Category: 139115-91-6

Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateIn 2020 ,《Reaction-based amine and alcohol gases detection with triazine ionic liquid materials》 appeared in Molecules. The author of the article were Li, Hsin-Yi; Chu, Yen-Ho. The article conveys some information:

The use of affinity ionic liquids, I and II, for chemoselective detection of amine and alc. gases on a quartz crystal microbalance (QCM) was reported. These detections of gaseous amines and alcs. were achieved by nucleophilic aromatic substitution reactions with the electrophilic 1,3,5-triazine-based affinity ionic liquids, I thin-coated on quartz chips. Starting with inexpensive reagents, bicyclic imidazolium ionic liquids, I and II were readily synthesized in six and four synthetic steps with high isolated yields: 51% and 63%, resp. The QCM platform developed in this work was readily applicable and highly sensitive to low mol. weight amine gases: for isobutylamine gas (a bacterial volatile) at 10 Hz decrease in resonance frequency (i.e., ΔF = -10 Hz), the detectability using affinity ionic liquids, I was 6.3 ppb. Our preliminary investigation on detection of the much less nucleophilic alc. gas by affinity ionic liquids, I was also promising. To our knowledge, no example to date of reports based on nucleophilic aromatic substitution reactions demonstrating sensitive gas detection in these triazine ionic liquids on a QCM was reported. The results came from multiple reactions, including the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2013,Li, Xiaoxiao; Hou, Jianjun; Wang, Chao; Liu, Xinjie; He, Hongyan; Xu, Ping; Yang, Zhenjun; Chen, Zili; Wu, Yun; Zhang, Lihe published 《Synthesis and biological evaluation of RGD-conjugated MEK1/2 kinase inhibitors for integrin-targeted cancer therapy》.Molecules published the findings.Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The information in the text is summarized as follows:

Two novel series of RGD-MEKI conjugates derived from a MEK1/2 kinase inhibitor – PD0325901 – have been developed for integrin receptor mediated anticancer therapy. The first series, alkoxylamine analog RGD-MEKI conjugates showed anti-proliferation activity in melanoma A375 cells by the same mechanism as that of PD0325901. PEGylation increased the IC50 value of (I) [P = dimer-c(RGD)] three-fold in the A375 assay, and the multi-cRGD peptide cargo significantly improved the receptor specific anti-proliferation activity of I (P = RGD-PEG4) in integrin-overexpressing U87 cells. In the second series, RGD-PD0325901 (II) [P = c(RGDyK)] exhibited significantly increased antitumor properties compared to the alkoxylamine analogs by both inhibition of the ERK pathway activity and DNA replication of the cancer cells. Furthermore, II displayed more potent anti-proliferation activity in the U87 assay than PD0325901 in a dose-dependent manner. All these data demonstrate that RGD-MEKI conjugates with an ester bond linkage enhanced anticancer efficacy with improved targeting capability toward integrin-overexpressing tumor cells. The experimental process involved the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Molecules included an article by Barre, Anais; Azzouz, Rabah; Gembus, Vincent; Papamicael, Cyril; Levacher, Vincent. Category: ethers-buliding-blocks. The article was titled 《Design, synthesis, and in-vitro biological activities of a bio-oxidizable prodrug to deliver both ChEs and DYRK1A inhibitors for AD therapy》. The information in the text is summarized as follows:

Despite their side effects, cholinesterase (ChE) inhibitors remain the only approved drugs to treat Alzheimer’s disease patients, along with the N-methyl-d-aspartate (NMDA) receptor antagonist memantine. In the last few years, the dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) has also been studied as a promising target for the development of new drugs for this pathol. In this context and based on previous characterization of bio-oxidizable prodrugs of potent acetylcholinesterase (AChE) inhibitors, a strategy involving the synthesis of a bio-oxidizable prodrug of both ChE and DYRK1A inhibitors was reported. To this end, a known potent inhibitor of DYRK1A, namely INDY was identified. The designed prodrug of both ChE and DYRK1A inhibitors was successfully synthesized, connecting both inhibitors by a carbonate link. This prodrug and its corresponding drug were then evaluated as ChEs and DYRK1A inhibitors. Remarkably, in-vitro results were in accordance with the starting hypothesis, showed a relative inactivity of the prodrug against DYRK1A and ChEs and a potent inhibition of ChEs by the oxidized form. Mol. docking and kinetic studies of ChE inhibition by the active compound were also discussed in this report. In the experiment, the researchers used many compounds, for example, tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Category: ethers-buliding-blocks)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateIn 2020 ,《Effects of modifying thioflavin T at the N3-position on its G4 binding and fluorescence emission》 was published in Molecules. The article was written by Kataoka, Yuka; Fujita, Hiroto; Endoh, Tamaki; Sugimoto, Naoki; Kuwahara, Masayasu. The article contains the following contents:

We previously synthesized thioflavin T (ThT) with a hydroxyethyl group introduced at the N3-position (ThT-HE), which binds predominantly to the parallel G-quadruplex (G4) structure found in c-Myc and emits strong fluorescence. In this study, to investigate the effects of introduced substituents on G4 binding and fluorescence emission, a ThT derivative in which the hydroxyl group of ThT-HE was replaced with an amino group (ThT-AE) was synthesized for the first time. Furthermore, three other N3-modified ThT derivatives (ThT-OE2, ThT-SP, and ThT-OE11) having different substituent structures were synthesized by the N-acylation of the terminal amino group of ThT-AE, and their G4-binding and emission properties were investigated. The results showed that, although ThT-AE shows binding selectivity depending on the type of G4, its emission intensity is significantly decreased as compared to that of ThT-HE. However, ThT-OE11, which features an 11-unit oxyethylene chain attached to the terminal amino group of ThT-AE, regained about one-half of the emission intensity of ThT-HE while retaining selectivity for G4s. Accordingly, ThT-OE11 may be used as a key intermediate for synthesizing the conjugates of G4 binders and probes. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2014,Magano, Javier; Conway, Brian G.; Farrand, Douglas; Lovdahl, Michael; Maloney, Mark T.; Pozzo, Mark J.; Teixeira, John J.; Rizzo, John; Tumelty, David published 《Scalable and cost-effective synthesis of a linker for bioconjugation with a peptide and a monoclonal antibody》.Synthesis published the findings.Application of 139115-91-6 The information in the text is summarized as follows:

An efficient, scalable, and cost-effective synthesis of a linker, that can be employed in a bioconjugation process with a peptide and a monoclonal antibody, is presented. Several routes were investigated that resulted in the identification of a short synthesis to a key acid intermediate from inexpensive and readily available starting materials. The final coupling of this acid with an aniline to afford the desired linker has been optimized to produce multi-gram quantities of material for clin. studies. The very limited purifications needed for both intermediates and final product make this route amenable to scale. The experimental process involved the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Application of 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Application of 139115-91-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

SDS of cas: 139115-91-6In 2019 ,《Design and synthesis of trivalent Tn glycoconjugate polymers by nitroxide-mediated polymerization》 was published in Tetrahedron. The article was written by Liu, Si-Xian; Tsai, Yun-Tzu; Lin, Yu-Tung; Li, Jia-Yue; Chang, Che-Chien. The article contains the following contents:

A new synthetic method for preparing Tn glycoconjugate polymers, containing tumor-associated carbohydrate antigens, by controlled living radical polymerization is reported. To mimic the authentic structures of Tn glycopeptide antigens and to explore the controlled living radical polymerization, three tumor-associated carbohydrate antigens (GalNAc, GalNAcα1-O-Ser, and GalNAcα1-O-Thr) were attached to a styrene-type monomer through a diethylene glycol spacer. Under nitroxide-mediated polymerization, controlled living radical polymerization proceeded to afford defined glycopeptide polymers with different Tn densities and compositions The polydispersity index (PDI) and mol. weights were increased and conversions were decreased upon increasing the concentration of Tn glycoconjugate monomers. The resulting Tn glycoconjugate polymers were characterized by NMR and IR. The spectral data indicate that the Tn glycoconjugate moiety did attach to the polymer chain and Tn glycoconjugate d. could be adjusted through the nitroxide-mediated polymerization conditions. The number of Tn units containing in the polymer chains could be estimated by NMR integration. This synthetic approach provides a new and efficient tool for constructing novel Tn glycoconjugate polymers. The results came from multiple reactions, including the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6SDS of cas: 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. SDS of cas: 139115-91-6 Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Take Immune Cells Back on Track: Glycopolymer-Engineered Tumor Cells for Triggering Immune Response》 were Liu, Qi; Jiang, Shuaibing; Liu, Bing; Yu, You; Zhao, Zhen-Ao; Wang, Chao; Liu, Zhuang; Chen, Gaojian; Chen, Hong. And the article was published in ACS Macro Letters in 2019. Category: ethers-buliding-blocks The author mentioned the following in the article:

The “”self-homing”” of cancer cells to primary or metastatic tumor sites indicates that they could serve as vehicles for self-targeted cancer therapy; this suggests a promising method for treating end-stage cancer. Inspired by this, we propose that engineering cancer cells to carry efficient “”coup”” mols. for in situ activation of immune cells in or near tumor sites to attack tumors is a promising strategy for cancer therapy. Therefore, herein we explored the potential of engineered tumor cells to enhance their anticancer activity by stimulating immune cells. We armed tumor cell surfaces with specific glycopolymer-ligands that bind to lectins on macrophages or dendritic cells by combining HaloTag protein (HTP) fusion technique with reversible addition-fragmentation chain transfer (RAFT) polymerization We demonstrated that two synthetic well-defined glycopolymers containing, resp., N-acetylglucosamine and N-acetylmannosamine units, were introduced and stably presented on the cell surfaces via the stable covalent binding of chloroalkane-terminated polymers with membrane-bound HTP. Furthermore, it was shown that the glycopolymer-engineered HeLa cells with HTP anchors increased expression of the typical marker for M1-type macrophages (CD86) and upregulated secretion of pro-inflammatory cytokines (IL-12p70, TNF-α, and iNOS), thereby accelerating HeLa cell lysis. The maturation of dendritic cells was also promoted. This study demonstrates the strong potential of glycopolymer-engineered tumor cells in cancer immunotherapy. In the experimental materials used by the author, we found tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Category: ethers-buliding-blocks)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

SDS of cas: 139115-91-6In 2021 ,《Conjugate of thiol and guanidyl units with oligoethylene glycol linkage for manipulation of oxidative protein folding》 was published in Molecules. The article was written by Okada, Shunsuke; Matsusaki, Motonori; Okumura, Masaki; Muraoka, Takahiro. The article contains the following contents:

Oxidative protein folding is a biol. process to obtain a native conformation of a protein through disulfide-bond formation between cysteine residues. In a cell, disulfide-catalysts such as protein disulfide isomerase promote the oxidative protein folding. Inspired by the active sites of the disulfide-catalysts, synthetic redox-active thiol compounds have been developed, which have shown significant promotion of the folding processes. In our previous study, coupling effects of a thiol group and guanidyl unit on the folding promotion were reported. Herein, we investigated the influences of a spacer between the thiol group and guanidyl unit. A conjugate between thiol and guanidyl units with a diethylene glycol spacer (GdnDEG-SH) showed lower folding promotion effect compared to the thiol-guanidyl conjugate without the spacer (GdnSH). Lower acidity and a more reductive property of the thiol group of GdnDEG-SH compared to those of GdnSH likely resulted in the reduced efficiency of the folding promotion. Thus, the spacer between the thiol and guanidyl groups is critical for the promotion of oxidative protein folding. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6SDS of cas: 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. SDS of cas: 139115-91-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2011,Liu, Run-feng; Zhang, Heng; Zhong, Wu published 《Preparation of 2-(2-((6-chlorohexyl)oxy)ethoxy)ethanamine》.Huaxue Shiji published the findings.Name: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The information in the text is summarized as follows:

A new method for the preparation of 2-(2-((6-chlorohexyl)oxy)ethoxy)ethanamine is described. 2-(2-Aminoethoxy)ethanol was protected by BOC group, followed by etherification and deprotection, providing the titled compd in overall yield of 11.4%. In the experimental materials used by the author, we found tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Name: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Name: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Room-Temperature-Processed Fullerene/TiO2 Nanocomposite Electron Transporting Layer for High-Efficiency Rigid and Flexible Planar Perovskite Solar Cells》 was written by Wang, Ping-Cheng; Govindan, Venkatesan; Chiang, Chien-Hung; Wu, Chun-Guey. Electric Literature of C9H19NO4 And the article was included in Solar RRL in 2020. The article conveys some information:

Room-temperature-processed TiO2 (R-Lt-TiO2) electron transporting layers (ETLs) possess low conductivity and connectivity, resulting in poor photovoltaic performance. Herein, an ethanol (EtOH)-soluble, highly conducting fullerene derivative, C60RT6, was used as an additive for Lt-TiO2 ETLs. Room-temperature processed nanocomposite ETL (R-Fu/Lt-TiO2) is prepared simply by spin coating a C60RT6 and G-TiO2 NPs (TiO2 nanoparticle prepared by grinding the bulk TiO2 powder) mixture R-Fu/Lt-TiO2 has better aligned with the frontier orbitals of the FAxMA1-xPbI3, better continuity, conductivity, flatness, and higher surface hydrophilicity compared to Lt-TiO2 ETL. Perovskite films spin coated on R-Fu/Lt-TiO2 ETLs also have slightly larger grains and thickness compared to those deposited on Lt-TiO2. Perovskite solar cells (PSCs) based on a R-Fu/Lt-TiO2 ETL possess higher power conversion efficiency (PCE, up to 20% on glass substrate), less (negligible) current hysteresis, and better long-term stability compared to those using R-Lt-TiO2 as an ETL. The flexible PSC (used indium tin oxide/polyethylene terephthalate (ITO/PET) as a substrate) with a R-Fu/Lt-TiO2 ETL achieves a PCE of 18.06% and retains 90% of the initial PCE after 500 bending cycles with a bending radius of 6 mm. The PCE of the flexible cell with a Lt-TiO2 ETL is only 8.2%, and loses 60% of the initial value after 500 bending cycles. In the experiment, the researchers used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Electric Literature of C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Electric Literature of C9H19NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem