6-dependent DLBCL cell-growth inhibition. BCL6-i is a cell-active chem. probe with the most potent BCL6 inhibitory activity reported to date. The discovery process of BCL6-i illustrates the utility of irreversible inhibition for identifying potent chem. probes for intractable target proteins. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Product Details of 139115-91-6In 2021 ,《Reversible covalent locking of a supramolecular hydrogel via UV-controlled anthracene dimerization》 was published in Polymer Chemistry. The article was written by Hou, Zhanyao; Nau, Werner M.; Hoogenboom, Richard. The article contains the following contents:

Supramol. hydrogels gained significant attention as shear-thinning, self-healing materials. However, the introduction of non-covalent crosslinks inherently decreases the strength and stability of the hydrogel. In this work, we developed a novel supramol. hydrogel that undergoes a reversible transformation to the corresponding covalently crosslinked hydrogel upon UV-irradiation The supramol. hydrogel was developed based on the ternary host-guest interaction of two anthracene moieties and one large macrocyclic host. Anthracene functionalized poly(N-acryloylmorpholine)s were synthesized by post-polymerization modification of a copolymer consisting of N-acryloylmorpholine and an activated ester comonomer, whereby two different polymers were prepared having either neutral anthracene side-chains or carrying a pos. charge next to the anthracene to enhance the interaction with the host. The binding affinity of the anthracene side chains with and without an addnl. cationic charge were studied with two macrocyclic hosts, namely cucurbit[8]uril and γ-cyclodextrin (γ-CD) by UV-Vis titration revealing a markedly stronger binding in the presence of the cationic charge due to addnl. ion-dipole one of the macrocyclic hosts, cucurbit[8]uril. Subsequently, the effect of the binding affinity on the hydrogelation was investigated, indicating that the stronger binding affinity facilitated the hydrogel formation at lower concentration Finally, the reversible transformation of the supramol. hydrogel to a chem. hydrogel by anthracene dimerization was studied by the UV irradiation of the hydrogel at 365 nm for covalent crosslinking or at 254 nm for decrosslinking. It could be demonstrated that the dynamic nature of the hydrogel, that is responsible for the shear-thinning behavior, was indeed lost upon UV-irradiation indicative of the formation of a covalently crosslinked hydrogel. The capabilities of the formed supramol. hydrogel that is easily processable and able to reversibly convert to a chem. hydrogel, provides potential applications in applying mech. robust covalently crosslinked hydrogels in complex shapes and difficult to reach locations making use of the dynamic nature of the supramol. crosslinks. In the experiment, the researchers used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Product Details of 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Product Details of 139115-91-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Triptolide Directly Inhibits dCTP Pyrophosphatase》 was written by Corson, Timothy W.; Cavga, Hueseyin; Aberle, Nicholas; Crews, Craig M.. Computed Properties of C9H19NO4This research focused ontriptolide dCTP pyrophosphatase inhibitor biotinylated derivative preparation cytotoxicity. The article conveys some information:

Triptolide is a potent natural product, with documented antiproliferative, immunosuppressive, anti-inflammatory, antifertility, and antipolycystic kidney disease effects. Despite a wealth of knowledge about the biol. of this compound, direct intracellular target proteins have remained elusive. The authors synthesized a biotinylated photoaffinity derivative of triptolide, and used it to identify dCTP pyrophosphatase 1 (DCTPP1) as a triptolide-interacting protein. Free triptolide interacts directly with recombinant DCTPP1, and inhibits the enzymic activity of this protein. Triptolide is thus the first dCTP pyrophosphatase inhibitor identified, and DCTPP1 is a biophys. validated target of triptolide. In addition to this study using tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate, there are many other studies that have used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Computed Properties of C9H19NO4) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Computed Properties of C9H19NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2015,Li, Daliang; Liu, Lin; Li, Wen-Hong published 《Genetic Targeting of a Small Fluorescent Zinc Indicator to Cell Surface for Monitoring Zinc Secretion》.ACS Chemical Biology published the findings.Computed Properties of C9H19NO4 The information in the text is summarized as follows:

Numerous mammalian cells contain Zn2+ in their secretory granules. During secretion, Zn2+ is coreleased with granular cargos into extracellular medium so Zn2+ serves as a convenient surrogate marker for tracking the dynamics of secretion. Fluorescent Zn2+ sensors that can be selectively targeted to cells of interest would be invaluable tools for imaging Zn2+ release in multicellular systems including tissues and live animals. Exploiting the HaloTag labeling technol. and using an optimized linker, the authors have engineered a fluorescent Zn2+ indicator that displayed a 15-fold fluorescence enhancement upon Zn2+ binding while reacting efficiently with a HaloTag enzyme in a cellular environment. Two-color imaging of ZIMIR-HaloTag and a red-emitting calcium indicator in pancreatic islet beta cells demonstrated that photoactivation of a channelrhodopsin was able to induce exocytosis of Zn2+/insulin granules and revealed heterogeneity in secretory activity along the cell membrane that was uncoupled from cellular Ca2+ activity. This integrated photonic approach for imaging and controlling the release of large dense core granules provides exquisite cellular selectivity and should facilitate future studies of stimulus-secretion coupling and paracrine signaling in secretory cells. In addition to this study using tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate, there are many other studies that have used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Computed Properties of C9H19NO4) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Computed Properties of C9H19NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2015,Kim, Eunha; Yang, Katherine S.; Kohler, Rainer H.; Dubach, John M.; Mikula, Hannes; Weissleder, Ralph published 《Optimized Near-IR Fluorescent Agents for in Vivo Imaging of Btk Expression》.Bioconjugate Chemistry published the findings.Application of 139115-91-6 The information in the text is summarized as follows:

Bruton’s tyrosine kinase (Btk) is intricately involved in anti-apoptotic signaling pathways in cancer and in regulating innate immune response. A number of Btk inhibitors are in development for use in treating B-cell malignancies and certain immunol. diseases. To develop robust companion imaging diagnostics for in vivo use, we set out to explore the effects of red wavelength fluorochrome modifications of two highly potent irreversible Btk inhibitors, Ibrutinib and AVL-292. Surprisingly, we found that subtle chem. differences in the fluorochrome had considerable effects on target localization. Based on iterative designs, we developed a single optimized version with superb in vivo imaging characteristics enabling single cell Btk imaging in vivo. This agent (Ibrutinib-SiR-COOH) is expected to be a valuable chem. tool in deciphering Btk biol. in cancer and host cells in vivo. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Application of 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Application of 139115-91-6 Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem