Category: 134-96-3

Babatunde, Oluwatoyin published the artcileDihydroquinazolin-4(1H)-one derivatives as novel and potential leads for diabetic management, Application In Synthesis of 134-96-3, the publication is Molecular Diversity (2022), 26(2), 849-868, database is CAplus and MEDLINE.

A variety of dihydroquinazolin-4(1H)-one derivatives (1-37) were synthesized via “one-pot” three-component reaction scheme by treating aniline and different aromatic aldehydes with isatoic anhydride in the presence of acetic acid. Chem. structures of compounds were deduced by different spectroscopic techniques including EI-MS, HREI-MS, 1H-, and 13C-NMR. Compounds were subjected to α-amylase and α-glucosidase inhibitory activities. A number of derivatives exhibited significant to moderate inhibition potential against α-amylase (IC₅₀ = 23.33 ± 0.02-88.65 ± 0.23 μM) and α -glucosidase (IC₅₀ = 25.01 ± 0.12-89.99 ± 0.09 μM) enzymes, resp. Results were compared with the standard acarbose (IC₅₀ = 17.08 ± 0.07 μM for α-amylase and IC₅₀ = 17.67 ± 0.09 μM for α -glucosidase). Structure-activity relationship (SAR) was rationalized by analyzing the substituents effects on inhibitory potential. Kinetic studies were implemented to find the mode of inhibition by compounds which revealed competitive inhibition for α-amylase and non-competitive inhibition for α-glucosidase. However, in silico study identified several important binding interactions of ligands (synthetic analogs) with the active site of both enzymes.

Molecular Diversity published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Application In Synthesis of 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kaal, Joeri published the artcileFingerprinting macrophyte Blue Carbon by pyrolysis-GC-compound specific isotope analysis (Py-CSIA), Category: ethers-buliding-blocks, the publication is Science of the Total Environment (2022), 155598, database is CAplus and MEDLINE.

There is a need for tools to determine the origin of organic matter (OM) in Blue Carbon Ecosystems (BCE) and marine sediments to (1) facilitate the implementation of Blue Carbon strategies into carbon accounting and crediting schemes and (2) decipher changes in ecosystem condition over decadal to millennial time scales and thus to understand and predict the stability of BCE in a changing world. Pyrolysis-GC-compound specific isotope anal. (Py-CSIA) is applied for the first time in marine environments and BCE research. We studied Australian mangrove, tidal marsh and seagrass sediments, in addition to potential sources of OM (Avicennia, Posidonia, Zostera, Sarcocornia, Ecklonia and Ulva species and seagrass epiphytes), to identify precursors of different biomacromol. constituents (lignin, polysaccharides and aliphatic structures). Firstly, the link between bulk δ¹³C and δ¹³C reconstructed from compound-specific δ¹³C showed that the pyrolysis approach allows for the isotopic screening of a representative portion of the OM. Secondly, for all samples, the C isotope fingerprint of the carbohydrate products (plant polysaccharides) was the heaviest (¹³C enriched), followed by lignin and aliphatic products. The differences in δ¹³C among macromols. and the overlap in δ¹³C among putative sources reflect the limitations of bulk δ¹³C analyses for deciphering OM provenance. Thirdly, phanerogams specimen had the heaviest carbohydrate and lignin, confirming that seagrass-derived lignocellulose can be traced based on δ13C. Consistent differences for individual compounds were identified between seagrasses and between Avicennia and Sarcocornia using Py-CSIA. Fourth, ecosystem shifts (colonization of seagrass habitats by mangrove) on millenary time scales, hypothesized in previous studies on the basis of bulk δ13C and Py-GC-MS, were confirmed by Py-CSIA. We conclude that Py-CSIA is useful in Blue Carbon research to decipher OM sources in marine sediments, identify ecosystem transitions in palaeoenvironmental records, and to understand the role of different OM compounds in Blue Carbon storage.

Science of the Total Environment published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Pawar, Gaurav published the artcileCu(I)-Catalyzed Microwave-Assisted Multicomponent Reaction Towards Synthesis of Diverse Fluorescent Quinazolino[4,3-b]quinazolin-8-ones and Their Photophysical Study, Related Products of ethers-buliding-blocks, the publication is ChemistrySelect (2022), 7(14), e202200500, database is CAplus.

A novel, base- and ligand-free one pot protocol for the synthesis of fused-quinazolinone under microwave irradiation using environmentally friendly PEG-400 as a solvent has been developed. Besides benzaldehyde, various benzyl alcs. and Me arenes were used in this protocol, which extend its synthetic applicability. Photophys. study of this highly fluorescent framework was studied by fluorescent study. DFT and ESI/MS studies were carried out to justify the proposed mechanism.

ChemistrySelect published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Guo, Xingjie published the artcileSelective hydrogenation of vanillin to vanillyl alcohol over Pd, Pt, and Au catalysts supported on an advanced nitrogen-containing carbon material produced from food waste, Synthetic Route of 134-96-3, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2022), 135885, database is CAplus.

Food waste worldwide has been threatening the environment and resulting in high carbon emissions. Although anaerobic fermentation is a potential solution transforming food waste into valuable chems., a large amount of the fermentation residue remains as solid waste. For closing the circular economy loop for food waste valorization, we proposed a thermo-chem. activation of a fermentation residue produced from a mixture of food waste and sludge to prepare a nitrogen-enriched, advanced carbon material. This could be used as a support to synthesize Pd/C, Pt/C and Au/C catalysts for the aqueous-phase hydrogenation of vanillin to vanillyl alc. at mild reaction conditions. The produced alc. increased sixfold the com. value of the original aldehyde. The catalytic performance (based on the vanillin conversion and vanillyl alc. yield) followed the order of Pd/C > Pt/C > Au/C. The Pd/C catalyst showed an excellent catalytic activity (>99% vanillin conversion and > 99% vanillyl alc. selectivity) at optimized reaction conditions (i.e., 30°C and 0.7 MPa H₂ for 90 min, with 2 mmol vanillin/10 mg catalyst), along with high reusability and stability (up to four consecutive runs). These catalytic features outperformed those of a com. Pd/C catalyst owing to: (i) high reduction degree and stabilization of the Pd particles on the carbon support, which accommodated a higher proportion of pyridinic than pyrrolic nitrogen, and (ii) rapid adsorption of the aldehyde group on the catalyst combined with rapid desorption of the newly formed hydroxymethyl group. This exceptional catalytic behavior was corroborated by efficient hydrogenation of other lignin-derived aromatic aldehydes, including p-hydroxybenzaldehyde and syringaldehyde, to their resp. alcs. Our results can bring a novel use for food waste in catalysis and represent a sustainable and efficient conversion of biomass into value-added chems. and advanced materials.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Synthetic Route of 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Katariya, Ashishkumar P. published the artcileIonic Liquid Promoted Regio-Selective Synthesis of 2-Methyl amino-3-Nitro-pyrano[3,2-c]chromen-5-ones, Related Products of ethers-buliding-blocks, the publication is ChemistrySelect (2022), 7(23), e202201295, database is CAplus.

An efficient, and simple protocol for the synthesis of extremely functionalized pyrano[3,2-c]chromen-5-ones has been developed. One-pot multicomponent cyclo-condensation of 4-hydroxycoumarin, aromatic-aldehydes, and (E)-N-methyl-1-(methylthio)-2-nitroethenamine (NMSM) catalyzed by ionic liquid [(EMIM)Ac] in two different methods as methanolic mediated and at solvent free condition is described which presumably involve the Knoevenagel reaction succeeding Michael-addition and O-cyclization with elimination of methanethiol. The noteworthy features of this protocol are use of ionic liquid as catalyst, good to excellent yield, optimum reaction time with easy exptl. procedure.

ChemistrySelect published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chen, Shuotong published the artcilePool complexity and molecular diversity shaped topsoil organic matter accumulation following decadal forest restoration in a karst terrain, Quality Control of 134-96-3, the publication is Soil Biology & Biochemistry (2022), 108553, database is CAplus.

Fast accumulation of soil organic matter (SOM) following forest restoration shifted from cropland has been widely reported, but how the pools and mol. composition change across soil aggregate fractions remains unclear. In this study, undisturbed topsoil (0-10 cm) samples were collected across a decadal chronosequence of forest stands (RL10, RL20 and RL40) restored for 10, 20 and 40 years following maize cropland (CL) abandonment in a karst terrain of Guizhou, Southwest China. SOM changes were explored using the size and d. fractionation of water-stable aggregates, 13C isotopic signalling and biomarker analyses as well as 13C solid-state NMR assays. Compared to that of CL, SOM content was increased by 24%, 79% and 181%, mass proportion of macroaggregates increased by 136%, 179% and 250%, and particulate organic matter (POM) increased by 13%, 108% and 382%, resp. at RL10, RL20 and RL40. With biomarker analyses, the relative abundances of plant-derived organics (lignin, cutin, suberin, wax and phytosterols), mostly protected in aggregates, increased, while those of microbe-derived OC, predominantly mineral bound, decreased in response to prolonged forest restoration. Calculated as per the Shannon diversity index (H’), changes in SOM pool complexity and mol. diversity were parallel to the SOM accumulation trend. The pool size ratio of POM to MAOM (mineral-associated organic matter) and the mol. abundance ratio of PL (plant-derived lipids) to ML (microbe-derived lipids) appeared to be indicative of SOM accumulation following forest restoration. With prolonged forest restoration, the topsoil OM shifted from microbial MAOM dominance to plant-derived POM dominance. Furthermore, the great topsoil OM enhancement in restored forest stands was shaped by pool complexity and mol. diversity changes with the complex interactions among plant-microbial-mineral assemblages in the karst topsoil. Both the pool complexity and mol. diversity of SOM should be considered in addressing carbon sequestration with forest restoration concerning the functioning of soil ecosystems and services under global change pressures.

Soil Biology & Biochemistry published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Quality Control of 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Vicente, Estela D. published the artcileCytotoxicity and mutagenicity of particulate matter from the open burning of pruning wastes, Safety of 4-Hydroxy-3,5-dimethoxybenzaldehyde, the publication is Air Quality, Atmosphere & Health (2022), 15(2), 299-310, database is CAplus.

Burning vegetative debris is a worldwide long-standing practice. The current study was designed to examine the cytotoxicity and mutagenicity of particulate matter with an aerodynamic diameter below 10 μm (PM10) released from the burning of pruning residues common in Portugal and other countries of the Mediterranean region. Field measurements were conducted to collect PM10 samples from open burning of vines, olive, willow and acacia pruning branches. To assess the cytotoxicity of the PM10 total organic extract, the A549 cell line, representative of the alveolar type II pneumocytes of the human lung, was used. The cytotoxicity was checked using two complementary methods: water-soluble tetrazolium (WST-8) test to evaluate the cell metabolic activity and lactate dehydrogenase (LDH) activity assay to assess the loss of cell membrane integrity. The mutagenicity of the PM10-bound polycyclic aromatic hydrocarbons (PAHs) was screened through the Ames test. PM10 organic extracts induced LDH release in a dose-dependent manner. Regarding the cellular metabolic activity, dose-dependency was lacking for the majority of the samples. Combined WST-8 and LDH data indicate that PM10 exposure induce a necrotic cell death pathway in which the cell membrane integrity is lost. Direct and indirect mutagenicity towards the TA98 Salmonella strain has been recorded for the PAH extracts of PM10 collected from combustion of vine and willow branches during the ignition/flaming combustion stage. Significant correlations were found between the cytotoxic responses (WST-8 and LDH) and the PM10 organic component.

Air Quality, Atmosphere & Health published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C12H25Br, Safety of 4-Hydroxy-3,5-dimethoxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Cody, Robert B. published the artcileIntegrated data analysis making use of the total information from gas chromatography and high-resolution time-of-flight mass spectrometry to identify qualitative differences between two whisky samples, Name: 4-Hydroxy-3,5-dimethoxybenzaldehyde, the publication is Rapid Communications in Mass Spectrometry (2022), 36(3), e9225, database is CAplus and MEDLINE.

Anal. of complex mixtures with gas chromatog. coupled with high-resolution time-of-flight mass spectrometry (GC/HRTOFMS) can produce a large amount of data. A new software program was recently reported that integrates all of the available mass spectrometric information from GC/HRTOFMS anal. into a concise report. New capabilities have now been added to the software to incorporate retention index data and to identify differences between two samples. Two Scotch whisky samples were sampled by solid-phase microextraction (SPME) and analyzed by GC/HRTOFMS. One of the two whisky samples (Sample B) was identical to the other sample (Sample A) except for an addnl. 6-mo storage in sherry casks. Both electron ionization (EI) and chem. ionization (CI) data were obtained using a new GC/TOFMS system (JEOL AccuTOF GC-Alpha) with enhanced resolving power and mass accuracy. Statistical anal. of replicate measurements of the whisky samples was carried out with a new software program (msFineAnal. version 3.2) to identify and assign differences between the samples. There were 124 peaks detected in the two whiskies. Thirteen compounds were detected with a relative peak area greater than 0.05% that were present in greater amounts in the whisky that had been stored in sherry casks for an addnl. 6 mo. Ten of these compounds were identified by the software with high confidence, two were identified as isomers with close retention indexes, and one was identified interactively. The software identified small differences between the two samples that resulted from sherry cask aging. Because all of the information available from the hard and soft ionization analyses for each compound is summarized in a concise integrated report, the operator can rapidly determine the level of confidence for each assignment and inspect the information for compounds that are not present in the database.

Rapid Communications in Mass Spectrometry published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Name: 4-Hydroxy-3,5-dimethoxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Suleman, Zubair published the artcileNeuroprotective effects of Lippia javanica (Burm.F.) Spreng. Herbal tea infusion on Lead-induced oxidative brain damage in Wistar rats, HPLC of Formula: 134-96-3, the publication is BMC Complementary Medicine and Therapies (2022), 22(1), 4, database is CAplus and MEDLINE.

Though Lippia javanica (Burm.f.) Spreng antioxidant activity has been demonstrated, its effect in protecting the brain from lead (Pb)-induced oxidative damage is unknown. This study investigated the effect of L. javanica against Pb-induced oxidative stress, inflammation, apoptosis and acetylcholinesterase activity in rats brain. L. javanica herbal tea infusion was prepared, its phytochem. constituent was revealed by liquid chromatog.-Mass spectrometer (LC-MS) and was administered simultaneously with Pb. Four groups of male Wistar rats (n = 5/group) were used: control received distilled water; Pb-acetate group received 50 mg Pb/ Kg bodyweight (bw), treatment group received 50 mg Pb/ Kg Pb-acetate + 5 mL/kg bw L. javanica and L. javanica group received 5 mL/Kg bw of L. javanica tea infusion only. After 6 wk of treatment, oxidative status, acetylcholinesterase activity, inflammation and apoptosis was assessed in brain tissue which was also histol. examined Mean brain and heart weight was reduced (p < 0.05) while liver and spleen weights were increased (p < 0.05) in Pb exposed animals but were prevented by L. juvanica treatment. Treatment with L. javanica increased (p < 0.05) overall brain antioxidant status (glutathione and superoxide dismutase activities) and reduced lipid peroxidation (p < 0.05) compared to the Pb exposed animals. Pro-inflammatory cytokine tumor necrotic factor-alpha, pro-apoptosis Bax protein and anticholinesterase activity were reduced (p < 0.05) in Pb-L. javanica treated animals compared to the Pb exposed group. Histol. examination confirmed neuroprotective effects of L. javanica as evidenced by reduced apoptosis/necrosis and inflammation-induced vacuolization and edema in the hippocampus. The L. javanica treatment alone had no detrimental effects to the rats. LC-MS anal. revealed L. javanica to be rich in phenolics. This study demonstrated that L. javanica, rich in phenolics was effective in reducing Pb-induced brain oxidative stress, inflammation, apoptosis, acetylcholinesterase activity and neuronal damage.

BMC Complementary Medicine and Therapies published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C23H43NP2, HPLC of Formula: 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yang, Yang published the artcileIncreasing contribution of microbial residues to soil organic carbon in grassland restoration chronosequence, Synthetic Route of 134-96-3, the publication is Soil Biology & Biochemistry (2022), 108688, database is CAplus.

Grassland restoration across the world increases soil organic carbon (SOC) sequestration which is critical for global C cycling and CO₂ removal from the atm. However, the relative importance of plant- and microbially-derived C for SOC is still an open question for temperate grasslands. Here, amino sugars and lignin phenols were used as biomarkers to investigate the relative microbial and plant residue contribution to SOC in a 30-yr (1-, 5-, 10-, 15-, 25-, 30-yr) restoration chronosequence of temperate grassland. The contribution of microbially-derived C (from 4.9 to 13 g kg^-1) to SOC was much greater than that of plant-derived C (from 1.3 to 2.3 g kg^-1). At the early stage of restoration (<15 years), grassland soils accumulated more C in the form of plant-derived C. In contrast, grassland soils at the late stage of restoration (>15 years) accumulated more microbially-derived C, and less from plant residues. These findings highlight the dominance of microbial contribution to SOC stabilization compared with plant residues. The contribution of bacteria-derived C to SOC gradually increased from 29% to 50% with progress of grassland restoration, while the contribution of fungal C to SOC decreased from 30% to 21%. Consequently, microbial residue contribution to SOC shifts from fungal and bacterial to mainly bacterial residues during grassland restoration. This shift may be due to the faster bacterial growth and a increasing living biomass during grassland restoration, leading to higher accumulation of bacterial residues. Correlation anal. and random forest models showed that belowground plant biomass, soil pH, and living microbial biomass were the main factors regulating plant-derived C. The microbially-derived C in SOC, however, was dependent on living microbial biomass, soil pH and dissolved organic C. Concluding, grassland restoration increased soil C sequestration primarily by microbial necromass (mainly bacterial necromass), and is affected by abiotic and biotic factors, as well as plant C input.

Soil Biology & Biochemistry published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C8H11BO3, Synthetic Route of 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem