Category: 135-02-4

《Green synthesis of 1H-pyrazolo[1,2-b]phthalazine-2-carbonitrile derivatives using a new bifunctional base-ionic liquid hybrid magnetic nanocatalyst》 was written by Hamidinasab, Mahdia; Bodaghifard, Mohammad Ali; Mobinikhaledi, Akbar. Synthetic Route of C8H8O2 And the article was included in Applied Organometallic Chemistry in 2020. The article conveys some information:

The ionic liquid-base N,N,2,2,6,6-hexamethyl-N-(3-(trimethoxysilyl)propyl)piperidin-4-ammonium iodide was grafted onto titana-coated NiFe2O4 nanoparticles for obtaining an efficient and reusable ionic liquid-base hybrid nanocatalyst. The structure of hybrid nanoparticles was characterized using FT-IR (Fourier-transform IR spectroscopy), field emission SEM, EDS (energy-dispersive X-ray spectroscopy), EDS map scan, Brunauer-Emmett-Teller surface area anal., CHN (elemental anal.), vibrating sample magnetometer and thermogravimetric anal. techniques. Furthermore, this novel hybrid catalyst was used in one-pot three-component synthesis of 3-amino-1-aryl-5,10-dioxo-1H-pyrazolo[1,2-b]phthalazine-2-carbonitrile derivatives I [R = H, 2-Cl, 4-NO2, etc.] under green and environmentally benign conditions. This protocol avoids the use of harmful catalysts, toxic solvents and harsh reaction conditions. The products were synthesized in excellent yields within short reaction time and identified using elemental anal., FT-IR, 1H NMR and 13C NMR spectroscopies. The results came from multiple reactions, including the reaction of 2-Methoxybenzaldehyde(cas: 135-02-4Synthetic Route of C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Synthetic Route of C8H8O2

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Ni0 NPs anchored on acid-activated montmorillonite (Ni0-Mont) as a highly efficient and reusable nanocatalyst for synthesis of biscoumarins and bisdimedones》 were Rahmani, Soleiman; Zeynizadeh, Behzad. And the article was published in Research on Chemical Intermediates in 2019. Electric Literature of C8H8O2 The author mentioned the following in the article:

Ni0 nanoparticles were immobilized on acid-activated montmorillonite (Ni0-Mont) by anchoring Ni(OAc)2·4H2O on modified micro/mesoporous montmorillonite followed by reduction with ethylene glycol. The prepared clay composite system was then characterized using Fourier-transform IR (FT-IR) spectroscopy, SEM, energy-dispersive X-ray (EDX) spectroscopy, X-ray diffraction (XRD) anal., and Brunauer-Emmett-Teller (BET) anal. SEM anal. revealed perfect dispersion of metallic nickel nanoparticles with size distribution of 6-41 nm on the clay matrix. Micro/mesoporous montmorillonite was prepared by activation of Na+-montmorillonite with HCl (4 M) under controlled conditions. The catalytic activity of the prepared Ni0-Mont clay was studied in one-pot microwave-assisted synthesis of biscoumarins and bisdimedones via Knoevenagel reaction of aromatic aldehydes with 4-hydroxycoumarin or dimedone in solvent-free conditions. All reactions were carried out at room temperature within 5-15 min (for biscoumarins) and 5-20 min (for bisdimedones) to afford the products in high to excellent yield. The reusability of the Ni0-Mont catalyst was also investigated in seven consecutive cycles, without significant loss of catalytic activity. In the experimental materials used by the author, we found 2-Methoxybenzaldehyde(cas: 135-02-4Electric Literature of C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Electric Literature of C8H8O2

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Ether – Wikipedia,
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SDS of cas: 135-02-4In 2020 ,《Experimental and DFT mechanistic insights into one-pot synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones under catalysis of DBU-based ionic liquids》 appeared in New Journal of Chemistry. The author of the article were Fallah-Ghasemi Gildeh, Sara; Mehrdad, Morteza; Roohi, Hossein; Ghauri, Khatereh; Fallah-Ghasemi Gildeh, Sahar; Rad-Moghadam, Kurosh. The article conveys some information:

Benzylation of DBU followed by anion exchange of the resulting salt with trifluoroacetate gave nearly quant. ionic liq [Bn-DBU][TFA]. It is shown here to be an efficient catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones I (Ar = 4-nitrophenyl, 3-chlorophenyl, 2-methylphenyl, etc.; X = CN, COOEt) via the three-component reaction of phthalhydrazide, aromatic aldehydes ArCHO, and active α-methylene nitriles XCH2CN. DFT calculations at the B3LYP/SVP level and the exptl. results are in agreement with a three-step mechanism for this reaction. Based on the DFT calculations, the catalytic effect largely arises from the intrinsic ionic properties of the ionic liquid rather than its action as a simple base. These calculations also predict the existence of two close-in-energy activated complexes whose rate determining roles and energies depend on their interaction with the anionic component of the ionic liquid, as [Bn-DBU][TFA] has shown a higher catalytic activity than [Bn-DBU][OAc]. This mechanistic approach opens up new and promising insights into the rational design of ionic liquid catalysts for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones I. The synthetic method presented here has several prominent advantages. The experimental part of the paper was very detailed, including the reaction process of 2-Methoxybenzaldehyde(cas: 135-02-4SDS of cas: 135-02-4)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.SDS of cas: 135-02-4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Benzaldehyde and derivatives N(4)-phenyl-3-thiosemicarbazones: synthesis, characterization and biological activity》 was written by Glinma, Bienvenu; Medegan, Sedami; Yayi, Eleonore; Kpoviessi, Salome; Bero, Joanne; Quetin-Leclercq, Joelle; Poupaert, Jacques; Accrombessi, Georges; Gbaguidi, Fernand. SDS of cas: 135-02-4This research focused onthiosemicarbazone preparation antiparasitic activity. The article conveys some information:

A class of small mols., thiosemicarbazones and derivatives have been studied over the last few years due to their wide pharmacol. versatility. Due to having this wide-spectrum biol. activity, interest on these compounds has been considerably increased in the pharmaceutical sector at the present time. Here, benzaldehyde and derivatives were used on N(4)-phenyl-3-thiosemicarbazide with glacial acetic acid to synthesize four thiosemicarbazones corresponding (1-4) in good yields (64-85%). Structures of compounds were characterized by spectrometric alanal.: FT-IR, NMR 1H & 13C and MS spectra. A theor. study based on their chem. structure has been made. In vitro antiparasitic activity of products has been evaluated on the on the bloodstream form of the strain 427 of Trypanosoma bruceibrucei. All compounds presented phys. properties compatible with reasonable pharmacokinetics and drug availability, but they showed a low half inhibitory concentration (IC50> 100 μM) and then were not actives on the trypanosomes tested. Other biol. activity would be explored on other pathogens. The experimental part of the paper was very detailed, including the reaction process of 2-Methoxybenzaldehyde(cas: 135-02-4SDS of cas: 135-02-4)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.SDS of cas: 135-02-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Khaligh, Nader Ghaffari; Mihankhah, Taraneh published an article in Polycyclic Aromatic Compounds. The title of the article was 《Green and Solid-Phase Synthesis of New Dihydro-[1,2,4]Triazolo[1,5-a]Pyrimidine Scaffolds by Using Poly-Melamine-Formaldehyde as a Nitrogen-Rich Porous Organocatalyst》.Category: ethers-buliding-blocks The author mentioned the following in the article:

This work presented a new catalytic application of porous poly-melamine-formaldehyde (mPMF) for the efficient synthesis of dihydro-[1,2,4]triazolo[1,5-a]pyrimidines I [Ar = 2-MeOC6H4, 4-O2NC6H4, 2,4,6-tri-MeOC6H2, etc.]. According to the principles of green chem., the reaction was performed by planetary ball milling process at ambient and neat conditions. The heterogeneous catalyst could be reused up to five runs with no reducing of catalytic efficiency. A variety of dihydro-[1,2,4]triazolo[1,5-a]pyrimidines I were obtained in good to excellent yields under eco-friendly conditions. This work revealed that bifunctional porous organic polymers (POPs) containing base sites and acceptor-donner hydrogen bonding groups, as well as high porosity could play a vital role in the promotion of the one-pot multicomponent reactions in the solid phase. The main merits of current methodol. included short reaction time, wide substrate-scope and use of a metal-free heterogeneous organocatalyst, simple work-up process. The results came from multiple reactions, including the reaction of 2-Methoxybenzaldehyde(cas: 135-02-4Category: ethers-buliding-blocks)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Category: ethers-buliding-blocks

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C8H8O2In 2020 ,《4,4′-Trimethylenedipiperidine (TMDP): An Efficient Organocatalyst for the Mechanosynthesis of Pyrano[4,3-b]pyrans under Solid-state Conditions》 appeared in Polycyclic Aromatic Compounds. The author of the article were Khaligh, Nader Ghaffari; Mihankhah, Taraneh; Rafie Johan, Mohd. The article conveys some information:

This paper presents a green protocol for the synthesis of pyrano[4,3-b]pyrans using a catalytic amount of 4,4′-trimethylenedipiperidine (TMDP) as a novel, efficient and recyclable organocatalyst through ball milling process at room temperature The essential part of this protocol is a Knoevenagel condensation and to the best of our knowledge, this is the first report that exhibits the catalytic efficiency 4,4′-TMDP for the one-pot multicomponent reaction under melt-state conditions. The scope of the present protocol was explored and demonstrated for the synthesis of pyrano[4,3-b]pyrans in an environment-friendly protocol. The several interesting features of the present methodol. are including a cost-effectiveness procedure, good to excellent yield of the desired products, high reaction rate, a broad substrate-scope, and recyclability of organocatalyst; as well as the 4,4′-TMDP is a nontoxic, inexpensive, and com. available catalyst. Furthermore, this efficient methodol. displays a combination of the synthetic virtues of conventional multicomponent reaction with ecol. benefits and convenience of a facile mechanochem. process. The experimental part of the paper was very detailed, including the reaction process of 2-Methoxybenzaldehyde(cas: 135-02-4Synthetic Route of C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Synthetic Route of C8H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Acidic Ionic Liquid [H-NP]HSO4 Promoted One-Pot Synthesis of Dihydro-1H-Indeno[1,2-b]pyridines and Polysubstituted Imidazoles》 was written by Alinezhad, Heshmatollah; Tajbakhsh, Mahmoud; Maleki, Behrooz; Pourshaban Oushibi, Fereshteh. Electric Literature of C8H8O2This research focused ontriphenyl imidazole one pot preparation green chem; tetraphenyl imidazole one pot preparation green chem; ethyl phenyl dihydroindenopyridine carboxylate one pot preparation green chem; pyrrolidonium sulfonate ionic liquid preparation recyclability. The article conveys some information:

A green and efficient protocol for the one-pot synthesis of dihydro-1H-indeno[1,2-b]pyridines and polysubstituted imidazoles using a recyclable acidic ionic liquid [H-NP]HSO4 (H-NPBS) was reported. Non-corrosiveness, safe, low waste, generality, simplicity, easy for separation, short reaction times, high yields and environmentally benign were some of the advantages of this methodol. The [H-NP]HSO4 (H-NPBS) was effectively recycled for six consecutive cycles without appreciable loss in its activity.2-Methoxybenzaldehyde(cas: 135-02-4Electric Literature of C8H8O2) was used in this study.

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Electric Literature of C8H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Journal of Molecular Structure included an article by Maddila, Surya Narayana; Maddila, Suresh; Khumalo, Mandlenkosi; Bhaskaruni, Sandeep V. H. S.; Jonnalagadda, Sreekantha B.. Reference of 2-Methoxybenzaldehyde. The article was titled 《An eco-friendly approach for synthesis of novel substituted 4H-chromenes in aqueous ethanol under ultra-sonication with 94% atom economy》. The information in the text is summarized as follows:

An operational approach for synthesis of eleven substituted 4H-chromene derivatives I (R = 2-CH3OC6H4, 4-CF3C6H4, pyridin-3-yl, etc.; R1 = Me, Et) by one-pot, three-component reaction of aromatic aldehydes RCHO, Me/Et cyanoacetate and 5,5 di-Me 1,3-cyclohexadione through ultrasound irradiation, in the presence of aqueous ethanol under catalyst-free condition is reported. Different spectral methods, including 1H, 13C and 15N NMR and HRMS were utilized to characterize the new mols. Benefits of the eco-friendly method are fast reaction (10 min), excellent yields (92-98%), no column chromatog. and no byproducts. Reaction offers 94% atom economy and 100% carbon capture. In the part of experimental materials, we found many familiar compounds, such as 2-Methoxybenzaldehyde(cas: 135-02-4Reference of 2-Methoxybenzaldehyde)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Reference of 2-Methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Synthesis and Anti-Microbial Activity of Benzylidenhydrazides of Glycyrrhetic Acid》 was written by Baltina, L. A.; Kondratenko, R. M.; Bulgakov, A. K.. COA of Formula: C8H8O2 And the article was included in Russian Journal of Bioorganic Chemistry in 2020. The article conveys some information:

New derivatives of glycyrrhetic acid with hydrazide pharmacophore groups I (R = C6H5, 4-HOC6H4, 4-MeOC6H4, 2-MeOC6H4, 4-(Me)2NC6H3) were synthesized and their antimicrobial activity was evaluated. Compound I (R = 4-HOC6H4) exhibited the highest antimicrobial activity. This compound had both an antibacterial effect against Escherichia coli, Proteus vulgaris, Klebsiella pneumonia, Staphylococcus aureus, Citrobacter diversus, Enterobacter aerogenes, Pseudomonas aeruginosa, and Enterobacter cloacae and antifungal activity against the Candida albicans fungus. The min. inhibitory concentrations of this compound and pimafucin were similar for Candida albicans. In the part of experimental materials, we found many familiar compounds, such as 2-Methoxybenzaldehyde(cas: 135-02-4COA of Formula: C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.COA of Formula: C8H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Introduction of a new bis-derivative of succinimide (Bis-Su) as a sustainable and efficient basic organo-catalyst for the synthesis of arylidene malononitrile and tetrahydrobenzo[b]pyran derivatives under green conditions》 was published in Research on Chemical Intermediates in 2020. These research results belong to Hassanzadeh, Fariba; Daneshvar, Nader; Shirini, Farhad; Mamaghani, Manouchehr. Product Details of 135-02-4 The article mentions the following:

In this work, a new bis-succinimide (Bis-Su) compound 1-[4-(2,5-dioxopyrrolidin-1-yl)butyl]pyrrolidine-2,5-dione is prepared, identified and used as a green and efficient basic organo-catalyst for the promotion of the synthesis of arylidene malononitriles ArCH=C(CN)2 (Ar = C6H5, 4-ClC6H4, (E)-4-NO2C6H4CH=CH, etc.) and tetrahydrobenzo[b]pyrans I. Using this method, both of the reactions were performed under mild conditions, during short reaction times in high yields. The catalyst can also be recycled and reused several times without a considerable decrease in its activity. In the experiment, the researchers used 2-Methoxybenzaldehyde(cas: 135-02-4Product Details of 135-02-4)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Product Details of 135-02-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem