Category: 13468-02-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13468-02-5, name is N,N-Dimethyl-2-phenoxyethanamine, A new synthetic method of this compound is introduced below., Recommanded Product: 13468-02-5

The N, N – dimethyl – N – [(2 – phenoxy) ethyl] amine (1.65 g, 10 . 00 mmol) dissolved in dichloromethane (10 ml) in, under ice bath slowly […] sulfonic acid (2.5 ml The system for the ice in the pouring, adding dichloromethane (50 ml), separating the organic layer, drying with anhydrous sodium sulfate, concentrated under reduced pressure to obtain the crude intermediate 6 a, directly Used for the next step reaction.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Chengdu Xiandao Pharmaceutical Development Co., Ltd.; Li Jin; Wang Wei; Chu Hongzhu; Lv Kaizhi; Liu Lichuan; Nong Yunhong; Chen Wei; (17 pag.)CN110256416; (2019); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 13468-02-5,Some common heterocyclic compound, 13468-02-5, name is N,N-Dimethyl-2-phenoxyethanamine, molecular formula is C10H15NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The oil XI 132g (0.8mol), 30% concentrated hydrochloric acid 195g (1.6mol) was dissolved in 400ml of water with stirring, at -10 temperature or less, 40% formaldehyde was slowly added dropwise a solution of 40g (0.8mol) reaction was continued for 2 hours; TLC monitoring completion of the reaction, the pH was adjusted to 8 with sodium carbonate to 9, and extracted twice with dichloromethane, organic phases were combined and concentrated to give an oil, 300ml ethyl acetate was added to dissolve,Was added dropwise 30% HCl / ethanol, precipitated crystals were filtered to give 112.7g compound XII, a yield of 56.3%;

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N,N-Dimethyl-2-phenoxyethanamine, its application will become more common.

Reference:
Patent; Weihai Di Su Pharmaceutical Co., Ltd.; Wu, Ronggui; Jiang, Kai; An, Donghua; Cui, Yangyang; Men, Lianbin; (7 pag.)CN105985257; (2016); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 13468-02-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13468-02-5 name is N,N-Dimethyl-2-phenoxyethanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Intermediate Example 2 Preparation of [2-(dimethylamino)ethoxy]phenyl-4-sulfonyl chloride 2 g of N,N-dimethyl-N-[(2-phenoxy)ethyl]amine was dissolved in 10 ml of dichloromethane and 3 ml of chlorosulfonic acid was slowly added under ice cooling. The mixture was stirred at room temperature for 3 hr and poured into ice. Dichloromethane (100 ml) was added and aqueous layer was neutralized by concentrated sodium carbonate solution with keeping temperature under 4 C. Dichloromethane layer was dried over anhydrous magnesium sulfate and evaporated under reduced pressure. 0.8 g of [2-(dimethylamino)ethoxy]phenyl-4-sulfonyl chloride was obtained.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, N,N-Dimethyl-2-phenoxyethanamine, and friends who are interested can also refer to it.

Reference:
Patent; Regents of the University of California; The United States of America as represented by the Department of Veteran Affairs; Winston Pharmaceuticals, LLC; US6559167; (2003); B1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 13468-02-5,Some common heterocyclic compound, 13468-02-5, name is N,N-Dimethyl-2-phenoxyethanamine, molecular formula is C10H15NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 5 – Sodium 4-(2-dimethylaminoethoxy)-benzenesulfonate 7.00 g (42.4 mmol) of dimethyl-(2-phenoxyethyl)-amine were dissolved in 35 mL of glacial acetic acid and cooled in an ice bath. 9.63 g (93.3 mmol) of 95% sulfuric acid were dropped in while maintaining an internal temperature of 10C or lower followed by stirring for 1 hour at room temperature. The solution was concentrated followed by the gradual addition of the concentrated residue to 1 mol/L sodium hydroxide to bring pH10, after which the solution was concentrated and dried. After extracting the residue with methanol, concentrating and drying, the residue was suspended in 100 mL of ethanol followed by cooling and filtration. The filtrate was concentrated and the precipitated crystals were filtered to obtain 8.36 g of the target substance (yield: 74%). 1H-NMR (400 MHz, D2O): delta = 7.68 (d,2H,J=8.8 Hz), 7.01 (d,2H,J=8.8 Hz), 4.33 (t,2H,J=5.0 Hz), 3.53 (t,2H,J=5.2 Hz) 13C-NMR (400 MHz, D2O): delta = 158.12, 133.61, 125.61, 112.90, 61.79, 59.66, 41.70 IR (KBr): nu = 3431, 3097, 2770, 1599, 1180, 1032, 844 cm-1

The synthetic route of 13468-02-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dainippon Ink and Chemicals, Incorporated; EP1736464; (2006); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem